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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Numerical study on a pool fire using large eddy simulation 显示文摘 | Alice L K C Richard K K Y | 2007 | A Treatise on the 4th Conference on the Development of Performance- Based Fire Code2007，，10： | 1 |
| 3 | An Investigation of Decision - Making Styles of Consumers in China 显示文摘 | Hiu Alice S Y Noel Y M Siu Charlie C L Wang Ludwig M K Chang | 2001 | The Journal of Consumer Affairs2001，35，2： | 1 |
| 4 | A phylogeny of Chloridoideae (Poaceae)based on matk sequences显示文摘 | Hilu K W Alice L A | 2001 | Syst Bot2001，26，2： | 1 |
| 5 | Backside-thinned CCDsfor keV electron detection显示文摘 | Mihir K Ravel Alice L Reinheimer | 1991 | SPIE1991，1447，： | 1 |
| 6 | The nucleoporin Nup 96 is required for proper expression of interferon-regulated proteins and functions 显示文摘 | Faria A M Levay A Wang Y M Alice O K Rosa M L | 2006 | Immunity2006，24，3： | 1 |
| 7 | Modeling intentional distribution system contamination and detection 显示文摘 | ALLMANN T P CARLSON ALICS K L | 2005 | J Am Water Works Assoc2005，97，1： | 1 |
| 8 | Haemophilus ingquenzae type b isolates show antigenic variation in a major outer membrane protein显示文摘 | Alice L E George E K | 1984 | Infect Immun1984，46，2： | 1 |
| 9 | An investigation of decision-making styles of consumers in China显示文摘 | Hiu Alice S Y Noel Y M Siu Charlie C L Wang Ludwig M K Chang | | 0，，02： | 1 |
| 10 | 2-Aryl benzimidazoles featuring alkyl-linked pendant alco- hols and amines as inhibitors of checkpoint kinase Chk2 显示文摘 | DanieUe K Alice L D Jonathan M | 2007 | Bioorganic & Medicinal Chemistry2007，17，： | 1 |
| 11 | Statistical Process Control to Improve Coding and Code Review显示文摘 | Alice L J Pillai S K | 2003 | IEEE Com- puter Society2003，5，： | 1 |
| 12 | The lysine requirement of lactating primiparous sows显示文摘 | Touchette K J Alice G L Newcomb M D | 1998 | Journal of Animal Science1998，76，： | 1 |
| 13 | Proactive personality and employee creativity: The effects of job creativity requirement and supervisor support for creativity显示文摘 | Tae-Yolo K Alice H Y Deog-Ro L | 2010 | Creativity Research Journal2010，22，1： | 1 |
| 14 | Phylogeny of Poaceae inferred from matK sequences显示文摘 | Hilu K W Alice L A Liang H | 1999 | Ann Miss Bot Gard1999，86，： | 1 |
| 15 | A phylogeny of the Chloridoideae (Poaceae)based on matK sequences显示文摘 | Hilu K W Alice L A | 2001 | Syst Bot2001，26，： | 1 |
| 16 | Phylogeny of Poaceae inferred from matK Sequences显示文摘 | Hilu K W Alice L A Liang H | 1999 | Ann Mo Bot Gard1999，86，4： | 1 |
| 17 | Does different exercise have the same effect of health promotion for the elderly?Comparison of training-speci?c effect of Tai Chi and swimming on motor control 显示文摘 | Alice M K Wong Shih-Wei C Shu-Chun H Ching L Hsieh-Ching C Wei-Hsien H Carl P C etal | 2011 | Archives of Gerontology and Geriatrics2011，53，： | 1 |
| 18 | Numerical study on a pool fire using large eddy simulation 显示文摘 | ALICE L K CHEUNG R YUEN K K | 2007 | A Treatise on the 4th Conference on the Develop- ment of Performance -- Based Fire Code2007，，10： | 1 |
| 19 | 14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity显示文摘 | Thorson J A Lily W K Alice L | 1998 | Mol Cell Biol1998，18，9： | 1 |
| 20 | , An investigation of decision - making styles of consumers in China显示文摘 | Hiu Alice S Y Noel Y M Siu Charlie C L Wang Ludwig M K Chang | 2001 | The Journal of Consumer Affairs2001，35，2： | 1 |
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