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| 1 | The design and construction of a pulsed beam generation system based on high intensity cyclotron显示文摘In order to perform the studies on a pulsed beam generation system based on a high intensity cyclotron, a test beam line with a pulsed beam generation for a 10 MeV compact cyclotron (CYCIAE-10) has been designed and constructed at China Institute of Atomic Energy (CIAE). A 70 MHz continuous H- beam can be pulsed to the pulse length of less than 10 ns with a repetition rate of 4.4 MHz. The sine waveform with a frequency of 2.2 MHz is adopted for the chopper and a mesh structure with single drift and dual gaps is used for the 70 MHz buncher. A helical resonator is designed and constructed based on simulations and experiments on the RF matching for the chopper. A helical inductance loop that is exceptionally large of its kind and equipped with water cooling for the resonator has been successfully wound and a 500 W solid RF amplifier has been manufactured. A special measuring device has been designed, which can be used to measure both the DC beam and the pulsed beam. The required pulsed beam was obtained after pulsed beam tuning. | AN ShiZhong YIN ZhiGuo LI PengZhan SONG GuoFang WU LongCheng GUAN FengPing XIE HuaiDong JIA XianLu LU YinLong ZHANG TianJue | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 3 |
| 2 | Clinical observation on pericardial effusion in patients with lung cancer treated by intrapericardial catheterization and infusion of highly agglutinative staphylococcin and cisplatin显示文摘Objective: To evaluate the therapeutic efficacy of injecting highly agglutinative staphylococcin (HASL) and cisplatin into pericardial cavity of lung cancer patients with pericardial effusion. Methods: 81 patients were randomized into two groups: 45 in the experimental group (HASL and Cisplatin) and 36 in the control group (Cisplatin). At first pericardial effusion was drained out from a intrapericardial catheter and then different drugs were infused, respectively. 24 h after perfusion the draining continued again until drainage quantity was less than 30 mL every day. The draining lasted 10–15 days. Results: The response rate was 91.1% for the experimental group and 80.6% for the control group. There was no significant difference between the two groups (P>0.05). The complete remission was 77.8% for the experimental group and 52.8% for the control group, which was statistically significant difference (P<0.05). The adverse effects were myelosuppression and nausea and vomiting, which were 35.6% and 40.0% in the experimental group and 72.2% and 66.7% in the control group, respectively (P<0.01, P<0.05). Conclusion: Inject- ing HASL and cisplatin into pericardial cavity may be a better way to control pericardial effusion of lung cancer. | Qi'an Jiang Yide Zhou Gui'e Cheng Fangyun Gong Shuyan Zhang Fengping Lang Meihong Zhao | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，5： | 3 |
| 3 | Comprehensive test stand for high-intensity cyclotron development显示文摘A comprehensive test stand for high-intensity cyclotron development,a 10 MeV 430 μA cyclotron,has been successfully constructed at China Institute of Atomic Energy (CIAE) for the experimental verification of the viability of a 100 MeV high-intensity cyclotron (CYCIAE-100) being constructed at CIAE.The verification includes the overall design technology,detail design and engineering technology for the crucial parts of the machine,e.g.main magnet and beam diagnostics.It will also pave the way for future enhancement of the beam intensity.The test stand consists of a H-ion source,axial injection system,central region,main magnet and coil,RF resonator,stripping extraction,and auxiliary systems,which include the RF power amplifier,high voltage and DC power supplies,electric apparatus,beam diagnostics,control,vacuum,water cooling,pneumatic system,and safety interlock.This paper presents the work regarding the design and sub-system development of the test sand,and the results of the beam commissioning of the machine. | ZHANG TianJue LI ZhenGuo CHU ChengJie XING JianSheng GUAN FengPing ZHONG JunQing JI Bin GE Tao YIN ZhiGuo HOU ShiGang PAN GaoFeng YAO HongJuan LU YinLong WANG ZhenHui WU LongCheng LIN Jun JIA XianLu WEI SuMin WEN LiPeng WANG Feng XIA Le CAI HongRu XIE HuaiDong CHEN RongFan ZHANG Yan ZHANG SuPing LIU GengShou ZOU Jian AN ShiZhong YANG JianJun BI YuanJie YANG Fang | 2011 | Chinese Science Bulletin2011，56，3： | 3 |
