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| 1 | Anti- HSV-1 activity and mechanism of action of some new synthesized substituted pyrimidine, thiopyrimidine and thiazolopyrimidine derivatives 显示文摘 | Mohamed S F Flefel E M Amr A E G E | 2010 | Eur J Med Chem2010，45，4： | 1 |
| 2 | A preliminary study of dexamethasone against ischernia/reperfusion liver injury in rats显示文摘 | Amr A F Mahmoud H E Arif M U | | 0，，02： | 1 |
| 3 | Comorbid psychiatric disor- ders in Arab children with autism spectrum disorders 显示文摘 | Amr M Raddad D E1-Mehesh F | 2012 | Res Au- tism Spectr Disord2012，6，1： | 1 |
| 4 | Unintended effects and their detection in genetically modified crops显示文摘 | Cellini F Chesson A Colquhoun I Constable A Davies HV Engel KH Gatehouse AMR K(a)renlampi S Kok EJ Leguay JJ Lehesranta S Noteborn HPJM Pedersen J Smith M | | 0，，07： | 1 |
| 5 | Low-Power Direct Digital Frequency Synthesis for Wireless Communications显示文摘 | ABDELLATIF B MICHAEL S O AMR M F | 2000 | IEEE Solid-State Circuits2000，35，： | 1 |
| 6 | Assessment of circulating levels of microRNA-326,microRNA-424,and microRNA-511 as biomarkers for hepatocellular carcinoma in Egyptians显示文摘BACKGROUND Hepatocellular carcinoma(HCC)is the fifth most common cancer.Differential expression of microRNAs(miRNAs)-326,miRNA-424,and miRNA-511 has been associated with the diagnosis and prognosis of HCC in different populations.However,limited information is available regarding their expression in Egyptian HCC patients.AIM To assess the role of circulating miRNAs-326,miRNA-424,and miRNA-511 in Egyptian HCC patients.METHODS This prospective observational study included 70 HCC patients and 25 healthy controls.The circulating levels of these three miRNAs were evaluated by real-time PCR.Receiver operating characteristic curve analysis was used to test the diagnostic accuracy of micro RNA expression levels.RESULTS All miRNAs were differentially expressed in HCC patients;miRNAs326 and miRNA-424 were upregulated,while miRNA-511 was downregulated.Both miRNA-326 and miRNA-424 showed sensitivity and specificity of 97%,71.4%,and 52%,60%,respectively,to differentiate HCC from controls.Moreover,miRNA-326 was associated with survival and could differentiate between Child grades(A vs B);miRNA-424 significantly differentiated early vs intermediate stages of HCC;while miRNA-511 was significantly correlated with response to modified Response Evaluation Criteria in Solid Tumors(m RECIST).CONCLUSION We conclude that miRNA-326,miRNA-424,and miRNA-511 have diagnostic and prognostic roles in Egyptian patients with hepatitis C virus-related HCC and should be considered for better disease management. | Samar Samir Youssef Asmaa Elfiky Mohamed M Nabeel Hend Ibrahim Shousha Tamer Elbaz Dalia Omran Mohammad Saeed Marie Mohammad A Elzahry Amr Abul-Fotouh Ahmed Hashem Mohamed F Guda Ashraf O Abdelaziz | 2022 | World Journal of Hepatology2022，14，8： | 1 |
| 7 | Comorbid psychi- atricdisorders in Arab children with autism spectrum disorders 显示文摘 | Amr M Raddad D E1-Mehesh F | 2012 | Res Autism Spectr Disord2012，6，1： | 1 |
| 8 | Comorbid psychiatric disorders in Arab children with Autism spectrum disorders显示文摘 | Amr M Raddad D El-Mehesh F | 2012 | Res Autism Spectrum Disorders2012，6，1： | 1 |
| 9 | Comorbid psychiat- ric disorders in Arab children with autism spectrum disor- ders显示文摘 | Amr M Raddad D E1 - Mehesh F | 2012 | Res Autism Spectr Disord2012，6，1： | 1 |
| 10 | Comorbid psychiatric disorders in Arab children with autism spectrum disorders显示文摘 | Amr M Raddad D El-Mehesh F | 2012 | Res Autism Spectr Disord2012，6，1： | 1 |
| 11 | Hepatic and gastrointestinal disturbances in Egyptian patients infected with coronavirus disease 2019: A multicentre cohort study显示文摘BACKGROUND Various liver and gastrointestinal involvements occur in patients with coronavirus disease 2019(COVID-19)at variable prevalence.Most studies report mild liver function disturbances correlated with COVID-19 severity,though liver failure is unusual.AIM To study liver and gastrointestinal dysfunctions in Egyptian patients with COVID-19 and their relation to disease outcomes METHODS This multicentre cohort study was conducted on 547 Egyptian patients from April 15,2020 to July 29,2020.Consecutive polymerase chain reaction-confirmed COVID-19 cases were included from four quarantine