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| 1 | Prevalence and risk factors of methotrexate hepatoxicity in Asian patients with psoriasis显示文摘AIM: To establish the prevalence of liver fibrosis and to evaluate the possible risk factors for fibrosis and progression in Asian with psoriasis treated with methotrexate (MTX) based on liver histology. METHODS: Patients with psoriasis treated with MTX referred to the Department of Gastroenterology, Tan Tock Seng Hospital for liver biopsy were identified and retrospectively studied. Patient case notes and electronic records were retrieved from the hospital database and relevant data collated. Histological changes of liver biopsies were staged according to Roengik score. The factors assessed were age, gender, ethnicity, cumulative dose of MTX, presence of comorbid conditions such as diabetes, hypertension, hyperlipidemia, and ethanol use. We also assessed the histological change in those with multiple liver biopsies. Statistical analysis was performed using Stata V.9.2. RESULTS: There were altogether 59 patients (median age 50 years old, range 22-81 years old, male, 88%) with 98 biopsies liver biopsies; 6 normal [median cumulative dose (MCD), 2285 mg]; 62 gradeⅠ (MCD 2885 mg), 23 grade Ⅱ (MCD 1800 mg) and 7 grade Ⅲ (MCD 1500 mg). There was no grade Ⅳ or cirrhosis. The prevalence of liver fibrosis (grade Ⅲ) was 12%. Of the factors assessed, diabetes (P=0.001) and hypertension (P=0.003) were significant for fibrosis on univariate analysis but not on multivariate analysis. Of the 26 patients who had more than one biopsy (median 2, range 2-6), 57.7% (n=15) were stable, 34.6% (n=9) had progression and 7.7% (n=2) had regression of histological grades. On univariate analysis, nonChinese ethnicity (P=0.031), diabetes (P=0.018), and hyperlipidemia (P=0.011) were predictive of progression of grades, but these were not significant on multivariate analysis. CONCLUSION: Liver fibrosis in Asian psoriatic population on MTX is comparable to the West. Cumulative dose was not associated with liver fibrosis. Metabolic syndrome is important factors. | Chong Meng Yeo Vui Heng Chong Arul Earnest Wei Lyn Yang | 2013 | World Journal of Hepatology2013，5，5： | 3 |
| 2 | Analysis of a tunnel failure caused by leakage of the shield tail seal system显示文摘This paper presents an analysis of a tunnel failure accident during shield tunnel construction on Foshan Metro Line 2 in China.The failure is caused by the leakage of the multilayer seal system,which consists of several brush seals at the tail of the shield.Four different failure modes for the multilayer seal system are discussed.A simple structural analysis of the brush seals is then conducted,and failure mode 4(failure due to brush seal deformation)is identified as a major reason for the Foshan tunnel accident.A finite element method(FEM)analysis is employed to validate the conclusions drawn from the simple structural analysis of the brush seals. | Chao Yu Annan Zhou Jun Chen Arul Arulrajah Suksun Horpibulsuk | 2020 | Underground Space2020，5，2： | 3 |
| 3 | Competing for enhancers: PVT1 fine-tunes MYC expression显示文摘 | Abhijit Parolia Marcin Cieslik Arul M. Chinnaiyan | 2018 | Cell Research2018，28，8： | 3 |
| 4 | Antifungal activity of chitosan on two postharvest pathogens of strawberry fruits显示文摘 | Ghaouth A Arul J Grenier J | 1992 | Phytopathology1992，82，： | 2 |
| 5 | Multi objective prediction and optimization of control parameters in the milling of aluminium hybrid metal matrix composites using ANN and Taguchi-grey relational analysis显示文摘This study aims to optimize the input parameters such as mass fraction and particle size of SiC along with depth of cut,feed and cutting speed in the milling of Al5059/SiC/MoS2.The hybrid metal matrix composites are generally fabricated by reinforcing of different sizes(10,20,40 μm)of SiC with aluminium at a different levels(5%,10%& 15%)whereas the MoS2 addition is fixed as 2%.The effect of each control factor on response variables are analyzed through Taguchi S/N ratio method.Also,the most significant method for prediction of response parameters is satisfied by ANN model than the regression model.Analysis of variance(ANOVA)results envisage that mass fraction of SiC,feed rate is the most domineering factor on response variable. | S.Ajith Arul Daniel R.Pugazhenthi R.Kumar S.Vijayananth | 2019 | Defence Technology(防务技术)2019，15，4： | 2 |
