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| 1 | Prevalence, risk factors, clinical course, and outcome of acute kidney injury in Chinese intensive care units: a prospective cohort study显示文摘 | WEN Ying JIANG Li XU Yuan QIAN Chuan-yun LI Shu-sheng QIN Tie-he CHEN Er-zhen LIN Jian-dong AI Yu- hang WU Da-wei WANG Yu-shan SUN Ren-hua HU Zhen-jie CAO Xiang-yuan ZHOU Fa-chun HE Zhen-yang ZHOU Li-hua AN You-zhong KANG Yan MA Xiao-chun YU Xiang-you ZHAO Ming-yan XI Xiu-ming DU Bin | 2013 | Chinese Medical Journal2013，，23： | 40 |
| 2 | Animal models for the study of hepatitis B virus infection显示文摘Even with an effective vaccine, an estimated 240 million people are chronically infected with hepatitis B virus(HBV) worldwide. Current antiviral therapies,including interferon and nucleot(s)ide analogues,rarely cure chronic hepatitis B. Animal models are very crucial for understanding the pathogenesis of chronic hepatitis B and developing new therapeutic drugs or strategies. HBV can only infect humans and chimpanzees, with the use of chimpanzees in HBV research strongly restricted. Thus, most advances in HBV research have been gained using mouse models with HBV replication or infection or models with HBV-related hepadnaviral infection. This review summarizes the animal models currently available for the study of HBV infection. | wei-na guo bin zhu ling ai dong-liang yang bao-ju wang | 2018 | Zoological Research2018，39，1： | 14 |
| 3 | Parallel Reinforcement Learning-Based Energy Efficiency Improvement for a Cyber-Physical System显示文摘As a complex and critical cyber-physical system(CPS),the hybrid electric powertrain is significant to mitigate air pollution and improve fuel economy.Energy management strategy(EMS)is playing a key role to improve the energy efficiency of this CPS.This paper presents a novel bidirectional long shortterm memory(LSTM)network based parallel reinforcement learning(PRL)approach to construct EMS for a hybrid tracked vehicle(HTV).This method contains two levels.The high-level establishes a parallel system first,which includes a real powertrain system and an artificial system.Then,the synthesized data from this parallel system is trained by a bidirectional LSTM network.The lower-level determines the optimal EMS using the trained action state function in the model-free reinforcement learning(RL)framework.PRL is a fully data-driven and learning-enabled approach that does not depend on any prediction and predefined rules.Finally,real vehicle testing is implemented and relevant experiment data is collected and calibrated.Experimental results validate that the proposed EMS can achieve considerable energy efficiency improvement by comparing with the conventional RL approach and deep RL. | Teng Liu Bin Tian Yunfeng Ai Fei-Yue Wang | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，2： | 14 |
| 4 | Predictors and in-hospital outcomes of preoperative acute kidney injury in patients with type A acute aortic dissection显示文摘BackgroundAcute 肾损害(AKI ) 在为尖锐大动脉的解剖(AAD ) 的外科以后是普通的并且增加在里面医院和长期的死亡。然而,很少数据与类型在病人在早外科手术前的 AKI 的临床、预示的关联上存在 AAD。我们试图在病人在在里面医院结果上决定外科手术前的 AKI 的发生和 AKI 的影响与打阿德梅索兹夫罗姆·梅 2009 到 2014 年 6 月,我们回顾地注册了为类型从症状发作和收到的开的外科在 48 h 以内进入我们的医院的 178 个病人 AAD。病人被划分成没有 AKI 和 AKI 组并且在 surgery.ResultsAKI 发生在 41 个病人(23.0%) 以前,根据 KDIGO 标准与 AKI 上演了严厉。在里面医院复杂并发症的发生在有与没有 AKI 相比的外科手术前的 AKI 的病人是显著地更高的(41.5% 对 9.5% , P <0.001 ) ,包括肾的梗塞(7.3% 对 0, P = 0.012 ) ,并且它与 AKI 严厉增加了(P 趋势 <0.001 ) 。尽管没有重要差别被发现,没有 AKI,有 AKI 的病人与病人相比有更高的在里面医院死亡(14.6% 对 5.1% , P = 0.079 ) 。Multivariate 分析显示那男性,承认上的心脏舒张的血压和双边的肾的动脉参与 AAD.ConclusionsEarly 是在有类型 A 的病人的外科手术前的 AKI 的独立预言者在外科前的 AKI 在有类型的病人是普通的 AAD,并且与增加的在里面医院复杂并发症被联系。男性,承认上的心脏舒张的血压和双边的肾的动脉参与是为外科手术前的 AKI 的主要预言者。 | Xiao WANG Hong-Mei PEN Chun-Yan HU Bin QUE Hui AI Chun-Mei WANG Li-Zhong SUN Shao-Ping NIE | 2016 | Journal of Geriatric Cardiology2016，13，8： | 12 |
