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| 1 | Timing of IUI Treatment after hCG Administration 1-48h Affecting Pregnancy Rate显示文摘Objective To compare the different time of administration of hCG affecting pregnancy rate of IUI. Methods A total of 189 infertile couples underwent 331 cycles of IUI with husband's sperm. They were separated into 3 groups according to the time of hCG administration in IUI: hCG 1-23 h (group A); hCG 24-36 h (group B); hCG 37-48 h (group C). Results There were no statistical differences among 3 groups. None of the other relative factors, such as the female age, the different methods of ovulation and the cause of infertility, showed differences in pregnancy rate among 3 groups. Conclusion IUI can be performed any time after administration of hCG (1-48 h). | Fan YANG Hui JIN Li-ping ZHU Kun-ming LI Jian-zhi YANG Zhi-qin CHEN Xiao-ming TENG Hui-fen CHEN Yu WANG Zu-mei SHI | 2008 | Journal of Reproduction and Contraception2008，19，3： | 10 |
| 2 | Recurrent miscarriage Are three miscarriages one too many? Analysis of a Scottish populationbased database of 151, 021 pregnancies显示文摘 | Sohinee Bhattacharya John Townend Siladitya Bhattacharya | 2010 | European Journal of Obstetrics & Gynecology and Reproductive Biology2010，15，： | 7 |
| 3 | Assisted Reproduction of Pretreatment with Laparoscopic “Core-pulling” Salpingectomy for Patients with Hydrosalpinx before in vitro Fertilization Embryo Transfer显示文摘Objective To investigate the reproduction-assisting effects of laparoscopic 'corepulling' salpingectomy for patients with hydrosalpinx on ovarian reserve,responsiveness to stimuli and outcomes of in vitro fertilization and embryo transfer(IVF-ET).Methods Infertile females receiving treatment in Reproductive Medicine Center of Yantai Yuhuangding Hospital due to fallopian tube disorders(n=214) were enrolled from July 2006 to December 2007 and further divided into three groups.'Core-pulling' procedure group(group A) consisted of patients receiving pretreatment with 'corepulling' salpingectomy due to hydrosalpinx in our center(n=31),wherein 16 patients received IVF-ET.Conventional procedure group(group B) consisted of patients receiving conventional salpingectomy for hydrosalpinx or ectopic pregnancy in our center or other institutes prior to IVF-ET(n=59).Control group(group C) consisted of patients receiving IVF-ET without the history of previous hydrosalpinx or salpingectomy(n=124).Results At baseline,the antral follicle count of group B was significantly less than that of groups A and C(8.6±2.5 vs 8.3±2.0 vs 9.8±2.4).The mature oocytes retrieved numbered less than the other two groups,in a statistically significant manner compared with group C(13.1±5.7 vs 10.6±5.0 vs 12.0±6.2).Patients of groups A and B received more gonadotropin while the dosage of group B differed significantly from group C(31.0±17.7 vs 37.6±8.3 vs 30.0±4.6).E2 level on hCG injection day was slightly lower in group B than in the other two groups,statistically significant compared with that of group C,but not compared with that of group A.After receiving IVF-ET,patients of group A showed significantly higher conception rate than groups B and C(62.5% vs 43.6% vs 39.2%).Conclusion Compared with the conventional procedure,laparoscopic 'core-pulling' salpingectomy should be recommended for patients with hydrosalpinx intending to receive IVF-ET,which did not interfere with the ovarian reserve or responsiveness but improve the conception rate in clinical practice. | Hong-chu BAO Cui-fang HAO Mei-mei WANG Li-li ZHUANG Xin-rong WANG | 2010 | Journal of Reproduction and Contraception2010，21，3： | 7 |
