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| 1 | 代谢酶NAT2多态性与大肠息肉及腺瘤的复发显示文摘目的 研究代谢酶基因NAT2多态性与大肠息肉及腺瘤复发的关系 ,探讨其与大肠癌遗传易感性。方法 在 1980年 ,建立了 40 76例大肠癌高危人群队列 ,这 40 76例均有大肠腺瘤或息肉史。从高危人群中随机抽取 5 2例息肉、腺瘤复发 2次以上者为复发组 ,另抽取 5 2例无复发者为对照 ,从抗凝外周血白细胞中提取DNA ,采用聚合酶链反应 限制性内切酶片段长度多态性 (PCR RFLP)方法分析 ,比较NAT2的多态性分布差异。结果 NAT2野生型Wt/Wt频率在无复发组 (17/ 5 2 ,32 7% )明显高于复发组 (8/ 5 2 ,15 .4% ) ,杂合型在复发组频率为 40 / 5 2 (76 .9% ) ,与无复发组频率30 / 5 2 (5 7.7% )比较 ,差异均有显著意义 (P <0 .0 5 )。以Wt/Wt基因型的危险度 (OR)为 1,则Wt/M 基因型的OR为 2 .96 ,95 %CI为 1.0 91~ 8.0 0 9,M /M 基因型的OR为 2 .12 5 ,95 %CI为 0 .6 6 6~6 781。在复发与无复发组中 ,未发现NAT2快速与慢速酶的差异。结论 NAT2野生型 (Wt/Wt)可能是大肠腺瘤复发的保护因素 。 | 郑树 刘希永 曹江 Rebecca A.Nelson 董琦 方永明 William Bennett 蔡善荣 张苏展 | 2001 | 中华医学杂志2001，81，15： | 7 |
| 2 | 当前玻璃耐火材料应用的趋势显示文摘 | Michael A.Nelson | 2005 | 玻璃与搪瓷2005，33，2： | 2 |
| 3 | ARE “GREEN TIDES” HARMFUL ALGAL BLOOMS? TOXIC PROPERTIES OF WATER‐SOLUBLE EXTRACTS FROM TWO BLOOM‐FORMING MACROALGAE, ULVA FENESTRATA AND ULVARIA OBSCURA (ULVOPHYCEAE)显示文摘 | Timothy A.Nelson Dejah J.Lee Bridget C.Smith | 2003 | Journal of Phycology2003，，5： | 1 |
| 4 | Competitive Balance and Game Attendance in Major League Baseball显示文摘 | James W.Meehan Jr Randy A.Nelson Thomas V.Richardson | | 0，，08： | 1 |
| 5 | Local Skull Trephination Before Transfer Is Associated With Favorable Outcomes in Cerebral Herniation from Epidural Hematoma显示文摘 | James A.Nelson | 2011 | Academic Emergency Medicine2011，，1： | 1 |
| 6 | Increased expression of the heterogeneous nuclear ribonucleoprotein K in pancreatic cancer and its association with the mutant p53显示文摘 | RenyuanZhou ReneéShanas Mark A.Nelson AchyutBhattacharyya JiaqiShi | 2009 | Int J Cancer2009，，2： | 1 |
| 7 | Enhancement of THz generation in LiNbO_(3) waveguides via multi-bounce velocity matching显示文摘To realize the full promise of terahertz polaritonics(waveguide-based terahertz field generation,interaction,and readout)as a viable spectroscopy platform,much stronger terahertz fields are needed to enable nonlinear and even robust linear terahertz measurements.We use a novel geometric approach in which the optical pump is totally internally reflected to increase the distance over which optical rectification occurs.Velocity matching is achieved by tuning the angle of internal reflection.By doing this,we are able to enhance terahertz spectral amplitude by over 10x compared to conventional single-pass terahertz generation.An analysis of the depletion mechanisms reveals that 3-photon absorption and divergence of the pump beam are the primary limiters of further enhancement.This level of enhancement is promising for enabling routine spectroscopic measurements in an integrated fashion and is made more encouraging by the prospect of further enhancement by using longer pump wavelengths. | Blake S.Dastrup Eric R.Sung Frank Wulf Clara Saraceno Keith A.Nelson | 2022 | Light(Science & Applications)2022，11，12： | 0 |
| 8 | Long-term cost and efficacy analysis of latanoprost versus timolol in glaucoma patients in Germany显示文摘AIM: To evaluate 5-year effectiveness and cos between latanoprost or timolol monotherapy in a pilot trial.METHODS: A retrospective, multi-center trial performed at 6 sites in Germany of patients who had a diagnosis of primary open-angle or pigmentary glaucoma, in at least one eye, initiated on monotherapy with latanoprost or timolol maleate. Qualified consecutive charts were reviewed in which 5-year efficacy, safety and cost data was abstracted.RESULTS: Seventy-seven latanoprost and 49 timolo patients were included, at the final visit no difference existed between the two groups in disc parameters including: rim area, rim area/disc area ratio, cup volume or vertical cup/disc ratio (P >0.05). There was no difference in intraocular pressure (IOP) between the initial latanoprost (17.4 ±2.6) and timolol (16.3 ±2.8mmHg) groups. There was less change in medicines over the follow-up period (0.1 vs 0.8) and fewer medications at the final visit (1.2 vs 1.8) with latanoprost compared to timolol. No patient treated with latanoprost discontinued therapy during follow-up, while 12% discontinued timolol mostly due to inadequate IOP control. Cost/year was less with initial timolol ($458±236) as compared to latanoprost ($552±202). CONCLUSION: Patients begun on latanoprost o timolol and followed over 5 years may have similar clinical outcomes. However, timolol patients may require more medicines and medicine changes to control IOP for long-term, but at a lower cost. | Ulrich Thelen Dietmar Schnober Sonja Schlzel Michael S.Kristoffersen Lindsay A.Nelson Jeanette A.Stewart William C.Stewart | 2013 | International Journal of Ophthalmology(English edition)2013，6，2： | 0 |
| 9 | 古海啸研究显示文摘 | B.Rhodes M.Tuttle B.Horton L.Doner H.Kelsey A.Nelson M.Cisternas 王晓权 | 2007 | 世界地震译丛2007，，4： | 0 |
| 10 | Ophthalmic community perception of new medication needs显示文摘AIM:To survey ophthalmologists(who have participated previously in clinical research) and ophthalmic industry professionals(who have been involved in ocular research and development) to indicate perceived needs for new pharmaceuticals in various ophthalmic subspecialties.METHODS:A prospective,industry-based survey was sent to ophthalmologists and ophthalmic industry professionals about the perceived needs for new pharmaceutical products.RESULTS:This survey was sent to 559 ophthalmic pharma professionals and ophthalmologists.We received 82(15%) responses.The results showed that the most commonly perceived need for new pharmaceuticals were dry and wet age-related macular degeneration,glaucoma,diabetic macular edema and dry eye.There was a statistical difference found between response groups(P<0.0001).Respondents indicated they would express their commitment to a new product they perceived as needed by recommending to colleagues(63%),prescribing(60%),participating as principle investigator in a related clinical trial(52%),advising the company(52%),lecturing on behalf of the product(43%),investing in the product(38%),taking no action(7%) or obtain a position in the company(1%).CONCLUSION:Ophthalmic pharma professionals and ophthalmologists perceive the greatest need for new medicines in ophthalmology to be in dry and wet agerelated macular degeneration,glaucoma,diabetic macular edema and dry eye. | William C.Stewart Jeanette A.Stewart Lindsay A.Nelson | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 0 |
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