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| 1 | All ileo-cecal ulcers are not Crohn's:Changing perspectives of symptomatic ileocecal ulcers显示文摘AIM To investigated clinical,endoscopic and histopathological parameters of the patients presenting with ileocecal ulcers on colonoscopy.METHODS Consecutive symptomatic patients undergoing colonoscopy,and diagnosed to have ulcerations in the ileocecal(I/C) region,were enrolled.Biopsy was obtained and theirclinical presentation and outcome were recorded.RESULTS Out of 1632 colonoscopies,104 patients had ulcerations in the I/C region and were included in the study.Their median age was 44.5 years and 59% were males.The predominant presentation was lower GI bleed(55,53%),pain abdomen ± diarrhea(36,35%),fever(32,31%),and diarrhea alone(9,9%).On colonoscopy,terminal ileum was entered in 96(92%) cases.The distribution of ulcers was as follows:Ileum alone 40%(38/96),cecum alone 33%(32/96),and both ileum plus cecum 27%(26/96).The ulcers were multiple in 98% and in 34% there were additional ulcers elsewhere in colon.Based on clinical presentation and investigations,the etiology of ulcers was classified into infective causes(43%) and noninfective causes(57%).Fourteen patients(13%) were diagnosed to have Crohn's disease(CD).CONCLUSION Non-specific ileocecal ulcers are most common ulcers seen in ileo-cecal region.And if all infections are clubbed together then infection is the most common(> 40%) cause of ulcerations of the I/C region.Cecal involvement and fever are important clues to infective cause.On the contrary CD account for only 13% cases as a cause of ileo-cecalulcers.So all symptomatic patients with I/C ulcers on colonoscopy are not Crohn's. | Jay Toshniwal Romesh Chawlani Amit Thawrani Rajesh Sharma Anil Arora Hardik L Kotecha Mohan Goyal Vijendra Kirnake Pankaj Jain Pankaj Tyagi Naresh Bansal Munish Sachdeva Piyush Ranjan Mandhir Kumar Praveen Sharma Vikas Singla Rinkesh Bansal Vineet Shah Sunita Bhalla Ashish Kumar | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，7： | 5 |
| 2 | Coexisting tubular adenoma with a neuroendocrine carcinoma of colon allowing early surgical intervention and implicating a shared stem cell origin显示文摘High-grade colonic neuroendocrine carcinomas (NECs) are uncommon but extremely aggressive. Their co-existence with tubular adenoma (TA) has rarely been reported. We present a 68-year-old man who was found on routine colonoscopy to have multiple colorectal TAs and an ulcerated lesion in the ascending colon. Microscopically, a poorly-differentiated invasive carcinoma juxtaposed with a TA was identified. Differential diagnosis included a poorly-differentiated adenocarcinoma, medullary carcinoma, high-grade NEC and lymphoma. The immunohistochemical profile showed positive staining for keratins, synaptophysin and chromogranin but negative for LCA, CDX2, CK7, CK20, TTF-1 and PSA, supporting the NEC diagnosis. Upon subsequent laparoscopic right hemicolectomy, the tumor was identified as a 3.0 cm umbilicated and ulcerated mass with an adjacent TA. Both TA and NEC showed positive staining for β-catenin indicating a shared colonic origin. The mitotic counts (77/10 high power fields) and a high proliferation rate (75% by Ki-67) corroborated a high-grade stratification. Mutational analysis indicated a wild-type BRAF and KRAS with mismatch repair proficiency. The AJCC(7th edition) pathologic stage is p T3, p N0, p Mx. The patient received adjuvant chemotherapy with cisplatin/etoposides for three cycles and will be followed up for a year to detect recurrence. In conclusion, the co-existence of TA with high grade-NEC in our case allowed early identificationand intervention of the otherwise asymptomatic but aggressive tumor. In addition, the finding of a highgrade NEC within a large TA in this case suggests a link between the two lesions and could represent a shared stem cell origin. | Mahmoud L Soliman Ashish Tiwari Qing Zhao | 2017 | World Journal of Gastroenterology2017，23，6： | 3 |
| 3 | Process de- velopment of an inherently safer oxidation: synthesis of 2-chloro-6-methylbenzoic acid in the R411 manufactur- ing process显示文摘 | Flavio C L Ashish S Maethonia T | 2005 | Organic Process Research ~ Develop- ment2005，9，： | 1 |
| 4 | Phytochelatin Plays a Role in UV-B Tolerance in N2-fixing Cyanobacterium Anabaena Doliolum显示文摘 | POONAM B ASHISH K S SNIGDHA U l | 2005 | J Plant Physiol(S0176-1617)2005，162，11： | 1 |
| 5 | Long-period fiber gratings as band-rejection filters显示文摘 | Ashish M V Paul J L Justin B J | 1996 | Lightwave Tech1996，14，1： | 1 |
| 6 | MicroRNAs and their target gene networks in breast cancer显示文摘 | Elizabeth O and Ashish L | 2010 | Breast Cancer Research2010，12，： | 1 |
| 7 | Photoacoustic tomography of joints aided by an Etanercept- conjugated gold nanoparticle contrast agent-an ex vivo preliminary rat study显示文摘 | David L Chamberland Ashish Agarwal Nicholas Kotov | 2008 | Nanotechnology2008，19，09： | 1 |
| 8 | A nearest neighbor bootstrap for resampling hydrologic time series 显示文摘 | UPMANU L ASHISH S | 1996 | Water Resour Res1996，32，3： | 1 |
