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| 1 | Diagnostic dilemma of abdominal tuberculosis in non-HIV patients:An ongoing challenge for physicians显示文摘AIM: To assess the clinical features, yield of the diagnostic tests and outcome of abdominal tuberculosis in non-HIV patients. METHODS: Adult patients with discharge diagnosis of abdominal tuberculosis (based upon; positive microbiology, histo-pathology, imaging or response to trial of anti TB drugs) during the period 1999 to 2004 were analyzed. Patient’s characteristics, laboratory investigations, radiological, endoscopic and surgical findings were evaluated. Abdominal site involved (intestinal, peritoneal, visceral, and nodal) and response to treatment was also noted. RESULTS: There were 209 patients enrolled. One hundred and twenty-three (59%) were females. Symptoms were abdominal pain 194 (93%), fever 134 (64%), night sweats 99 (48%), weight loss 98 (47%), vomiting 75 (36%), ascites 74 (35%), constipation 64 (31%), and diarrhea 25 (12%). Sub-acute and acute intestinal obstruction was seen in 28 (13%) and 12 (11%) respectively. Radiological evidence of pulmonary tuberculosis was found in 134 (64%) patients. Basis of diagnosis of abdominal tuberculosis were radiology (Chest and barium X-Rays, Ultrasound and CT scan abdomen) in 111 (53%) and histo-pathology (tissue obtained during surgery, colonoscopy, CT or ultrasound guided biopsy, laparoscopy and upper gastro intestinal endoscopy) in 87 (42%) patients. Mycobacterium culture was positive in 6/87 (7%) patients and response to therapeutic trial of anti tubercular drugs was the basis of diagnosis in 5 (2.3%) patients. Predominant site of involvement by abdominal TB was intestinal in 103 (49%) patients, peritoneal in 87 (42%) patients, solid viscera in 10 (5%) and nodal in 9 (4%) patients. Response to medical treatment was found in 158 (76%) patients andadditionally 35 (17%) patients also underwent surgery. In a 425 ± 120 d follow-up period 12 patients died (eight post operative) and no case of relapse was noted. CONCLUSION: Abdominal TB has diverse and non- specific symptomatology. No single test is adequate for diagnosis of abdominal tuberculosis in all patients. Abdominal TB in non-HIV patients remains an ongoing diagnostic dilemma requiring a high index of clinical suspicion. | Rustam Khan Shahab Abid Wasim Jafri Zaigham Abbas Khalid Hameed Zubair Ahmad | 2006 | World Journal of Gastroenterology2006，12，39： | 17 |
| 2 | Functional gastrointestinal disorders and gut-brain axis: What does the future hold?显示文摘Despite their high prevalence, lack of understanding of the exact pathophysiology of the functional gastrointestinal disorders has restricted us to symptomatic diagnostic tools and therapies. Complex mechanisms underlying the disturbances in the bidirectional communication between the gastrointestinal tract and the brain have a vital role in the pathogenesis and are key to our understanding of the disease phenomenon. Although we have come a long way in our understanding of these complex disorders with the help of studies on animals especially rodents, there need to be more studies in humans, especially to identify the therapeutic targets. This review study looks at the anatomical features of the gut-brain axis in order to discuss the different factors and underlying molecular mechanisms that may have a role in the pathogenesis of functional gastrointestinal disorders. These molecules and their receptors can be targeted in future for further studies and possible therapeutic interventions. The article also discusses the potential role of artificial intelligence and machine learning and its possible role in our understanding of these scientifically challenging disorders. | Kashif Mukhtar Hasham Nawaz Shahab Abid | 2019 | World Journal of Gastroenterology2019，25，5： | 15 |
