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| 1 | Interleukin-6 and its soluble receptor in patients with liver cirrhosis and hepatocellular carcinoma显示文摘瞄准:为了评估免疫, interleukin-6 ( IL-6 )和从有肝细胞癌( HCC )和浆液的病人的肿瘤组织标本上的 IL-6 受体( IL-6R )的组织化学的本地化与 HCC 以及肝肝硬化( LC )在一组病人 IL-6 和 sIL-6R 铺平在一组有独自一个的 LC 并且在一个控制组的病人。方法:三组题目被学习:组我(n = 83 ) 受不了 HCC 和 LC,组 II (n = 72 ) 受不了独自一个的 LC 和组 III (n = 42 ) 同样健康的控制。所有病人有丙肝病毒感染。浆液 IL-6 和 IL-6R 层次用一个商业地可得到的 ELISA 工具包被决定。Immunohistochemistry 对 IL-6 和 IL-6R 用 streptavidin-biotin 建筑群和兔子 polyclonal 抗体被执行。结果:Immunohistochemistry 分析显示出媒介到强壮细胞质并且为 IL-6 和 IL-6R 的膜反应分别地在 HCC 的至少 40% 盒子,而肝肝硬化病人和控制为 IL-6 是否定的或为 IL-6R 显示出很温和、焦点的像点的细胞质的反应。在 HCC 组的浆液 IL-6 层次比在 LC 和控制组的那些显著地高(P <
0.0001 ) 。在在 3 个组之中的 sIL-6R 集中没有有效差量。当有 HCC 的病人根据 Okuda 的分类被划分成组时, IL-6 和 sIL-6R 水平的重要浆液增加从舞台被观察我上演 III (P <
0.02, P <
0.0005 ) 。当 HCC 和 LC 病人根据孩子呸被划分成肝硬化严厉的 3 个班时,在 HCC 病人的价值比在为各相应的班的 LC 病人的那些显著地高(P <
0.01 ).CONCLUSION:在 HCC 病人的 IL-6 浆液层次比在 LC 病人和控制的那些高,建议由肿瘤的房间的这 cytokine 的增加的生产。sIL-6R 价值在所有组是类似的,仅仅在阶段 III HCC 病人增加。这些数据建议他们与肿瘤的团而非与剩余的工作有一种更靠近的关系肝的质量。 | Soresi Maurizio Giannitrapani Lydia D'Antona Fabio Florena Ada Maria La Spada Emanuele Terranova Angela Cervello Melchiorre D'Alessandro Natale Montalto Giuseppe | 2006 | World Journal of Gastroenterology2006，12，16： | 25 |
| 2 | Correlation between expression of cyclooxygenase-2 and the presence of inflammatory cells in human primary hepatocellular carcinoma: Possible role in tumor promotion and angiogenesis显示文摘AIM: To investigate the association of cyclooxygenase-2(COX-2) expression with angiogenesis and the number and type of inflammatory cells (macrophages/Kupffer cells;mast cells) within primary hepatocellular carcinoma (HCC)tissues and adjacent non-tumorous (MT) tissues.METHODS: Immunohistochemistry for COX-2, CD34,CD68 and mast cell tryptase (MCT) was performed on 14 well-characterized series of liver-cirrhosis-associated HCC patients. COX-2 expression and the number of inflammatory cells in tumor lesions and surrounding liver tissues of each specimen were compared. Moreover,COX-2, CD34 staining and the number of inflammatory cells in areas with different histological degrees within each tumor sample were comparatively analyzed.RESULTS: The percentage of COX-2 positive cells was significantly higher in NT tissues than in tumors. COX-2 expression was higher in well-differentiated HCC than in poorly-differentiated tissues. Few mast cells were observed within the tumor mass, whereas a higher number was observed in the surrounding tissue, especially in peri-portal spaces of NT tissues. Abundant macrophages/Kupffer cells were observed in NT tissues, whereas the number of cells was significantly lower in the tumor mass.However, a higher cell number was observed in the well-differentiated tumor and progressively decreased in relation to the differentiation grade. Within the tumor, a positive correlation was found between COX-2 expression and the number of macrophages/Kupffer cells and mast cells. Moreover, there was a positive correlation between CD34 and COX-2 expression in tumor tissues. Comparison between well- and poorly-differentiated HCC showed that the number of CD34-positive cells decreased with dedifferentiation. However, COX-2 was the only independent variable showing a positive correlation with CD34 in a multivariate analysis.CONCLUSION: The presence of inflammatory cells and COX-2 expression in liver tumor suggests a possible relationship with tumor angiogenesis. COX-2 expressing cells and the number of macrophages/Kupffer cells and mast cells decrease with progression of the disease. | Melchiorre Cervello Daniela Foderà Ada Maria Florena Maurizio Soresi Claudio Tripodo Natale D'Alessandro Giuseppe Montalto | 2005 | World Journal of Gastroenterology2005，11，30： | 21 |
