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| 1 | 抗精子抗体介导不育的再认识显示文摘男、女性体内抗精子抗体(ASA)可以降低生育力,导致不育。但ASA介导免疫不育的关系非常复杂,目前认识仍有限。本文基于笔者30多年ASA的检测实践及以往文献审读,围绕ASA检测、ASA对睾丸精子发生、精索静脉曲张、流产的影响,以及宫腔内人工授精(IUI)、体外受精(IVF)、卵胞质内精子注射(ICSI)治疗ASA不育患者的疗效进行了评价;并针对当前ASA的阳性率、抗体水平、一般治疗效果等问题提出看法,以期增进ASA与生殖效应相互关系的深入认识。 | 朱伟杰 | 2017 | 生殖与避孕2017，37，1： | 14 |
| 2 | 多囊卵巢综合征不孕妇女抗精子抗体的评价显示文摘目的:探讨多囊卵巢综合征(PCOS)不孕妇女抗精子抗体(ASA)的水平,阐明ASA是否介导了PCOS不孕妇女的生育力下降。方法:选择26~35岁的PCOS不孕妇女127例,按体质量指数(BMI)分为肥胖型PCOS不孕组(obese组,42例)和非肥胖型PCOS不孕组(non-obese组,85例),选择门诊同期24~36岁体重正常的非PCOS不孕患者90例作为对照(control组)。采用间接免疫珠试验检测3组患者血清标本中ASA-Ig G和ASAIg A水平,以黏附免疫珠的活动精子数>50%为阳性,另设20%~49%为弱阳性,<20%为阴性。结果:Obese和non-obese组没有检出ASA-Ig G阳性,control组检出2例ASA-Ig G阳性,阳性率为2.2%。Obese、non-obese和control组分别检出1、2和2例ASA-Ig G弱阳性,弱阳性率分别为2.4%、2.4%和2.2%,3组弱阳性率无显著差异。3组均未检出ASA-Ig A阳性。结论:ASA没有参与介导PCOS不孕妇女的生育力下降,临床仍需重视不孕妇女ASA的筛查。 | 江欢 李晓红 朱伟杰 | 2018 | 中国病理生理杂志2018，34，8： | 4 |
| 3 | Evaluation on Antisperm Antibody in Infertile Men with Oligoasthenoteratozoospermia显示文摘Objective To evaluate the level of antisperm antibody(ASA) in infertile men with oligoasthenoteratozoospermia(OAT).Methods Forty-six infertile men with OAT were enrolled into this study. Sperm samples were screened by the direct immunobead test for ASA type IgG and IgA according to the WHO laboratory manual.Results Of the 46 patients with OAT assessed for ASA-IgG, 2 had immunobead binding which were 22% and 27%, respectively, and the sub-positive rate was 4.3%. No case had the clinical positive level according to the WHO criteria(≥ 50% of the motile sperm with immunobead binding). ASA-IgA was not detected in all cases.Conclusion A significant incidence or high level of ASA could not be found in infertile men with OAT, which suggests that ASA is not associated with the pathogenesis of infertile men with OAT. | Yi-chao XU Jing LI Wei-bao LIANG Wei-jie ZHU | 2014 | Journal of Reproduction and Contraception2014，25，1： | 2 |
| 4 | Evaluation on Antisperm Antibody of Infertile Men with Absolute Immotile Sperm显示文摘Objective To investigate the level of antisperm antibodies(ASA) in infertile men with absolute immotile sperm(AIS).Methods Thirteen men with AIS were enrolled into this study. Sperm immotility of ejaculates from these infertile men was proven by two or three consecutive semen analyses. Sperm vitality was assessed by the eosin exclusion. Serum and seminal plasma were screened by the indirect immunobead test(IBT) for ASA type IgG and IgA according to the WHO laboratory manual.Results Semen samples from these patients showed ejaculate volume, pH, and sperm count in the normal range. Sperm vitality, sperm concentration, and sperm abnormal forms in these cases were 40.2 ± 11.1%, 45.0 ± 11.9 × 106/ml, and 97.8 ± 1.4%,respectively. No case had the positive or sub-positive level of ASA type IgG and IgA in samples of both serum and seminal plasma.Conclusion ASA is not associated with the pathogenesis of AIS-associated infertility. | Yi-chao XU Wei-jie ZHU Huan JIANG | 2014 | Journal of Reproduction and Contraception2014，25，2： | 1 |
| 5 | Evaluation on Antisperm Antibody in Infertile Women with Chronic Salpingitis显示文摘Objective To evaluate the level of antisperm antibody(ASA) in infertile women with chronic salpingtis.Methods Forty-eight infertile women with chronic salpingtis were enrolled into this study. Serum samples were screened by the direct immunobead test for ASA type IgG and IgA according to the WHO laboratory manual. About 50% or more of the motile sperm attaching to one or more immunobeads were regarded as clinical positivity according to the WHO criteria. About 20%-50% motile sperm that had adherent particles were deemed to be sub-positive.Results Of the 48 patients with chronic salpingtis assessed for ASA-IgG, 4 had immunobead bindings ranged from 50% to 60%, and the positive rate was 8.3%. In addition, 5 cases had 20%-40% of immunobead bindings, and the sub-positive rate was 10.4%. For ASA-IgA detecting, 2 cases with ASA-IgG positivity also had ASA-IgA immunobead bindings, and the positive rates were 22%, and 28%, respectively.Conclusion The incidence of ASA could be found in infertile women with chronic salpingtis, which suggests that an increased risk for the production of ASA would exist in the inflammatory status of fallopian tube. | Qi-zhi LIU Wei-jie ZHU Hai-peng LIU Huan JIANG | 2014 | Journal of Reproduction and Contraception2014，25，3： | 1 |
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