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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children显示文摘AIM: To identify the prevalence, risk factors and manifestations of asymptomatic hepatitis C virus (HCV) infection in Egyptian children. METHODS: Children at the age of 1-9 years were screened for HCV antibodies and alanine aminotransferase (ALT) levels. Every child with elevated ALT and/or detectable HCV antibodies was tested for HCV RNA by RT-PCR and compared with two negative controls for risk factors and signs and symptoms of liver disease.RESULTS: We screened 1042 children, six of them had elevated ALT, negative HCV antibody and positive RNA, likely representing acute hepatitis C cases. Fifteen children were HCV seropositive, 5 of them were HCV RNA positive. Asymptomatic HCV infection was present in 2.02% (positive results for either HCV antibodies or HCV-RNA or both). Symptoms such as diarrhea, abdominal pain, history of fatigue and school absence because of illness and risk factors such as dental care were significantly more common among HCV positive cases than among controls. None of the HCV positive children was diagnosed as having signs of advanced liver disease upon clinical or ultrasonographic examination. CONCLUSION: Asymptomatic HCV infection is detectable in 2.02% Egyptian children. | MS El-Raziky M El-Hawary G Esmat AM Abouzied N El-Koofy N Mohsen S Mansour A Shaheen M Abdel Hamid H El-Karaksy | 2007 | World Journal of Gastroenterology2007，13，12： | 4 |
| 3 | Human urotensinⅡis a potent vasoconstrictory and agonist for the orphan receptor GPR14 显示文摘 | Ames R S Sarau H M Chambers J K | 1999 | Nature1999，401，6750： | 3 |
| 4 | 脂质组学改善传统危险因素预测的2型糖尿病患者的心血管事件显示文摘临床脂质测定并未显示出糖尿病或心血管病相关的脂质代谢改变的复杂性。脂质组学则能够评估可作为疾病风险潜在标志物的数百种脂质种类。方法:纳入来自糖尿病治疗和血管保护行动。 | 刘莉 叶鹏 Alshehry ZH Mundra PA Barlow CK Mellett NA Wong G McConville MJ Simes J Tonkin AM Sullivan DR Barnes EH Nestel PJ Kingwell BA Marre M Neal B Poulter NR Rodgers A Williams B Zoungas S Hillis GS Chalmers J Woodward M Meikle PJ | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 5 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 6 | Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprutein显示文摘 | Baltes S Gastens AM Fedrowitz M | 2007 | Neuropharmacology2007，52，2： | 1 |
| 7 | Observational study of patient-ventilator asynchrony and relationship to sedation level 显示文摘 | de Wit M Pedram S Best AM | 2009 | J Crit Care2009，24，1： | 1 |
| 8 | Opioid pharmacology 显示文摘 | Trescot AM Datta S Lee M | 2008 | Pain physician2008，11，2： | 1 |
| 9 | Association between HLA-G genotype and risk of pre-eclampsia:a case-control study using family triads显示文摘 | Andersen AM Melbye M | 2004 | Mol Hum Reprod2004，10，4： | 1 |
| 10 | Indoleamine 2,3-dioxygenase expression in transplanted NOD islets prolongs gratt snrvlvat aster adoptive transter of diabetogenic splenocytes显示文摘 | Crawford M Bertera S | 2002 | Diabetes2002，51，： | 1 |
| 11 | Ab- sence of CD4^ + CD25^+ regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter pylori-infected mice 显示文摘 | Raghavan S Fredrikssen M Svennerholm AM | 2003 | Clin Exp Immunol2003，132，3： | 1 |
| 12 | Gene expression of humanbeta-defensins in healthy and inflamed human dental pulps显示文摘 | Paris S Wolgin M Kielbassa AM | 2009 | Bi-ology2009，35，4： | 1 |
| 13 | Pivotalrole of TLR4 receptors in alcohol-induced neuroinflammation andbrain damage显示文摘 | Alfonso-Loeches S Pascual-Lucas M Blanco AM | 2010 | J Neurosci2010，30，24： | 1 |
| 14 | Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice显示文摘 | Gil-Bernabe AM Ferjancic S Tlalka M | 2012 | Blood2012，119，13： | 1 |
| 15 | A pentatricopeptide repeat protein of rice is essential for the chloroplast biogenesis 显示文摘 | Gothand'am K M Kim E S Cho H | 2005 | Plant Molecular Biology2005，58，： | 1 |
| 16 | Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy in BT4C rat glioma model 显示文摘 | Sandmair AM Turunen M Vanninen R Vainio P Kauppinen R Johansson R Vapalahti M Yla-Herttuala S | 2002 | Cancer Gene Ther2002，9，11： | 1 |
| 17 | Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency显示文摘 | Marinaki AM Arenas M | 2002 | Hum Genet2002，111，45： | 1 |
| 18 | Apparent diffusion coefficient: a quantitative parameter for in vivo tumor characterization显示文摘 | Herneth AM Guccione S Bednarski M | 2003 | Eur J Radiol2003，45，3： | 1 |
| 19 | Surgical treatment of mitral valve regurgitation indilated cardiomyopathy显示文摘 | Calaf iore AM M au roMD Gal lina S | 2004 | Heart Su rg Forum2004，7，： | 1 |
| 20 | Acid deposition and its efects in China: an overview显示文摘 | Thorjorn L Hans M L Ames S | 1999 | Environmental Science and Policy1999，2，： | 1 |
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