| 4 | Oocyte Cryopreservation in Human Assited Reproduction显示文摘Embryo cryopreservation(CP) has became a very important part of the clinical use of in vitro fertilization. Oocyte CP offers more advantages compared with embryo freezing with regard to less ethical, legal and moral problems. However, the efficiency of this procedure is still low, which prevents its clinical application in wide range. The aim of our paper is to review the basic principles, technical and safety aspects and current status of oocyte cryopreservation in human assisted reproduction. | J Konc S Cseh E Varga R Kriston K Kanyó | 2006 | Journal of Reproduction and Contraception2006，17，2： | 7 |
| 5 | Effects of Growth Hormone Supplementation in Patients Undergoing IVF/ICSI-ET with Poor Ovarian Response to Gonadotropin显示文摘Objective To analyze the effects of growth hormone(GH) supplementation during IVF/ICSI-ET in Chinese patients who had prior IVF cycle with poor response to gonadotropin(Gn).Methods Ovulation was stimulated in 389 consecutive patients who all had poor ovarian response, among them, 102 patients(GH cycle) received 4 IU GH and the other 287patients(non-GH cycle) underwent IVF without GH. Fisher's exact test, Chi square test and Student's t-test were used to analyze IVF/ICSI-ET outcomes.Results After GH treatment, 102 patients had significantly more large- and mediumsized follicles, oocytes retrieved, 2 pronucleus oocytes, metaphase II stage(MII) oocytes,and high-quality embryos than in previous cycles without GH. However, the number of embryos transferred, clinical pregnancy rate, transfer rate and biochemical pregnancy rate were not significantly different. Furthermore, the 102 patients given GH had significantly lower luteinizing hormone levels and biochemical pregnancy rates; thicker endometrium and more Gn administration days; and more large- and medium-sized follicles and MII oocytes than 287 other patients undergoing IVF/ICSI-ET without GH.However, these groups did not differ significantly in clinical pregnancies, high-quality embryos, MII oocytes, and embryo implantation rates.Conclusion GH may improve some IVF/ICSI-ET outcomes for women with poor ovarian response. | Zhi-ping HU Ying WANG Xiao-guo DU Rong LI Xin-na CHEN Hai-yan WANG Ping LIU Cai-hong MA Jie QIAO | 2014 | Journal of Reproduction and Contraception2014，25，1： | 7 |
| 6 | Clinical Analysis on IVF-ET Treatment of 9 Cases of Post-cesarean Section Uterine Diverticulum显示文摘Objective To evaluate the influence of uterine diverticulum patients who have a history of cesarean section on IVF-ET process and pregnancy outcome. Methods Nine patients with uterine diverticulum after cesarean were retrospectively analyzed, who have received IVF-ET treatment. Clinical pregnancy rate and embryo implantation rate were measured. Results There were 9 infertility patients in all, 7 cases with tubal factor, 2 with unexplained factor; 3 cases were associated with prolonged menstruation period, including 1 patient was misdiagnosed as dysfunctioned uterine bleeding. There were a total of 16 transplantation cycles, including14 fresh cycles and 2 thawing cycles. Each cycle had at least one high-quality embryo available for transfer. Five cases were difficult to transfer. Two were clinical pregnancie, the implantation rate was 5.13% (2/39). Conclusion In this study, 14 fresh cycles all had high-quality embryo transfer, uterine diverticulum had no effect on the development of ovums and the formation of high-quality embryos. But forming uterine diverticulum after cesarean section may lead to secondary infertility or patients with prolonged menstruation period, it also may lead it difficult to transfer during the treatment of IVF-ET and affect embryo implantation. So the patients with a history of cesarean section shall receive ultrasonic examination or hysteroscopy routinely before IVF treatment. If necessary surgical treatment is required. | Qiong-fang WU Ling NIE Yin ZHANG | 2011 | Journal of Reproduction and Contraception2011，22，3： | 6 |