| 3 | A new framework for service supply chains显示文摘 | BALTACIOGLU T ADA E KAPLAN M D | 2007 | The Service Industries Journal2007，27，2： | 1 |
| 4 | A new framework for service supply chains显示文摘 | Baltacioglu T Ada E Kaplan M D Yurt O and Kaplan Y C | 2007 | The Service Industries Journal2007，27，2： | 1 |
| 5 | A new framework for service supply chains显示文摘 | BALTACIOGLU U ERHAN ADA KAPLAN M D | 2007 | The Service Industries Journal2007，3，27： | 1 |
| 6 | UCI repository of machine learning Databases显示文摘 | MURPHY R ADA D | 1994 | Tech Rep Dept Comput Sci Univ California Irvine1994，，： | 1 |
| 7 | A new framework for service supply chains显示文摘 | BALTACIOGLU T ERHAN ADA KAPLAN M D | 2007 | The Service Industries Journal2007，3，27： | 1 |
| 8 | Clinical pharmacokinetics of clopidogrel and its metabolites in patients with cardiovascular diseases显示文摘 | Kara?niewicz-?ada M Danielak D Burchardt P | 2014 | Clin Pharmcokinet2014，53，2： | 1 |
| 9 | A new framework for service supply chains显示文摘 | Baltacioglu T Ada E Kaplan M D | 2007 | The Service Industries Journal2007，，2： | 1 |
| 10 | Fatal Kawasake disease to coronary aneurysm rupture with massive cardiac tamponade 显示文摘 | Hunsaker D M Hunsaker J C Ada ms K C | 2002 | J Ky Med Assoc2002，101，6： | 1 |
| 11 | 1-aminocyclobutane- 1-carboxylate synthase, a key enzyme in ethylene bio-synthesis 显示文摘 | Yu B Y Adas D O Yang S F | 1979 | Arch Biochem Biophys1979，198，1： | 1 |
| 12 | 窄谱中波紫外线治疗尿毒性瘙痒症:一项开放的前导性研究 | Ada S Sec.kin D BudakǒOzdemir F.N 刘安 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，10： | 1 |
| 13 | Effect of tooth type and ferrule on the survival of pulpless teeth restored with fiber posts:a 3-year clinical study显示文摘 | Mancebo JC Jiménez-Castellanos E Caadas D | 2010 | Am J Dent2010，23，6： | 1 |
| 14 | A new framework for service supply chaina显示文摘 | BALTACIOGLU T ADA E KAPLAN M D | | 0，，02： | 1 |
| 15 | Biodiesel stability under commercial storage conditions over one year 显示文摘 | Paolo B Ada G Laura D B | 2003 | European Journal of Lipid Science and Technology2003，105，12： | 1 |
| 16 | The prediction of biodiesel storage stability: proposal for a quick test 显示文摘 | Paolo B Ada G Laura D B | 2004 | European Journal of Lipid Science and Technology2004，106，12： | 1 |
| 17 | The role of thiophosphoryl disulfide on the co-cure of CR-EPDM blends: Effect of white fillers 显示文摘 | ADas S C Debnath D De | 2004 | Polymers for Advanced Technologies2004，15，9： | 1 |
| 18 | Finite element model updating of a bowstring-arch railway bridge based on experimental modal parameters 显示文摘 | Ribeiro D Cal~ada R Delgado R | 2012 | Engineering Structures2012，40，： | 1 |
| 19 | Efficient mining of association rules in distributed databases显示文摘 | Cheung D W Vincent T N Ada W F | 1996 | IEEE Trans on Knowledge and Data Engineering1996，8，6： | 1 |
| 20 | A new framework for service supply chains显示文摘 | Baltacioglu T Ada E Kaplan M D | 2007 | The Service Industries J2007，27，2： | 1 |
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