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| 1 | 哀牢山-红河剪切带的热年代学研究——多重扩散域模式的应用实例显示文摘洛弗拉等人(1989)把Dodson(1973)建立的单一扩散域模式扩展成矿物扩散域不连续分布的模式,即多重扩散域模式,与之对应具有某一封闭温度范围,因此利用单个K-长石矿物样品可以揭示更长时间段上的冷却过程。对云南哀牢山-红河剪切带的K-长石样品(FA-2-1)进行^(40)Ar/^(39)Ar同位素分析,利用多重扩散域模式,揭示在距今约20~19Ma问该带存在一快速冷却过程,这与西藏南部曲水地区快速抬升的时间是一致的。 | 陈文寄 TM哈里森 OM洛弗拉 | 1992 | 地震地质1992,14,2: | 48 |
| 2 | 青藏高原西部的抬升速率:叶城-狮泉河花岗岩^(40)Ar-^(39)Ar年龄的地质解释显示文摘通过对叶城-狮泉河剖面花岗岩中黑云母40Ar-39Ar法年龄研究,获得西昆仑北岩带库地岩体海拔高度2950m和2850m黑云母的封闭年龄分别为396.9Ma和388.9Ma,西昆仑南岩带塔西土路克、三十里营房和奇台大坂岩体黑云母的封闭年龄为195.8~183.9Ma,班公湖-喀喇昆仑北岩带日土岩体黑云母封闭年龄为80.3~79.6Ma,其时代分别为加里东期、印支期和燕山晚期。年龄结果表明,同一岩体海拔高的黑云母封闭年龄大于海拔低的黑云母封闭年龄,根据海拔高程差和坪年龄差计算出岩体的抬升速率,表明青藏高原西部从加里东期到燕山晚期,隆起速度有增大的趋势,而且具脉动性。 | 张玉泉 朱炳泉 谢应雯 TM哈里森 WSF基德 | 1998 | 岩石学报1998,14,1: | 36 |
| 3 | Preoperative functional MR imaging localization of language and motor areas: effect on therapeutic decision making in patients with potentially resectable brain tumors显示文摘 | Petrella JR Shah LM Harris KM Friedman AH George TM Sampson JH Pekala JS Voyvodic JT | 2006 | 中国神经肿瘤杂志2006,4,2: | 14 |
| 4 | 儿童肥胖相关高血压显示文摘从1980年以来,儿童和青少年的肥胖率已经增长了将近2倍。据估计,目前在年龄2~19岁的儿童中,肥胖约占17%,如果按这个比例计算,在美国,有约1270万的肥胖儿童。如果再加上超重儿童,美国约有2500万的超重/肥胖儿童(占30%),这个数据是非常惊人的。除了这个数据本身,数据背后的意义更值得关注。肥胖儿童的心血管病风险明显增加:他们的收缩压、舒张压水平更高,发生血脂异常和胰岛素抵抗的比例更多。研究显示,有70%的肥胖儿童至少有1项心血管病危险因素,39%的肥胖儿童有≥2项的危险因素。 | Brady TM 张刘锋 | 2018 | 中华高血压杂志2018,26,1: | 11 |
| 5 | Telomerase catalytic subunit homologs from fission yeast and human显示文摘 | Nakamura TM Morin GB Chapman KB | | 0,,: | 10 |
| 6 | Rabeprazole vs esomeprazole in non-erosive gastro-esophageal reflux disease: A randomized, double-blind study in urban Asia显示文摘AIM:Gastro-esophageal reflux disease (GERD) is becoming increasingly common in Asia. Data on the efficacy of proton pump inhibitors in patients with non-erosive GERD (NERD)in Asia is lacking. This double-blind study compared the efficacy and safety of rabeprazole with esomeprazole in relief of symptoms in patients with NERD.METHODS: One hundred and thirty-four patients with reflux symptoms of NERD and normal endoscopy were randomized to receive rabeprazole 10 mg or esomeprazole 20 mg once daily for 4 wk. Symptoms were recorded in a diary and changes in severity of symptoms noted.RESULTS: At 4 wk of treatment, rabeprazole 10 mg and esomeprazole 20 mg were comparable with regards to the primary endpoint of time to achieve 24-h symptomfree interval for heartburn 8.5 d vs9 d and regurgitation 6 d vs 7.5 d. Rabeprazole and esomeprazole were also similarly efficacious in term of patient's global evaluation with 96% of patients on rabeprazole and 87.9% of patients on esomeprazole, reporting that symptoms improved(P=NS). Satisfactory relief of day- and night-time symptoms was achieved in 98% of patients receiving rabeprazole and 81.4% of patients receiving esomeprazole. Adverse events were comparable in both groups (P = NS).CONCLUSION: Rabeprazole 10 mg has a similar efficacy and safety profile in Asians with NERD as esomeprazole 20 mg. Further study is necessary to investigate whether the small differences between the two drugs seen in this study are related to the improved pharmacodynamicpro perties of rabeprazole. Both drugs were well tolerated. | KM Fock EK Teo TL Ang TS Chua TM Ng YL Tan | 2005 | World Journal of Gastroenterology2005,11,20: | 8 |
| 7 | 埃索美拉唑能有效控制内镜阴性胃食管反流症状——6个月“按需治疗”对照试验显示文摘 | Talley NJ Lauritsen K Tunturi-Hihnala H Lind T Moum B Bang C Schulz T Omland TM Delle M Junghard O 钟捷 | 2003 | 中华消化杂志2003,23,1: | 6 |