| 7 | Effect of IFN-γ/IL-10 on IL-10 Receptor Expression of Human Decidual Stromal Cells in Early Pregnancy显示文摘Objective To study the role of IFN-γ /IL-10 cytokines on IL-10 receptor gene and protein expression of human decidual stromal cells(DSC) in human early pregnancy in vitro. Methods Human DSC was isolated and cultured in vitro, and the expression of IL-10R1 and IL-10R2 gene was analyzed after cells had been treated with TH2-type cytokines IL-10 and TH1-type cytokines IFN-γ within 60 min with semiquantitative reverse transcriptase-PCR, then the influence of IL-10 and IFN-γ on expression of IL-10R protein was examined by first trimester DSC using flow cytometry. In addition, the vitality of DSC was detected by MTT. Results IL-10R1 mRNA levels of DSC treated with IL-10 (10 ng/ml) reached the peak level within 15 min, and were significantly lower at 30 min, then were not detected at 45 min. The expression of IL-10R1 were induced to moderate level by IFN-γ(10 ng/ml) within 30 min, and reduced to undetected levels at 60 min. There was no significant difference of IL-10R2 expression (P>0.05) between treated and not with the above- mentioned cytokines. The IL-10R protein expression and vitality of DSC were significantly enhanced by IL-10 (10 ng/ml) and IFN-γ (10 ng/ml) which treated DSC 48 h (P<0.05). Conclusion IL-10 and IFN-γ may play an important role of biologic function in early pregnancy by influencing IL-10R expression of DSC. | Chang-ying XING Sui-qi GUI | 2006 | Journal of Reproduction and Contraception2006，17，2： | 6 |
| 8 | Circulating Antisperm Antibody (ASA) in Women is not Associated with Missed Abortions at the First-trimester Pregnancy显示文摘Objective To determine the role of the circulating antisperm antibody (ASA) in the pathogenesis of missed abortion at the first-trimester pregnancy. Methods Sixty-two patients with a history of missed abortion at the first-trimester pregnancy were enrolled into this study. Indirect immunobead test (IBT) was used to measure the circulating ASA levels. Fifty healthy women with the first-trimester pregnancy set as the control. Results No case had the positive level of ASA according to the World Health Organization criteria (50% or more of the motile sperm with immunobead binding). Only 1 case in patient group and 1 case in the control had 10%-20% of the motile spermatozoa with ASA-IgG bead binding. In both patient and control groups, ASA-IgA was found to be completely negative binding. Conclusion The circulating ASA is not associated with the pathogenesis of missed abortions at the first-trimester pregnancy. | Yu-xia WANG Wei-jie ZHU | 2011 | Journal of Reproduction and Contraception2011，22，3： | 6 |
| 9 | 大熊猫人工授精的研究显示文摘繁殖大熊猫的目的是圈养种群的自我维持和保持遗传多样性。由于圈养种群中有自然交配能力的雄兽很少 ,人工授精则成为有效的遗传管理的重要手段。本研究的目的是确定单纯人工授精的效率。 1 998年至 2 0 0 0年期间 ,在中国保护大熊猫研究中心 ,对 7只大熊猫进行了人工授精 (每只连续 2d) ,精液通过人工采精方法从 6只不同的雄兽中获得 ,使用鲜精、冷藏精液和冻精多种方法进行人工授精。 6只雄兽的精液平均值是 :采精量 3.3±0 .5ml;精子密度 1 ,42 9.8± 2 35 .4× 1 0 6/ml;活力 81 .7± 2 .1 % ;运动状态 ( 0~ 5 ,5 =最好 )3 1± 0 .1 ;精子正常率 79 3± 9.2 %。对 7只大熊猫进行的 1 4次人工授精中 ,使用的精液体积为 2 4± 0 3ml;活力是 73.5± 2 .9% ;运动状态为 2 .5± 0 .1 ;每次人工授精总活动精子数是 684.2± 1 1 8.2× 1 0 6。 7只大熊猫有 4只受孕 ( 5 7.1 % ) ,共产 5仔。平均孕娠期 1 31 .5±9.7d ,每胎平均 1 .3± 0 .3仔。同时 ,运用自然交配与人工授精相结合的方法 ,进行了 1 8只次实验 ,成功 1 2只次 ,产仔 2 0只 ,繁殖成功率为 66.7%。本研究结果表明 ,人工授精能有效地使不能自然交配的雄性大熊猫参与繁殖 ,提高繁殖率 ,增加圈养大熊猫的遗传多样性。 | 黄炎 王鹏彦 张贵权 张和民 李德生 汤纯香 魏荣平 胡大明 冯莉 Howard J G | 2002 | Developmental and Reproductive Biology2002，11，2： | 6 |