| 4 | Prediction of adolescent subjective well being: A machine learning approach显示文摘Background Subjective well-being(SWB),also known as happiness,plays an important role in evaluating both mental and physical health.Adolescents deserve specific attention because they are under a great variety of stresses and are at risk for mental disorders during adulthood.Aim The present paper aims to predict undergraduate students1 SWB by machine learning method.Methods Gradient Boosting Classifier which was an innovative yet validated machine learning approach was used to analyse data from 10518 Chinese adolescents.The online survey included 298 factors such as depression and personality.Quality control procedure was used to minimise biases due to online survey reports.We applied feature selection to achieve the balance between optimal prediction and result interpretation.Results The top 20 happiness risks and protective factors were finally brought into the predicting model.Approximately 90%individuals'SWB can be predicted correctly,and the sensitivity and specificity were about 92%and 90%,respectively.Conclusions This result identifies at-risk individuals according to new characteristics and established the foundation for adolescent prevention strategies. | Naixin Zhang Chuanxin Liu Zhixuan Chen Lin An Decheng Ren Fan Yuan Ruixue Yuan Lei Ji Yan Bi Zhenming Guo Gaini Ma Fei Xu Fengping Yang Liping Zhu Gabirel Robert Yifeng Xu Lin He Bo Bai Tao Yu Guang He | 2019 | General Psychiatry2019，32，5： | 1 |
| 5 | Beneficial effects of AOS-iron supplementation on intestinal structure and microbiota in IDA rats显示文摘The objective of this study was to investigate the effects of agar oligosaccharide-iron(AOS-iron)on intestinal tissue pathology and microbiota in IDA rats induced by a low-iron diet,further to find the relationship between intestinal microbiota and iron metabolic disorders.After 4 weeks of AOS-iron supplementation,the fecal iron content of IDA rats markedly increased in a dose-dependent manner,only the damaged cecum and colon tissues in medium-dose(MD)and high-dose(HD)groups were repaired to the baseline,while the diversity of gut microbiota was improved even at low dose(LD).Furthermore,the supplementation of AOS-iron altered the composition of gut microbiota.At the genus level,the beneficial microbiota was enriched in AOS-iron groups,but the relative abundance of potential opportunistic pathogens obviously reduced compared to that in the anemia model(AM)group.Spearman’s correlation analysis revealed that biochemical parameters,including blood metabolic parameters,iron contents,body weight,GSH-PX and T-AOC activity,were positively correlated with SMB53,Anaerotruncus,Anaerostipes and Coprobacillus but negatively correlated with Morganella,Fusobacterium and Serratia.These findings indicated that AOS-iron effectively repaired the damaged intestinal tissue and ameliorated iron metabolic disorders by regulating gut microbiota desirably,which could provide references for the treatment of IDA. | Hong He Hui Teng Qun Huang Dan He Fengping An Lei Chen Hongbo Song | 2021 | Food Science and Human Wellness2021，10，1： | 1 |
| 6 | Mobile-Service Based Max-Min Fairness Resource Scheduling for Heterogeneous Vehicular Networks显示文摘This paper investigates the resource scheduling for heterogeneous vehicular networks, where some moving vehicles are selected and scheduled as helping relays to assist information transmission between the roadside infrastructure and other moving vehicles. For such a system, we propose a mobile-service based max-min fairness resource scheduling scheme, where service amount which is more suitable for high mobility scenarios is adopted to characterize the information transmission capacity of the links and the max-min criteria is adopted to meet the fairness requirement of the moving vehicles. Simulation results demonstrate the effectiveness of our proposed scheme. It is shown that our proposed scheme archives higher throughput and better fairness compared with random scheduling scheme and non-relaying scheme. | ZHANG Yu XIONG Ke AN Fengping DI Xiaofei SU Jingtao | 2015 | China Communications2015，12，S2： | 0 |
