|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 2 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 3 | Honeysuckle-encoded atypical microRNA2911 directly Largets influenza A viruses显示文摘 | Zhen Zhou Xihan Li Jinxiong Liu Lei Dong Qun Chen Jialing Liu Huihui Kongt Qianyi Zhang Xian Qi Dongxia Hou Lin Zhang Guoquan Zhang Yuchen Liu Yujing Zhang Jing Li Jin Wang Xi Chen Hua Wang Junfeng Zhang Hualan Chen Ke Zen Chen-Yu Zhang | 2015 | Cell Research2015，25，1： | 104 |
| 4 | Identification of plasma microRNA-21 as a biomarker for early detection and chemosensitivity of non-small cell lung cancer显示文摘Studies have shown cell-free microRNA(miRNA) circulating in the serum and plasma with specific expression in cancer,indicating the potential of using miRNAs as biomarkers for cancer diagnosis and therapy.This study was to investigate whether plasma miRNA-21(miR-21) can be used as a biomarker for the early detection of non-small cell lung cancer(NSCLC) and to explore its association with clinicopathologic features and sensitivity to platinum-based chemotherapy.We used real-time RT-PCR to investigate the expression of miR-21 in the plasma of 63 NSCLC patients and 30 healthy controls and correlated the findings with early diagnosis,pathologic parameters,and treatment.Thirty-five patients(stages IIIB and IV) were evaluable for chemotherapeutic responses:11 had partial response(PR);24 had stable and progressive disease(SD+PD).Plasma miR-21 was significantly higher in NSCLC patients than in age-and sex-matched controls(P<0.001).miR-21 was related to TNM stage(P<0.001),but not related to age,sex,smoking status,histological classification,lymph node status,and metastasis(all P>0.05).This marker yielded a receiver operating characteristic(ROC) curve area of 0.775(95% CI:0.681-0.868) with 76.2% sensitivity and 70.0% specificity.Importantly,miR-21 plasma levels in PR samples were several folds lower than that in SD plus PD samples(P=0.049),and were close to that in healthy controls(P=0.130).Plasma miR-21 can serve as a circulating tumor biomarker for the early diagnosis of NSCLC and is related to the sensitivity to platinum-base chemotherapy. | Juan Wei Wen Gao Cheng-Jun Zhu Yi-Qian Liu Zhu Mei Ting Cheng Yong-Qian Shu | 2011 | Chinese Journal of Cancer2011，30，6： | 63 |
| 5 | Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA显示文摘Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated.Much of the newly-discovered transcriptome appears to represent long non-coding RNA(lncRNA),a heterogeneous group of largely uncharacterised transcripts.Understanding the biological function of these molecules represents a major challenge and in this review we discuss some of the progress made to date.One major theme of lncRNA biology seems to be the existence of a network of interactions with microRNA(miRNA) pathways.lnc RNA has been shown to act as both a source and an inhibitory regulator of mi RNA.At the transcriptional level,a model is emerging whereby lnc RNA bridges DNA and protein by binding to chromatin and serving as a scaffold for modifying protein complexes.Such a mechanism can bridge promoters to enhancers or enhancer-like non-coding genes by regulating chromatin looping,as well as conferring specificity on histone modifying complexes by directing them to specific loci. | Iain M.Dykes Costanza Emanueli | 2017 | Genomics, Proteomics & Bioinformatics2017，15，3： | 71 |