hospitals affiliated to the Egyptian ministry of health.Demographic information,laboratory characteristics,treatments,fibrosis-4(FIB-4)index,COVID-19 severity,and outcomes were recorded and compared according to the degree of liver enzyme elevation and the presence of gastrointestinal symptoms.Follow-ups were conducted until discharge or death.Regression analyses were performed to determine the independent factors affecting mortality.RESULTS This study included 547 patients,of whom 53(9.68%)died during hospitalization and 1 was discharged upon his request.Patients’mean age was 45.04±17.61 years,and 21.98%had severe or critical COVID-19.Alanine aminotransferase(ALT)and aspartate aminotransferase(AST)were available for 430 and 428 patients,respectively.In total,26%and 32%of patients had elevated ALT and AST,respectively.Significant liver injury with ALT or AST elevation exceeding 3-fold was recorded in 21(4.91%)and 16(3.73%)patients,respectively.Male gender,smoking,hypertension,chronic hepatitis C,and lung involvement were associated with elevated AST or ALT.AST was elevated in 50%of patients over 60-years-old.FIB-4 was significantly higher in patients admitted to the intensive care unit(ICU),those with more severe COVID-19,and non-survivors.The independent variables affecting outcome were supplementary vitamin C intake(1 g daily capsules)[odds ratio(OR):0.05,95%confidence interval(CI):0.008–0.337];lung consolidation(OR:4.540,95%CI:1.155–17.840);ICU admission(OR:25.032,95%CI:7.110–88.128);and FIB-4 score>3.25(OR:10.393,95%CI:2.459-43.925).Among 60(13.98%)patients with gastrointestinal symptoms,52(86.67%)had diarrhoea.Patients with gastrointestinal symptoms were predominantly females with higher body mass index,and 50(83.40%)patients had non-severe COVID-19.CONCLUSION Few Egyptian patients with COVID-19 developed a significant liver injury.The independent variables affecting mortality were supplementary vitamin C intake,lung consolidation,ICU admission,and FIB-4 score. | Hend Ibrahim Shousha Shimaa Afify Rabab Maher Noha Asem Eman Fouad Ehab F Mostafa Mohammed A Medhat Amr Abdalazeem Hazem Elmorsy Miriam M Aziz Rateba S Mohammed Mohamed Ibrahem Hassan Elgarem Dalia Omran Mohamed Hassany Bassem Elsayed Ahmed Y Abdelaziz Mohamed El Kassas | 2021 | World Journal of Gastroenterology2021，27，40： | 1 |
| 12 | Effect of reperfusion strategy on QT dispersion in patients with acute myocardial infarction:Impact on in-hospital arrhythmia显示文摘BACKGROUND Myocardial ischemia and ST-elevation myocardial infarction(STEMI)increase QT dispersion(QTD)and corrected QT dispersion(QTcD),and are also associated with ventricular arrhythmia.AIM To evaluate the effects of reperfusion strategy[primary percutaneous coronary intervention(PPCI)or fibrinolytic therapy]on QTD and QTcD in STEMI patients and assess the impact of the chosen strategy on the occurrence of in-hospital arrhythmia.METHODS This prospective,observational,multicenter study included 240 patients admitted with STEMI who were treated with either PPCI(group I)or fibrinolytic therapy(group II).QTD and QTcD were measured on admission and 24 hr after reperfusion,and patients were observed to detect in-hospital arrhythmia.RESULTS There were significant reductions in QTD and QTcD from admission to 24 hr in both group I and group II patients.QTD and QTcD were found to be shorter in group I patients at 24 hr than those in group II(53±19 msec vs 60±18 msec,P=0.005 and 60±21 msec vs 69+22 msec,P=0.003,respectively).The occurrence of in-hospital arrhythmia was significantly more frequent in group II than in group I(25 patients,20.8%vs 8 patients,6.7%,P=0.001).Furthermore,QTD and QTcD were higher in patients with in-hospital arrhythmia than those without(P=0.001 and P=0.02,respectively).CONCLUSION In STEMI patients,PPCI and fibrinolytic therapy effectively reduced QTD and QTcD,with a higher observed reduction using PPCI.PPCI was associated with a lower incidence of in-hospital arrhythmia than fibrinolytic therapy.In addition,QTD and QTcD were shorter in patients not experiencing in-hospital arrhythmia than those with arrhythmia. | Mohamed Aboel-Kassem F Abdelmegid Mohamed M Bakr Hamdy Shams-Eddin Amr A Youssef Ahmed Abdel-Galeel | 2023 | World Journal of Cardiology2023，15，3： | 0 |
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