| 8 | 应用Rho激酶抑制剂对大鼠阴茎勃起的作用显示文摘目的 :探讨将RhoA/Rho激酶抑制剂Y 2 76 32涂抹于阴茎白膜表面以及阴茎龟头皮肤表面有无促进阴茎勃起的作用及其对体循环的影响。 方法 :2 0只成年雄性SD大鼠 ,体重为 2 5 0~ 30 0g ,随机分为实验组和对照组。全身麻醉后颈动脉和海绵体插管连续监测平均动脉压 (MAP)和阴茎海绵体内压 (CCP)的变化。寻找盆腔星状神经节(MPG)并以系列电刺激诱发勃起。向海绵体白膜表面及阴茎龟头皮肤表面涂抹Y 2 76 32 ,观察用药前后阴茎勃起的改变及MAP的改变。 结果 :将Rho激酶抑制剂Y 2 76 32涂抹于大鼠阴茎白膜表面和阴茎龟头皮肤表面均可促进在无阴茎支配神经电刺激下发生勃起 (ICP/MAP明显升高 ) ,在系列电刺激MPG时用药后发生的勃起反应较用药前亦明显增强。表面用药后还发现大鼠体循环血压有不同程度的降低。 结论 :阴茎皮肤表面应用Rho激酶抑制剂是一种安全有效的ED治疗方法 。 | 戴玉田 孙则禹 Chitaley K Webb RC Mills TM Lewis RW | 2004 | 中华男科学杂志2004,10,8: | 5 |
| 9 | 难治性疼痛和高血压在急性B型主动脉夹层中的重要性:国际急性主动脉夹层登记的意见显示文摘急性B型主动脉夹层患者,可表现出对药物治疗无效的反复、难治性疼痛和(或)难治性高血压,当出现这些症状时有时可作为介入治疗的指征。研究者利用国际急性主动脉夹层登记(international registry of a-cute aortic dissection,IRAD)的资料调查难治性疼痛和(或)难治性高血压对急性B型主动脉夹层患者临床转归的影响。 | 张玲玉 叶鹏 Trimarchi S Eagle KA Nienaber CA Pyeritz RE Jonker FH Suzuki T O'Gara PT Hutchinson SJ Rampoldi V Grassi V Bossone E Muhs BE Evangelista A Tsai TT Froehlich JB Cooper JV Montgomery D Mein-hardt G Myrmel T Upchurch GR Sundt TM Issel-bacher EM | 2010 | 中华高血压杂志2010,18,12: | 4 |
| 10 | THE DEFECT ITERATION OF THE FINITE ELEMENT FOR ELLIPTIC BOUNDARY VALUE PROBLEMS AND PETROV-GALERKIN APPROXIMATION显示文摘In this paper we introduce a Petrov-Galerkin approximation model to the solution of linear and semi-linear elliptic boundary value problems in which piecewise quadratic polynomial space and piecewise linear polynomial space are used as the shape function space and the test function space, respectively. We prove that the approximation order of the standard quadratic finite element can be attained in this Petrov-Galerkin model. Based on the so-called 'contractivity' of the interpolation operator, we further prove that the defect iterative sequence of the linear finite element solution converge to the proposed Petrov-Galerkin approximate sohution. | Gao, JB Yang, YD Shih, TM | 1998 | Journal of Computational Mathematics1998,16,2: | 4 |
| 11 | 加强干部培训需求调查和分析课题研究显示文摘 | 中组部第三期TM班课题组 | 2003 | 组织人事学研究2003,,4: | 4 |
| 12 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018,13,4: | 4 |
| 13 | 反应停在风湿性疾病治疗中的作用显示文摘 | Lena.,TM 董怡 等 | 2001 | 世界医学杂志2001,5,2: | 3 |
| 14 | Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases显示文摘 | Pawlik TM Scoggins CR Zorzi D | | Annals of Surgery0,,: | 3 |
| 15 | In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells显示文摘 | Johnstone B Hering TM Caplan AI | | 0,,: | 3 |
| 16 | Diagnosing, planning and evaluating osteochondral ankle defects with imaging modalities显示文摘This current concepts review outlines the role of diffe-rent imaging modalities in the diagnosis, preoperative planning, and follow-up of osteochondral ankle defects. An osteochondral ankle defect involves the articular cartilage and subchondral bone(usually of the talus) and is mostly caused by an ankle supination trauma. Conventional radiographs are useful as an initial imaging tool in the diagnostic process, but have only moderate sensitivity for the detection of osteochondral defects. Computed tomography(CT) and magnetic resonance imaging(MRI) are more accurate imaging modalities. Recently, ultrasonography and single photon emission CT have been described for the evaluation of osteochondral talar defects. CT is the most valuable modality for assessing the exact location and size of bony lesions. Cartilage and