| 6 | Suppression of cell growth and invasion by miR-205 in breast cancer显示文摘MicroRNAs (miRNAs ) 内长的、小、非编码的 RNA,它能够在 post-transcriptional 的 silencing 基因表示铺平。在这研究,我们报导 miR-205 是显著地在与匹配的正常的胸织物相比的胸肿瘤的 underexpressed。同样,包括 MCF-7 和 MDA-MB-231,乳癌房间行比非恶意的 MCF-10A 房间表示低级 miR-205。兴趣, miR-205 的宫外的表示显著地禁止房间增长和抛锚独立人士生长,以及房间侵略。而且, miR-205 被显示在一个动物模型压制肺转移。最后,西方的污点与试金表明的酶记者结合了那 ErbB3 和脉管的 endothelial 生长因素 A ( VEGF --一)是为 miR-205 的直接目标,并且这 miR-205-mediated 抑制通过和在 ErbB3 和 VEGF 的 3 鈥? untranslated 区域( 3 鈥? UTR )的通常认为的 miR-205 绑定地点的直接相互作用是可能的--一。一起,这些结果建议 miR-205 是在乳癌的肿瘤 suppressor。 | Hailong Wu Shoumin Zhu Yin-Yuan Mo | 2009 | Cell Research2009，19，4： | 56 |
| 7 | MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2显示文摘新兴的证据与肿瘤开发和前进显示出异常地表示的 microRNAs (miRNAs ) 的协会。然而,很少在胃的 carcinogenesis 对 miRNAs 的潜在的角色被知道。这里,我们执行了 miRNA microarray 屏蔽在配对的胃的癌症和他们的邻近的 nontumor 纸巾表示并且发现 miR-375 是的 miRNAs 差别极大地在胃的癌症纸巾的 downregulated。量的即时 PCR 分析证实那 miR-375 表情显著地从经历胃的切除术的病人与他们的 nontumor 对应物相比在超过 90% 主要胃的癌症被减少。miR-375 的 Overexpression 显著地在 vitro 并且在 vivo 禁止了胃的癌症房间增长。在胃的癌症房间的 miR-375 的强迫的表示显著地减少了 Janus kinase 的蛋白质水平 2 ( JAK2 )并且镇压带 JAK2 的 3 鈥? untranslated 区域的一个酶记者的活动,被预言的 miR-375-binding 地点的变化废除,显示那 JAK2 可以是 miR-375 目标基因。由由 RNAi 的 JAK2 的 AG490 或 silencing 的 JAK2 活动的任何一个抑制压制了类似于 miR-375 overexpression 的胃的癌症房间增长。而且, JAK2 的宫外的表示能部分颠倒 miR-375 引起的房间增长的抑制。最后,我们在胃的癌症发现了在 miR-375 表示和 JAK2 蛋白质水平之间的重要反的关联。因此,这些数据建议 miR-375 可以作为肿瘤 suppressor 工作由指向 JAK2 oncogene 潜在地调整胃的癌症房间增长,含有在胃的癌症的致病的 miR-375 的一个角色。 | Ling Ding Yanjun Xu Wei Zhang Yujie Deng Misi Si Ying Du Haomi Yao Xuyan Liu Yuehai Ke Jianmin Si Tianhua Zhou | 2010 | Cell Research2010，20，7： | 59 |
| 8 | 植物盐胁迫抗性的分子机制研究进展显示文摘土壤盐渍化是目前影响农作物产量和质量的主要环境因子之一。植物对盐胁迫的适应非常复杂,提高作物的耐盐性仍然面临着极大的挑战。本文对SOS信号(salt overly sensitive)转导途径、microRNA和转录因子在盐胁迫中的调控作用进行了综述,旨在为后期抗盐性研究与耐盐育种提供基础支持。 | 蔡晓锋 胡体旭 叶杰 张余洋 李汉霞 叶志彪 | 2015 | 华中农业大学学报2015，34，3： | 55 |
| 9 | Growth-Regulating Factors (GRFs): A Small Transcription Factor Family with Important Functions in Plant Biology显示文摘调整生长的因素(GRF ) 是原来在茎和叶开发为他们的角色被识别的植物特定的抄写因素,但是最近的研究加亮他们为在不利环境条件下面包括生长过程的花和种子形成,根发展,和协作的另外的中央发展过程同样重要。几 GRF 的表达式被 microRNA miR396 控制,并且 GRF-miRNA396 规章的模块看起来对几这些进程中央。另外, GRF 和 miR396 在上游的抄写因素被发现了,并且下游地逐渐地指向 GRF 的基因被解开。这里,我们考察 GRF 执行的生物功能的当前的知识并且调查可得到的分子的数据说明他们怎么在细胞的水平施加角色。 | Mohammad Amin Omidbakhshfard Sebastian Proost Ushio Fujikura Bernd Mueller-Roeber | 2015 | Molecular Plant2015，8，7： | 51 |
| 10 | A Rare Allele of GS2 Enhances Grain Size anc Grain Yield in Rice显示文摘谷物尺寸决定谷物重量并且影响谷物质量。调整谷物尺寸的几主要量的特点 loci (QTL ) 被克隆;然而,我们调整米饭谷物的尺寸的内在的机制的理解仍然保持碎片。这里,我们报导克隆和主导的 QTL 的描述,染色体 2 上的谷物尺寸(GS2 ) 编码调整生长的因素 4,一个 transcriptional 管理者。GS2 本地化到原子核并且可以充当抄写使活跃之物。影响 microRNA 的有约束力的地点的 GS2 的一个稀罕变化, OsmiR396c,原因提高了 GS2/OsGRF4 的表示。GS2 表示的增加导致更大的房间和房间的增加的数字,它因此提高谷物重量和产量。进米饭栽培变种的 GS2/OsGRF4 的这稀罕等位基因的介绍能显著地提高谷物重量和增加谷物产量,用在引起产量很高的米饭变化的可能的应用。 | Jiang Hu Yuexing Wang Yunxia Fang Longjun Zeng Jie Xu Haiping Yu Zhenyuan Shi Jiangjie Pan Dong Zhang Shujing Kang Li Zhu Guojun Dong Longbiao Guo Dali Zeng Guangheng Zhang Lihong Xie Guosheng Xiong Jiayang Li Qian Qian | 2015 | Molecular Plant2015，8，10： | 57 |
