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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Evaluation and Management of Adult Hypoglycemic Disorders: An Endocrine Society Clinical Practice Guideline显示文摘 | Philip E. Cryer Lloyd Axelrod Ashley B. Grossman Simon R. Heller Victor M. Montori Elizabeth R. Seaquist F John Service | 2009 | The Journal of Clinical Endocrinology & Metabolism2009，，3： | 2 |
| 3 | The effects of ω3 fatty acids and coenzyme Q10 on blood pressure and heart rate in chronic kidney disease: a randomized controlled trial显示文摘 | Trevor A Mori Valerie Burke Ian B Puddey Ashley B Irish Christine A Cowpland Lawrence J Beilin Gursharan K Dogra Gerald F Watts | 2009 | Journal of Hypertension2009，，9： | 1 |
| 4 | Discrimination of hydrothermally altered rocks and unaltered rocks in visible and near infrared multi- spectral images显示文摘 | ROWAN L C GOETZ A F H ASHLEY R P | 1977 | Geophysics1977，42，3： | 1 |
| 5 | Improving the safety of chemo- therapy administration:An oncology nurse failure mode and effects a- nalysis显示文摘 | Ashley L Dexter R Marshall F | 2011 | Oncol Nurs For2011，38，6： | 1 |
| 6 | On Radar Detection and Direction Finding using Sparse Arrays显示文摘 | Ashley F Engdahl C Sunnergren P | | IEEE Transactions on Aerospace and Electronic Systems0，43，4： | 1 |
| 7 | Prognostic value of heart rate incrase at onset of exercise testing显示文摘 | Leeper N J Dewey F E Ashley E A | 2007 | Circulation2007，115，4： | 1 |
| 8 | Overexpression of AtCpNifS enhances selenium tolerance and accumulation in Arabidopsis显示文摘 | Douglas V H Gulnara F G Ashley R A | 2005 | Plant Physiol2005，139，： | 1 |
| 9 | Stereotactic radiotherapy ( SABR )for the treatment of primary non-small cell lung cancer; systematic review and comparison with a surgical cohort显示文摘 | Sold t F Lodge M Ashley S | 2013 | Radiother Oncol2013，109，1： | 1 |
| 10 | Bacterial endophytes: recent developments and applications显示文摘 | Robert P R Kieran G Ashley F | 2008 | FEMS Microbiol Letters2008，278，1： | 1 |
| 11 | Discrimination of hydrothermally altered and unaltered rocks in visible and near infrared multispectral images显示文摘 | Rowan L C Goetz A F H Ashley R P | 1977 | Geophysics1977，42，： | 1 |
| 12 | Staging system for breast cancer: revisions for the 6th edition of the AJCC Cancer Staging Manual显示文摘 | S.Eva Singletary Craig Allred Pandora Ashley Lawrence W Bassett Donald Berry Kirby I Bland Patrick I Borgen Gary M Clark Stephen B Edge Daniel F Hayes Lorie L Hughes Robert V.P Hutter Monica Morrow David L Page Abram Recht Richard L Theriault Ann Thor Don | 2003 | Surgical Clinics of North America2003，，4： | 1 |
| 13 | Discrimination of hydro thermally altered and unaltered rocks in visible and near infrared multi-spectral images 显示文摘 | ROWAN L C GOETZ A F H ASHLEY P | 1977 | Geophysics1977，，42： | 1 |
| 14 | A Gis-supported model for the simulation of the spatial structure of wild land fire,Cass Basin显示文摘 | George L M Perry Ashley D Sparrow Lan F Owens | 1999 | Journal of Applied Ecology1999，，36： | 1 |
| 15 | Face-lift complications: a study of 922 cases performed in a 6-year period显示文摘 | THOMPSON D P ASHLEY F L | 1978 | Plast Recon- str Surg1978，61，1： | 1 |
| 16 | Natural gas conversion to liquid fuels in a zone reactor显示文摘 | Ashley Breed Michael F Doherty Sagar Gadewar | 2005 | Catalysis Today2005，106，1234： | 1 |
| 17 | Improving the safety of chemotherapy administration: an oncology nurse- led fail- ure mode and effects analysis显示文摘 | Ashley L Dexter R Marshall F | 2011 | Oncol Nuts Forum2011，38，6： | 1 |
| 18 | Crossing Extreme Mechanistic Barriers By Antibody Catalysis:Syn Elimination to a Cis Olefin显示文摘 | Cravatt B F Ashley J A Janda K D | 1994 | J Am Chem Soc1994，116，13： | 1 |
| 19 | Expres- sion of interferon (IFN)-stimulated genes in extrau- terine tissues during early pregnancy in sheep is the consequence of endocrine IFN-tau release from the uterine vein 显示文摘 | Oliveira J F Henkes L E Ashley R L | 2008 | Endocrinol2008，149，3： | 1 |
| 20 | Antenna-coupled microbolometer arrays with aerogel thermal isolation 显示文摘 | Gonzalez F J Ashley C S Clem P G | 2004 | Infrared Physics & Technology2004，45，： | 1 |
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