| 9 | The Effect of Multi-purpose Shop on Price and Location Strategy for Grocery Stores显示文摘 | Peter T L Popkowski Leszczyc Ashish Sinha AnriaSahgal | 2004 | Journal of Retailing2004，80，2： | 1 |
| 10 | The New Economy and Opportunities for Airports 显示文摘 | David G Ashish L | 2002 | Journal of Air Transport Management2002，8，1： | 1 |
| 11 | Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol显示文摘 | ASHISH L FRANCISCO N CHRISTOPHER A M | 2008 | Neuron2008，59，2： | 1 |
| 12 | The direct economic burden of blunt and penetrating trauma in a managed care population显示文摘 | Keith L Davis MA Ashish V | 2007 | J Trauma2007，62，3： | 1 |
| 13 | Giant idiopathic renal arteriovenous fistula managed by coils and amplatzer device:Case report and literature review显示文摘An idiopathic renal arteriovenous(AV) fistula is a rare malformation of the kidney that may present insidiously with heart failure or hematuria.The treatment may be challenging due to large fistula size that may limit endovascular management.The authors report a case of an 85-year-old Caucasian woman who presented with acute heart failure and was found to have a right renal AV fistula.Since she had no prior history of renal intervention or trauma,a diagnosis of idiopathic renal AV fistula was made.She was managed by endoluminal occlusion using multiple stainless steel coils and Amplatzer vascular plug II device.The follow-up computed tomography showed complete occlusion of the fistula.This report highlights the late presentation of this rare disease and presents the utility of the combination of coils and Amplatzer device for management of a large fistula.It also reiterates that even if large,these fistulas can be managed by endovascular occlusion. | Prashant Nagpal Girish Bathla Sachin S Saboo Ashish Khandelwal Abhishek Goyal Frank J Rybicki Michael L Steigner | 2016 | World Journal of Clinical Cases2016，4，11： | 1 |
| 14 | Prediction of extrudate swell in polymer melt extrusion using an Arbitrary Lagrangian Eulerian (ALE) based finite element method显示文摘 | VTVEK G ASHISH L ROCHISH T | 2009 | Journal of Non-Newtonian Fluid Mechanics2009，156，： | 1 |
| 15 | Surface-enhanced Raman spectroeleetrochemistry of TTF-modified self-assembled monolayers显示文摘 | Walter F Paxton Samuel L Kleinman Ashish N Basuray | 2011 | J Phys Chem Lett2011，2，10： | 1 |
| 16 | Peripresthetic joint infection: the incidence, timing, and predisposing factors显示文摘 | Pulido L ( harlem E Ashish Joshi M D M P H | 2008 | Clinical Orthopaedics and Related Research2008，466，7： | 1 |
| 17 | A rheological study on the kinetics of hybrid formation in polypropylene nanocomposites显示文摘 | GIRISH G RAMESH C ASHISH L | 2001 | Macromolecules2001，3，4： | 1 |
| 18 | Infection does not increase long-term mortality in patients with acute severe alcoholic hepatitis treated with corticosteroids显示文摘AIM To determine whether infection in patients with acute severe alcoholic hepatitis(AAH) treated with corticosteroids is associated with increased mortality.METHODS Consecutive patients with AAH were treated with steroids and recruited to the study. Clinically relevant infections(body temperature > 38 ℃ or < 36 ℃ for more than 4 h, ascitic neutrophil count > 0.25 ×109/L, consolidation on chest radiograph or clinically relevant positive microbiological culture of bodily fluid) were recorded prospectively. Clinical and laboratory parameters were recorded and survival at 90 d and 6 mo was determined. Univariate analysis of factors associated with 90-d mortality was performed and significant variables included in a multivariate analysis.RESULTS Seventy-two patients were included in the final analysis(mean age 47.9 years, 26% female, mean discriminant function 53.0). Overall mortality in the group occurred in 15(21%), 23(32%) and 31(43%) at day 28, day 90 and 1 year respectively. 36(50%) had a clinically relevant infection during their hospitalisation(23 after initiation of steroids). The median time to development of incident infection after commencement of steroids was 10 d. The commonest site of infection was ascites(31%) and bacteraemia(31%) followed by urinary tract(19%) and respiratory tract(8%). Forty-one separate organisms were isolated in 33 patients; the most frequent genus was Escherichia(22%) and Enterococcus(20%). Infection was not associated with 90-d or 1 year mortality but was associated with higher creatinine, model for end-stage liver disease and Lille score. Baseline urea was the only independent predictor of 90-d mortality.CONCLUSION Clinically relevant infections are common in patients with AAH but are not associated with increased 90-d or 1 year mortality. | Ashwin D Dhanda Ashish Sinha Vicky Hunt Sarah Saleem Matthew E Cramp Peter L Collins | 2017 | World Journal of Gastroenterology2017，23，11： | 1 |
| 19 | Hard Segment Connectivity in Low Molecular Weight Model 'Trisegment' Polyurethanes Based on Monols显示文摘 | Ashish A G L Wilkes | 2004 | Polymer2004，45，： | 1 |
| 20 | HuR post-trsnscriptional paths to malignancy显示文摘 | Isabel López de Silanes Ashish Lal Myriam Gorospe | 2005 | RNA Biology2005，2，1： | 1 |
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