| 11 | Role of microRNAs in translation regulation and cancer显示文摘MicroRNAs(miRNAs) are pervasively expressed and regulate most biological functions. They function by modulating transcriptional and translational programs and therefore they orchestrate both physiological and pathological processes, such as development, cell differentiation, proliferation, apoptosis and tumor growth. miRNAs work as small guide molecules in RNA silencing, by negatively regulating the expression of several genes both at mRNA and protein level, by degrading their mRNA target and/or by silencing translation. One of the most recent advances in the field is the comprehension of their role in oncogenesis. The number of miRNA genes is increasing and an alteration in the level of miRNAs is involved in the initiation, progression and metastases formation of several tumors. Some tumor types show a distinct miRNA signature that distinguishes them from normal tissues and from other cancer types. Genetic and biochemical evidence supports the essential role of miRNAs in tumor development. Although the abnormal expression of miRNAs in cancer cells is a widely accepted phenomenon, the cause of this dysregulation is still unknown. Here, we discuss the biogenesis of miRNAs, focusing on the mechanisms by which they regulate protein synthesis. In addition we debate on their role in cancer, highlighting their potential to become therapeutic targets. | Stefania Oliveto Marilena Mancino Nicola Manfrini Stefano Biffo | 2017 | World Journal of Biological Chemistry2017，8，1： | 60 |
| 12 | MiRNA as potential biomarkers and therapeutic targets for gastric cancer显示文摘Gastric cancer is one of the leading causes of cancer mortality in the world.Aberrant expression of microRNAs(miRNAs)is the hallmarks of this disease.MiRNAs are endogenous non-coding RNAs that involved in many biological processes(e.g.,cell proliferation,differentiation,apoptosis,invasion and development)through gene repression.Deregulation of miRNA expression in gastric tumors and cancer cell lines have been documented to contribute in tumorigenesis,and the expression signature may correlate with different cancer types and clinicopathological features.Here,we summarized the updated gastric cancer-associated miRNAs and the downstream targets in the process of tumorigenesis.Recently,many researchers make use of the miRNA microarray platform to profile miRNA expression in gastric cancer and correlated with different clinical parameters.Its application on cancer diagnosis,prognosis and predictive treatment response rate are still underway and needs further investigation.Emerging roles of miRNAs with oncogenic or tumor suppressive properties in gastric tumorigenesis were discussed.Epigenetic silencing of miRNA by hypermethylation of promoter CpG island was also observed in gastric cancer.However,detailed mechanisms of how miRNAs regulate gene expression in gastric cancer has not been well studied.In this review,we highlight the upto-date findings on the deregulated miRNAs in gastric cancer,and the potential use of miRNA in the clinical settings,such as diagnostic/prognostic markers and chemotherapeutic tools. | Vivian Yvonne Shin Kent-Man Chu | 2014 | World Journal of Gastroenterology2014，20，30： | 59 |