| 5 | Consequence alimentary reconstruction in nutritional status after total gastrectomy for gastric cancer显示文摘NTODUCTIONToinvestigatethenutritionalconsequencesofgastroentericreconstructioninpatientswithgastriccanceraftertotalgastrecto... | WU Yin Ai 1, LU Bin 1, LIU Jun 1, LI Jiang 1, CHEN Jiang Rong 2 and HU Shi Xiong 1 | 1999 | World Journal of Gastroenterology1999，5，1： | 8 |
| 6 | Parallel Reinforcement Learning:A Framework and Case Study显示文摘In this paper, a new machine learning framework is developed for complex system control, called parallel reinforcement learning. To overcome data deficiency of current data-driven algorithms, a parallel system is built to improve complex learning system by self-guidance. Based on the Markov chain(MC) theory, we combine the transfer learning, predictive learning, deep learning and reinforcement learning to tackle the data and action processes and to express the knowledge. Parallel reinforcement learning framework is formulated and several case studies for real-world problems are finally introduced. | Teng Liu Bin Tian Yunfeng Ai Li Li Dongpu Cao Fei-Yue Wang | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，4： | 8 |
| 7 | H2 strain attenuated live hepatitis A vaccines:protective efficacy in a hepatitis A outbreak显示文摘AIM To investigate the protective efficacy ofH2 strain attenuated live hepatitis A vaccines(H2-strain vaccines)in hepatitis A(HA)outbreaks.METHODS With the permission of theirparents,5551 pre-school and grade 1-3 primaryschool children were inoculated with 1 dose(106.5TCID50)of H2-strain vaccines in anonrandomized,controlled trial conducted inFucheng County,Hebei Province in May 1997.Another 6485 children in the same grades andcompatible in gender and age were enrolled ascontrols.Epidemiological and serological surveywas conducted to evaluate the protectiveefficacy of the vaccines.ELISA was used todetect serum IgM anti-HAV.RESULTS HA outbreak started in early May1998,peaked in the middle of the same month,and lasted about 80 days.Overall 302 HA caseswere found,192(53.58%)were 5-9 years old.One vaccinee and 25 control cases were found tohave hepatitis A,which account for 0.28%(1/356)and 5.92%(25/422)of all vaccinees andcontrols in the 14 villages,respectively.The protective efficacy of vaccines was 95.27%(95% Cl:85.83%-104.72%).In subjects testedfor anti-HAV IgM from 13 villages,1(0.40%)overt and 11(4.06%)asymptomatic HAV caseswere found in 271 vaccinees,but 21(6.69%)ofovert and asymptomatic ones were found in 314controls.CONCLUSION H2 strain vaccines were excellent in preventing overt hepatitis A, but not so effective in preventing asymptomatic hepatitis A virus infection. A booster dose might be needed to get permanent reliable immunity. | Yu Liang Zhao Zong Da Meng Zhi Yi Xu Jun Jie Guo Shao Ai Chai Cheng Gang Duo Xuan Yi Wang Jin Feng Yao Hong Bin Liu Shun Xiang Qi Hui Bin Zhu | 2000 | World Journal of Gastroenterology2000，6，6： | 7 |
| 8 | miRNA expression profile during fluid shear stress-induced osteogenic differentiation in MC3T3-E1 cells显示文摘 | MAI Zhi-hui PENG Zhu-li ZHANG Jing-lan CHEN Lin LIANG Huan-you CAI Bin AI Hong | 2013 | Chinese Medical Journal2013，，8： | 7 |
