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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Predicting anterior cruciate ligament integrity in patients with osteoarthritis 显示文摘 | Trompeter A J Gill K Appleton M | 2009 | Knee Surgery Sports Traumatology Arthroscopy2009，17，6： | 1 |
| 3 | Contemplating cyc- ling to work: attitudes and perceptions in different stages of change显示文摘 | Gatersleben B Appleton K M | 2007 | Transportation Research Part A2007，41，4： | 1 |
| 4 | Contemplating Cycling to Work:Attitudes and Perceptions in Different Stages of Change显示文摘 | Gatersleben B Appleton K M | 2007 | Transportation Research Part A2007，41，4： | 1 |
| 5 | Contemplating cycling to work: attitudes and perceptions in different stages of change 显示文摘 | Gatersleben B Appleton K M | 2007 | Transportation Research Part A: Policy and Practice2007，41，4： | 1 |
| 6 | Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes显示文摘 | Strathdee G Appleton K Illand M | 2001 | Am J Pathol2001，158，3： | 1 |
| 7 | Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes显示文摘 | Strathdee G Appleton K Illand M | 2001 | Am J Pathol2001，158，3： | 1 |
| 8 | Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes 显示文摘 | Strathdee G Appleton K Ⅲ and M | 2001 | Am J Pathol2001，158，3： | 1 |
| 9 | Contemplating Cycling to Work: Attitudes and Perceptions in Different Stages of Change显示文摘 | Gatersleben B Appleton K M | 2007 | Transportation Research Part A: Policy and Practice2007，41，4： | 1 |
| 10 | The heavy metal content of the teeth of the bank vole (Clethrionomys glareolus) as an exposure marker of environmental pollution in Poland 显示文摘 | Appleton J Lee K M Sawicka Kapusta K | 2000 | Environmental pollution2000，110，： | 1 |
| 11 | Left ventricular diastolic dysfunction as a predictor of the first diagnosed nonvalvular atrial fibrillation in 840 elderly men and women显示文摘 | Tsang T S Gersh B J Appleton C P Tajik A J Barnes M E Bailey K R | 2002 | J Am Coll Cardiol2002，40，： | 1 |
| 12 | Food and mood 显示文摘 | Appleton K M Rogers P J | 2004 | Women''s Health Medicine2004，1，1： | 1 |
| 13 | Primary ovarian carcinomas display multiple methylator phenotype involving known tumor suppressor genes 显示文摘 | Strathdee G Appleton K IIIand M | 2001 | Am J Pathol2001，158，： | 1 |
| 14 | 伴颈动脉狭窄的急性缺血性卒中患者应用透皮吸收的硝酸甘油降压是安全的显示文摘背景对伴有颈动脉狭窄的急性卒中患者给予降压治疗可能会损害大脑灌注和患者转归,临床上一直对此存在顾虑。我们应用一氧化氮对卒中疗效研究(Efficacy of Nitric Oxide inStroke,ENOS)的数据,评价了硝酸甘油(GTN)对伴颈动脉狭窄的患者的效应。 | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath 霍永丰(译) | 2019 | 英国医学杂志中文版2019，22，5： | 0 |
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