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| 1 | Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer显示文摘AIM:To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer.METHODS:One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study.The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay.RESULTS:Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001).Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance,tumor size,depth of wall invasion,lymph node metastasis,liver metastasis,perineural invasion,and pathological stage.They were not significantly associated with age,gender,tumor location,or histological type.CONCLUSION:Increased MMP-1 and TIMP-1 were associated with gastric cancer.Although these markers are not good markers for diagnosis,these markers show in advanced gastric cancer. | Ozgur Kemik Ahu Sarbay Kemik Aziz Sümer Ahmet Cumhur Dulger Mine Adas Huseyin Begenik Ismail Hasirci Ozkan Yilmaz Sevim Purisa Erol Kisli Sefa Tuzun Cetin Kotan | 2011 | World Journal of Gastroenterology2011，17，16： | 10 |
| 2 | Gene expression profiling and endothelin in acute experimental pancreatitis显示文摘AIM:To analyze gene expression profiles in an experimental pancreatitis and provide functional reversal of hypersensitivity with candidate gene endothelin-1 antagonists.METHODS:Dibutyltin dichloride(DBTC) is a chemical used as a polyvinyl carbonate stabilizer/catalyzer,biocide in agriculture,antifouling agent in paint and fabric.DBTC induces an acute pancreatitis flare through generation of reactive oxygen species.Lewis-inbred rats received a single i.v.injection with either DBTC or vehicle.Spinal cord and dorsal root ganglia(DRG) were taken at the peak of inflammation and processed for transcriptional profiling with a cDNA microarray biased for rat brain-specific genes.In a second study,groups of animals with DBTC-induced pancreatitis were treated with endothelin(ET) receptor antagonists [ET-A(BQ123) and ET-B BQ788)].Spontaneous pain related mechanical and thermal hypersensitivity were measured.Immunohistochemical analysis was performed using anti-ET-A and ET-B antibodies on sections from pancreatic tissues and DRG of the T10-12 spinal segments.RESULTS:Animals developed acute pancreatic inflammation persisting 7-10 d as confirmed by pathological studies(edema in parenchyma,loss of pancreatic architecture and islets,infiltration of inflammatory cells,neutrophil and mononuclear cells,degeneration,vacuolization and necrosis of acinar cells) and the painrelated behaviors(cutaneous secondary mechanical and thermal hypersensitivity).Gene expression profile was different in the spinal cord from animals with pancreatitis compared to the vehicle control group.Over 260 up-regulated and 60 down-regulated unique genes could be classified into 8 functional gene families:circulatory/acute phase/immunomodulatory;extracellular matrix;structural;channel/receptor/transporter;signaling transduction;transcription/translation-related;antioxidants/chaperones/heat shock;pancreatic and other enzymes.ET-1 was among the 52 candidate genes upregulated greater than 2-fold in animals with pancreatic inflammation and visceral pain-related behavior.Treatments with the ET-A(BQ123) and ET-B(BQ-788) antagonists revealed significant protection against inflammatory pain related mechanical and thermal hypersensitivity behaviors in animals with pancreatitis(P < 0.05).Open field spontaneous behavioral activity(at baseline,day 6 and 30 min after drug treatments(BQ123,BQ788) showed overall stable activity levels indicating that the drugs produced no undesirable effects on normal exploratory behaviors,except for a trend toward reduction of the active time and increase in resting time at the highest dose(300 μmol/L).Immunocytochemical localization revealed that expression of ET-A and ET-B receptors increased in DRG from animals with pancreatitis.Endothelin receptor localization was combined in dual staining with neuronal marker NeuN,and glia marker,glial fibrillary acidic protein.ET-A was expressed in the cell bodies and occasional nuclei of DRG neurons in na ve animals.However,phenotypic expression of ET-A receptor was greatly increased in neurons of all sizes in animals with pancreatitis.Similarly,ET-B receptor was localized in neurons and in the satellite glia,as well as in the Schwann cell glial myelin sheaths surrounding the axons passing through the DRG.CONCLUSION:Endothelin-receptor antagonists protect against inflammatory pain responses without interfering with normal exploratory behaviors.Candidate genes can serve as future biomarkers for diagnosis and/or targeted gene therapy. | Helieh S Oz Ying Lu Louis P Vera-Portocarrero Pei Ge Ada Silos-Santiago Karin N Westlund | 2012 | World Journal of Gastroenterology2012，18，32： | 6 |