| 3 | Is it time to replace propranolol with carvedilol for portal hypertension?显示文摘Beta-adrenergic receptor antagonists(β-blockers) have been well established for use in portal hypertension for more than three decades. Different Non-selective β-blockers like propranolol, nadolol, timolol, atenolol, metoprolol and carvedilol have been in clinical practice in patients with cirrhosis. Carvedilol has proven 2-4 times more potent than propranolol as a beta-receptor blocker in trials conducted testing its efficacy for heart failure. Whether the same effect extends to its potency in the reduction of portal venous pressures is a topic of on-going debate. The aim of this review is to compare the hemodynamic and clinical effects of carvedilol with propranolol, and attempt assess whether carvedilol can be used instead of propranolol in patients with cirrhosis. Carvedilol is a promising agent among the beta blockers of recent time that has shown significant effects in portal hypertension hemodynamics. It has also demonstrated an effective profile in its clinical application specifically for the prevention of variceal bleeding. Carvedilol has more potent desired physiological effects when compared to Propranolol. However, it is uncertain at the present juncture whether the improvement in hemodynamics also translates into a decreased rate of disease progression and complications when compared to propranolol. Currently Carvedilol shows promise as a therapy for portal hypertension but more clinical trials need to be carried out before we can consider it as a superior option and a replacement for propranolol. | Shahab Abid Saadat Ali Muhammad Asif Baig Anam Akbar Waheed | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，5： | 13 |
| 4 | 干旱条件下棉花根际真菌多样性分析显示文摘植物根际微生物群落对植物生长和适逆性至关重要,本研究对干旱条件下棉花根际真菌群落进行分析,旨在探明干旱胁迫对棉花根际真菌多样性和群落结构的影响,为利用有益微生物提高棉花水分利用率提供理论依据。以陆地棉Jin 668(Gossypium hirsutum cv.Jin668)为试验材料,采用盆栽控水方式,对处于开花期的棉花根际土壤(SDP)和未种植棉花土壤(SOPD)进行干旱处理,正常浇水的棉花根际土壤(SPN)和无棉花土壤(SNPN)为对照。从中采集土壤样品,提取DNA,采用Illumina Miseq对真菌ITS1区域进行高通量测序,研究土壤中真菌多样性。结果共鉴定到970个OTUs,SNPN、SOPD、SPN和SDP样品中真菌OTUs数量分别为481、528、743和752个,其中288个OTUs为所有组共有。对获得OTUs进行门、纲、目、科和属5个分类水平的划分表明,棉花根际真菌群落结构主要由子囊菌门(82.70%)和担子菌门(10.15%)组成;干旱处理使粪壳菌纲(Sordariomycetes)、粪壳菌目(Sordariales)和毛壳菌科(Chaetomiaceae)丰度显著降低,而散囊菌目(Eurotiales)、发菌科(Trichocomaceae)、曲霉属(Aspergillus)和青霉属(Penicillum)的丰度显著增加。多样性分析结果显示,与未种棉花的土壤相比,有棉花的土壤中真菌群落的α多样性显著增加;同时,SPN和SDP之间的真菌群落结构更相似,而与SNPN和SOPD间差异较大。研究表明,棉花根际存在丰富的真菌群落,干旱对土壤中真菌的丰度和多样性有显著影响。本研究从微生物的角度为提高棉花耐旱性的研究提供新见解。 | 岳丹丹 韩贝 Abid Ullah 张献龙 杨细燕 | 2021 | 作物学报2021，47，9： | 9 |
| 5 | Metachronous cancer of gallbladder and pancreas with pancreatobiliary maljunction显示文摘Pancreaticobiliary maljunction is a congenital anomaly in which the junction between the pancreatic duct and the common bile duct is located outside the sphincter of Oddi.It is well known that pancreaticobiliary maljunction is frequently associated with carcinoma of the biliary tract.We report a case of metachronous cancer of the gallbladder and pancreas associated with pancreaticobiliary maljunction and cystic dilatation of common bile duct in a 68-year-old Tunisian woman who underwent