| 10 | Clinical Analysis on Laparoscopic Salpingectomy for Ectopic Pregnancy Following IVF/ICSI-ET显示文摘Objective To investigate whether laparoscopic surgery is valuable during early pregnancy and its influence on delivery outcome of the patients.Methods A retrospective analysis was undertaken of 14 heterotopic pregnancies conceived by IVF/ICSI-ET and underwent laparoscopic salpingectomy from December 2001 to September 2009.Results The mean age of 14 patients was 29 ± 5.3 years with range of 21-39 years.The ectopic pregnancy was located in the ampulla(11 patients,78.57%) and isthmus(3 patients,21.43%).All 14 patients underwent successful laparoscopic salpingectomy without complications.Eleven(78.57%) patients delivered live singleton infants at full term via caesarean section while 3(21.43%) had spontaneous abortion.The birth weight of viable newborns ranged from 2 600 g to 3 720 g and had a high Apgar score.Conclusion During early pregnancy,the heterotopic pregnancy should be diagnosed and treated early and laparoscopic salpingectomy can be a safe and effective choice.The well experienced surgeons and accessibility of the modern equipments are mandatory. | Rumana JAFAREY | 2010 | Journal of Reproduction and Contraception2010，21，3： | 6 |
| 11 | Comparison of Clinical Efficacy of Three Methods for Cervical Ripening followed by Surgical Evacuation in Early Missed Abortion显示文摘Objective To compare clinical efficacy of three cervical preparations for surgical evacuation in first trimester missed abortion.Methods Two hundred and ten women with early missed abortion were equally randomized into three groups.Three cervical preparations,Dilapan-dilator method(group A,n=70),mifepristone method(group B,n=70),and misoprostol method(group C,n=70),were used 24 h before curettage for terminating missed abortion,respectively.Clinical outcomes and complications for these three methods were compared.Results No differences were found in rates of successful treatment among the three groups(P>0.05).The incidence of fitting number 8 Hegar dilator was slightly high in group A,but it was not different compared with that in group B or group C(P>0.05).Bleeding in previous 24 h in group C was significantly greater than that in group A or group B(P<0.01).The cases of blood loss(>50 ml) during evacuation in group B were more than those in group A(P>0.05).Women in group B had less abdominal pain than those in group A or group C(P<0.01).Side effects in group C were more than those in group A on nausea(P<0.01),vomiting(P<0.05),and diarrhea(P<0.01).Group B had the highest acceptability among the three groups(P<0.05).Conclusion Three methods have the similar clinical efficacies in cervical ripening for surgical treatment of early missed abortion.Based on individual characteristics,different approach would be chosen to avoid some adverse events and improve the clinical application of Dilapan-dilator. | Yu-xia WANG Mi-jiao HUANG Ting HE Rong ZENG Wei-jie ZHU Mei TU | 2012 | Journal of Reproduction and Contraception2012，23，2： | 6 |
| 12 | Evaluation of Adiponectin, Resistin, IL-6, TNF-α in Obese and Non-obese Women with Polycystic Ovary Syndrome显示文摘Objective To evaluate possible clinical effects of adiponectin, resistin, IL-6, and TNF-α in obese and non-obese patients with polycystic ovary syndrome (PCOS). Methods Seventy selected PCOS patients were recruited for this study, and were divided into two groups based on their body mass index (BMI): 35 obese (BMI ≥ 25kg/m2 , group A), 35 non-obese (BMI<25kg/m2 , group B). In addition, 35 healthy non-obese women (BMI<25kg/m2 ) were enrolled as the control (group C). Serum levels of FSH, LH, T, glucose, insulin, adiponectin, resistin, IL-6, TNF-α