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| 1 | Antioxidant and antimutagenic activities of bark extract of Terminalia arjuna显示文摘Objective:The alcoholic extract of stem bark of Terminalia arjuna(ALTA) was screened for antioxidant and antimutagenic(anticlastogenic) activity.Methods:Antioxidant property was determined by l,l,Diphynyl,2-Picryl hydrazyl(DPPH) assay,super oxide radical scavenging activity,lipid peroxidation assay and total polyphenolic content was determined by Folin-Ciocalteau’s reagent.Antimutagenic activity was evaluated using micronucleus test in mice. Results:The ALTA has shown potent antioxidant activity with EC50 of 2.491±0.160,50.110±0.150 & 71.000±0.250 in DPPH assay,superoxide radical scavenging activity and lipid peroxidation assay, which is comparable with ascorbic acid with EC50 of 2.471±0.140,40.500±0.390 and 63.000±0.360 respectively.In micronucleus test,ALTA(100 & 200 mg/kg,p.o.) showed significant reduction in percentage of micronucleus in both polychromatic erythrocytes(PCE) and normochromatie erythrocytes(NCE) and also shown significant reduction in P/N ratio.Conclusions:These results suggested that ALTA possess significant antioxidant and antimutagenic activity. | Gollapalle Lakshminarayana shastry Viswanatha Santosh Kumar Vaidya Ramesh C Nandakumar Krishnadas Srinath Rangappa | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 9 |
| 2 | Genetically modified mouse models for the study of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is associated with obesity,insulin resistance,and type 2 diabetes.NAFLD represents a large spectrum of diseases ranging from(1) fatty liver(hepatic steatosis);(2) steatosis with inflammation and necrosis;to(3) cirrhosis.The animal models to study NAFLD/nonalcoholic steatohepatitis(NASH) are extremely useful,as there are still many events to be elucidated in the pathology of NASH.The study of the established animal models has provided many clues in the pathogenesis of steatosis and steatohepatitis,but these remain incompletely understood.The different mouse models can be classified in two large groups.The first one includes genetically modified(transgenic or knockout) mice that spontaneously develop liver disease,and the second one includes mice that acquire the disease after dietary or pharmacological manipulation.Although the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex,genetically modified animal models may be a key for the treatment of NAFLD.Ideal animal models for NASH should closely resemble the pathological characteristics observed in humans.To date,no single animal model has encompassed the full spectrum of human disease progression,but they can imitate particular characteristics of human disease.Therefore,it is important that the researchers choose the appropriate animal model.This review discusses various genetically modified animal models developed and used in research on NAFLD. | Perumal Nagarajan M Jerald Mahesh Kuma Ramasamy Venkatesan Subeer S Majundar Ramesh C Juyal M Jerald Mahesh Kuma | 2012 | World Journal of Gastroenterology2012，18，11： | 7 |
| 3 | Endoscopic closure of a gastrocolic fistula using the over-the-scope-clip-system显示文摘Gastrointestinal (GI) defects such as fistulas and leaks can be potentially closed endoscopically using hemo-clips and loops. However, hemoclips may not allow for closure of large defects and they do not exert enough tensile force to keep fibrotic defects larger than 5 mm approximated. Herein we present a case of successful endoscopic closure of a gastrocolic fistula in a severely malnourished patient with complex post-surgical upper GI anatomy. We strongly believe that this device is a major breakthrough for