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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Optimized combined harmonic filtering system显示文摘 | Dimitrie Alexa Sirbu A | 2001 | IEEE Transactions on Industrial Electronics2001，48，6： | 1 |
| 3 | Isolation and analysis of mRNA from environmental microbial communities 显示文摘 | MCGRATH K C THOMAS-HALL S R CHENG C T LEO L ALEXA A SCHMIDT S SCHENK P M | 2008 | J Microbiol Meth2008，75，17： | 1 |
| 4 | A sketch-based interface for detail-preserving mesh editing显示文摘 | Nealen A Sorkine O Alexa M | 2005 | ACM Transactions on Graphics2005，24，3： | 1 |
| 5 | A sketch-based interface for detail-preserving mesh editing 显示文摘 | Nealen A Sorkine O Alexa M | 2005 | ACM Transactions on Graphics2005，24，3： | 1 |
| 6 | Context-based Surface Completion显示文摘 | Sharp A Alexa M | 2007 | ACM Transactions on Graphics2007，23，3： | 1 |
| 7 | A sketch-based interface for detail preserving mesh editing显示文摘 | Nealen A Sorkine O Alexa M | 2005 | ACM Transactions on Graphics2005，24，3： | 1 |
| 8 | Factor interaction analysis for chromosome 8 and DNA methylation alterations highlights innate immune response suppression and cytoskeletal changes in prostate cancer显示文摘 | Schulz WA Alexa A Jung V | 2007 | Mol Cancer2007，6，： | 1 |
| 9 | Multi level partition of unity implicits 显示文摘 | Ohtake Y Belyaev A Alexa M | 2003 | ACM Transactions on Graphics2003，22，3： | 1 |
| 10 | Multi-level partition of unity implicits显示文摘 | OHTAKE Y BELYAEW A ALEXA M | 2003 | ACM Transactions on Graphics2003，22，3： | 1 |
| 11 | The moderating effects of personal reputation on accountability-strain relationships显示文摘 | Laird Mary Dana Hochwarter Wayne A Ferris Gerald R Perryman Alexa A and Zinko Robert | 2009 | Journal of Occupational Health Psychology2009，，1： | 1 |
| 12 | Detection and characterization of Clostridium perfringens in the fece of healthy and diarrheic dogs显示文摘 | Goldstein M R Kruth S A Alexa M E | 2012 | Can J Vet Res2012，76，： | 1 |
| 13 | Structural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5(ERK5)module显示文摘 | GLATZ G GGL G ALEXA A | 2013 | J Biol Chem2013，288，12： | 1 |
| 14 | A Sketch-- based Interface for Detail--preserving Mesh Editing 显示文摘 | Nealen A Sorkine O Alexa M | 2005 | ACM Transactions on Graphics2005，24，3： | 1 |
| 15 | Multi-level Partition of Unity Implicits显示文摘 | Ohtake Y Belyaev A Alexa | 2003 | ACM Transactions on Graphics2003，22，3： | 1 |
| 16 | Multi-level partition of unity implicits显示文摘 | Ohtake Y Belyaev A Alexa M | 2003 | ACM Transactions on Graphics(Proc SIGGRAPH)2003，22，3： | 1 |
| 17 | Multi-level partition of unity implicits 显示文摘 | Ohtake Y Belyaev A Alexa M | 2003 | ACM Transactions on Graphics2003，22，3： | 1 |
| 18 | Multi-level partition of unity implicits显示文摘 | OHTAKE Y BELYAEV A ALEXA M | 2003 | ACM Transactions on Graphics2003，22，3： | 1 |
| 19 | Multi-level partition of unity implicits 显示文摘 | Ohtake Y Belyaev A Alexa M | 2003 | ACM Transactions on Graphics2003，22，3： | 1 |
| 20 | A sketch-based interface for detail-preserving mesh editing显示文摘 | Nealen A Sorkine O Alexa M | 2005 | ACM Transactions on Graphics2005，24，3： | 1 |
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