were detected, and compared the differences of them among three groups. Results Blood glucose levels among three groups had no difference (P>0.05). Blood insulin level was significantly greater in group A than in group B or group C (P<0.05), and a significant difference existed between group B and group C (P<0.05). The ratio of glucose/insulin was significantly higher in group A than in group B or group C (P<0.05), and the ratio in group B was significantly higher than that in group C (P<0.05). Adiponectin level was significantly lower and resistin level was significantly higher in group A than in group B or group C (P<0.05). IL-6 level in group C was significantly lower than that in group A or group B (P<0.05), and significant difference was found between group A and group B (P<0.05). TNF-α level was a slight high in group B, whereas there was no statistical difference among three groups (P>0.05). Conclusion Disturbances of some metabolic and inflammatory adipokines could involve the pathogenesis of PCOS in both obese and non-obese women. Low-grade chronic inflammation might have negative effects on the development of PCOS in non-obese women. | Yu-xia WANG Wei-jie ZHU | 2012 | Journal of Reproduction and Contraception2012，23，4： | 6 |
| 13 | Effect of Depot Medroxyprogesterone Acetate (DMPA) on Bone Mineral Density in Women of Reproductive Age显示文摘Objective To compare bone mineral density (BMD) between users of intramuscular depot medroxyprogesterone acetate(DMPA) and nonhormonal control subjects. Methods The study included 68 women aged between 25 and 40 years using depot medroxyprogesterone acetate for 24 months and 59 women aged between 25 and 40 years using nonhormonal contraception as control subjects. BMD of the lumbar spine and femoral neck were obtained using dual energy X-ray absorptiometry. Results At 24 months of treatment, as compared with baseline, the mean BMD in lumbar spine and femoral neck was decreased by 5.5% and 5.9%, respectively. Lumbar spine and femoral neck BMD in women who used DMPA were significantly decreased compared with the subjects in nonuser (P<0.001). Conclusion These results show BMD declined during using DMPA in women aged 25-40 years old. | Ling GAI Jing-lu ZHANG Hui-zhen ZHANG Ping GAI Yong-hong LIU | 2009 | Journal of Reproduction and Contraception2009，20，1： | 6 |
| 14 | Evaluation on Sensitivity of the Human Sperm Motility Assay for Detecting Endotoxin in Culture Medium显示文摘Objective To investigate the sensitivity of the human sperm motility assay for detecting endotoxin in culture medium Materials & Methods Motile sperm were separated and exposed to different concentrations of endotoxin (0.5 ng/mL, 1 ng/mL, 10 ng/mL, 1 000 ng/mL, 10 000 ng/mL, and 50 000 ng/mL), and sperm motility was determined after incubation. Effects of endotoxin on sperm motility in media without albumin were also examined. In addition, at the same concentrations of endotoxin (0.5 ng/mL, 1 ng/mL, and 10 ng/mL), the sensitivity of the human sperm motility assay was compared to those of 1-cell and 2-cell mouse embryo bioassays.Results At levels of 0.5 ng/mL~1 000 ng/mL endotoxin in media with 2 mg/mL albumin, sperm did not show significant change in motility during 24 h of incubation when compared with the control (P>0.05). However, the sperm motility was significantly inhibited at endotoxin dosages of 10 000 and 50 000 ng/mL. In the absence of albumin supplementation, at endotoxin levels of 50 000 ng/mL, and 1 000 ng/mL, there was a marked decrease in sperm motility compared with the control after 2 h or 8 h of incubation, respectively (P<0.01). In media containing 0.5 ng/mL and 1 ng/mL endotoxin, 1-cell and 2-cell