a cholecystectomy for acute cholecystitis.The pancreatic tumor was an adenosquamous carcinoma.Pancreaticobiliary maljunction allows for pancreatobiliary or biliopancreatic reflux which may induce biliary tract carcinoma.Few cases of multifocal cancer associated with this anomaly have been reported.The association with pancreatic carcinoma remains rare.Close attention should be given to both the biliary tract system and pancreas during the long-term follow-up of patients with pancreaticobiliary maljunction,especially after they have undergone a choledochojejunostomy. | Ahlem Lahmar Sadri Ben Abid Mohamed Nafaa Arfa Rached Bayar Mohamed Tahar Khalfallah Sabah Mzabi-Regaya | 2010 | World Journal of Gastrointestinal Surgery2010，2，4： | 8 |
| 6 | Predictive factors for early aspiration in liver abscess显示文摘AIM: To determine the predictive factors for early aspiration in liver abscess. METHODS: A retrospective analysis of all patients with liver abscess from 1995 to 2004 was performed. Abscess was diagnosed as amebic in 661 (68%) patients, pyogenic in 200 (21%), indeterminate in 73 (8%) and mixed in 32 (3%). Multiple logistic regression analysis was performed to determine predictive factors for aspiration of liver abscess. RESULTS: A total of 966 patients, 738 (76%) male, mean age 43 ± 17 years, were evaluated: 540 patients responded to medical therapy while adjunctive percutaneous aspiration was performed in 426 patients. Predictive factors for aspiration of liver abscess were: age ≥ 55 years, size of abscess ≥ 5 cm, involvement of both lobes of the liver and duration of symptoms ≥ 7 d. Hospital stay in the aspiration group was relatively longer than in the non aspiration group. Twelve patients died in the aspiration group and this mortality was not statistically significant when compared to the non aspiration group. CONCLUSION: Patients with advanced age, abscess size > 5 cm, both lobes of the liver involvement and duration of symptoms > 7 d were likely to undergo aspiration of the liver abscess, regardless of etiology. | Rustam Khan Saeed Hamid Shahab Abid Wasim Jafri Zaigham Abbas Mohammed Islam Hasnain Shan Shaalan Beg | 2008 | World Journal of Gastroenterology2008，14，13： | 8 |
| 7 | Helicobacter pylori infection and micronutrient deficiencies显示文摘It is known that deficiencies of micronutrients due to infections increase morbidity and mortality. This phenomenon depicts itself conspicuously in developing countries.Deficiencies of iron, vitamins A, E, C, B12, etc are widely prevalent among populations living in the third world countries. Helicobacterpylori (Hpylori) infection has a high prevalence throughout the world. Deficiencies of several micronutrients due to Hpylori infection may be concomitantly present and vary from subtle sub-clinical states to severe clinical disorders. These essential trace elementsl micronutrients are involved in host defense mechanisms,maintaining epithelial cell integrity, glycoprotein synthesis,transport mechanisms, myocardial contractility, brain development, cholesterol and glucose metabolism. In this paper Hpyloriinfection in associaed with various micronutrients deficiencies is briefly reviewed. | Javed Yakoob Wasim Jafri Shahab Abid | 2003 | World Journal of Gastroenterology2003，9，10： | 7 |
