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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Relation of Transmitral Flow Velocity Patterns to Left Ventrieular Diastolic Function: New Insights from a Combined Hemodynamic and Doppler Eehocardiographie Study显示文摘 | Appleton C P Hatle L K Popp R L | 1988 | J Am Coil Cardiol1988，12，2： | 1 |
| 3 | Demonstration of Restrictive Ventricular Physiology by Doppler Eehocardiography显示文摘 | Appleton C P Hatle L K Popp R L | 1988 | J Am Coll Cardiol1988，11，4： | 1 |
| 4 | Efficacy and tolerability of topiramate in childhood and adolescent epilepsy:a clinical experience显示文摘 | Mohamed K Appleton R Rosenbloom L | 2000 | Seizure2000，9，2： | 1 |
| 5 | Rural landscape visualisation from GIS database:A comparison of approaches,oNions and roblems显示文摘 | APPLETON K LOVETT A SUNNENBERG G | 2002 | Computers Environment and Urban Systems2002，26，： | 1 |
| 6 | The manufacture, characterisation andmicrowave properties of aligned M ferrite fibres显示文摘 | PULLAR R C APPLETON S G BHATTACHARYA A K | 1998 | J Magn Magn Mater1998，186，： | 1 |
| 7 | Aetiology,course and outcome of children admitted to paediatric intensive care with convulsive status epilepticus:a retrospective 5-year review显示文摘 | Hussain N Appleton R Thorburn K | | 0，，： | 1 |
| 8 | Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors显示文摘 | Appleton K Mackay HJ Judson I | 2007 | J Clin Oncol2007，25，29： | 1 |
| 9 | Predicting anterior cruciate ligament integrity in patients with osteoarthritis 显示文摘 | Trompeter A J Gill K Appleton M | 2009 | Knee Surgery Sports Traumatology Arthroscopy2009，17，6： | 1 |
| 10 | Gastroprotective and antiulcerogenic effects of red algae Gracilaria changii extract显示文摘 | Meng H Shu D Appleton K | 2013 | BMC complementary and alternative medicine2013，2，13： | 1 |
| 11 | Efficacy and tolerability of topiramate in childhood and adolescent epilepsy:a clinicalexperience显示文摘 | Mohamed K Appleton R RosenbloomL | 2000 | Seizure2000，9，： | 1 |
| 12 | Rural Landscape Visualisation from GIS Databases: A Comparison of Approaches, Options and Problems显示文摘 | Appleton K Lovett A Sünnenberg G | 2002 | Computers Environment and Urban Systems2002，26，： | 1 |
| 13 | Contemplating cyc- ling to work: attitudes and perceptions in different stages of change显示文摘 | Gatersleben B Appleton K M | 2007 | Transportation Research Part A2007，41，4： | 1 |
| 14 | The manufacture, characterization and microwave properties of aligned M ferrite fibres显示文摘 | Pullar R C Appleton S G Bhattacharya A K | 1998 | J Magn Magn Mater1998，186，： | 1 |
| 15 | Efficacy and tolerability of topiramate in childhood and adolescent epilepsy:a clinical experience 显示文摘 | Mohamed K Appleton R Rosenbloom L | 2000 | Seizure2000，9，2： | 1 |
| 16 | Relation of transmitral flow velocity patterns to left ventrieular diastolic function, New insights from a combined hemodynamie and Doppler echocardiographic study显示文摘 | APPLETON C P HATLE L K POPP R L | 1988 | J Am Coll Cardiol1988，12，2： | 1 |
| 17 | Heme oxygenase activity in placenta: direct dependence on oxygen availability显示文摘 | Appleton SD Marks GS Nakatsu K | 2002 | Am J Physikl Heart Circ Physil2002，282，： | 1 |
| 18 | Rural landscape visualization from GIS databases:a comparison of approaches,options an problems显示文摘 | APPLETON K LOVETF A SUNNENBERG G | 2002 | Computers Environment and Urban Systems2002，26，2： | 1 |
| 19 | Left ventricular diastolic dysfunction as a predictor of the first diagnosed nonvalvular atrial fibrillation in 840 elderly men and women显示文摘 | Teresa S.M Tsang Bernard J Gersh Christopher P Appleton A.Jamil Tajik Marion E Barnes Kent R Bailey Jae K Oh Cynthia Leibson Samantha C Montgomery James B Seward | 2002 | Journal of the American College of Cardiology2002，，： | 1 |
| 20 | GIS-based visualisation of rural landscapes defining sufficient realism for environmental decision-making显示文摘 | Appleton K Lovett A | 2003 | Landscape and Urban Planning2003，65，： | 1 |
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