|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 生态博物馆理念及其在少数民族社区景观保护中的作用——以贵州梭嘎生态博物馆为例显示文摘生态博物馆是兴起于20世纪70年代的一种创新的文化景观保护与展示方式,其基本理念是以生态学为基础,以特定地域某一特定群体的全部文化内涵为展示内容。与传统博物馆相比,其最明显的创新在于,它以社区为基础,以就地保护的方式进行原生态状况下的'活态文化遗产'的保护和展示。中挪合作项目贵州梭嘎生态博物馆是中国和亚洲第一座生态博物馆,是以'长角苗'民族文化景观为特征,由12个相连的苗族山区村寨组成。馆区自开放以来已接待了大量的参观游览者,在充分发挥其良好的社会展示功能的同时,也获得了较好的经济效益。从梭嘎生态博物馆的建设与运行中,也发现了一些值得进一步探讨的问题,如展示与保护内容的界定问题、文化保护与旅游发展的关系处理问题、区内接待规模与环境容量的测定问题,等等。 | 刘沛林 Abby Liu Geoff Wall | 2005 | 长江流域资源与环境2005，14，2： | 41 |
| 2 | Transjugular intrahepatic portosystemic shunt in cirrhosis: An exhaustive critical update显示文摘More than five decades after it was originally conceptualized as rescue therapy for patients with intractable variceal bleeding,the transjugular intrahepatic portosystemic shunt(TIPS)procedure continues to remain a focus of intense clinical and biomedical research.By the impressive reduction in portal pressure achieved by this intervention,coupled with its minimally invasive nature,TIPS has gained increasing acceptance in the treatment of complications of portal hypertension.The early years of TIPS were plagued by poor long-term patency of the stents and increased incidence of hepatic encephalopathy.Moreover,the diversion of portal flow after placement of TIPS often resulted in derangement of hepatic functions,which was occasionally severe.While the incidence of shunt dysfunction has markedly reduced with the advent of covered stents,hepatic encephalopathy and instances of early liver failure continue to remain a significant issue after TIPS.It has emerged over the years that careful selection of patients and diligent post-procedural care is of paramount importance to optimize the outcome after TIPS.The past twenty years have seen multiple studies redefining the role of TIPS in the management of variceal bleeding and refractory ascites while exploring its application in other complications of cirrhosis like hepatic hydrothorax,portal hypertensive gastropathy,ectopic varices,hepatorenal and hepatopulmonary syndromes,non-tumoral portal vein thrombosis and chylous ascites.It has also been utilized to good effect before extrahepatic abdominal surgery to reduce perioperative morbidity and mortality.The current article aims to review the updated literature on the status of TIPS in the management of patients with liver cirrhosis. | Sasidharan Rajesh Tom George Cyriac Abby Philips Rizwan Ahamed Sandeep Kumbar Narain Mohan Meera Mohanan Philip Augustine | 2020 | World Journal of Gastroenterology2020，26，37： | 26 |
| 3 | Less common neoplasms of the pancreas显示文摘最近,有除管的腺癌以外的胰的瘤的增加的识别。尽管因为在那里的胰腺的腺癌是展出多样的生物行为和恶意的变化的度的许多不同损害,不也学习了或描绘。这些损害包括:内分泌的瘤,囊性瘤,稳固的假乳头瘤,腺泡房间癌,有鳞的房间癌,胰的主要淋巴瘤,和到胰的变形损害。当诊断成像的数字和敏感学习增加,这些不太普通的瘤更经常正在被诊断。这篇评论文章讨论这些更少的临床的功课,诊断,和治疗普通,却相当相关,胰的瘤。 | Abby L Mulkeen Peter S Yoo Charles Cha | 2006 | World Journal of Gastroenterology2006，12，20： | 24 |
| 4 | Potent antiviral therapy improves survival in acute on chronic liver failure due to hepatitis B virus reactivation显示文摘Acute on chronic liver failure(ACLF)is a disease entity with a high mortality rate.The acute event arises from drugs and toxins,viral infections,bacterial sepsis,interventions(both surgical and non-surgical)and vascular events on top of a known or occult chronic liver disease.ACLF secondary to reactivation of chronic hepatitis B virus is a distinct condition;the high mortality of which can be managed in the wake of new potent antiviral therapy.For example,lamivudine and entecavir use has shown definite short-term survival benefits,even though drug resistance is a concern in the former.The renoprotective effects of telbivudine have been shown in a few studies to be useful in the presence of renal dysfunction.Monotherapy with newer agents such as tenofovir and a combination of nucleos(t)ides is promising for improving survival in this special group of liver disease patients.This review describes the current status of potent antiviral therapy in patient with acute on chronic liver failure due to reactivation of chronic hepatitis B,thereby providing an algorithm in management of such patients. | Cyriac Abby Philips Shiv Kumar Sarin | 2014 | World Journal of Gastroenterology2014，20，43： | 20 |