| 8 | Congenital extrahepatic portosystemic shunt complicated by the development of hepatocellular carcinoma显示文摘Congenital extrahepatic portosystemic shunt,also known as Abernethy malformation, is a rare congenital malformation. It causes shunting of blood through a communication between the portal and systemic veins such as a patent ductus venous. We report 3 cases of Abernethy malformation complicated by the development of hepatocellular carcinoma. Additionally, we comprehensively reviewed all previously reported cases and highlighted common features that may help in early diagnosis and appropriate management.Patients with Abernethy malformation may have an increased propensity to develop hepatocellular carcinoma. All 5 previously reported cases, plus the three of our patients, have a type 1(complete) shunt suggesting a role for absent portal blood flow in the pathogenesis of hepatocellular carcinoma. Congenital extrahepatic portosystemic shunt should be sought for in cases with raised serum ammonia, hepatic encephalopathy or hepatocellular carcinoma in the absence of cirrhosis. | Ruchi Sharma Abid Suddle Alberto Quaglia Praveen Peddu John Karani Thomas Satyadas | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，5： | 7 |
| 9 | Recent advances in immunotherapy for hepatocellular carcinoma显示文摘Background:Treatment of hepatocellular carcinoma(HCC)is challenging as most patients are diagnosed at advanced stage with underlying chronic liver conditions.Conventional systemic chemotherapy has failed in HCC,and the clinical efficacy of FDA-approved molecular targeted agents such as sorafenib and lenvatinib remains unsatisfactory.Data sources:Literature search was conducted in Pub Med for relevant articles published before January 2021.The search aimed to identify recent developments in immune-based treatment approaches for HCC.Information of clinical trials was obtained from http://gffzzd3f38a9638994581s6f0xk5pb569n6q9n.ffgz.tsg.suse.edu.cn/.Results:Two immune checkpoint inhibitors(ICIs),nivolumab and pembrolizumab were approved as monotherapies,which has revolutionized HCC treatment.Besides,combination ICIs have also got accelerated FDA approval recently.Immune-based therapies have challenged targeted drugs owing to their safety,tolerability,and survival benefits.In addition to the significant success in ICIs,other immunotherapeutic strategies such as cancer vaccine,chimeric antigen receptor T-cells,natural killer cells,cytokines,and combination therapy,have also shown promising outcomes in clinical trials.Various diagnostic and prognostic biomarkers have been identified which can help in clinical decision making when starting treatment with ICIs.Conclusions:Immunotherapy has emerged as one of the mainstream treatment modalities for advanced HCC in recent years.However,challenges such as low response rate and acquired resistance in previously respondent patients still exist.Further research is needed to understand the unique resistance mechanism to immunotherapy and to discover more predictive biomarkers to guide clinical decision making. | Abid Ali Khan Zhi-Kun Liu Xiao Xu | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，6： | 7 |