mouse embryos had significantly reduced developmental rates in all developmental stages, and at the level of 10 ng/mL, the development of the embryos was arrested.Conclusion The human sperm motility assay could detect high levels of endotoxin in culture medium but its sensitivity to endotoxin would be inferior to that of the 1-cell or 2-cell mouse embryo bioassay. In the absence of albumin supplementation, the sensitivity of the sperm motility assay could be improved. | Wei-jieZHU JingLI Wen-hongZHANG Kang-shouYAO | 2003 | Journal of Reproduction and Contraception2003，14，1： | 5 |
| 15 | Evaluation of Circulating Antisperm Antibody in Infertile Women with Polycystic Ovary Syndrome显示文摘Objective To evaluate levels of the circulating antisperm antibody (ASA) in infertile women with polycystic ovary syndrome (PCOS). Methods Forty-six infertile women with PCOS were enrolled into this study. The serum was screened by the indirect immunobead test for ASA type IgG and IgA according to the WHO laboratory manual. Results Of the 46 patients assessed for ASA-IgG, 3 cases had immunobead binding which were 20%, 27% and 35%, respectively, and the sub-positive rate was 6.5%. No case had the clinical positive level according to the WHO criteria (50% or more of the motile sperm with immunobead binding). ASA-IgA was not detected in all cases. Conclusion The circulating ASA is not associated with the pathogenesis of infertile women with PCOS. | Xiao-yi YANG Wei-jie ZHU Jing LI | 2012 | Journal of Reproduction and Contraception2012，23，1： | 5 |
| 16 | 泥螺卵子发生的超微结构研究显示文摘利用透射电镜观察了泥螺卵子发生过程。结果表明 ,泥螺的卵子发生可划分为卵原细胞、卵黄发生早期、卵黄发生中期及卵黄发生后期卵母细胞 4个时期。卵原细胞核大而圆 ,胞质内分布有少量的线粒体和高尔基囊泡 ,细胞表面具微绒毛。卵黄发生早期的卵母细胞 ,胞质中各类细胞器发达 ,并出现数量较多的类朦胧子。卵黄发生中期的卵母细胞胞体迅速增大 ,核伸出伪足状突起 ,卵质中各种细胞器活动活跃 ,并参与形成卵黄粒和脂滴。此期还可观察到卵母细胞与滤泡细胞间的物质交换现象。卵黄发生后期的卵母细胞体积增至最大 ,细胞器数量减少。本文就卵黄发生前后卵母细胞内部构造的变化。 | 应雪萍 | 2002 | Developmental and Reproductive Biology2002，11，1： | 5 |
| 17 | Role of TGF-β_1 in the Formation of Ovarian Interstitial Fibrosis in PCOS Rat显示文摘Objective To study the role of TGF-β1 in the formation of interstitial fibrosis and capsular thickening in the PCOS rats. Methods PCOS rat model were established by subcutaneous injection DHEA. Estradiol (E2), testosterone (T), follicular stimulating hormone (FSH), luteinizing hormone (LH), LH/FSH and fasting insulin (FINS) hormone values of the model were tested by microparticle enzyme immunoassay, the pathohistology of PCOS rat ovaries was observed by HE staining, and their ultrastructure was tested by transmission electron microscope (TEM). The expressions of TGF-β1 in PCOS group (n=20), and control group(n=20) were detected and evaluated by immunohistochemistry and image analysis system. Results The results of serum E2, T, LH/FSH, FINS, the ovarian pathological-histology and the ultrastructure showed that the model was established successfully. Compared with control group: there was no significant difference of TGF-β1 expression intensity in oocytes, granulosa cells of the different developing stages of follicle in PCOS (P>0.05). But it was markedly higher expressed in the theca cells of antral follicles (P<0.01), and stromal cells (P<0.05) in PCOS group than in control group. Conclusion The abnormal expression of TGF-β1 in PCOS is the main cause of capsular thickening and interstitial fibrosis. TGF-β1 also takes part in regulating PCOS follicle development and atresia. | Zhu-lin MIAO Zu-neng WANG Yan-dong YANG Long-qiu CHEN Rong CUI Xiao-lan WANG Ru-qiang OU | 2008 | Journal of Reproduction and Contraception2008，19，2： | 5 |
