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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia显示文摘 | Pearlstein DP Ali MH Mungai PT | 2002 | Arterioscler Thromb Vasc Biol2002，22，4： | 1 |
| 3 | Detection of asymmetric giaucomatous damage using automated pupillography, the swinging flashlight method and the magnified-assisted swinging flashlight method 显示文摘 | WAISBOURD M LEE B ALI MH LU L MARTINEZ P FARIA B | 2015 | Eye (Lond)2015，29，10： | 1 |
| 4 | Application and assessment of a dipstick assay in the diagnosis of hydatidosis and trichinosis显示文摘 | Al-Sherbiny MM Farrag AA Fayad MH Makled MK Tawfeek GM Ali NM 2004 | 2004 | Parasitol Res2004，93，2： | 1 |
| 5 | A comprehensive anesthesia proto-col that emphasizes peripheral nerve blockade for total knee and totalhip arthroplasty显示文摘 | Hebl JR Kopp SL Ali MH | 2005 | J Bone Joint Surg Am2005，87，： | 1 |
| 6 | A comprehensiveanesthesia protocol that emphasizes peripheral nerveblockade for total knee and total hip arthroplasty显示文摘 | Hebl JR Kopp SL Ali MH | 2006 | JBone Joint Surg Am2006，88，： | 1 |
| 7 | The effect of immature oocytes quantity on the rates of oocytes maturity and morphology, fertilization,and embryo development in ICSI cycles 显示文摘 | Halvaei I Ali KM Razi MH | 2012 | J Assist Reprod Genet2012，29，： | 1 |
| 8 | Effect of myopic LASIK on corneal sensitivity and morphology of subbasal nerves显示文摘 | Linna TU Vesaluoma MH Pérez-Santonja JJ Petroll WM Alió JL Tervo TM | | 0，，02： | 1 |
| 9 | Endoscopic assessment of thedacryocystorhinostomy ostium after powered endoscopic surgery :behaviour beyond 4 weeks 显示文摘 | Ali MJ Psaltis AJ Ali MH | 2015 | Clin Experiment Ophthalmol2015，43，2： | 1 |
| 10 | Effect of a gonadotropin releasinghormone analogue on cyclophosphamide induced ovarian toxicity in adult mice 显示文摘 | Kishk EA Mohammed Ali MH | 2013 | Arch Gynecol Obstet2013，287，5： | 1 |
| 11 | UIJ-success of extracorporeal shockwave lithotripsy for distal ureteric stones in patients with and without hydronephrosis显示文摘 | Hafez H Ali MH Salem T | | 0，，05： | 1 |
| 12 | Endothelial permeability and IL-6 production during hypoxia: role of ROS in signal transduction显示文摘 | Ali MH Schlidt SA Chandel NS | 1999 | Am J Physiol1999，277，21： | 1 |
| 13 | Intraparotid facial nerve schwannoma: a case report显示文摘 | Ali WM Aslam M Beg MH | 2011 | Int J Case Rep Image2011，2，8： | 1 |
| 14 | A comprehensiveanesthesia protocol that emphasizes peripheral nerveblockade for total knee and total hip arthroplasty 显示文摘 | Hebl JR Kopp SL Ali MH | 2010 | Journal of Bone and Joint Surgery American Volume2010，22，16： | 1 |
| 15 | A comprehensive anesthesia protocol that emphasizes peripheral nerve blockade for lotal knee and total hip arthroplasty显示文摘 | Hebl JR Kopp SL Ali MH | 2006 | J Bone Joint Surg Am2006，88，： | 1 |
| 16 | A comprehensive anesthesia protocol that emphasizes peripheral nerve blockade for total knee and total hip arthroplasty显示文摘 | HeW JP~ Kopp BL Ali MH et aI | 2005 | J Bone Joint Burg Am2005，67，： | 1 |
| 17 | A reverse complementary multimodal imaging system to visualize microRNA9-involved neuro-genesis using peptide targeting transferrin receptor-conjugated mag-netic fluorescence nanoparticles 显示文摘 | Jo MH Ali BA Al-Khedhairy AA | 2012 | Biomaterials2012，33，： | 1 |
| 18 | Functionalised ZnO - nanorod - based selective electrochemical sensor for intracellular glucose 显示文摘 | Asif MH Ali SM Nur O | 2010 | Biosens Bioelectron2010，25，10： | 1 |
| 19 | Angiolymphoid hyperplasia with eosinophilia associated with tetanus toxoid vaccination Asee comments显示文摘 | Akosa AB Ali MH Khoo CT | 1990 | Histopathology1990，16，6： | 1 |
| 20 | Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitoehondrial oxidants显示文摘 | Ali MH Mungai PT Schumacker PT | 2006 | Am J Physiol Lung Cell Mol Physiol2006，291，1： | 1 |
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