| 9 | Relationship between acute kidney injury before thoracic endovascular aneurysm repair and in-hospital outcomes in patients with type B acute aortic dissection显示文摘ObjectiveAcute 肾损害(AKI ) 经常发生在基于导管的 interventional 过程和增加死亡以后。然而,类型 B 尖锐大动脉的解剖(AAD ) 的 AKI 以前胸的 endovascular 动脉瘤修理(TEVAR ) 的含意仍然保持不清楚。这研究与类型 B AAD.MethodsBetween 2009 在病人在 TEVAR 前评估了 AKI 的发生,预言者,和在里面医院结果并且 2013, 76 个病人回顾地被评估从症状发作在 36 h 以内为类型 B AAD 收到了 TEVAR。病人被分类进 no-AKI 对 AKI 组,并且 AKI 的严厉进一步根据肾疾病被上演:在外科手术前的 AKI 的 TEVAR.ResultsThe 发生前改进全球结果标准是 36.8% 。在里面医院复杂并发症与 no-AKI 相比在有外科手术前的 AKI 的病人是显著地更高的(50.0% 对 4.2% 分别地;P <0.001 ) ,包括尖锐肾的失败(21.4% 对 0 分别地;P <0.001 ) ,并且他们与 AKI 的严厉增加了(P <0.001 ) 。身体温度和白血房间计数的最大的层次是以前显著地与最大的浆液 creatinine 有关铺平 TEVAR。Multivariate 分析在承认上显示出那收缩血压(或:1.023;95% CI:1.003-1.044;P = 0.0238 ) 并且双边的肾的动脉参与(或:19.076;95% CI:1.914-190.164;P = 0.0120 ) 外科手术前的 AKI.ConclusionsPreoperative AKI 的强壮的预言者经常与类型 B AAD 在病人被发生,并且与更高的在里面医院复杂并发症相关并且提高了煽动性的反应。承认和双边的肾的动脉参与上的收缩血压是为在 TEVAR 前的 AKI 的主要风险因素。 | Hong-Mei REN Xiao WANG Chun-Yan HU Bin QUE Hui AI Chun-Mei WANG Li-Zhong SUN Shao-Ping NIE | 2015 | Journal of Geriatric Cardiology2015，12，3： | 7 |
| 10 | Meanders of the Jialing River in China: Morphology and formation显示文摘As a fundamental category of river system, comparisons in diverse regions and types with quantitative parameters on meander morphology will help to distinguish different characteristics and approach formations and evolutions. It also can provide scientific basis of geomorphology for their protections and exploitation of the meander resources. Based on the images of Google Earth, meanders’ parame- ters are proposed and then measured and calculated. The result suggests that incised meanders in the Jialing River are among the most complex, irregular and sinuous channels. Special river gradient, geological structures, strata and lithology, backwater effect of landform are key factors to shape me- anders of the Jialing River. The evolution of meander in the Jialing River obeys the principle of mini- mum-maximum energy dissipation. Easy acquisitions of remote sensing data make regional and global comparisons possible, and then the differences of formations can be explored. The morphology can probably provide an evidence of antecedent river and demonstrate the channel incisions and crustal uplifts. Meander core in Chinese is named after the isolated hills in the Jialing River. The incised me- ander is a kind of resource and needs to be protected. | ZHANG Bin AI NanShan HUANG ZhengWen YI ChengBo QIN FaCao | 2008 | Chinese Science Bulletin2008，53，2： | 6 |
| 11 | Adsorption/desorption of toluene on a hypercrosslinked polymeric resin in a highly humid gas stream显示文摘In many sources of volatile organic compounds (VOCs), large amounts of water vapor come from the air and the reactors. The relative humidity (RH) of exhaust gas is normally >60% and is supersaturated. Maintaining the property of adsorbent on VOCs in a highly humid gas stream is a serious industrial problem. In this study, the adsorption/desorption behavior of toluene in a micro-mesoporous polymeric resin was investigated in a highly humid environment to explore the influence of abound water vapor on resin adsorption and regeneration. This resin could selectively adsorb toluene at an RH of 80%, and its adsorption property was unaffected by the presence of water vapor. In the case of humidity saturation, the resin displayed a high adsorption capacity at a moisture content of <30%. Therefore, the polymer resin is an excellent water-resistant adsorbent of VOCs. In the regenerative experiment, the resin maintained its original adsorption capability after four adsorption/ desorption cycles of toluene purging with nitrogen gas at 120℃. The resin exhibited excellent regeneration performance at high humidity. | Bing Zhou Bin Sun Wenjuan Qiu Ying Zhou Junqian He Xiao'ai Lu Hanfeng Lu | 2019 | Chinese Journal of Chemical Engineering2019，27，4： | 6 |
