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| 1 | 北京PM_(2.5)化学物种的质量平衡特征显示文摘以北京 2个采样点连续采集的样品对PM2 5中的元素、水溶性离子和含碳组分进行分析 .车公庄和清华园PM2 5中有机物的含量分别为 2 7 8%和 30 9% ,是含量最丰富的物种 ,其次是二次无机粒子、土壤尘、元素碳和微量元素 .PM2 5中约有 2 4 %的质量未能鉴别成分 ,相关性分析表明 ,含碳物种的估算所引起的偏差可能是主要的原因 .采暖期重污染周和春季沙尘周PM2 5的化学物种构成悬殊 ,反映了季节性变化的源排放和特殊气象条件的综合作用 . | 杨复沫 贺克斌 马永亮 张强 Cadle S H Chan T Mulawa P A | 2004 | 环境化学2004，23，3： | 63 |
| 2 | MicroRNA in TLR signaling and endotoxin tolerance显示文摘Toll-like receptors(TLRs)in innate immune cells are the prime cellular sensors for microbial components.TLR activation leads to the production of proinflammatory mediators and thus TLR signaling must be properly regulated by various mechanisms to maintain homeostasis.TLR4-ligand lipopolysaccharide(LPS)-induced tolerance or cross-tolerance is one such mechanism,and it plays an important role in innate immunity.Tolerance is established and sustained by the activity of the microRNA miR-146a,which is known to target key elements of the myeloid differentiation factor 88(MyD88)signaling pathway,including IL-1 receptor-associated kinase(IRAK1),IRAK2 and tumor-necrosis factor(TNF)receptor-associated factor 6(TRAF6).In this review,we comprehensively examine the TLR signaling involved in innate immunity,with special focus on LPS-induced tolerance.The function of TLR ligand-induced microRNAs,including miR-146a,miR-155 and miR-132,in regulating inflammatory mediators,and their impact on the immune system and human diseases,are discussed.Modulation of these microRNAs may affect TLR pathway activation and help to develop therapeutics against inflammatory diseases. | Md A Nahid Minoru Satoh Edward KL Chan | 2011 | Cellular & Molecular Immunology2011，8，5： | 34 |
| 3 | 基于人工智能干预措施的临床试验方案指南:SPIRIT-AI扩展显示文摘《干预试验方案报告标准》(Standard Protocol Items:Recommendations for Interventional Trials,SPIRIT)2013通过为试验最小条目集的确定提供基于证据的建议,旨在改善临床试验方案报告的完整性。该指南有助于促进新干预措施的透明评估。近年来,人们越来越认识到,涉及人工智能(artificial interlligence,AI)的干预措施需要经过严格的前瞻性临床研究评估,以证明其对健康结局的影响。《人工智能干预试验方案报告标准(Standard Protocol Items:Recommendations for Interventional Trials-Artificial Intelligence,SPIRIT-AI)扩展》是一份新的评估AI干预措施的临床试验方案的报告指南。它与配套的《人工智能试验报告统一标准》(Consolidated Standards of Reporting Trials-Artificial Intelligence,CONSORT-AI)是同步编制的。这两项指南的编制通过分阶段的文献回顾和专家咨询等过程达成共识,产生26项候选条目。由国际多方利益相关小组在两阶段德尔菲调查(103个利益相关者)中对这些条目进行了咨询,并在共识会议上达成一致意见(31个利益相关者),通过34个试点参与进行了改进和优化。SPI RI T-AI扩展包括15项对AI干预的临床试验方案非常重要的新条目。除SPIRIT 2013的核心条目外,这些新条目也应定期报告。SPIRIT-AI建议研究人员提供关于AI干预的清晰描述,包括使用AI所需的说明和操作技能、AI干预集成环境的设置、输入和输出数据处理的注意事项、人-AI交互和错误案例分析。SPI RI T-AI将有助于提高AI干预临床试验方案的透明度和完整性,也有助于编辑、同行评审以及普通读者理解、解释和严格评估临床试验的设计和偏倚风险。 | 熊云云(译) 李子孝(译) 丁玲玲(译) 谷鸿秋(译) 王春娟(译) 王春雪(译) 赵性泉(译) 王拥军(译) CRUZ RIVERA S LIU X CHAN A | 2020 | 中国卒中杂志2020，15，11： | 20 |
| 4 | 延胡索酸水合酶缺陷型肾细胞癌32例临床病理和分子分析显示文摘延胡索酸水合酶缺陷型肾细胞癌属于罕见的、新近发现的与遗传性平滑肌瘤病和肾细胞癌综合征相关的肿瘤实体。延胡索酸水合酶缺陷型肾细胞癌可表现出多种临床和病理学表现,但通常表现为局部进展和转移性疾病,预后较差。作者通过延胡索酸水合酶免疫组化和(或)延胡索酸水合酶突变分析确定32例延胡索酸水合酶缺陷型肾细胞癌,并对其临床和病理特征进行回顾性分析。 | Lau H D Chan E Fan A C 魏建国(摘译) 方三高(审校) | 2020 | 临床与实验病理学杂志2020，36，3： | 19 |
| 5 | Colonoscopy-induced ischemic colitis in patients without risk factors显示文摘Ischemic colitis is the most common form of intestinal ischemia.It is a condition that is commonly seen in the elderly and among individuals with risk factors for ischemia.Common predisposing conditions for ischemic colitis are major vascular occlusion,small vessel disorder,shock,some medications,colonic obstructions and hematologic disorders.Ischemic colitis following colonoscopy is rare.Here,we report two cases of ischemic colitis after a routine screening colonoscopy in patients without risk factors for ischemia. | Sang Ok Lee Sae Hee Kim Sung Hee Jung Chan Woong Park Min Ji Lee Jin A Lee Hyun Cheol Koo Anna Kim Hyun-Young Han Dong-Wook Kang | 2014 | World Journal of Gastroenterology2014，20，13： | 9 |