| 13 | Alcoholic liver disease and the gut-liver axis显示文摘Alcoholic liver disease (ALD) is one of the leading causes of liver diseases and liver-related death worldwide. Of the many factors that contribute to the pathogenesis of ALD, gut-derived lipopolysaccharide (LPS) plays a central role in induction of steatosis, inflammation, and fi brosis in the liver. In this review, we discuss the mechanisms by which alcohol contributes to increased gut permeability, the activation of Kupffer cells, and the infl ammatory cascade by LPS. The role of the Toll-like receptor 4 (TLR4) complex in LPS recognition and the importance of the TLR4-induced signaling pathways are evaluated in ALD. | Gyongyi Szabo Shashi Bala | 2010 | World Journal of Gastroenterology2010，16，11： | 50 |
| 14 | BMP-6 inhibits microRNA-21 expression in breast cancer through repressing 6EF1 and AP-1显示文摘 | Jun Du Shuang Yang Di An Fen Hu Wei Yuan Chunli Zhai Tianhui Zhu | 2009 | Cell Research2009，19，4： | 44 |
| 15 | Apoptosis and the target genes of microRNA-21显示文摘MicroRNA-21(miR-21) is frequently up-regulated in cancer and the majority of its reported targets are tumor suppressors.Through functional suppression,miR-21 is implicated in practically every walk of oncogenic life:the promotion of cell proliferation,invasion and metastasis,genome instability and mutation,inflammation,replicative immortalization,abnormal metabolism,angiogenesis,and evading apoptosis,immune destruction,and growth suppressors.In particular,miR-21 is strongly involved in apoptosis.In this article,we reviewed the experimentally validated targets of miR-21 and found that two thirds are linked to intrinsic and/or extrinsic pathways of cellular apoptosis.This suggests that miR-21 is an oncogene which plays a key role in resisting programmed cell death in cancer cells and that targeting apoptosis is a viable therapeutic option against cancers expressing miR-21. | Lindsey E.Becker Buscaglia | 2011 | Chinese Journal of Cancer2011，30，6： | 49 |
| 16 | EMT-associated microRNAs and their roles in cancer stemness and drug resistance显示文摘Epithelial-to-mesenchymal transition(EMT)is implicated in a wide array of malignant behaviors of cancers,including proliferation,invasion,and metastasis.Most notably,previou studies have indicated that both cancer stem-like properties and drug resistance were associated with EMT.Furthermore,microRNAs(miRNAs)play a pivotal role in the regulation of EMT phenotype,as a result,some miRNAs impact cancer stemness and drug resistance.Therefore,understanding the relationship between EMT-associated miRNAs and cancer stemness/drug resistance is beneficial to both basic research and clinical treatment.In this review,we preliminarily looked into the various roles that the EMT-associated miRNAs play in the stem-like nature of malignant cells.Then,we reviewed the interaction between EMT-associated miRNAs and the drugresistant complex signaling pathways of multiple cancers including lung cancer,gastric cancer,gynecologic cancer,breast cancer,liver cancer,colorectal cancer,pancreatic cancer,esophageal cancer,and nasopharyngeal cancer.We finally discussed the relationship between EMT,cancer stemness,and drug resistance,as well as looked forward to the potential applications of miRNA therapy for malignant tumors. | Guangtao Pan Yuhan Liu Luorui Shang Fangyuan Zhou Shenglan Yang | 2021 | Cancer Communications2021，41，3： | 46 |
