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| 1 | 身体功能恢复的脑卒中患者仍存在认知障碍、抑郁症状和重返社会障碍显示文摘脑卒中后的功能预后往往通过改良的Rankin量表进行评估,仅对主要日常生活活动能力进行评估。但脑卒中患者可能在重新融入社会生活的时候遇到困难,心理上感觉孤立,生活质量差,即便是身体功能完全恢复的患者也存在上述问题。 | Kapoor A Lanctt KL Bayley M Kiss A Herrmann N Murray BJ Swartz RH 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 16 |
| 2 | Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor显示文摘AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver cirrhosis.METHODS: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on in-hospitalmortality.RESULTS: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p < 0.000001). patients with infection had significantly increased in-hospital-mortality(34% vs 17%, p < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy.CONCLUSION: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria. | Mireen Friedrich-Rust Beate Wanger Florian Heupel Natalie Filmann Reinhard Brodt Volkhard AJ Kempf Johanna Kessel Thomas A Wichelhaus Eva Herrmann Stefan Zeuzem Joerg Bojunga | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 3 | Clinical use of bone-targeting radiopharmaceuticals with focus on alpha-emitters显示文摘Various single or multi-modality therapeutic options are available to treat pain of bone metastasis in patients with prostate cancer.Different radionuclides that emitβ-rays such as 153Samarium and 89Strontium and achieve palliation are commercially available.In contrast toβ-emitters,223Radium as a a-emitter has a short path-length.The advantage of the a-emitter is thus a highly localized biological effect that is caused by radiation induced DNA double-strand breaks and subsequent cell killing and/or limited effectiveness of cellular repair mechanisms.Due to the limited range of the a-particles the bone surface to red bone marrow dose ratio is also lower for 223Radium which is expressed in a lower myelotoxicity.The a emitter 223Radium dichloride is the first radiopharmaceutical that significantly prolongslife in castrate resistant prostate cancer patients with wide-spread bone metastatic disease.In a phaseⅢ,randomized,double-blind,placebo-controlled study 921patients with castration-resistant prostate cancer and bone metastases were randomly assigned.The analysis confirmed the 223Radium survival benefit compared to the placebo(median,14.9 mo vs 11.3 mo;P<0.001).In addition,the treatment results in pain palliation and thus,improved quality of life and a delay of skeletal related events.At the same time the toxicity profile of223Radium was favourable.Since May 2013,223Radium dichloride(Xofigo?)is approved by the US Food and Drug Administration. | Hinrich A Wieder Michael Lassmann Martin S Allen-Auerbach Johannes Czernin Ken Herrmann | 2014 | World Journal of Radiology2014，6，7： | 4 |
| 4 | Modeling slow deformation of polygonal particles using DEM显示文摘We introduce two improvements in the numerical scheme to simulate collision and slow shearing of irregular particles. First, we propose an alternative approach based on simple relations to compute the frictional contact forces. The approach improves efficiency and accuracy of the Discrete Element Method (DEM) when modeling the dynamics of the granular packing. We determine the proper upper limit for the integration step in the standard numerical scheme using a wide range of material parameters. To this end, we study the kinetic energy decay in a stress controlled test between two particles. Second, we show that the usual way of defining the contact plane between two polygonal particles is, in general, not unique which leads to discontinuities in the direction of the contact plane while particles move. To solve this drawback, we introduce an accurate definition for the contact plane based on the shape of the overlap area between touching particles, which evolves continuously in time. | Andrés A. Pea Pedro G. Lind Hans J. Herrmann | 2008 | Particuology2008，6，6： | 2 |
| 5 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 6 | Effect of lake trophic status and rooted macrophytes on community composition and abundance of ammonia-oxidizing prokaryotes in freshwater sediments显示文摘 | Herrmann M Saunders A M Schramm A | 2009 | Appl Environ Microbiol2009，75，10： | 1 |
| 7 | Functional and neuroanatomic correlations in poststroke depression:the Sunnybrook Stroke Study显示文摘 | Singh A Black SE Herrmann N | 2000 | Stroke2000，31，： | 1 |
| 8 | Chelating N-heterocyclic carbene ligands in palladium-catalyzed heck- type reactions 显示文摘 | HERRMANN W A REIS1NGER C P SPIEGLER M | 1998 | Journal of Organometal|ic Chemistry1998，557，： | 1 |
| 9 | Cardiovascular effect of intracoronary atrial natriuretic peptide administration in man显示文摘 | Herrmann H C Rosen A D Davia C A | 1990 | Am Heart1990，120，： | 1 |
| 10 | Simulation-based study of the combined effect on cod-end size selection of turning meshes by 90° and reducing the number of meshes in the circumference for round fish显示文摘 | Herrmann B Priour D Krag L A | 2007 | Fish Res2007，84，2： | 1 |
| 11 | Target design for high fusion yield with the double Z-pinch-driven hohlraum 显示文摘 | VESEY R A HERRMANN M C LEMKE R W | 2007 | Physics of Plasmas2007，14，05： | 1 |
| 12 | The social influence of brand community: Evidence from European car clubs 显示文摘 | Algesheimer R Dholakia U M Herrmann A | 2005 | Journal of Marketing2005，69，3： | 1 |
| 13 | Quantitative detection of the 35S promoter and the NOS terminator using quantitative competitive PCR显示文摘 | Hardegger M Brodmann P Herrmann A | 1999 | European Food Research and Technology1999，209，2： | 1 |
| 14 | Comparison of different commercial DNA extraction kits to detect Toxoplasma gondii oocysts in cat faeces显示文摘 | Herrmann D C Maksimov A Pantchev N | 2011 | Berl Munch Tierarztl Wochenschr2011，124，1112： | 1 |
| 15 | Electrochemical corrosion of solid and liquid phase sintered silicon carbide in acidic and alkaline environments 显示文摘 | Andrews A Herrmann M Sephton M Machio Chr Michaelis A | 2007 | Euro Ceram Soci2007，275，： | 1 |
| 16 | Irrigation of treated wastewater in Braunschweig, option to remove pharmaceuticals and musk fragrances 显示文摘 | TERNES T A BONERZ M HERRMANN N | 2007 | Chemosphere2007，66，5： | 1 |
| 17 | Functional and neuroanatomic correlations in poststroke depression: the sunnybrook stroke study显示文摘 | Singh A Black S E Herrmann N | 2000 | Stroke2000，31，3： | 1 |
| 18 | N-Heterocyclic carbene complexes of palladium(0): synthesis and application in the Suzuki cross-coupling reaction显示文摘 | BOHM V P W CSTOTFMAYR C W K HERRMANN W A | 2000 | Jour- nal of Organometallic Chemistry2000，595，18： | 1 |
| 19 | Applications of group technology in distributed manufacturing显示文摘 | Candadai A Herrmann JW Minis I | 1996 | J Intell Manufact1996，，7： | 1 |
| 20 | The Common Modelling Protocol: A hierarchical framework for simulation of agricultural and environmental systems 显示文摘 | Moore A D Holzworth D P Herrmann N I | 2007 | Agri Syst2007，95，： | 1 |
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