| 3 | A Short Amino-Terminal Part of Arabidopsis Phytochrome A Induces Constitutive Photomorphogenic Response显示文摘Phytochrome A (phyA ) 是在 Arabidopsis thaliana 察觉到的 far-red 光的主导的光敏电阻器。phyA 在发信号的变白的幼苗,和导致光的 phyA 的细胞质在高水平积累被一个复杂规章的网络调停。这包括光 -- 并且进在 vivo 的原子核的本国的 phyA 的 FHY1/FHL 蛋白质依赖者 translocation。phyA (PHYA406 ) 的短 N 终端碎片对 phenocopy 足够,这也被显示出在 vitro 的这个高度调整的细胞的过程。为了测试这 N 终端的生物活动,在 planta phyA 碎裂,我们生产了表示 PHYA406YFP 的转基因的 phyA-201 植物(黄荧光灯蛋白质) DD, PHYA406YFPDDNLS (原子本地化信号) ,和 PHYA406YFPDDNES (原子出口信号) 熔化蛋白质。这里,我们报导 PHYA406YFPDD 被进口进原子核,而 PHYA406YFPDDNLS 和 PHYA406YFPDDNES 显示期望的组成的本地化模式,这进程部分是轻依赖者的。我们的结果证明这些截断的 phyA 蛋白质是轻马厩的,当局部性时,他们在他们的原子核,和两个都不触发组成的象 photomorphogenic 一样回答导致合适的 phyA 发信号。我们证明在 vitro 并且在 vivo PHYA406, Pfr 和 Pr 绑 COP1, photomorphogenesis 的一个一般抑压者,并且在原子身体与它共同本地化。因此,我们断定在 planta,截断的 PHYA406 蛋白质以一种光无关的方式在原子核使 COP1 失去活性。 | Andra's Viczia'n E'va Ada'm Iris Wolf Ja'nos Bindics Stefan Kircher Marc Heijde Roman Ulm Eberhard Scha'fer Ferenc Nagy | 2012 | Molecular Plant2012，5，3： | 2 |
| 4 | Game theoretical multi-agent modelling of coalition formation for multilateral trades显示文摘 | Yeung Chris S K Poon Ada S Y | 1999 | IEEE Trans on Power Systems1999，14，3： | 1 |
| 5 | Direct contact with particulate matter increases oxidative stress in differ- ent brain structures 显示文摘 | Fagundes LS Fleck Ada S Zanchi AC | 2015 | Inhalation Toxicology2015，27，10： | 1 |
| 6 | Optimization of process parameters to achieve high quality as-deposited indium-tin oxide films for display applications 显示文摘 | Gupta S Ada E | 2005 | J Vac Sci Technol A2005，23，4： | 1 |
| 7 | Epidemiological data of different human papillomavirus genotypes in cervical specimens of HIV-1-infected womenwithouthistory of cervical pathology显示文摘 | Videla S Darwich L Ca(n)adas MP | | 0，，： | 1 |
| 8 | Nasal involvement in obstructive sleep apnea syndrome显示文摘 | Michels Dde S Rodrigues Ada M Nakanishi M | 2014 | Int J Otolaryngol2014，2014，71： | 1 |
| 9 | Demand-driven acquisition at HKUST library: the new normal显示文摘 | Catherine S Y Kwok Diana L H Chan Ada S M Cheung | 2014 | Interlending & DocumentSupply2014，42，4： | 1 |
| 10 | Factors af- fecting the success of a construction project显示文摘 | ALBERT P C C DAVID S ADA P L C | 2004 | Jour- nal of Construction Engineering and Management2004，130，1： | 1 |
| 11 | Servitization of business: adding value by adding services 显示文摘 | Vandermerwe S l~ada J | 1988 | European Management Journal1988，6，4： | 1 |
| 12 | Comparison of laparoscopic common bile duct exploration and endoscopic retrograde cholangiopancreatography plus laparoscopic cholecystectomy for choledocholithiasis : a prospective randomized study 显示文摘 | Koc B Karahan S Adas G | 2013 | Am J Surg2013，206，45： | 1 |
| 13 | An evaluation of low molecular weight heparin and hyperbaric oxygen treatment in the prevention of intra-abdominal adhesions and wound hea-ling显示文摘 | ARIKAN S ADAS G BARUT G | 2005 | Am J Surg2005，189，2： | 1 |
| 14 | Strengthening interventions increase strength and improve activity after stroke:a systematic review显示文摘 | Ada L Dorsch S Canning CG | 2006 | Aust J Physiother2006，52，4： | 1 |
| 15 | Estrogen and progesterone cerbB2,p53 and Bcl2 in thirtythree invasive micropapillary breast carcinoma显示文摘 | LunaMoré S de los Santos F Bretón J J Caadas M A | 1996 | Pathol Res Pract1996，192，1： | 1 |
| 16 | Intensity- modulated and 3D-conformal radiotherapy for whole-ven- tricular irradiation as compared with conventional whole- brain irradiation in the management of localized central nervous system germ cell tumors 显示文摘 | Chen MJ Santos Ada S Sakuraba RK | 2010 | Int J Radiat Oncol Biol Phys2010，76，2： | 1 |
| 17 | Evidence- based practice guidelines,standards,and related recom- mendations and documents for diabetes care显示文摘 | The American Diabetes Association's (ADA) | 2012 | Diabetes Care2012，35，1： | 1 |
| 18 | Frequency of vascular variations and anomalies accompanying intracranial aneurysms显示文摘 | Karazincir S Ada E Sarsilmaz A | 2007 | Tani Girisim Radyol2007，10，2： | 1 |
| 19 | Comparison of laparoscopic common bile duct exploration and endoscopic retrograde cholangiopancreatography plus laparoscopic cholecystectomy for choledocholithiasis:a prospective randomized study显示文摘 | Koc B Karahan S Adas G | 2013 | Am J Surg2013，206，4： | 1 |
| 20 | Improving quality of life by increasing outings after stroke:study protocol for the Out-andAbout trial显示文摘 | McCluskey A Ada L Middleton S | | 0，，01： | 1 |
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