| 6 | High level of preoperative carbohydrate antigen 19-9 is a poor survival predictor in gastric cancer显示文摘AIM:To assess the clinical significance and the prognostic value of preoperative serum carbohydrate antigen 19-9(CA 19-9)level in gastric cancer.METHODS:Between January 2005 and December2006,1960 patients underwent surgery for histologically confirmed gastric cancer.Of these,163 patients had elevated serum levels of CA 19-9 preoperatively,and1628 patients had normal serum levels of CA 19-9 preoperatively.For this study,325 patients were selected from the group of 1628 patients by age,sex,and cancer stage to serve as controls.Statistically significant differences in survival rates were calculated using the log-rank test.A P value less than 0.05 was considered statistically significant and was determined using SAS software.RESULTS:The baseline characteristics showed some differences between the two groups with regard to histology.Overall survival(OS)in the elevated and nonelevated group was 37.90 and 68.67 mo,respectively(P<0.001).N stage(P=0.001)was a significant predictor of disease-free survival by multivariate analysis.Also,N stage(P<0.001),and the presence of peritoneal metastasis(P<0.001)remained independent factors in predicting OS by multivariate analysis.Additionally,preoperative serum CA 19-9 levels were significantly associated with OS in univariate(P=0.009)and multivariate(P=0.021)analyses.CONCLUSION:Serum CA 19-9 can be considered an independent prognostic factor in predicting OS in patients anticipating surgery for gastric cancer. | A Ra Choi Jun Chul Park Jie-Hyun Kim Sung Kwan Shin Sang Kil Lee Yong Chan Lee Jae Bock Chung | 2013 | World Journal of Gastroenterology2013，19，32： | 8 |
| 7 | Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation显示文摘BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two groups.This study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus LDLT.METHODS:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver transplantation.The frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and LDLT.The response of anastomotic stricture to endoscopic therapy was also analyzed.RESULTS:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary complications.Thirty-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic stricture.When comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver transplantation.Anastomotic strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups. | Calvin HY Chan Fergal Donnellan Michael F Byrne Alan Coss Mazhar Haque Holly Wiesenger Charles H Scudamore Urs P Steinbrecher Alan A Weiss Eric M Yoshida | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 8 | Inflammatory bowel disease in Asia: A systematic review显示文摘 | Lani Prideaux Michael A Kamm Peter P De Cruz Francis K L Chan Siew C Ng | 2012 | Journal of Gastroenterology and Hepatology2012，，8： | 5 |
| 9 | 堆石体宏细观力学特性演化机制的离散元模拟显示文摘以具有尖角的堆石颗粒材料为研究对象,采用自主开发的多边形离散单元法程序PDEM对其在双轴压缩试验过程中的宏-细观力学特性及变形破坏机制进行系统分析.根据数值试验中试样在不同围压下应力及变形的发展,从颗粒运动角度探讨试样宏观应力应变剪胀特性演化的细观机制;细观组构与宏观应力变形的发展之间具有同步性,反映试样宏细观演化的统一性;通过对颗粒细观各向异性的统计分析,揭示颗粒间摩擦及咬合作用是维持细观力学结构相对稳定的重要因素;通过对力链网络的形态演化分析,发现试样大主应力方向与各向异性主方向一致,力链密集程度随压缩过程先上升后下降,试样孔隙度也随之先减小后增大,反映了试样宏观先减缩后剪胀的特性. | 罗滔 李刚 OOIE T CHAN A HC 傅少君 邹维列 | 2018 | 武汉大学学报(工学版)2018，51，7： | 4 |