| 12 | Multifunctional dextran micelles as drug delivery carriers and magnetic resonance imaging probes显示文摘Multifunctional nanoparticles combining diagnostic and therapeutic agents into a single platform make cancer theranostics possible and have attracted wide interests in the field. In this study, a multifunctional nanocomposite based on dextran and superparamagnetic iron oxide nanoparticles(SPIO) was prepared for drug delivery and magnetic resonance imaging(MRI). Amphiphilic dextran was synthesized by grafting stearyl acid onto the carbohydrate backbone, and micelle was formed by the resulted amphiphilic dextran with low critical micelle concentration at 1.8 mg L-1. Doxorubicin(DOX) and a cluster of the manganese-doped iron oxide nanoparticles(Mn-SPIO)nanocrystals were then coencapsulated successfully inside the core of dextran micelles, resulting in nanocomposites with diameter at about 100 nm. Cell culture experiments demonstrated the potential of these Mn-SPIO/DOX nanocomposites as an effective multifunctional nanoplatform for the delivery of anticancer drug DOX with a loading content(DLC) of 16 %. Confocal laser scanning microscopyreveals that the Mn-SPIO/DOX had excellent internalization ability against MCF-7/Adr cells after 2-h labeling compared with free DOXáHCl. Under a 3.0-T MRI scanner, Mn-SPIO/DOX nanocomposite-labeled cells in gelatin phantom show much darker images than the control. Their transverse relaxation(T2) rate is also significantly higher than that of the control cells(33.9 versus 2.3 s-1). Our result offers an effective strategy to treat MCF-7/Adr at optimized low dosages with imaging capability. | Bingbing Lin Hongying Su Rongrong Jin Danyang Li Changqiang Wu Xin Jiang Chunchao Xia Qiyong Gong Bin Song Hua Ai | 2015 | Science Bulletin2015，60，14： | 6 |
| 13 | Robust fault detection for a class of nonlinear network control system with communication delay显示文摘To investigate a class of nonlinear network control system,a robust fault diagnosis method is presented based on the robust state observer.To access the objective that the designed robust filter is maximally tolerant to disturbances and sensitive to fault,the robustness and stability properties of the fault diagnosis scheme are established rigorously.Using the residual vector,a fault tolerant controller is established in order to guarantee the stability of the closed-loop system,and the controller law can be obtained by solving a set of linear matrix inequalities. Then,some relevant sufficient conditions for the existence of a solution are given by applying Lyapunov stability theory.Finally,a simulation example is performed to show the effectiveness of the proposed approach. | Ai Qiangyu Liu Chunsheng Jiang Bin | 2009 | Journal of Systems Engineering and Electronics2009，20，5： | 5 |
| 14 | Amphiphilic dextran/magnetite nanocomposites as magnetic resonance imaging probes显示文摘Superparamagnetic iron oxide (SPIO) nanoparticles are effective contrast agents for enhancement of magnetic resonance imaging at the tissue, cellular or even molecular levels. High quality SPIO nanoparticles can be synthesized in the organic phase but need to be transferred into water before any biomedical applications. In this study, amphiphilic poly(ε-caprolactone) grafted dextran (Dex-g-PCL) was used as carriers for particle encapsulation and stabilization in the aqueous phase. Multiple SPIO nanoparticles were self-assembled together with the help of Dex-g-PCL during phase transfer from chloroform to water, and diameters of Dex-g-PCL/SPIO nanocomposites were (64 ± 22) nm through