subchondral bone damage can be visualized using MRI, but the defect size tends to be overestimated due to bone edema. CT with the ankle in full plantar flexion has been shown a reliable tool for preoperative planning of the surgical approach. Postoperative imaging is useful for objective assessment of repair tissue or degenerative changes of the ankle joint. Plain radiography, CT and MRI have been used in outcome studies, and different scoring systems are available. | Christiaan JA van Bergen Rogier M Gerards Kim TM Opdam Maaike P Terra Gino MMJ Kerkhoffs | 2015 | World Journal of Orthopedics2015,6,11: | 3 |
| 17 | Distribution of central corneal thickness and intraocular pressure in emmetropic eyes of healthy children of Palestine: a representative cross-sectional study显示文摘AIM: To determine the distributions of central corneal thickness(CCT) and intraocular pressure(IOP) in emmetropic eyes of healthy children of Palestine.METHODS: This representative cross sectional study included a total of 1156 eyes from 578 healthy school children aged 7-15 y. Inclusion criteria included emmetropia, no previous history of ocular or systemic diseases, no previous history of contact lens use, and the availability of both eyes. CCT and IOP were measured using ultrasound pachymeter and Goldmann applanation tonometer, respectively. The relationship of the results with age and gender was investigated.RESULTS: The mean age of school children was 11.13±2.8 y. Mean CCT was 542.2±37.4 and 544.3±39.2 μm for right and left eyes, respectively. Mean IOP was 12.5±2.2 and 12.3±2.2 mm Hg for right and left eyes, respectively. A positive correlation was observed between CCT and IOP of the right eye(P<0.001, R=0.358) and CCT and IOP of the left eye(P<0.001, R=0.324). No significant differences were observed in CCT and IOP due to age or gender(P>0.05). There were significant differences in mean CCT and IOP between right and left eyes(P=0.004, P=0.001, respectively).CONCLUSION: A population profile of CCT and IOP is established in Palestinian children for the first time. Mean CCT is comparable to some studies but differ from others. Mean IOP is considerably lower than that of majority children of other ethnic groups. Intereye difference of more than 36 μm in CCT, and 5 mm Hg in IOP should prompt evaluation for potential ocular disorders. | Hamed Tm Alkhodari | 2019 | International Journal of Ophthalmology(English edition)2019,12,3: | 3 |
| 18 | Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects显示文摘 | Owen, KR Groves, CJ Hanson, RL Knowler, WC Shuldiner, AR Elbein, SC Mitchell, BD Froguel,P Ng, MCY Chan, JC Jia, WP Deloukas, P Hitman, GA Walker, M Frayling, TM Hattersley, AT Zeggini, E McCarthy, MI | 2007 | 中国生物学文摘2007,21,11: | 2 |
| 19 | 美国重症肌无力基金会关于重症肌无力临床试验的建议显示文摘由美国重症肌无力基金会(MGFA)的医学科学建议委员会(MSAB)组成工作组,于2010年在美国和2011年在意大利召开专家共识会议讨论重症肌无力(MG)临床试验的问题,与会代表包括来自美国和欧洲的神经科医生、统计学家、企业界代表、MG患者以及MGFA和欧洲重症肌无力协会的平民代表。 | Benatar M Sanders DB Burns TM Cutter GR Guptill JT Baggi F Kaminski HJ Mantegazza R Meriggioli MN Quan J Wolfe GI 李海峰(摘译) 高翔(摘译) | 2013 | 中国神经免疫学和神经病学杂志2013,20,1: | 2 |
| 20 | 抗纤维化药物对特发性肺纤维化患者的临床疗效分析显示文摘背景及目的:抗肺纤维化药物毗非尼酮及尼达尼布上市以来,尚无真实世界研究或随机临床试验来评价其对于特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)患者病死率和住院率等重要临床转归指标的影响。方法:通过美国医疗保险数据库纳入2014年10月1日至2018年3月1日期间诊断的IPF患者8098例。 | Dempsey TM Sangaralingham LR Yao X 邵池 黄慧 | 2019 | 中华结核和呼吸杂志2019,42,12: | 2 |