|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ultralight X-type lattice sandwich structure (Ⅱ):Micromechanics modeling and finite element analysis显示文摘The methods of homogenization and finite elements are employed to predict the effective elastic constants and stress-strain responses of a new type of lattice structure,the X-structure proposed by the authors in a companion paper. It is shown that in most cases the predictions by the equivalent homogenization theory agree well with the experimental and 3-dimensional finite element calculated results. The theoretical and numerical study supports the argument that the X-structure is superior to the pyramid lattice structure in terms of mechanical strength. | ZHANG QianCheng1,CHEN AiPing 2,CHEN ChangQing2,3 & LU TianJian2 1 State Key Laboratory for Mechanical Behavior of Materials,School of Material Science and Engineering,Xi’an Jiaotong University,Xi’an 710049,China 2 MOE Key Laboratory for Strength and Vibration,School of Aerospace,Xi’an Jiaotong University,Xi’an 710049,China 3 Department of Engineering Mechanics,AML,Tsinghua University,Beijing 100084,China | 2009 | Science China(Technological Sciences)2009，52，9： | 9 |
| 2 | Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans. | Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier | 2018 | Bone Research2018，6，1： | 5 |
| 3 | Role of color Doppler in differentiation of Graves' disease and thyroiditis in thyrotoxicosis显示文摘AIM:To evaluate the role of thyroid blood flow assessment by color-flow Doppler ultrasonography in the differential diagnosis of thyrotoxicosis and compare it to technetium pertechnetate thyroid scanning. METHODS:Twenty-six patients with thyrotoxicosis were included in the study. Clinical history was taken and physical examination and thyroid function tests were performed for all patients. Thyroid autoantibodies were measured. The thyroid glands of all patients were evaluated by gray scale ultrasonography for size, shape and echotexture. Color-flow Doppler ultrasonography of the thyroid tissue was performed and spectral flow analysis of both inferior thyroid arteries was assessed. Technetium99 pertechnetate scanning of the thyroid gland was done for all patients. According to thyroid scintigraphy, the patients were divided into two groups:18 cases with Graves' disease and 8 cases with Hashimoto's thyroiditis. All patients had suppressed thyrotropin. The diagnosis of Graves' disease and Hashimoto's thyroiditis was supported by the clinical picture and follow up of patients. RESULTS:Peak systolic velocities of the inferior thyroid arteries were significantly higher in patients with Graves' disease than in patients with thyroiditis (P = 0.004 in the right inferior thyroid artery and P = 0.001 in left inferior thyroid artery). Color-flow Doppler ultrasonography parameters demonstrated a sensitivity of 88.9% and a specificity of 87.5% in the differential diagnosis of thyrotoxicosis. CONCLUSION:Color Doppler flow of the inferior thyroid artery can be used in the differential diagnosis of thyrotoxicosis, especially when there is a contraindication of thyroid scintigraphy by radioactive material in some patients. | Ragab Hani Donkol Aml Mohamed Nada Sami Boughattas | 2013 | World Journal of Radiology2013，5，4： | 4 |
| 4 | Effect of treatment of overt hypothyroidism on insulin resistance显示文摘AIM: To investigate the impact of hypothyroidism and thyroxine therapy on insulin sensitivity in patients with overt hypothyroidism.METHODS: The study included twenty seven overtly hypothyroid and fifteen healthy euthyroid South Western Asian females.Both groups had matching age and body mass index.Physiological and pathological conditions as well as medications that may alter thyroid function,glucose homeostasis or serum lipids were ruled out.Serum thyrotropin(TSH),free tetraiodothyronine(FT4),free triiodothyronine(FT3),fasting insulin(FI),fasting plasma glucose(FPG),total cholesterol and triglycerides were measured before and six months after initiating thyroxine therapy for hypothyroid patients and once for the control group.Insulin resistance(IR) was estimated using homeostasis model assessment(HOMA-IR) and Body mass index(BMI) was calculated.RESULTS: Both study groups,hypothyroid patients and euthyroid control subjects,had