the management of various types of discontinuity defects or fistulas. In addition, we show the usefulness of placing a direct jejunostomy using the double balloon enteroscopy (DBE) technique during the same procedure. The concept of providing direct jejunal feedings while allowing for upper gas-trointestinal bowel rest to promote the healing of the minimally invasive endoscopic operation is novel. Thus, our case is unique and exemplifies the utility of mini-mally invasive endoscopic endoluminal surgery. | Klaus Mnkemüller Shajan Peter Basem Alkurdi Jayapal Ramesh Daniel Popa C Mel Wilcox | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，8： | 5 |
| 4 | Inhibition of Apoptotic Signaling and Neointimal Hyperplasia by Tempol and Nitric Oxide Synthase following Vascular Injury显示文摘 | Jagadeesha Dammanahalli K Miller Jr Francis J Bhalla Ramesh C | 2009 | Journal of Vascular Research2009，，2： | 2 |
| 5 | Experimental and finite element modeling studies on single-layer and multi-layer 1-3 piezocomposite transducers显示文摘 | RAMESH R PRASAD C D VINOD KUMAR T K | 2006 | Ultrasonics2006，44，2006： | 1 |
| 6 | Molecular markers and their applications in wheat breeding显示文摘 | P K Gupta R K Varshney P C Sharma B Ramesh | 1999 | Plant Breeding1999，118，： | 1 |
| 7 | Special issue on video communnications,processing,and understanding for third generation surveillance systems显示文摘 | C REGAZZONI V RAMESH | | 0，，10： | 1 |
| 8 | Topology Discovery for Public IPv6 Networks 显示文摘 | Daniel G W Fangzhe C Ramesh V | 2003 | Computer Communications Review2003，33，3： | 1 |
| 9 | A Fuzzy Multiobjective Approach to Contingency Constrained OPF 显示文摘 | Ramesh V C LI Xuan | 1997 | IEEE Trans on Power Systems1997，12，3： | 1 |
| 10 | Modulation of neurotoxic behavior in F-344 rats by temporal disposition of benzo(a)pyrene显示文摘 | SAUNDERS C R RAMESH A SHOCKLEY D C | 2002 | Toxicol Lett2002，129，12： | 1 |
| 11 | Friction and wear behaviour of cast A1 6063 based in situ metal matrix composites 显示文摘 | RAMESH C S AHAMED A | 2011 | Wear2011，271，： | 1 |
| 12 | Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery显示文摘 | Ramesh G Krawczeski C D Woo J G | | 0，，03： | 1 |
| 13 | Graphite nanoplatelet-epoxy composite thermal interface materials显示文摘 | Yu A P Ramesh P hkis M E Bekyarova E Haddon R C | | 0，，： | 1 |
| 14 | Monitoring the structure and dynamics of a dense moist evergreen forest in the Western Ghats(Kodagu District,Kernataka,India)显示文摘 | Elouard C Pascal J-P Pelissier R Ramesh BR Houllier F Durand M Aravjy S Moravie M-A Gimaret-Carpentier | | 0，，02： | 1 |
| 15 | The compressive viscoplastie response of an A359/SiCe metal - matrix composite and the A359 aluminum alloy matrix显示文摘 | Li Y Ramesh K T Chin E S C | 2000 | International Journal of Solids and Structures2000，37，： | 1 |
| 16 | Properties of hydroxylapatite produced by annealing of bovine bone显示文摘 | Ooi C Y Hamdi M Ramesh S | 2007 | Ceramics International2007，33，7： | 1 |
| 17 | Topology dis- covery for public IPv6 networks 显示文摘 | Daniel G W Fangzhe C Ramesh V | 2003 | Computer Communi- cations Review2003，33，3： | 1 |
| 18 | Requirements traceability :Theoryand practice 显示文摘 | Ramesh B Stubbs C Powers T | 1997 | Annals of software engineering1997，3，1： | 1 |
| 19 | Finite element analysis of cylindrical shells with a constrained viscoelastic layer 显示文摘 | Ramesh T C Ganesan N | 1994 | Journal of Sound and Vibration1994，172，3： | 1 |
| 20 | A simple, mild and efficient procedure for selective cleavage of pre- nyl esters using silica-supported sodium hydrogen sulphate as a heterogenous catalyst 显示文摘 | Ramesh C Mahender G Ravindranath N Biswanath D | 2003 | Tetrahedron letters2003，44，7： | 1 |
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