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134篇 您的检索式：作者名="AMLING M"

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	题名	作者	年代	出处	被引量
1	Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans.	Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier	2018	Bone Research2018，6，1：	5
2	c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption 显示文摘	TANAKA S AMLING M NEFF L	1996	Nature1996，383，6600：	1
3	Microcallus formations of the ancellous bone:a quantitative analysis of the human spine显示文摘	Hahn M Vogel M Amling M	1995	J Bone Miner Res1995，10，9：	1
4	Osteopenia and decreased bone formation in osteonectin-deficient mice显示文摘	Delany AM Amling M Priemel M	2000	J Clin Invest2000，105，7：	1
5	Leptin Inhibits Bone Formation through a Hypothalamic Relay: A Central Control of Bone Mass 显示文摘	Ducy P Amling M Takeda S	2000	Cell2000，1100，2：	1
6	Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development显示文摘	LANSKE B AMLING M NEFF L	1999	J Clin Invest1999，104，4：	1
7	bcl-2 lies down-stream of parathyroid hormone-related peptide (PTHrP) in the signaling pathway that regulates chondrocyte maturation during skeletal development显示文摘	AMLING M NEFF L MTARAKA S		0，，01：	1
8	Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass显示文摘	Ducy P Amling M Takeda S	2000	Cell2000，100，：	1
9	Normalization of mineral ion homeostasis by dietary means prevents hyperparathy-roidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice显示文摘	Li YC Amling M Pirro AE	1998	Endocrinology1998，139，10：	1
10	Leptin inhibits bones formation through a hypothalamic relay: a central control of bone mass显示文摘	DUCY P AMLING M TAKEDA S	2000	Cell2000，100，2：	1
11	Targeted ablation of the vita- min D receptor: an animal model of vitamin D-dependent rickets type II with alopecia显示文摘	Li YC Pirro AE Amling M	1997	Proc Natl Acad Sci USA1997，94，8：	1
12	Multi-institutional analysis of robotic radical cystectomy for bladder cancer:perioperative outcomes and complications in227patients显示文摘	Smith A B Raynor M Amling C L	2012	J Laparoendosc Adv Surg Tech A2012，22，1：	1
13	Leptin inhibits bone formation through a hypothalamic relay:a central control of bone mass显示文摘	Ducy P Amling M Takeda S	2000	Cell2000，100，2：	1
14	Ablation of PTHrP gene or PTH/PTHrP receptor gene leads to distinct abnormalities in bone development显示文摘	Lanske B Amling M Neff L	1999	J Clin Invest1999，104，：	1
15	Leptin inhibits bone forma-tion through a hy pothala mic relay: a central control of bone mass,Cell显示文摘	Duey P Amling M Takeda S	2000	100:197-2072000，100，：	1
16	Bone mineralization defects and vitamin D deficiency:histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients显示文摘	Priemel M von Domarus C Klatte TO Kessler S Schlie J Meier S Proksch N Pastor F Netter C Streichert T Püschel K Amling M		0，，：	1
17	Leptin inhibits bone formation through a hyperthalamic relay: a central control of bone mass显示文摘	Ducy P Amling M Takeda S	2000	Cell2000，100，2：	1
18	Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass 显示文摘	Ducy P Amling M Takeda S	2000	Cell2000，100，2：	1
19	P-glycoprotein in osteosarcoma显示文摘	Grahl K Amling M	1996	Pathologe1996，17，1：	1
20	Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass显示文摘	Ducy P Amling M Takeda S	2000	Cell2000，100，：	1

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