dynamic light scattering measurement. These nanocomposites were superparamagnetic at 300 K with saturated magnetization of 88 emu/g Fe. In the magnetic field of 1.5 T, Dex-g-PCL/SPIO nanocomposites had a T2 relaxivity of 363 Fe mL·mol-1·s-1. This unique nanocomposite brought significant mouse liver contrast with signal intensity changes of -60% at 5 min after intravenous administration. However, uptake of Dex-g-PCL/SPIO nanocomposites in liver reticuloendothelial cells (Kupffer cells) did not immediately happen at shorter time points (<4 h) as verified by histology studies, and it was evident that more iron staining would be located in Kupffer cells 24 h after contrast agent administration. After 24 h and 10 d, the signal intensities (SI) gradually recovered, and SI changes were -44% and -31%, respectively. From our observation, the time window for enhanced-MRI could last at least 12 days and totally recovered after 16 days. This novel sensitive MRI contrast agent may find potential applications in discovering small liver lesions such as early tumor diagnosis. | WANG QiaoYing SU HongYing XIA ChunChao SUN JiaYu LIU Chen WANG ZhiYong GONG QiYong SONG Bin GAO FaBao AI Hua GU ZhongWei | 2009 | Chinese Science Bulletin2009，54，17： | 5 |
| 15 | Epidermal growth factor receptor mutation analysis in cytological specimens and responsiveness to gefitinib in advanced non-small cell lung cancer patients显示文摘Background: Epidermal growth factor receptor(EGFR) mutation is the key predictor of EGFR tyrosine kinase inhibitors(TKIs) efficacy in non-small cell lung cancer(NSCLC). We conducted this study to verify the feasibility of EGFR mutation analysis in cytological specimens and investigate the responsiveness to gefitinib treatment in patients carrying EGFR mutations.Methods: A total of 210 cytological specimens were collected for EGFR mutation detection by both direct sequencing and amplification refractory mutation system(ARMS). We analyzed EGFR mutation status by both methods and evaluated the responsiveness to gefitinib treatment in patients harboring EGFR mutations by overall response rate(ORR), disease control rate(DCR) and progression free survival(PFS).Results: Of all patients, EGFR mutation rate was 28.6%(60/210) by direct sequencing and 45.2%(95/210) by ARMS(P<0.001) respectively. Among the EGFR wild type patients tested by direct sequencing, 26.7% of them were positive by ARMS. For the 72 EGFR mutation positive patients treated with gefitinib, the ORR, DCR and median PFS were 69.4%, 90.2% and 9.3 months respectively. The patients whose EGFR mutation status was negative by direct sequencing but positive by ARMS had lower ORR(48.0% vs. 80.9%, P=0.004) and shorter median PFS(7.4 vs. 10.5 months, P=0.009) as compared with that of EGFR mutation positive patients by both detection methods. Conclusions: Our study verified the feasibility of EGFR analysis in cytological specimens in advanced NSCLC. ARMS is more sensitive than direct sequencing in EGFR mutation detection. EGFR Mutation status tested on cytological samples is applicable for predicting the response to gefitinib. Abundance of EGFR mutations might have an influence on TKIs efficacy. | Lin Li Zijin Zhang Zhixin Bie Zheng Wang Ping Zhang Xin Nie Yuanming Li Hui Wang Bin Ai Gang Cheng | 2015 | Chinese Journal of Cancer Research2015，27，3： | 5 |
