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| 1 | Omentum facilitates liver regeneration显示文摘AIM:To investigate the mechanism of liver regeneration induced by fusing the omentum to a small traumatic injury created in the liver. We studied three groups of rats. In one group the rats were omentectomized; in another group the omentum was left in situ and was not activated,and in the third group the omentum was activated by polydextran particles. METHODS:We pre-activated the omentum by injecting polydextran particles and then made a small wedge wound in the rat liver to allow the omentum to fuse to the wound. We monitored the regeneration of the liver by determining the ratio of liver weight/body weight,by histological evaluation (including immune staining for cytokeratin-19,an oval cell marker),and by testing for developmental gene activation using reverse transcription polymerase chain reaction (RT-PCR). RESULTS:There was no liver regeneration in the omentectomized rats,nor was there significant regeneration when the omentum was not activated,even though in this instance the omentum had fusedwith the liver. In contrast,the liver in the rats with the activated omentum expanded to a size 50% greater than the original,and there was histologically an interlying tissue between the wounded liver and the activated omentum in which bile ducts,containing cytokeratin-19 positive oval cells,extended from the wound edge. In this interlying tissue,oval cells were abundant and appeared to proliferate to form new liver tissue. In rats pre-treated with drugs that inhibited hepatocyte growth,liver proliferation was ongoing,indicating that regeneration of the liver was the result of oval cell expansion. CONCLUSION:Activated omentum facilitates liver regeneration following injury by a mechanism that depends largely on oval cell proliferation. | Ashok K Singh Nishit Pancholi Jilpa Patel Natalia O Litbarg Krishnamurthy P Gudehithlu Perianna Sethupathi Mark Kraus George Dunea Jose AL Arruda | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 2 | Probing the role of calmodulin in A1 toxicity in maize显示文摘 | JORGE R A MENOSSI M ARRUDA P | 2001 | Phytochemistry2001，58，3： | 1 |
| 3 | Pathogenesis of porcine epidemic diarrhea virus isolate(US/Iowa/18984/2013)in 3-week-old weaned pigs显示文摘 | MADSON D M MAGSTADT D R ARRUDA P H | 2014 | Vet Microbiol2014，174，12： | 1 |
| 4 | LBL assembled laminates with hierarchical organization from nano to microscale: high-toughness nanomaterials and deformation imaging显示文摘 | PODSIADLO P ARRUDA E M KHENG E | 2009 | ACS Nano2009，3，6： | 1 |
| 5 | Genetically modified sugarcane for bioenergy generation 显示文摘 | ARRUDA P | 2012 | Current Opinion in Biotechnology2012，23，5： | 1 |
| 6 | Adhesion of a humanfecal Escherichia coli strain to mousecolonic mucus显示文摘 | COHEN P S ARRUDA J C WILLIAMS T J | 1985 | Infect Immun1985，48，1： | 1 |
| 7 | Effects that bovine sperm cryopreservation using two different extenders has on sperm membranes and chromatin显示文摘 | Celeghini E C de Arruda R P de Andrade A F Nascimento J Raphael C F Rodrigues P H | | 0，，： | 1 |
| 8 | COI1 affectsmyrosinase activity and controls the expression of two flower-specificmyrosinase-binding protein homologues in Arabidopsis显示文摘 | CAPELLA A N MENOSSI M ARRUDA P | 2001 | Planta2001，213，： | 1 |
| 9 | Aluminum-induced organic acids exudation by roots of an aluminum-tolerant tropical maize显示文摘 | Jorge R A Arruda P | 1997 | Phytochemistry1997，45，： | 1 |
| 10 | Role of glycerol addition on xylose-to-xylitol bioconversion by Candida guiUiermondii 显示文摘 | Arruda P V Felipe M G | 2009 | Current Microbiology2009，58，3： | 1 |
| 11 | A Method for Extracting the Fundamental Frequency Positive Sequence Voltage Vector Based on Simple Mathematical Transformations显示文摘 | Helber E P de Souza Fabrício Bradaschia Francisco A S Neves Marcelo C Cavalcanti Gustavo M S Azevedo Josué P de Arruda | | 0，，05： | 1 |
| 12 | Ultmstrong and Stiff Lay- ered Polymer Nanocomposites显示文摘 | Podsiadlo P Kaushik A K Arruda E M | 2007 | Science2007，318，： | 1 |
| 13 | The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient 显示文摘 | Costantini DL Arruda EP Agarwal P | 2005 | Cell2005，123，2： | 1 |
| 14 | Effects that bovine sperm cryopreservation using two different extenders has on sperm membranes and chromatin 显示文摘 | CELEGHINI E C C ARRUDA R P ANDRADE A F C | 2008 | Animal ReproductionScience2008，14，： | 1 |
| 15 | Ultrastrong and stiff layered polymer nanocomposites显示文摘 | Podsiadlo P Kaushik A K Arruda E M | 2007 | Science2007，，318： | 1 |
| 16 | Sugarcane (Saccharum X officinarum) : A reference study for the regulation of genetically modified cuhivars in Brazil 显示文摘 | CHEAVEGATTI- GIANOTTO A DE ABREU H M C ARRUDA P | 2011 | Tropical Plant Biology2011，4，1： | 1 |
| 17 | Cockroach allergens and asthma显示文摘 | Arruda L K Vailes L D Ferriani V P | 2001 | J Allergy Clin Immunol2001，107，3： | 1 |
| 18 | Molecular evi-dence that sugarcane yellow leaf virus(SCYLV)is a member of the Luteoviridae family显示文摘 | Maia I G Goncalves M C Arruda P | | 0，，05： | 1 |
| 19 | RNA expression profiles and data mining of sugarcane response to low temperature显示文摘 | NOGUEIRA F T S DE ROSA V E MENOSSI J M ULIAN E C ARRUDA P | 2003 | Plant Physiology2003，132，： | 1 |
| 20 | High-lysine maize: the key discoveries that have made it possible显示文摘 | Azevedo R A Arruda P | 2010 | Amino Acids2010，39，： | 1 |
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