| 17 | High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells显示文摘AIM: To analyze the relevance of the microRNA miR-196a for colorectal oncogenesis. METHODS: The impact of miR-196a on the restriction targets HoxA7, HoxB8, HoxC8 and HoxD8 was analyzed by reverse transcription polymerase chain reaction (RT-PCR) after transient transfection of SW480 cancer cells. The miR-196a transcription profile in colorectal cancer samples, mucosa samples and diverse cancer cell lines was quantifi ed by RT-PCR. Transiently miR-196a-transfected colorectal cancer cells were used for diverse functional assays in vitro and for a xenograft lung metastasis model in vivo. RESULTS: HoxA7, HoxB8, HoxC8 and HoxD8 were restricted by miR-196a in a dose-dependent and gene-specific manner. High levels of miR-196a activated the AKT signaling pathway as indicated by increased phosphorylation of AKT. In addition, high levels of miR-196a promoted cancer cell detachment,migration, invasion and chemosensitivity towards platin derivatives but did not impact on proliferation or apoptosis. Furthermore, miR-196a increased the development of lung metastases in mice after tail vein injection. CONCLUSION: miR-196a exerts a pro-oncogenic influence in colorectal cancer. | Carl Christoph Schimanski Kirsten Frerichs Fareed Rahman Martin Berger Hauke Lang Peter R Galle Markus Moehler Ines Gockel | 2009 | World Journal of Gastroenterology2009，15，17： | 40 |
| 18 | Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma显示文摘MicroRNAs 是否定地在 post-transcriptional 水平调制基因表示的短规章的 RNA,并且深深地涉及癌症的几种类型的致病。调查特定的 miRNAs 和他们的目标基因是否参予喉的癌的分子的致病, oligonucleotide microarrays 被用来与正常纸巾相比在喉的癌纸巾估计 microRNAs 和 mRNAs 的微分表示侧面。oncogenic miRNA, microRNA-21 (miR-21 ) ,被发现是在喉的癌纸巾的 upregulated。由特定的 antisense oligonucleotides 的 miR-21 击倒而 miR-21 的 overexpression 提高了细胞的生长活动,由殖民地形成试金检测了,禁止了 HEp-2 细胞的增长潜力。miR-21 抑制引起的房间数字减小由于 G1-S 阶段转变的控制的损失,而不是 apoptosis 的显著增加。随后, miR-21 的新目标基因, BTG2,被发现是在喉的癌纸巾的 downregulated。BTG2 被知道充当一个平底锅房间周期管理者和肿瘤 suppressor。这些调查结果显示 miR-21 的那异常表情可以由维持 BTG2 的底层贡献喉的癌的恶意的显型。oncogenic miR-21 和它的目标基因的鉴定, BTG2,为癌症诊断和治疗在喉的癌是潜在地珍贵的。 | Min Liu Haidong Wu Tao Liu Yixuan Li Fang Wang Haiying Wan Xin Li Hua Tang | 2009 | Cell Research2009，19，7： | 40 |
| 19 | MicroRNA定量检测方法的研究进展显示文摘MicroRNA是一类内源性的非编码小分子RNA,通过下调蛋白编码基因的表达而对不同的细胞发育过程起到重要的调控作用。分析组织或细胞样本中microRNA的表达可为研究这类分子的生物学功能提供重要的信息。近年来,研究者发展了许多方法检测不同的生理和病理学过程中microRNA的表达差异,并发现microRNA的异常表达与癌症、神经紊乱和心脏疾病等的发生相关。文章系统地介绍了最新发展的microRNA定量检测方法,详细阐述了基于探针杂交技术的Northern blotting法、微阵列芯片法、纳米金标记法、桥连同位素标记法,以及基于扩增技术的定量PCR检测法、滚环扩增法、引物入侵法和新一代大规模高通量测序法等,并对这些方法的优缺点进行了分析比较。 | 景花 宋沁馨 周国华 | 2010 | 遗传2010，32，1： | 40 |
| 20 | MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells显示文摘 | Godlewski J Nowicki MO Bronisz A Nuovo G Palatini J De Lay M Van Brocklyn J Ostrowskl MC Chlocca EA Lawler SE. | 2010 | 中国神经肿瘤杂志2010，8，1： | 37 |
您所在的机构暂未开通此部分的功能，请联系管理员