| 16 | Prevalence of Metabolic Syndrome in Chinese Nickel-exposed Workers显示文摘The prevalence of metabolic syndrome(MS was investigated in Chinese nickel-exposed workers A total of 35 104 subjects were enrolled in this study.The age-adjusted prevalence of MS,BMI≥25diabetes,hypertension,and abnormal lipid was13.9%,29.5%,12.8%,27.5%,and 47.1%respectively.The prevalence of BMI≥25hyperglycemia,and hypertension increased | YANG Ai Min BAI Ya Na PU Hong Quan ZHENG Tong Zhang CHENG Ning LI Juan Sheng LI Hai Yan ZHANG Ya Wei DING Jiao SU Hui REN Xiao Wei HU Xiao Bin | 2014 | Biomedical and Environmental Sciences2014，27，6： | 5 |
| 17 | Scaling behavior of magnitude clusters in aftershock sequence:An example of the Wenchuan Earthquake,China显示文摘The Gutenberg-Richter and Omori Laws, which are generally used to characterize the temporal distribution of aftershock, failed to reflect the statistic properties of climatic outbreak of aftershock energy. Based on a new concept of magnitude clusters describing the fluctuation of aftershock energy release of the Wenchuan Earthquake, we discovered that the pattern of the continuous high-magnitude aftershock follows a power-law rather than a non-Poisson distribution. This suggests that the after-shocks with high magnitudes are statistically clustered. We then divided the aftershock sequences into three sections and demonstrated that though the probability of strong outbreaks decreased with time, there exists a high possibility of the occurrence of isolated high-magnitude aftershocks in the future. Based on self-organized criticality theory, the mechanisms of the power-law pattern of magnitude clusters are discussed. This discovery may be used to guide future aftershock predication and the associated post-disaster reconstruction. | ZHANG Bin SHI Kai LIU ChunQiong YAO LingKan DI BaoFeng AI NanShan | 2012 | Science China Earth Sciences2012，55，3： | 4 |
| 18 | Transplantation of tissue-engineered human corneal epithelium in limbal stem cell deficiency rabbit models显示文摘·AIM:To evaluate the biological functions of tissue- engineered human corneal epithelium (TE-HCEP) by corneal transplantation in limbal stem cell deficiency (LSCD) rabbit models.·METHODS:TE-HCEPs were reconstructed with DiI-labeled untransfected HCEP cells and denuded amniotic membrane (dAM) in air-liquid interface culture, and their morphology and structure were characterized by hematoxylin-eosin (HE) staining of paraffin-sections, immunohistochemistry and electron microscopy. LSCD models were established by mechanical and alcohol treatment of the left eyes of New Zealand white rabbits, and their eyes were transplanted with TE-HCEPs with dAM surface outside by lamellar keratoplasty (LKP). Corneal transparency, neovascularization, thickness, and epithelial integrality of both traumatic and post transplantation eyes were checked once a week by slit-lamp corneal microscopy, a corneal pachymeter, and periodic acid-Schiff (PAS) staining. At day 120 post surgery, the rabbits in each group were sacrificed and their corneas were examined by DiI label observation, HE staining, immunohistochemistry and electron microscopy.·RESULTS:After cultured for 5 days on dAM, HCEP cells, maintaining keratin 3 expression, reconstructed a 6-7 layer TE-HCEP with normal morphology and structure. The traumatic rabbit corneas, entirely opaque, conjunctivalized and with invaded blood vessels, were used as LSCD models for TE-HCEP transplantation. After transplantation, obvious edema was not found in TE-HCEP-transplanted corneas which became more and more transparent, the invaded blood vessels reduced gradually throughout the monitoring period. The corneas decreased to normal thickness on day 25, while those of dAM eyes were over 575μm in thickness during the monitoring period. A 4-5 layer of epithelium consisting of TE-HCEP originated cells attached tightly to the anterior surface of stroma was reconstructed 