| 10 | Prevalence of non-Helicobacter pylori duodenal ulcer in Karachi,Pakistan显示文摘AIM: To determine the prevalence of non-Helicobacter pylori (H pylori)-related duodenal ulcer in patients with acid-peptic diseases.METHODS: Medical records of patients who attended the Gastroenterology Department at Aga Khan University Hospital from 1999 to 2001 and had endoscopic diagnosis of duodenal ulcers were reviewed. Duodenal ulcer associated with H pylori was diagnosed on the basis of endoscopy,rapid urease test and histopathology whereas histories of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) related duodenal ulcers. Non-H pylori, non-NSAID duodenal ulcers were those without H pylori infection and history of NSAID intake. Co-morbid conditions associated were noted.RESULTS: Of 2 260 patients, 10% (217/2 260) had duodenal ulcer. Duodenal ulcer related to H pylori infectionaccounted for 53% (116/217), NSAID-related 10% (22/217),non-H pylori non-NSAID 29% (62/217), and 8% (17/217) had both Hpyloriinfection and histories of NSAID intake. Fifteen percent (18/116)_patients had past histories of peptic ulcer disease in Hpyloriinfection, while 8% (5/62) in non-Hpylorinon-NSAID ulcer. Co-morbid conditions in H pylori infection were seen in 23% (27/116) and 34%(21/62) in non-H pylori non-NSAID ulcer.CONCLUSION: Incidence of H pylori infection related with duodenal ulcer is common. In the presence of co-morbids, non-Hpyloriand non-NSAID duodenal ulcer is likely to be present. | Javed Yakoob Wasim Jafri Nadim Jafri Muhammad Islam Shahab Abid Saeed Hamid Hasnain AliShah Hizbullah Shaikh | 2005 | World Journal of Gastroenterology2005，11，23： | 6 |
| 11 | Itopride for gastric volume,gastric emptying and drinking capacity in functional dyspepsia显示文摘AIM To study the effect of itopride on gastric accommodation, gastric emptying and drinking capacity in functional dyspepsia(FD). METHODS Randomized controlled trial was conducted to check the effect of itopride on gastric accommodation, gastric emptying, capacity of tolerating nutrient liquid and symptoms of FD. We recruited a total of 31 patients having FD on the basis of ROME III criteria. After randomization, itopride was received by 15 patients while 16 patients received placebo. Gastric accommodation was determined using Gastric Scintigraphy. ^(13) C labeled octanoic breadth test was performed to assess gastric emptying. Capacity of tolerating nutrient liquid drink was checked using satiety drinking capacity test. Theintervention group comprised of 150 mg itopride. Patients in both arms were followed for 4 wk. RESULTS Mean age of the recruited participant 33 years(SD = 7.6) and most of the recruited individuals, i.e., 21(67.7%) were males. We found that there was no effect of itopride on gastric accommodation as measured at different in volumes in the itopride and control group with the empty stomach(P = 0.14), at 20 min(P = 0.38), 30 min(P = 0.30), 40 min(P = 0.43), 50 min(P = 0.50), 60 min(P = 0.81), 90 min(P = 0.25) and 120 min(P = 0.67). Gastric emptying done on a sub sample(n = 11) showed no significant difference(P = 0.58) between itopride and placebo group. There was no significant improvement in the capacity to tolerate liquid in the itopride group as compared to placebo(P = 0.51). Similarly there was no significant improvement of symptoms as assessed through a composite symptom score(P = 0.74). The change in QT interval in itopride group was not significantly different from placebo(0.10). CONCLUSION Our study found no effect of itopride on gastric accommodation, gastric emptying and maximum tolerated volume in patients with FD. | Shahab Abid Wasim Jafri Maseeh Uz Zaman Rakhshanda Bilal Safia Awan Aamir Abbas | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 6 |
| 12 | 不同含水量条件下稻田土壤中杀虫剂的生态影响(英文)显示文摘在控制条件下 ,研究了不同含水量 (风干土、5 0 %和 10 0 %田间持水量、淹水状态 ) ,加与不加杀虫剂 (三唑磷田间施用量 ) ,对稻田土壤部分性质的影响。含水量对土壤电子运输系统活度 (ETS) /脱氢酶、总酚、蛋白质、磷脂含量产生显著影响 ,但杀虫剂的加入不产生显著变化。ETS和总酚含量随含水量增加呈线性上升趋势。与不加杀虫剂对照相比 ,在所有含水量条件下 ,ETS略有降低 ,低含水量时稍明显 ;总酚的含量略有增加 ,但不显著。蛋白质不受杀虫剂影响。 5 0 %田间持水量时 ,土壤蛋白质有所降低 ,表明此时有较强的 N-矿化作用。5 0 %田间持水量时磷脂含量达最大值 ,之后随含水量增加直线下降 ;在淹水条件下 ,磷脂含量最低。与不加杀虫剂对照相比 ,在较低含水量时 ,磷脂含量略有减少。上述研究也说明 5 0 | Abid SUBHANI 廖敏 黄昌勇 谢正苗 | 2001 | 中国水稻科学2001，15，2： | 6 |