| 5 | Multiligament knee injuries with associated tibial plateau fractures: A report of two cases显示文摘The management of a combination of fracture and multiligament knee injury(MKI) in traumatic knee injury remains controversial, and there are evolving treatment recommendations. Currently, there are no studies focusing on older adult patients with MKI's in combination with tibia fractures. As a result, there is no well-established treatment algorithm for older adult patients with these complex injuries. We report two cases of MKI's with concomitant fractures in patients fifty years of age or older. Both patients were treated surgically for their associated tibial plateau fractures, but were managed with conservative treatment of the multiligamentous knee injuries. We also provide a review of the literature and guidelines for older adult patients with these types of complex traumatic injuries. Early to mid term acceptable outcomes were achieved for both patients through surgical fixation of the tibial plateau fracture and conservative treatment of the ligament injuries. We propose a comprehensive treatment algorithm for management of these complex injuries. | Vani J Sabesan Paul J Danielsky Abby Childs Tom Valikodath | 2015 | World Journal of Orthopedics2015，6，3： | 14 |
| 6 | Treating inflammatory bowel disease by adsorptive leucocytapheresis:A desire to treat without drugs显示文摘Ulcerative colitis and Crohn’s disease are the major phenotypes of the idiopathic inflammatory bowel disease(IBD),which afflicts millions of individuals throughout the world with debilitating symptoms,impairing function and quality of life.Current medications are aimed at reducing the symptoms or suppressing exacerbations.However,patients require life-long medications,and this can lead to drug dependency,loss of response together with adverse side effects.Indeed,drug side effects become additional morbidity factor in many patients on long-term medications.Nonetheless,the efficacy of anti-tumour necrosis factors(TNF)-αbiologics has validated the role of inflammatory cytokines notably TNF-αin the exacerbation of IBD.However,inflammatory cytokines are released by patients’own cellular elements including myeloid lineage leucocytes,which in patients with IBD are elevated with activation behaviour and prolonged survival.Accordingly,these leucocytes appear logical targets of therapy and can be depleted by adsorptive granulocyte/monocyte apheresis(GMA)with an Adacolumn.Based on this background,recently GMA has been applied to treat patients with IBD in Japan and in the European Union countries.Efficacy rates have been impressive as well as disappointing.In fact the clinical response to GMA seems to define the patients’disease course,response to medications,duration of active disease,and severity at entry.The best responders have been first episode cases(up to 100%)followed by steroid nave and patients with a short duration of active disease prior to GMA.Patients with deep ulcers together with extensive loss of the mucosal tissue and cases with a long duration of IBD refractory to existing medications are not likely to benefit from GMA.It is clinically interesting that patients who respond to GMA have a good long-term disease course by avoiding drugs including corticosteroids in the early stage of their IBD.Additionally,GMA is very much favoured by patients for its good safety profile.GMA in 21st century reminds us of phlebotomy as a major medical practice at the time of Hippocrates.However,in patients with IBD,there is a scope for removing from the body the sources of proinflammatory cytokines and achieve disease remission.The bottom line is that by introducing GMA at an early stage following the onset of IBD or before patients develop extensive mucosal damage and become refractory to medications,many patients should respond to GMA and avoid pharmacologics.This should fulfill the desire to treat without drugs. | Abbi R Saniabadi Tomotaka Tanaka Toshihide Ohmori Koji Sawada Takayuki Yamamoto Hiroyuki Hanai | 2014 | World Journal of Gastroenterology2014，20，29： | 11 |