120 days after TE-HCEP transplantation, which was similar to the normal control eye in morphology and structure. In contrast, intense corneal edema, turbid, invaded blood vessels were found in dAM eyes, and no multilayer epithelium was found but only a few scattered conjunctiva-like cells appeared. ·CONCLUSION:The TE-HCEP, with similar morphology and structure to those of innate HCEP, could reconstruct a multilayer corneal epithelium with normal functions in restoring corneal transparency and thickness of LSCD rabbits after transplantation. It may be a promising HCEP equivalent for clinical therapy of corneal epithelial disorders. | Bin Xu Ting-Jun Fan Jun Zhao Ai Sun Rui-Xin Wang Xiu-Zhong Hu Hao-Ze Yu Xian-Yuan Fan and Xiao-Hui Xu | 2012 | International Journal of Ophthalmology(English edition)2012，5，4： | 4 |
| 19 | Phase I safety and pharmacokinetic study of bevacizumab in Chinese patients with advanced cancer显示文摘背景 bevacizumab 是人性化的 recombinant 脉管的 endothelial 生长因素(VEGF ) monoclonal 抗体,明确地绑在 VEGF 并且禁止肿瘤细胞生长,增长和转移。我们试图与先进癌症在中国病人调查 bevacizumab 的安全和 pharmacokinetics。方法 39 个中国病人与变形或 relapsed 癌症没有通过优先的治疗的人,在我 bevacizumab 学习的这个阶段被注册。Bevacizumab 被计算的泵在 90 分钟从 5 mg/kg 在剂量灌输到 15 mg/kg。病人们经历了连续 pharmacokinetic 评估。收到了 bevacizumab 的至少一注入的病人在 35 个病人都完成了 5 注入列在后面的安全 study.Results 被包括协议。一个病人由于等级 3 proteinuria 在 3 以后撤退了注入。普通不利事件可能与学习药有关是 proteinuria ( 17/39 ,43.6%),高血压( 13/39 ,33.3%),齿龈的流血( 7/39 ,17.9%), epistaxis ( 6/39 ,15.4%),咽头的发炎( 6/39 ,15.4%),疲劳(6/39,15.4%)和口炎(4/39,10.3%)。Bevacizumab pharmacokinetics 在 5 mg/kg q2w-10 mg/kg q2w 和 15 mg/kg q3w 的范围以内是线性的。CL (清理) , Vd (在消除的分发的体积) 和 Vss (以稳定的状态的 diatribution 的体积) 在在 5,10 和 15 mg/kg 的单个、多重的剂量以后是类似的。结论 Bevacizumab 很好在中国病人被容忍。没有意外不利事件被观察。在 pharmacokinetics 没有种族差别。 | WU Jian-yu WU Xiao-nan DING Li ZHAO Yun-bo AI Bin LI Yang HU Xin CHENG Gang | 2010 | Chinese Medical Journal2010，，7： | 4 |
| 20 | Near-infrared fluorescent amphiphilic polycation wrapped magnetite nanoparticles as multimodality probes显示文摘Construction of multifunctional/multimodality nanoparticles for cancer diagnosis and therapy has become an attractive area of investigation. In this report, we designed a multimodality nanoprobe for cell labeling, and can be detectable by both magnetic resonance and near infrared (NIR) fluorescence imaging. Multiple hydrophobic superparamagnetic iron oxide (SPIO) nanocrystals are self-assembled into nanocomposites in water phase with the help of partially alkylated hyperbranched polycation, polyethylenimine (PEI), which already conjugated with the indocyanine dye Cy5.5 and can be used for cell imaging under NIR fluorescence imaging. The amphiphilic PEI/SPIO nanocomposites have a strong T 2 relaxivity. The iron uptake process in MCF-7/Adr displays a time dependent behavior. Confocal laser scanning microscopy reveals that the nanoprobes are internalized into the cytoplasm of MCF-7/Adr after 24 h labeling. Both MR and NIR fluorescence imaging showed strong image contrast against unlabeled cells. Under a clinical MRI scanner, labeled cells in gelatin phantom present much darker images than controlled ones. The T2 relaxation rate of the labeled cells is 98.2 s 1 , significantly higher than that of the control ones of 2.3 s 1 . This study provides an important alternative to label MCF-7/Adr at optimized low dosages with high efficiency, and may be useful to label other biologically important cells and track their behaviors in vivo. | WANG Dan SU HongYing LIU yanHong WU ChangQiang XIA ChunChao SUN JiaYu GAO FaBao GONG QiYong SONG Bin AI Hua | 2012 | Chinese Science Bulletin2012，57，31： | 4 |
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