| 10 | Consolidation and dynamics of 3D unsaturated porous seabed under rigid caisson breakwater loaded by hydrostatic pressure and wave显示文摘In this study,based on the dynamic Biot's theory 'u-p' approximation,a 3D finite element method(FEM) numerical soil model is developed,in which the Generalized Newmark-β method is adopted to determine the time integration.The developed 3D FEM soil model is a part of the coupled model PORO-WSSI 3D for 3D wave-seabed-marine structures interaction problem,and is validated by the analytical solution proposed by Wang(2000) for a laterally infinite seabed loaded by a uniform force.By adopting the developed 3D soil model,the consolidation of seabed under a caisson breakwater and hydrostatic pressure is investigated.The numerical results show that the caisson breakwater built on seabed has very significant effect on the stresses/displacements fields in the seabed foundation after the transient deformation and primary consolidation are completed.The parametric study indicates that the Young's modulus E of seabed is the most important parameter to affect the settlement of breakwater,and the displacement fields in seabed foundation.Taking the consolidation status as the initial condition,the interaction between ocean wave,caisson breakwater and seabed foundation is briefly investigated.The 3D ocean wave is determined by solving the Navier-Stokes equations with finite volume method(FVM).The numerical results indicate that there is intensive interaction between | YE JianHong JENG DongSheng CHAN A H C | 2012 | Science China(Technological Sciences)2012，55，8： | 4 |
| 11 | One-year record of organic and elemental carbon in fine particles in downtown Beijing and Shanghai显示文摘 | Yang F. He K. Ye B. Chen X. Cha L. Cadle S. H. Chan T. Mulawa P. A | 2005 | Atmospheric Chemistry and Physics2005，，51： | 3 |
| 12 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 13 | Long-term evaluation of biliary reconstruction after partial resection of segments IV and V in iatrogenic injuries显示文摘 | Miguel ángel Mercado M.D. Carlos Chan M.D. Héctor Orozco M.D. José M. Villalta M.D. Alexandra Barajas-Olivas M.D. Javier Era?a M.D. Ismael Domínguez M.D | 2006 | Journal of Gastrointestinal Surgery2006，，1： | 3 |
| 14 | 一种模拟堆石料的二维多边形离散单元法及程序显示文摘在考虑堆石料真实颗粒形状的基础上,将每个颗粒用一个多边形离散单元表示,基于一种线性搜索算法对多边形-多边形之间的接触详情进行检索计算,引入基于势能原理的法向多边形-多边形接触模型及切向库仑摩擦模型,形成了一种多边形离散元计算方法,并开发了相应的PDEM程序。可以从颗粒尺度层面展示颗粒之间的相互作用以及每个颗粒的位移和转动,帮助进一步揭示颗粒的细观特性(形状、大小、材料特性等)对堆石料的宏观强度和变形的影响。最后采用PDEM程序对某粗粒料的二维模型试验进行了数值模拟,得到了与室内试验一致的应力变形规律,展现了其方法和程序用于研究堆石料的有效性。 | 罗滔 OOI E T CHAN A H C 傅少君 | 2017 | 岩土力学2017，38，3： | 2 |
| 15 | Antifungal and antiviral products of marine organisms显示文摘 | Randy Chi Fai Cheung Jack Ho Wong Wen Liang Pan Yau Sang Chan Cui Ming Yin Xiu Li Dan He Xiang Wang Evandro Fei Fang Sze Kwan Lam Patrick Hung Kui Ngai Li Xin Xia Fang Liu Xiu Yun Ye Guo Qing Zhang Qing Hong Liu Ou Sha Peng Lin Chan Ki Adnan A Bekhit Alaa | 2014 | Applied Microbiology and Biotechnology2014，，8： | 2 |
| 16 | Soluble E-cadherin is a valid prognostic marker in gastric carcinoma显示文摘 | Chan A O Lam S K Chu K M | 2001 | Gut2001，48，6： | 2 |
| 17 | Uncondi-tionally stable staggered solution procedure for soil-pore fluid interaction problems显示文摘 | Zienkiewicz O C Paul D K Chan A H | 1988 | Int J for Numerical Methods in Engineering1988，26，： | 2 |
| 18 | A novel polymorphism in the aldose reductase gene promoter region is strongly associated with diabetic retinopathy in adolescents with type 1 diabetes显示文摘 | Kao Y L Donaghue K Chan A | | 0，，： | 2 |
| 19 | Catalyst layer models for proton exchange membrane fuel cells显示文摘 | CHAN S H TUN W A | 2001 | J Chem Eng Technol2001，24，1： | 2 |
| 20 | Image restoration显示文摘 | Chan A Meloche J | 1997 | Journal of Statistical Planning and Inference1997，65，： | 2 |
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