| 7 | 开平碉楼景观的类型、价值及其遗产管理模式显示文摘广东开平碉楼景观是侨乡民众为了抵御当时猖獗的匪盗而修建的一种堡垒式建筑,是一种典型的中西结合且以西式风格为外部特征的文化景观。开平碉楼在平面上往往以楼群为主要建筑形式,在立面上则形成具有起伏的天际线。开平碉楼是开平华侨在特定历史条件下所创造的特殊文化景观,是国际文化传播过程中典型的“文化反渗”现象,具有重要的遗产价值。广东省及开平市所倡导的“政府托管制”和“居民直接管理”等一系列政策和措施,是对遗产保护与管理模式的重要创新。 | 申秀英 刘沛林 Abby Liu | 2006 | 湖南文理学院学报(社会科学版)2006，31，4： | 11 |
| 8 | Post-transcriptional regulation of vascular endothelial growth factor: Implications for tumor angiogenesis显示文摘脉管的内皮生长因素(VEGF ) 是一个有势力为批评的分泌 mitogen 生理并且肿瘤血管生成。VEGF 的规定发生在几个层次,包括抄写, mRNA 稳定,翻译,和各种各样的 isoforms 的微分细胞的本地化。在我们 VEGF 的 post-transcriptional 规定的理解的最近的进展在 VEGF mRNA 的 5'UTR 包括内部 ribosomal 入口地点的稳定的 mRNA 绑定蛋白质,投,和发现的鉴定。Monoclonal anti-VEGF 抗体最近在人为使用被同意,但是为高全身的剂量受不了需要。RNA 干扰(RNAi ) 技术正在被使用在试管内并且在有有希望的结果的动物模型。这里,我们在 VEGF 的 post-transcriptional 规定上考察文学并且在为治疗学的利益指向这些机制描述最近的进步。 | Peter S Yoo Abby L Mulkeen Charles H Cha | 2006 | World Journal of Gastroenterology2006，12，31： | 11 |
| 9 | Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis显示文摘瞄准:调查在临床的活动索引的 ulcerative (UC )( 蔡) 和 IL-1ra, IL-10, IL-6 和 IL-18 的传播层次之间的关系。方法:IL-1ra, IL-10, IL-6 和 IL-18 的血层次与活跃 UC 在 31 个病人被测量,吝啬的蔡是 11.1,从 5-25 ;并且是的 12 个健康个人控制。病人们与 Adacolumn 被给粒细胞和单核白血球 adsorptive 词首字母的脱落(GMA ) 。忍受 FcgammaR 并且补充受体的白细胞被吸附到列 leucocytapheresis 搬运人。每个病人能在 8 wk 上收到多达 11 个 GMA 会议。结果:我们发现了在蔡和 IL-10 之间的强壮的关联(r = 0.827, P <
0.001 ) , IL-6 (r = 0.785, P <
0.001 ) 并且 IL-18 (r = 0.791, P <
0.001 ) 。IL-1ra 没与蔡一起被相关。后面的 GMA 治疗, 31 个病人中的 24 个完成了宽恕,所有 4 cytokines 的层次掉在健康控制里到层次。进一步, IL-1ra 和 IL-10 的血层次在从遵守了搬运人的白细胞建议版本的 60 min 在列流出和流入增加了。 | Hiroyuki Hanai Takayuki Iida Masami Yamada Yoshihiko Sato Ken Takeuchi Tatsuo Tanaka Kenji Kondo Masataka Kikuyama Yasuhiko Maruyama Yasushi Iwaoka Akiko Nakamura Kazuhisa Hirayama Abby R Saniabadi Fumitoshi Watanabe | 2006 | World Journal of Gastroenterology2006，12，21： | 8 |
| 10 | Elevated plasma cryofibrinogen in patients with active inflammatory bowel disease is morbigenous显示文摘瞄准:在活跃的煽动性的肠疾病(IBD ) 调查冷沉纤维蛋白(CF ) 的角色。方法:CF 是在 284 个题目的 assayed:61 与活跃并且 63 与不活跃的 ulcerative (UC ) , 45 有 proctocolectomy, 35 与活跃并且 20 与不活跃的 Crohn 的疾病(CD ) , 40 与另外的疾病和 20 健康控制。胰岛素禁止者(TI ) 和 TI 抗体(TI-Ab ) 被 ELISA 在血浆和 CF 建筑群测量。结果:在活跃 UC 的 CF 与所有另外的组(c2<0.001 ) 相比惊人地高。同样, CF 比在不活跃的 CD 或在控制(c2<0.01 ) 在活跃 CD 是显著地更高的。在 UC,高 CF 和 TI-Ab 与对操作的需要被联系。进一步,在血浆的高 CF, CF/fibrinogen 比率,低 TI 和高 TI-Ab 与疾病活动或倔强被联系到药。提高的 CF 没与相似 C 反应的蛋白质和白血房间除了红细胞沉降率数的尖锐反应物被联系,建议那提高的 CF 不是急性炎的后果。结论:在活跃 IBD 的提高的 CF 看起来是致病。CF 经由二主要机制支持 IBD, TI (一种反煽动性的物质) 熄灭并且损害由形成蛋白质总数的微脉管的灌注。CF 可以也用作长期的 IBD 的一个简历标记。另外的研究被保证充分在 IBD 评估 CF 的角色,结果应该贡献 IBD 的致病的更好的理解。 | Koji Sawada Ryouki Takahashi Abbi R Saniabadi Maiko Ohdo Takashi Shimoyama | 2006 | World Journal of Gastroenterology2006，12，10： | 7 |
| 11 | What Determines Corporate Transparency?显示文摘 | ROBERT M.BUSHMAN JOSEPH D.PIOTROSKI ABBIE J.SMITH | 2004 | Journal of Accounting Research2004，，2： | 6 |
| 12 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 13 | Financial accounting information and corporate governance显示文摘 | Robert M. Bushman Abbie J. Smith | 2001 | Journal of Accounting and Economics2001，，1： | 4 |