matching age and body mass index(P-value 0.444,0.607 respectively).No significant difference was found between the hypothyroid patients and the euthyroid control group regarding fasting plasma glucose,fasting insulin,insulin resistance,total cholesterol and triglycerides(P-values 0.432,0.621,0.883,0.586,0.05 respectively).In the hypothyroid patients,triglycerides showed direct correlation to TSH and inverse correlation to FT3.Similarly total cholesterol inversely correlated to FT3 but its direct correlation to TSH did not reach statistical significance.After thyroxine replacement and reaching an euthyroid state as confirmed by clinical and laboratory data,there was no significant change in fasting plasma glucose,insulin resistance or triglyceride level(P-value 0.216,0.204,0.175 respectively) while total cholesterol significantly decreased(P-value 0.043) and fasting insulin significantly increased(P-value 0.047).CONCLUSION: Hypothyroidism has no impact on insulin sensitivity.Correction of hypothyroidism is not associated with a significant change of insulin sensitivity or triglycerides,but with a significant reduction of total cholesterol. | Aml Mohamed Nada | 2013 | World Journal of Diabetes2013，4，4： | 2 |
| 5 | A systematic collaborative overview of randomized trials comparing idarubicin with daunorubicin(or other anthracyclines)as induction therapy for acute myeloid leukaemia显示文摘 | AML COLLABORATIVE GROUP | 1998 | Br J Haematol1998，103，： | 1 |
| 6 | Ureteral stenting after ureteroscopy for distal ureteral calculi:a multi-institutional prospective randomized controlled study assessing pain,outcomes and complications显示文摘 | Borboroglu PG Amling CL Schenkman NS | 2001 | J Urol2001，166，5： | 1 |
| 7 | Serum hepatitis B surface antigen quantitation can refect hepatitis B vivns in the liver and pre- dict treatment response 显示文摘 | Chan HLY Wong VWS Tse AML | 2007 | Clin Gastroenterol Hepatol2007，5，： | 1 |
| 8 | Management and extended outcome of patients with synchronous bilateral solid renal neoplasms in the absence of yon Hippel-Lindau disease显示文摘 | Blute ML Amling CL Bryant SC | 2000 | Mayo Clin Proc2000，75，10： | 1 |
| 9 | Palliative transurethral prostate resection for bladder outlet obstruction in patients with locally advanced prostate cancer显示文摘 | Crain D S Amling C L Kane CJ | 2004 | J Urol2004，171，21： | 1 |
| 10 | Relationship between obesity and race in predicting adverse pathologic variables in patients undergoing radical prostatectomy显示文摘 | AMLING CL KANE CJ RIFFENBURGH RH | 2001 | Urology2001，58，5： | 1 |
| 11 | c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption 显示文摘 | TANAKA S AMLING M NEFF L | 1996 | Nature1996，383，6600： | 1 |
| 12 | Serum hepatitisB surface, antigen quantitation can refect hepatitis B vivns in the liver and pre- dict treatment response 显示文摘 | Chan HLY Wong VWS Tse AML | 2007 | Clin Gastroenterol Hepatol2007，5，： | 1 |
| 13 | Pathologic variables and recurrence rates as related to obesity and race in men with prostate cancer undergoing radical prostatectomy显示文摘 | AMLING CL RIFFENBURGH RH SUN L | 2004 | J Clin Oncol2004，22，3： | 1 |
| 14 | Microcallus formations of the ancellous bone:a quantitative analysis of the human spine显示文摘 | Hahn M Vogel M Amling M | 1995 | J Bone Miner Res1995，10，9： | 1 |
| 15 | Osteopenia and decreased bone formation in osteonectin-deficient mice显示文摘 | Delany AM Amling M Priemel M | 2000 | J Clin Invest2000，105，7： | 1 |
| 16 | Leptin Inhibits Bone Formation through a Hypothalamic Relay: A Central Control of Bone Mass 显示文摘 | Ducy P Amling M Takeda S | 2000 | Cell2000，1100，2： | 1 |
| 17 | Diagnosis and management of superficial bladdercancer显示文摘 | Amling CL | 2001 | Curr Probl Cancer2001，25，4： | 1 |
| 18 | Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development显示文摘 | LANSKE B AMLING M NEFF L | 1999 | J Clin Invest1999，104，4： | 1 |
| 19 | Eupus erythematosus tu- midus is a separate subtype of cutaneous lupus erythematosus显示文摘 | Schmitt V Meuth AM Amle S | 2010 | British Journal of Dermatology2010，162，： | 1 |
| 20 | bcl-2 lies down-stream of parathyroid hormone-related peptide (PTHrP) in the signaling pathway that regulates chondrocyte maturation during skeletal development显示文摘 | AMLING M NEFF L MTARAKA S | | 0，，01： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员