| 18 | An Intervention Study of Reproductive Tract Infections among Married Women of Reproductive Age in Shanghai显示文摘Objective To evaluate the impacts of reproductive tract infections (RTIs) intervention on RTIs-related knowledge, attitudes, practices and prevalence of married women at reproductive age. Methods Four sub-districts from Xuhui district, Shanghai were selected by multistage cluster random sampling and residence committees were randomly assigned to either an intervention group or a control one. RTIs intervention was implemented in interven- tion group, while routine family planning program was conducted in control group. Results Compared with control group, intervention group have improved the following targets: the increment of RTI knowledge score was higher than that in control group (OR=9.22, 95%CI:7.01-12.14); the increment score of individual health behaviors (6.31) was higher than that in control group (4.50) (OR=1.60, 95%CI: 1.21-2.10); the increase of condom use frequency in intervention group was higher than that in control group (4.12% vs 0.69%) (OR=1.84, 95%CI: 1.31-2.57); the decreased RTIs rate was higher than that in control group (7.45% vs 0.96%) (OR=0.68, 95%CI: 0.49-0.95). Conclusion It is an effective way to conduct community-based intervention to increase women’s RTIs knowledge, improve RTIs-related attitudes, promote good individual health behaviors, so as to decrease RTIs prevalence. | Zong-min JIANG Yu-yan LI Jun-qing WU Wen-ying LI Zeng-yu WEN Er-sheng GAO Xiao-ping ZHOU Ben-cheng ZHOU | 2007 | Journal of Reproduction and Contraception2007，18，2： | 5 |
| 19 | Effect of Long Protocol on the Outcome of In Vitro Fertilization-embryo Transfer in Patients with Endometriosis Compared with Prolonged Protocol显示文摘Objective To investigate the effect of different down-regulation protocol on the in vitro fertilization-embryo transfer(IVF-ET) outcomes in infertile patients with endometriosis(EMs).Methods A retrospective case control study was performed. Totally 294 infertile patients with EMs were enrolled. And 109 patients(116 cycles) received prolonged protocol as the control, 185 patients(193 cycles) received long protocol as case group, all followed by standard controlled ovarian hyperstimulation(COH). Response to gonadotropins,the fertilization rate, the cleavage rate, the implantation rate, the clinical pregnancy rate and the miscarriage rate were measured and analyzed between the two groups.Results A trend toward better ovarian response was observed in long protocol group.Higher fertilization rate, lower total dose of rFSH, shorter duration of stimulation and more endometrial thickness on the day of hCG injection were observed in long protocol group compared with those of prolonged protocol group, and the difference was significant(P<0.05). In addition, the clinical pregnancy rate, the cleavage rate and the implantation rate also had an increase trend in long protocol group compared with those of prolonged protocol group, but without significant differences.Conclusion Long protocol regimen before IVF-ET in patients with EMs resulted in a trend toward better ovarian response and higher clinical pregnancy rates than prolonged protocol regimen did. | Jian-ping ZHANG Xue-qing WU Xing-yu BI Bing-bing CHEN Si-ping ZHANG Hui-ping LIU | 2014 | Journal of Reproduction and Contraception2014，25，2： | 5 |
| 20 | 不同人群精液质量现状的分析显示文摘通过对 434例有生育力、346例生育力不明男性的精液质量进行检测 ,并与同实验室 80年代前期 1 1 0例的数据相比较 ,评价目前男性精子质量的现状。结果表明 ,精子质量均明显降低 ,以精子数目中的计数和总数的降低最为明显 ,分别降低 5 4 .2 %~ 98.9%和 39.7%~ 1 1 4.5 % ;出现异常指标的异常百分率以精子活动性中的活动率、a级活力、a +b级活力最高 ,分别达到 1 8.4%~ 42 .3%、37.5 %~ 68.1 %、39.5 %~ 75 .2 % ;各指标在正常值范围内的比率仅占 33.6%和 2 6.0 %。因此 ,提出精液质量的普遍降低应引起足够重视。 | 张树成 孟小波 刘彬 贺斌 楚林钢 王弘毅 史延超 王介东 | 2002 | Developmental and Reproductive Biology2002，11，2： | 5 |
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