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| 1 | Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry. | Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni | 2015 | World Journal of Psychiatry2015，5，1： | 6 |
| 2 | Biliary Drainage in Patients With Unresectable, Malignant Obstruction Where ERCP Fails: Endoscopic Ultrasonography-Guided Choledochoduodenostomy Versus Percutaneous Drainage显示文摘 | Everson L.A. Artifon Dayse Aparicio Jose B. Paione Simon K. Lo Andre Bordini Carolina Rabello Jose P. Otoch Kapil Gupta | 2012 | Journal of Clinical Gastroenterology2012，，9： | 5 |
| 3 | 电压暂降过程中的双馈风力发电机无功功率调节能力(英文)显示文摘西班牙风力发电容量日益增加,已迫使输电系统运营机构(TSO)对电压骤降期间风力发电机无功出力提出新的要求.在稳态运行条件下,双馈风力发电机方便调节无功功率;但在电压暂降过程中,难于提供足够的无功功率.论文仿真分析了双馈风力发电机的无功出力,考虑保护系统和电网侧换流器共同作用,以满足无功平衡要求;故障瞬间,Crowbar电阻及其连接时间对无功平衡影响大,而电网侧换流器充当STATCOM作用,有助于改善电压波形,以实现转子侧换流器的重接. | N. Aparicio Z. Chen H. Beltran E. Belenguer | 2008 | 电力科学与技术学报2008，23，3： | 3 |
| 4 | Gastrointestinal pathology in the University Teaching Hospital, Lusaka, Zambia: review of endoscopic and pathology records显示文摘 | Paul Kelly Mwamba Katema Beatrice Amadi Lameck Zimba Sylvia Aparicio Victor Mudenda K. Sridutt Baboo Isaac Zulu | 2007 | Transactions of the Royal Society of Tropical Medicine and Hygiene2007，，2： | 3 |
| 5 | Small bowel adenocarcinoma: Epidemiology, risk factors, diagnosis and treatment显示文摘 | Thomas Aparicio Aziz Zaanan Magali Svrcek Pierre Laurent-Puig Nicolas Carrere Sylvain Manfredi Christophe Locher Pauline Afchain | 2014 | Digestive and Liver Disease2014，，2： | 3 |
| 6 | Framingham研究中年轻成人缺血性脑卒中发病的时间趋势显示文摘中年脑卒中对残疾造成的相关生活质量损失影响极大。在这个年龄段,缺血性脑卒中发病率可能会增加。该研究调查了按照中年和老年发病的脑卒中进行分层的社区样本中,缺血性脑卒中发病率和脑卒中危险因素变化的长期趋势。Framingham研究自1948年开始对脑卒中事件进行监测,研究人员对年龄35.<55和>55岁的患者开始进行随访观察,使用Cox模型检查经年龄和性别调整后的10年缺血性脑卒中发病率。在4个时期内进行线性趋势检验,并控制各期之间的时间距离。 | 刘莉(译) 叶鹏(审校) Aparicio HJ Himali JJ Satizabal CL Pase MP Romero JR Kase CS Beiser A S Seshadri S | 2019 | 中华高血压杂志2019，27，8： | 2 |
| 7 | Translational pancreatic cancer research:a comparative study on patient-derived xenograft models显示文摘AIM To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice.METHODS This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were obtained surgically from patients with a pathological diagnosis of pancreatic adenocarcinoma. Tumour samples from pancreatic cancer patients were transplanted into nude mice in three different locations(intraperitoneal, subcutaneous and pancreatic). Histological analysis(haematoxylin-eosin and Masson's trichrome staining) and immunohistochemical assessment of apoptosis(TUNEL), proliferation(Ki-67), angiogenesis(CD31) and fibrogenesis(α-SMA) were performed. When a tumour xenograft reached the target size, it was reimplanted in a new nude mouse. Three sequential tumour xenograft generations were generated(F1, F2 and F3).RESULTS The overall tumour engraftment rate was 61.1%. The subcutaneous model was most effective in terms of tissue growth(69.9%), followed by intraperitoneal(57.6%) and pancreatic(55%) models. Tumour development was faster in the subcutaneous model(17.7 ± 2.6 wk) compared with the pancreatic(23.1 ± 2.3 wk) and intraperitoneal(25.0 ± 2.7 wk) models(P = 0.064). There was a progressive increase in the tumour engraftment rate over successive generations for all three models(F1 28.1% vs F2 71.4% vs F3 80.9%, P < 0.001). There were no significant differences in tumour xenograft differentiation and cell proliferation between human samples and the three experimental models among the sequential generations of tumour xenografts. However, a progressive decrease in fibrosis, fibrogenesis, tumour vascularisation and apoptosis was observed in the three experimental models compared with the human samples. All three pancreatic patient-derived xenograft models presented similar histological and immunohistochemical characteristics.CONCLUSION In our experience, the faster development andgreatest number of viable xenografts could make the subcutaneous model the best option for experimentation in pancreatic cancer. | Mercedes Rubio-Manzanares Dorado Luis Miguel Marín Gómez Daniel Aparicio Sánchez Sheila Pereira Arenas Juan Manuel Praena-Fernández Juan Jose Borrero Martín Francisco Farfán López Miguel ángel Gómez Bravo Jordi Muntané Relat Javier Padillo Ruiz | 2018 | World Journal of Gastroenterology2018，24，7： | 2 |