| 13 | Validity and cost comparison of ^(14)carbon urea breath test for diagnosis of H Pylori in dyspeptic patients显示文摘AIM: To validate and compare the cost of microdose 14C urea breath test (UBT) with histology and rapid urease test for the diagnosis of H Pylori. METHODS: Ninety-four consecutive patients with dyspeptic symptoms undergoing gastroscopy were enrolled. Gastric biopsies were taken for histology and rapid urease test. UBT was performed after gastroscopy by microdose 14C urea capsules. Sensitivity, specificity and accuracy of UBT were calculated and compared with histology and rapid urease test. Cost comparison of these tests was also performed. RESULTS: H pylori was diagnosed by histology and rapid urease test in 66 (70%) and 61 (65%) patients, while 14C UBT detected infection in 63 (67%). Accuracy of UBT was 93% in comparison with histology while its positive and negative predictive values were 97% and 84%, respectively. Comparison of 14C UBT with rapid urease test gives an accuracy of 96%, with positive and negative predictive values of 95% and 97%, respectively. These results were highly reproducible with a Kappa test (P value < 0.001). Cost of histology or rapid urease test with gastroscopy was 110 USD or 95 USD respectively while the cost of UBT was 15 USD. CONCLUSION: Microdose 14C UBT was comparable to histology and rapid urease test. 14C UBT is an economical, self sufficient and suitable test to diagnose active H pylori infection in less developed countries. | Shahid Rasool Shahab Abid Wasim Jafri | 2007 | World Journal of Gastroenterology2007，13，6： | 5 |
| 14 | Do inhaled corticosteroids increase the risk of Pneumocystis pneumonia in people with lung cancer?显示文摘Pneumocystis pneumonia(PCP) is a life-threatening infection in immunocompromised patients. It is relatively uncommon in patients with lung cancer. We report a case of PCP in a 59-year-old man with a past medical history of chronic obstructive pulmonary disease treated with formoterol and a moderate daily dose of inhaled budesonide. He had also advanced stage non-small lung cancer treated with concurrent chemo-radiation with a cisplatin-etoposide containing regimen. The diagnosis of PCP was suspected based on the context of rapidly increasing dyspnea, lymphopenia and the imaging findings. Polymerase chain reaction testing on an induced sputum specimen was positive for Pneumocystis jirovecii. The patient was treated with oral trimethoprim-sulfamethoxazole and systemic corticotherapy and had showed clinical and radiological improvement. Six months after the PCP diagnosis, he developed a malignant pleural effusion and expired on hospice care. Through this case, we remind the importance of screening for PCP in lung cancer patients under chemotherapeutic regimens and with increasing dyspnea. In addition, we alert to the fact that long-term inhaled corticosteroids may be a risk factor for PCP in patients with lung cancer. Despite intensive treatment, the mortality of PCP remains high, hence the importance of chemoprophylaxis should be considered. | Sameh Msaad Ilhem Yangui Najla Bahloul Narjes Abid Makram Koubaa Yosr Hentati Mounir Ben Jemaa Samy Kammoun | 2015 | World Journal of Clinical Cases2015，3，9： | 5 |