| 14 | Identifying microRNA panels specifically associated with hepatocellular carcinoma and its different etiologies显示文摘Aim:Deregulation of microRNAs(miRNAs)expression has been identified in hepatocellular carcinoma(HCC),but few results are consistent.The objective of this study is to investigate“HCC tumor type specific”and“tumor common”miRNA panels.Methods:The authors integrate and analyze clinical,etiologic and miRNA profiles data from 9 types of solid tumors in The Cancer Genome Atlas(TCGA)and HCC data from Columbia University Medical Center(CUMC).Results:Levels of 33 miRNAs were significant different between HCC tumor and paired non-tumor tissues(over 2-fold changes)after Bonferroni correction for multiple comparisons,and most(28 miRNAs)were down-regulated in HCC tumors.Using this panel,the authors well classified HCC tumor tissues with 4 misclassifications among 48 paired tissues.Validating this panel in an additional 302 HCC tumor tissues,the authors almost perfectly distinguished tumor from non-tumor tissues with only two misclassifications(99%of HCC tissues correctly classified).Evaluating miRNA profiles in 32 independent HCC paired tissues from CUMC,the authors observed 40 miRNAs significantly deregulated in HCC with over 2-fold changes;14 overlapped with those identified in TCGA.Subgroup analyses by HCC etiology found that 4 upregulated and 8 downregulated miRNAs were significantly associated with alcohol-related HCC.There were 7 and 4 miRNAs significantly associated with hepatitis B virus-and hepatitis C virus-related HCC,respectively.Data for the first time revealed that miR-24-1,miR-130a and miR-505 were significantly down-regulated only in HCC tumors;miR-142 and miR-455 were significantly down-regulated in HCC,but up-regulated in 5 other solid tumors;suggesting their HCC“tumor type specific”characteristics.A panel of 8 miRNAs was significant in at least 5 tumor types,including HCC,and was identified as“tumor common”marker.Conclusion:The authors concluded that aberrant miRNA panels have HCC“tumor type specificity”and may be affected by etiologic factors. | Jing Shen Abby B.Siegel Helen Remotti Qiao Wang Regina M.Santella | 2016 | Hepatoma Research2016，2，1： | 4 |
| 15 | JAK/STAT/SOCS‐signaling pathway and colon and rectal cancer显示文摘 | Martha L. Slattery Abbie Lundgreen Susan A. Kadlubar Kristina L. Bondurant Roger K. Wolff | 2011 | Carcinog2011，，2： | 4 |
| 16 | What Determines Corporate Transparency?显示文摘 | ROBERT M.BUSHMAN JOSEPH D.PIOTROSKI ABBIE J.SMITH | 2004 | Journal of Accounting Research2004，，2： | 3 |
| 17 | Update on diagnosis and management of sepsis in cirrhosis: Current advances显示文摘Sepsis and septic shock are catastrophic disease entities that portend high mortality in patients with cirrhosis.In cirrhosis,hemodynamic perturbations,immune dysregulation,and persistent systemic inflammation with altered gut microbiota in the background of portal hypertension enhance the risk of infections and resistance to antimicrobials.Patients with cirrhosis develop recurrent lifethreatening infections that progress to multiple organ failure.The definition,pathophysiology,and treatment options for sepsis have been ever evolving.In this exhaustive review,we discuss novel advances in the understanding of sepsis,describe current and future biomarkers and scoring systems for sepsis,and delineate newer modalities and adjuvant therapies for the treatment of sepsis from existing literature to extrapolate the same concerning the management of sepsis in cirrhosis.We also provide insights into the role of gut microbiota in initiation and progression of sepsis and finally,propose a treatment algorithm for management of sepsis in patients with cirrhosis. | Cyriac Abby Philips Rizwan Ahamed Sasidharan Rajesh Tom George Meera Mohanan Philip Augustine | 2020 | World Journal of Hepatology2020，12，8： | 2 |
| 18 | Randomized Trial on Silicone Intubation in Endoscopic Mechanical Dacryocystorhinostomy (SEND) for Primary Nasolacrimal Duct Obstruction显示文摘 | Kelvin K.L. Chong Frank H.P. Lai Mary Ho Abbie Luk Ben W. Wong Alvin Young | 2013 | Ophthalmology2013，，： | 2 |
| 19 | Gender-Typed Play Behavior in Early Childhood: Adopted Children with Lesbian, Gay, and Heterosexual Parents显示文摘 | Abbie E. Goldberg Deborah A. Kashy JuliAnna Z. Smith | 2012 | Sex Roles2012，，9： | 2 |
| 20 | Apoptosis in the failing human heart显示文摘 | Olivetti G Abbi R Quaini F | 1997 | N Engl J Med1997，336，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员