| 6 | Venous thromboembolism prophylaxis practice and its association with outcomes in Australia and New Zealand burns patients显示文摘Background:Patients with burn injuries are considered to have an increased risk of venous thromboembolism(VTE).While untreated VTEs can be fatal,no studies have examined chemoprophylaxis effectiveness.This study aimed to quantify the variation in prevalence of VTE prophylaxis use in patients in Australian and New Zealand burns units and whether prophylaxis use is associated with in-hospital outcomes following burn injury.Methods:Admission data for adult burns patients(aged≥16 years)admitted between 1 July 2016 and 31 December 2018 were extracted from the Burns Registry of Australia and New Zealand.Mixed effects logistic regression modelling investigated whether VTE prophylaxis usewas associated with the primary outcome of in-hospital mortality.Results:There were 5066 admissions over the study period.Of these patients,81%(n=3799)with a valid response to the VTE prophylaxis data field received some form of VTE prophylaxis.Use of VTE prophylaxis ranged from 48.6%to 94.8%of patients between units.In-hospital death was recorded in<1%of patients(n=33).After adjusting for confounders,receiving VTE prophylaxis was associated with a decrease in the adjusted odds of in-hospital mortality(adjusted odds ratio=0.21;95%CI,0.07–0.63;p=0.006).Conclusions:Variation in the use of VTE prophylaxis was observed between the units,and prophylaxis use was associated with a decrease in the odds of mortality.These findings provide an opportunity to engage with units to further explore differences in prophylaxis use and develop future best practice guidelines. | Lincoln M.Tracy Peter A.Cameron Yvonne Singer Arul Earnest Fiona Wood Heather Cleland Belinda J.Gabbe | 2021 | Burns & Trauma2021，9，1： | 2 |
| 7 | Scheduled dataflow execution paradigm architecture, and performance evaluation 显示文摘 | Krishna M K Roberto Giorgi Joseph Arul | 2001 | IEEE Transactions on Computers2001，50，8： | 1 |
| 8 | Chitosan coatingeffect on storability and quality of fresh strawberries显示文摘 | Ghaouth A Arul J Ponnampalam R | 1991 | Journalof Food Science1991，56，6： | 1 |
| 9 | Chitosan coating effect on storability and quality of fresh strawberries 显示文摘 | Ghaouth A Arul J Ponnampalam R | 1991 | Journal of Food Science1991，56，6： | 1 |
| 10 | Suitability of Plastic Films for Modified Atmosphere Packaging of Fruits and Vegetables显示文摘 | Exama A Arul J Lencki R W | 1993 | Food Science1993，58，6： | 1 |
| 11 | Endovascular Treatment Options in the Management of Lower Limb Deep Venous Thrombosis显示文摘 | Sarfraz Ahmed Nazir Arul Ganeshan Sheraz Nazir Raman Uberoi | 2009 | CardioVascular and Interventional Radiology2009，，5： | 1 |
| 12 | Bioconversion of gallic acid into pyrogallol by immobilized citrobacter freundii TB3 显示文摘 | AJAY K R ARUL J MANICKAM L | 1992 | Journal of Fermentation and Bioengineering1992，74，3： | 1 |
| 13 | Use of chitosan coating to reduce water loss and maintain quality of cucumber and bell pepper fruit显示文摘 | El Ghaouth A Arul J Ponnampalam R | 1991 | J Food Proc Preserv1991，15，： | 1 |
| 14 | FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex显示文摘 | Marta Muzio Arul M Chinnaiyan Frank C Kischkel Karen O’Rourke Andrej Shevchenko Jian Ni Carsten Scaffidi James D Bretz Mei Zhang Reiner Gentz Matthias Mann Peter H Krammer Marcus E Peter Vishva M Dixit | 1996 | Cell1996，，： | 1 |
| 15 | Studies on effects of Pelargonium citrosa leaf extracts on malarial vector, Anopheles stephensiListon显示文摘 | Jeyabalan D Arul N Thangamathi P | 2003 | Bioresour Technol2003，89，2： | 1 |
| 16 | Antifungai activity of chitosan on the postharvest pathogens of strawberry fruits显示文摘 | Chaouth AE Arul J GrenierJ | 1992 | Phytopathology1992，82，4： | 1 |
| 17 | New control paradigm for integration of photovoltaic energy sources with utility network显示文摘 | Habeebullah S H Arul D S | 2011 | International Journal of Electrical Power & Energy Systems2011，33，1： | 1 |
| 18 | Chitosan coating effect on storability and quality of fresh strawberries显示文摘 | Ghaouth A E Arul J Ponnampalam R | 1991 | Journal of Food Science1991，56，6： | 1 |
| 19 | Suitability of plastic films for modified-atmosphere packaging of fruits and vegetables显示文摘 | EXAMA A ARUL J LENCKI R W | 1993 | Journal of Food Science1993，58，6： | 1 |
| 20 | Chitosan coating effect on storability and quality: of fresh strawberries显示文摘 | GHAOUTH A ARUL J PONNAMPALAM R | 1991 | Journal of Food Science1991，56，6： | 1 |
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