| 15 | Fungi as chemical industries and genetic engineering for the production of biologically active secondary metabolites显示文摘Fungi is somewhere in between the micro and macro organisms which is a good source of producing biologically active secondary metabolites.Fungi have been used as tool for producing different types of secondary metabolites by providing different nutrients at different laboratory conditions.The fungi have been engineered for the desired secondary metabolites by using different laboratory techniques,for example,homologous and heterologous expressions.This review reported how the fungi are used as chemical industry for the production of secondary metabolites and how they are engineered in laboratory for the production of desirable metabolites:also the biosynthetic pathways of the bio-organic-molecules were reported. | Abid Ali Khan Nafees Bacha Bashir Ahmad Ghosia Lutfullah Umar Farooq Russell John Cox | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，11： | 5 |
| 16 | 潜伏期和染病期均具有传染性的媒介传染病模型的全局稳定性分析(英文)显示文摘讨论潜伏期和染病期均具有传染性的媒介传染病模型.得到模型基本再生数的表达式,证明了当基本再生数小于1时,无病平衡点是全局渐近稳定的,此时疾病消亡;当基本再生数大于1时,无病平衡点是不稳定的,系统存在全局渐近稳定的地方病平衡点,此时,疾病将在人群中持续存在,数值模拟验证了理论结果. | Abid Ali Lashari Muhammad Ozair Gul Zaman 李学志 | 2012 | 应用泛函分析学报2012，14，4： | 5 |
| 17 | Effect of No-Reflow During Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction on Six-Month Mortality显示文摘 | David Brosh Abid R. Assali Aviv Mager Avital Porter David Hasdai Igal Teplitsky Eldad Rechavia Shmuel Fuchs Alexander Battler Ran Kornowski | 2007 | The American Journal of Cardiology2007，，4： | 4 |
| 18 | 不同类型药剂对水稻褐飞虱的活性及复配增效作用显示文摘采用稻茎浸渍法测定了18种杀虫剂对褐飞虱的毒力,选活性较好的药剂进行复配,筛选出具有较高活性的混剂,测定不同类型增效剂的增效作用与复合增效作用,并研究混剂与复合增效剂的最佳增效配伍。结果表明,18种药剂对褐飞虱的毒力大小次序为:氟虫腈〉噻嗪酮〉烯啶虫胺〉氟铃脲〉噻虫嗪〉甲维盐〉吡蚜酮〉阿维菌素〉丁醚脲〉毒死蜱〉速灭威〉啶虫脒〉异丙威〉联苯菊酯〉吡虫啉〉高效氯氟氰菊酯〉三唑磷〉马拉硫磷,其中氟虫腈的活性最高,是吡虫啉的128.38倍。不同药剂复配中,烯啶虫胺与噻嗪酮(30∶70)复配的共毒系数最高,为246.02。6种增效剂与药剂混配增效作用,以氮酮、有机硅最好,增效比在2.69~2.85之间,并且将两者按40∶60配比后,其联合增效作用有显著提高。 | 王昱莎 邹啸文 梁立成 Abid Ali 黄秀枝 贤振华 | 2015 | 植物保护2015，41，2： | 4 |
| 19 | Impact of direct acting antivirals on occurrence and recurrence of hepatocellular carcinoma: Biologically plausible or an epiphenomenon?显示文摘Hepatocellular carcinoma(HCC) is a major cause of morbidity and mortality worldwide. Chronic hepatitis C virus infection(HCV) is the most common cause of HCC in many European countries, Japan and Pakistan. Introduction of the new direct acting antivirals(DAAs) has revolutionized the management of HCV worldwide, with high rates of sustained virologic response in patients who could not have tolerated the previous interferon based treatments. However, recently there have been reports raising caution about the long term effects of DAAs, particularly a possible increased risk of HCC. Therefore this review explores the current molecular studies as well as clinical data that investigate the impact of DAAs on occurrence and recurrence of HCC. | Amna Subhan Butt Fatima Sharif Shahab Abid | 2018 | World Journal of Hepatology2018，10，2： | 4 |
| 20 | 牧场奶牛蹄叶炎与血液生化指标以及常量元素相关性的分析显示文摘为探究牧场奶牛蹄叶炎与奶牛血液中生化指标的相关性,在哈尔滨市某牧场采集了20个亚临床性蹄叶炎病例,20个慢性蹄叶炎病例以及20个健康牛的血液样本。检测其心功、肝功、肾功和常量元素指标,结果显示:临床性蹄叶炎患病组,慢性蹄叶炎与健康组比较,高密度脂蛋白(HDL)均显著性降低(P<0.05),总胆固醇(TC)均显著性升高(P<0.05),尿酸(UA)显著性升高(P<0.05);亚临床蹄叶炎患病组奶牛与健康组比较,磷(P)显著性降低(P<0.05),但慢性蹄叶炎患病组奶牛与健康组比较,P无显著性差异(P>0.05);慢性蹄叶炎患病组奶牛与健康组比较,总胆红素(TBILI)显著性升高(P<0.05),但亚临床性蹄叶炎患病组奶牛与健康组比较,TBILI无显著性差异(P>0.05)。说明血清中以上指标的含量变化与蹄叶炎的发病密切相关。 | 张献颢 丁嘉烽 宋乔志 李岳鹏 HAYAT Muhammad Abid 张建涛 王洪斌 | 2020 | 中国兽医学报2020，40，5： | 4 |
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