| 7 | Superconducting Coil System of 230 MeV Superconducting Cyclotron Having Been Delivered to CIAE显示文摘The superconducting coil system of CYCIAE-230superconducting proton cyclotron consists of two coil windings,cryostat,GM coolers,and the liquid helium condenser,along with multiple thermometers,pressure gauges,liquid level gauges,load cells,a vacuum pump,apower supply and quench protection equipments.After | WANG Chuan YIN Meng ZHANG Suping LYU Yinlong GE Tao CUI Tao LI Ming YIN Zhiguo LIN Jun LI Xiuli WANG Zhenhui GUAN Fengping AN Shizhong ZHANG Tianjue | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 8 | Association between SLC17A7 gene polymorphisms and venlafaxine for major depressive disorder in a Chinese Han population:a prospective pharmacogenetic case-control study显示文摘Objective: Venlafaxine is a common antidepressant and its therapeutic effect varies among people with different genetic backgrounds. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in theSLC17A7 gene are associated with the treatment outcome of venlafaxine in a Chinese Han population with major depressive disorder.Methods: This prospective pharmacogenetic case-control study that involved genotyping of four SNPs ofSLC17A7 was conducted on 175 major depressive disorder patients of Chinese Han origin, aged 18 to 65 years, participated in the study from April 2005 to September 2006. Comparisons of allele and genotype frequencies of all SNPs were performed between the responder/remission group and the nonresponder/nonremission group. This study was approved by the Institutional Ethics Committee of Sichuan University (approval No. 20151112-265).Results: The allele and genotype frequencies of the four candidate SNPs inSCL17A7 showed no significant difference between responders and nonresponders. Meanwhile, no significant difference was detected in the four investigatedSLC17A7 SNPs between patients who did and did not exhibit remission. Although one of the investigatedSLC17A7 variants (rs1578944) demonstrated a significant association (P=0.022) with a response to venlafaxine after 6 weeks of treatment in the survival analysis, the association was unclear after a Bonferroni multiple comparisons test was conducted.Conclusion: No significant association exists between the four candidate SNPs (rs1043558, rs1320301, rs1578944, and rs74174284) inSLC17A7 and venlafaxine treatment in the Chinese Han population. | Liangile Liu Decheng Ren Fan Yuan Yan Bi Zhenming Guo Gaini Ma Fei Xu Binyin Hou Lei Ji Zhixuan Chen Lin An Naixin Zhang Tao Yu Xingwang Li Fengping Yang Xueli Sun Zaiquan Dong Shunying Yu Zhenghui Yi Yifeng Xu Lin He Shaochang Wu Longyou Zhao Changqun Cai Guang He Yi Shi | 2021 | Journal of Bio-X Research2021，4，3： | 0 |
| 9 | Isolation and Identification of Pathogenic Bacteria Causing Bovine Subclinical Mastitis in Eastern Hebei Province显示文摘In this study, the milk samples of 1 021 cows in eight dairy farms in Eastern Hebei Province were collected and detected with LMT reagent and somatic cell count for subclinical mastitis. Pathogenic bacteria in subclinical mastitis positive milk samples were isolated and identified.The results showed that 60.63%(619/1 021) of the sampled cows were diagnosed with subclinical mastitis, and mixed infections accounted for 88.21%(546/619) of the cases. In addition, 82 strains of 14 species were isolated from the subclinical mastitis positive milk samples, including 36 strains of Staphylococcus(43.90%), 33 strains of Streptococcus(40.24%), 8 strains of Enterobacteriaceae(9.76%) and 5 strains of Corynebacterium(6.10%), respectively. The results proved that Staphylococcus aureus and Streptococcus agalactiae are the main pathogenic bacteria causing bovine subclinical mastitis in Eastern Hebei Province. | Gao Guisheng Wu Tonglei Zhang Zhiqiang Yang Zongze Fu Zhixin Zou Fengping Gao Guangping An Jiwei Yao Weiping Shi Qiumei | 2018 | Animal Husbandry and Feed Science2018，10，1： | 0 |
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