| 8 | Initial experience with EUS-guided cholangiopancreatography for biliary and pancreatic duct drainage: a Spanish national survey显示文摘 | Juan J. Vila Manuel Pérez-Miranda Enrique Vazquez-Sequeiros Monder Abu-Suboh Abadia Antonio Pérez-Millán Ferrán González-Huix Joan Gornals Julio Iglesias-Garcia Carlos De la Serna José R. Aparicio José C. Subtil Alberto álvarez Felipe de la Morena Jesús G | 2012 | Gastrointestinal Endoscopy2012，，6： | 2 |
| 9 | 载脂蛋白E及脂肪酸与脑卒中、冠状动脉粥样硬化性心脏病、死亡风险的关系显示文摘膳食脂肪对心血管健康和死亡率的作用仍然存在争议。由于载脂蛋白E(apolipoprotein E,APOE)是脂质运输和代谢的核心,研究者通过检测APOE—ε4基因型,评估了血浆脂肪酸与脑卒中、冠状动脉粥样硬化性心脏病(冠心病)、死亡风险之间的关系。 | 刘青 叶鹏 Satizabal CL Samieri C Davis-Plourde KL Voetsch B Aparicio HJ Pase MP Romero JR Helmer C Vasan RS Kase CS Debette S Beiser AS Seshadr Sudhai | 2018 | 中华高血压杂志2018，26，11： | 2 |
| 10 | Biomimetic mineralized hybrid scaffolds with antimicrobial peptides显示文摘Infection in hard tissue regeneration is a clinically-relevant challenge.Development of scaffolds with dual function for promoting bone/dental tissue growth and preventing bacterial infections is a critical need in the field.Here we fabricated hybrid scaffolds by intrafibrillar-mineralization of collagen using a biomimetic process and subsequently coating the scaffold with an antimicrobial designer peptide with cationic and amphipathic properties.The highly hydrophilic mineralized collagen scaffolds provided an ideal substrate to form a dense and stable coating of the antimicrobial peptides.The amount of hydroxyapatite in the mineralized fibers modulated the rheological behavior of the scaffolds with no influence on the amount of recruited peptides and the resulting increase in hydrophobicity.The developed scaffolds were potent by contact killing of Gram-negative Escherichia coli and Gram-positive Streptococcus gordonii as well as cytocompatible to human bone marrow-derived mesenchymal stromal cells.The process of scaffold fabrication is versatile and can be used to control mineral load and/or intrafibrillar-mineralized scaffolds made of other biopolymers. | Zhou Ye Xiao Zhu Isha Mutreja Sunil Kumar Bod Nicholas G.Fischer Anqi Zhang Christine Lui Yipin Qi Conrado Aparicio | 2021 | Bioactive Materials2021，6，8： | 2 |
| 11 | Pharmacogenomics in lung cancer: an analysis of DNA repair gene expression in patients treated with platinum-based chemotherapy 显示文摘 | Garcia-Campelo R Alonso-Curbera G Anton Aparicio L M | 2005 | Expert Opin Pharmacother2005，6，12： | 1 |
| 12 | Cerium hybrid silica coatings on stainless steel AISI 304 substrate显示文摘 | PEPE A APARICIO M DURAN A | 2006 | Journal of Sol-Gel Science and Technology2006，39，2： | 1 |
| 13 | Phosphorus and protein restriction and parathyroid function in chronic renal failure显示文摘 | Combe C Aparicio M | 1994 | Kidney Int1994，5，： | 1 |
| 14 | Hemostasis and coagulation monitoring and management during liver transplantation 显示文摘 | Dalmau A Sabate A Aparicio I | 2009 | Curr Opin Organ Transplant2009，14，： | 1 |
| 15 | The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin显示文摘 | Aparicio J F Molnar Ⅰ | 1995 | Proc NatlAcad Sci USA1995，92，： | 1 |
| 16 | Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus:analysis of the enzymatic domains in the modular polyketide synthase显示文摘 | Aparicio JF Molnar I Schwecke T | 1996 | Gene1996，169，： | 1 |
| 17 | Extragonadal nongestational choriocarcinoma involving the lung: a report of three cases显示文摘 | Aparicio J Oltra A Martinez-Moragon E | 1996 | Respiration1996，63，4： | 1 |
| 18 | Leptin and Ob-Rb receptor isoform in the human digestive tract during fetal development显示文摘 | Aparicio T Kermorgant S Darmoul D | 2005 | J Clin Endocrinol Metab2005，90，11： | 1 |
| 19 | Changes in the volatile composition of virgin olive oil during oxidation: flavor and off-flavor 显示文摘 | MORALES M T APARICIO R | 1997 | Journal of Agricultural and Food Chemistry1997，45，： | 1 |
| 20 | Bottlenecks for plantrecruitment in woodland remnants: An ornithochorous shrub ina Mediterranean ‘relictual’ landscape 显示文摘 | González-Varoa J P Norab S Aparicio A | 2012 | Perspect Plant Ecol2012，14，11： | 1 |
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