共被期刊论文引用了2次
您的检索式：您选中1篇文献正在查看引证文献汇总
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tamoxifen induced multinucleated cells (symplasts) and distortion of seminiferous tubules in rat testis显示文摘Aim: To evaluate the effect of tamoxifen citrate on male reproductive system of rat. Methods: Groups of male rats were gavaged with tamoxifen at doses of 200 mg.kg·^-1.d^-1, 400 mg·kg·^-1.d^-1 or 800 mg.kg^-1·d^-1 in 0.1 mL olive oil for 10 consecutive days. Controls were treated with 0.1 mL olive oil. Rats were anesthetized and killed on d 3, d 15 or d 35 after the last dose. Testes were collected, processed for paraffin embedding, sectioned at 5μm thickness, stained with H&E and analyzed microscopically. Results: There was a dose-dependent increase in the occurrence of seminiferous tubular distortion with germinal cell sloughing. The highest dose increased the number of multinucleated giant cells on d 3 and d 15. Conclusion: Tamoxifen citrate induces multinucleated giant cells and germinal epithelial sloughing in a dose-dependent manner and these changes are detrimental to male fertility. (Asian J Androl 2003 Sep; 5: 217-220) | Urban J.A.D'Souza | 2003 | Asian Journal of Andrology2003，5，3： | 5 |
| 2 | Effect of piperine on the epididymis of adult male rats显示文摘瞄准:在成年雄的老鼠的附睾抗氧化剂系统上学习胡椒碱的效果。方法:成年雄的老鼠每天是在 1 mg/kg, 10 mg/kg 和 100 mg/kg 体重的剂量的口头上地管理的胡椒碱 30 连续的天了。在最后治疗以后的 24 个小时,老鼠与醚和附睾被称并且杀死从身体被把。从附睾的尾区域收集的精子被用于对它的计数,活动性和生存能力的评价。头,语料库和附睾的尾区域被分开并且独立一致获得 10 % homogenates。上层清液被用于涎的的酸的、超级氧化物歧化酶的试金,过氧化氢酶,谷胱甘肽过氧化物酶,谷胱甘肽还原酶,类脂化合物每氧化和过氧化氢产生。结果:对待胡椒碱的老鼠的体重仍然保持未改变。头,语料库和附睾的尾区域的重量显著地在 100 mg/kg 的剂量减少了。附睾精子计数和活动性在 10 mg/kg 和 100 mg/kg 减少了,并且精子生存能力在 100 mg/kg 显著地减少了。当在尾区域的重要减少独自在 10 mg/kg 被观察时,在附睾的涎的酸层次在 100 mg/kg 显著地减少了。在超级氧化物歧化酶,过氧化氢酶,谷胱甘肽过氧化物酶和谷胱甘肽还原酶的活动的重要衰落,与过氧化氢的增加一起,产生和类脂化合物在 10 mg/kg 和 100 mg/kg 每氧化被观察。结论:在抗氧化剂酶和涎的酸的活动引起减少的胡椒碱在附睾和能损坏附睾环境和精子功能的从而增加的反应的氧种类层次铺平。 | S.C.D'cruz P.P.Mathur | 2005 | Asian Journal of Andrology2005，7，4： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员