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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | Impaired swallowing mechanics of post radiation therapy head and neck cancer patients: A retrospective videofluoroscopic study显示文摘AIM: To determine swallowing outcomes and hyolaryngeal mechanics associated with post radiation therapy head and neck cancer(rt HNC) patients using videofluoroscopic swallow studies. METHODS: In this retrospective cohort study, video-fluoroscopic images of rt HNC patients(n = 21) were compared with age and gender matched controls(n = 21). Penetration-aspiration of the bolus and bolus residue were measured as swallowing outcome variables. Timing and displacement measurements of the anterior and posterior muscular slings elevating the hyolaryngeal complex were acquired. Coordinate data of anatomical landmarks mapping the action of the anterior muscles(suprahyoid muscles) and posterior muscles(long pharyngeal muscles) were used to calculate the distance measurements, and slice numbers were used to calculate time intervals. Canonical variate analysis with post-hoc discriminant function analysis was performed on coordinate data to determine multivariate mechanics of swallowing associated with treatment. Pharyngeal constriction ratio(PCR) was also measured to determine if weak pharyngeal constriction is associated with post radiation therapy.RESULTS: The rt HNC group was characterized by poor swallowing outcomes compared to the control group in regards to: Penetration-aspiration scale(P < 0.0001), normalized residue ratio scale(NRRS) for the valleculae(P = 0.002) and NRRS for the piriform sinuses(P = 0.003). Timing and distance measurements of the anterior muscular sling were not significantly different in the two groups, whereas for the PMS time of displacement was abbreviated(P = 0.002) and distance of excursion was reduced(P = 0.02) in the rt HNC group. A canonical variate analysis shows a significant reduction in pharyngeal mechanics in the rt HNC group(P < 0.0001). The PCR was significantly higher in the test group than the control group(P = 0.0001) indicating reduced efficiency in pharyngeal clearance. CONCLUSION: Using videofluoroscopy, this study shows rt HNC patients have worse swallowing outcomes associated with reduced hyolaryngeal mechanics and pharyngeal constriction compared with controls. | William G Pearson Jr Alisa A Davidoff Zachary M Smith Dorothy E Adams Susan E Langmore | 2016 | World Journal of Radiology2016，8，2： | 2 |
| 4 | Short - channel effects and drain - induced barrier lowering in nanometerscale GaAs MESFET's 显示文摘 | James A Adams Thayne I G Wilkinson C D W | 1993 | IEEE Trans Electron Devices1993，40，6： | 1 |
| 5 | Consequence of O2 - generation during a bacterially induced hyper-sensifive reaction in tobacco: Detrcioration of membrane lipids显示文摘 | Adam A Farkas T Somlyai G | 1989 | Physiol Mol Plant Pathol1989，34，1： | 1 |
| 6 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial显示文摘 | John R Teerlink Gad Cotter Beth A Davison G Michael Felker Gerasimos Filippatos Barry H Greenberg Piotr Ponikowski Elaine Unemori Adriaan A Voors Kirkwood F Adams Maria I Dorobantu Liliana R Grinfeld Guillaume Jondeau Alon Marmor Josep Masip Peter S Pang | 2013 | The Lancet . 2013 (9860)2013，，9860： | 1 |
| 7 | The Effects and Limitations of Automated Text Condensing on Reading Comprehension Performance显示文摘 | Morris A H Kaspcr G M Adams D A | 1992 | Information Systems Research1992，，1： | 1 |
| 8 | Tissue Kallikrein Actions at the Rabbit Natural or Recombinant Kinin B2 Receptors显示文摘 | Houle S Molinaro G Adam A | 2003 | Hypertension(S0194- 911X)2003，41，3： | 1 |
| 9 | Diffusion -weignted MR Imaging for differentiation of benign fracture edema and tumor infiltration of the vertebral body显示文摘 | Spuentrup E Buecker A Adam G | 2001 | AJR2001，176，2： | 1 |
| 10 | Fuzzy integral显示文摘 | Ralescu D A Adams G | 1980 | Journal of Mathematical Analysis and Applications1980，75，2： | 1 |
| 11 | Sensing of GMAW droplet transfer modes using an ER100S-1 electrode显示文摘 | Adam G Siewert T A | 1990 | Welding Journal1990，69，3： | 1 |
| 12 | Petroscopic observations of rock fracturing ahead of stope faces in deep-level gold mines显示文摘 | ADAMS G R JAGER A J | 1980 | Journal of the South African Institute of Mining and Metallurgy1980，80，6： | 1 |
| 13 | Diagnosis of perioperative myocardial infarction with measurement of cardiac troponin I显示文摘 | Sicard G A Allen B T | 1994 | N Engl J Med1994，330，： | 1 |
| 14 | Localized infusion of IGF-I resuits in skeletal muscle hypertrophy in rats显示文摘 | Adams G R McCue S A | 1998 | J Appl Physiol1998，84，5： | 1 |
| 15 | Cross-competition for binding of alpha 1-antitrypsin (alpha 1 AT)-elastase complexes to the serpin-enzyme complex receptor by other serpin-enzyme complexes and by proteolytically modified alpha 1 AT显示文摘 | Joslin G Wittwer A Adams S | 1993 | Journal of Biological Chemistry1993，268，3： | 1 |
| 16 | Diffusion-Weighted MR Imaging for Differentiation of Benign Fracture Edema and Tumor Infiltration of Vertebral Body显示文摘 | Spuentrup E Buecker A Adam G | 2001 | AJR2001，176，2： | 1 |
| 17 | Transposon derived Brucella abortus rough mutants are attenuated and exhibit reduced intracellular survival显示文摘 | Allen C A Adams L G Ficht T A | 1998 | Infect Immun1998，66，： | 1 |
| 18 | A Light Interception Method for Measuring Row Crop Ground Cover显示文摘 | Adams J E A G F | 1977 | Soil Science Society of America Journal1977，41，4： | 1 |
| 19 | Microstrueture of dense thin sheets of γ-TiAl fabricated by hot isostatic pressing of tape-cast monotapes 显示文摘 | ADAMS A G RAHAMAN M N DUTTON R E | 2008 | Materials Science and Engineering2008，447，： | 1 |
| 20 | Ovarian superstimulatory response relative to follicular wave emergence in heifers显示文摘 | Nasser L Adams G P Bo G A | 2003 | Theriogenology2003，40，： | 1 |
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