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| 1 | Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests显示文摘AIM: To assess whether non invasive blood flow measurement by arterial spin labeling in several brain regions detects minimal hepatic encephalopathy. METHODS: Blood flow(BF) was analyzed by arterial spin labeling(ASL) in different brain areas of 14 controls, 24 cirrhotic patients without and 16 cirrhotic patients with minimal hepatic encephalopathy(MHE). Images were collected using a 3 Tesla MR scanner(Achieva 3T-TX, Philips, Netherlands). Pulsed ASL was performed. Patients showing MHE were detected using the battery Psychometric Hepatic Encephalopathy Score(PHES) consisting of five tests. Different cognitive and motor functions were also assessed: alterations in selective attention were evaluated using the Stroop test. Patients and controls also performed visuo-motor and bimanual coordination tests. Several biochemical parameters were measured: serum pro-inflammatory interleukins(IL-6 and IL-18), 3-nitrotyrosine, cGMP and nitrates+nitrites in plasma, and blood ammonia. Bivariate correlations were evaluated.RESULTS: In patients with MHE, BF was increased in cerebellar hemisphere(P = 0.03) and vermis(P = 0.012) and reduced in occipital lobe(P = 0.017). BF in cerebellar hemisphere was also increased in patients without MHE(P = 0.02). Bimanual coordination was impaired in patients without MHE(P = 0.05) and much more in patients with MHE(P < 0.0001). Visuo-motor coordination was impaired only in patients with MHE(P < 0.0001). Attention was slightly affected in patients without MHE and more strongly in patients with MHE(P< 0.0001). BF in cerebellar hemisphere and vermis correlated with performance in most tests of PHES [(number connection tests A(NCT-A), B(NCT-B)and line tracing test] and in the congruent task of Stroop test. BF in frontal lobe correlated with NCT-A. Performance in bimanual and visuomotor coordination tests correlated only with BF in cerebellar hemisphere. BF in occipital lobe correlates with performance in the PHES battery and with CFF. BF in cerebellar hemisphere correlates with plasma cGMP and nitric oxide(NO) metabolites. BF in vermis cerebellar also correlates with NO metabolites and with 3-nitrotyrosine. IL-18 in plasma correlates with BF in thalamus and occipital lobe.CONCLUSION: Non invasive BF determination in cerebellum using ASL may detect MHE earlier than the PHES. Altered NO-cGMP pathway seems to be associated to altered BF in cerebellum. | Vicente Felipo Amparo Urios Carla Giménez-Garzó Omar Cauli Maria-Jesús Andrés-Costa Olga González Miguel A Serra Javier Sánchez-González Roberto Aliaga Remedios Giner-Durán Vicente Belloch Carmina Montoliu | 2014 | World Journal of Gastroenterology2014，20，33： | 12 |
| 2 | Predictors of morbidity and mortality after the first episode of upper gastrointestinal bleeding in liver cirrhosis显示文摘 | Juan A.del Olmo Andrés Pe?a Miguel A Serra Abdallah H Wassel Adolfo Benages José M Rodrigo | 2000 | Journal of Hepatology2000，，1： | 2 |
| 3 | Hot - dip A1uminiumDeposit as a Permeation Barrier for MANET Stee1 显示文摘 | E Serra H G1asbrenner A Perujo | 1998 | Fusion Engineering and Design1998，41，： | 1 |
| 4 | Glucocorticoid receptor deficiency increases vulnerability of the nigrostriatal dopaminergic system: critical role of glial nitric oxide显示文摘 | MORALE M C SERRA P A DELOGU M R | 2004 | FASEB J2004，18，1： | 1 |
| 5 | Wavefront-guided ablation with Bausch and Lomb Zyoptix for retreatments after laser in situ keratomileuswas for myopia显示文摘 | Castanera J Serra A Rios C | 2004 | J Refract Surg2004，20，5： | 1 |
| 6 | Involvement of the cyclin dependent kinase 4 inhibitor (CDKN2) gene in the pathogenesis of lymphoid blast crisis of chronic myelogenous leukemia 显示文摘 | SERRA A COTTARDI E DELLA F | 1995 | BrJ Haematol1995，91，3： | 1 |
| 7 | A global movement toward an ecosystem approach to management of marine resources显示文摘 | Sherman K Sissenwine M Christensen V Duda A Hempel G Ibe C Levin S Liuch-Belda D Matishov G McGlade J O'Toole M Switzinger S Serra R Skjoldat H-R Tang Q Thulin J Vandeweerd V Zwanenburg K | | 0，，： | 1 |
| 8 | UV generation of a multifunctional hyperbranched thermal crosslinker to cureepoxy resins显示文摘 | Foix D Ramis X Serra A | | 0，，15： | 1 |
| 9 | Ap- plicability of muhisyringe chromatography coupled to cold- vapor atomic fluorescence spectrometry for mercury speci- ation analysis 显示文摘 | Guzman-Mar J L Hinojosa-Reyes L Serra A M | 2011 | Analytica Chimica Acta2011，708，12： | 1 |
| 10 | Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management显示文摘 | Sechi G Serra A | 2007 | Lancet Neurol2007，6，： | 1 |
| 11 | Os- RMC, a negative regulator of salt stress response in rice, is regu- lated by two AP2/ERF transcription factors显示文摘 | SERRA T S FIGUEIREDO D D CORDEIRO A M | 2013 | Plant Molecular Biology2013，82，45： | 1 |
| 12 | Performance of SVM Controlled Matrix Converter with Input and Output Unbalanced Conditions 显示文摘 | Casadei D Serra G Tani A | 1995 | Proceedings of EPE''951995，2，2： | 1 |
| 13 | On isoperimetric connectivity in vertex-transitive graphs 显示文摘 | Hamidoune Y O Llada A S Serra O | 2000 | SIAM Journal on Discrete Mathematics2000，13，1： | 1 |
| 14 | Anglographic quantification of thrombus in ST-elevation acute myocardial infarction presenting with an occluded infarctrelated artery and its relationship with results of percutaneous intervention显示文摘 | Miranda-Guardiola F Rossi A Serra A | 2009 | J Interv Cardiol2009，22，3： | 1 |
| 15 | Surface nitridation of titanium by pulsed Nd:YAG laser irradiation 显示文摘 | Gyorgy E P6rez del Pino A Serra P | 2003 | Applied Surface Science2003，186，1234： | 1 |
| 16 | Atomistic study of diffusional mass transport in metals显示文摘 | OSETSKY Y N BACON D J SERRA A | | 0，，1： | 1 |
| 17 | Paraquat intoxication 显示文摘 | SERRA A DOMINGOS F PRATA M M | 2003 | Acta Med Port2003，16，1： | 1 |
| 18 | Wernicke's encephalopathy in a woman on slimming diet显示文摘 | Sechi GP Serra A Pirastru MI | 2002 | Neurology2002，58，11： | 1 |
| 19 | Genomic variants inthe coding region of neuronal nitric oxide synthase(NOSl)ininfantile hypertrophic pyloric stenosis显示文摘 | Serra A Schuchardt K Genuneit J | 2011 | J Pediatr Surg2011，46，10： | 1 |
| 20 | Paraquat intoxication显示文摘 | Serra A Domingos F Prat MM | | 0，，： | 1 |
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