|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Molecular overview of progressive familial intrahepatic cholestasis显示文摘Cholestasis is a clinical condition resulting from the imapairment of bile flow.This condition could be caused by defects of the hepatocytes,which are responsible for the complex process of bile formation and secretion,and/or caused by defects in the secretory machinery of cholangiocytes.Several mutations and pathways that lead to cholestasis have been described.Progressive familial intrahepatic cholestasis(PFIC)is a group of rare diseases caused by autosomal recessive mutations in the genes that encode proteins expressed mainly in the apical membrane of the hepatocytes.PFIC 1,also known as Byler’s disease,is caused by mutations of the ATP8B1 gene,which encodes the familial intrahepatic cholestasis 1 protein.PFIC 2 is characterized by the downregulation or absence of functional bile salt export pump(BSEP)expression via variations in the ABCB11 gene.Mutations of the ABCB4 gene result in lower expression of the multidrug resistance class 3 glycoprotein,leading to the third type of PFIC.Newer variations of this disease have been described.Loss of function of the tight junction protein 2 protein results in PFIC 4,while mutations of the NR1H4 gene,which encodes farnesoid X receptor,an important transcription factor for bile formation,cause PFIC 5.A recently described type of PFIC is associated with a mutation in the MYO5B gene,important for the trafficking of BSEP and hepatocyte membrane polarization.In this review,we provide a brief overview of the molecular mechanisms and clinical features associated with each type of PFIC based on peer reviewed journals published between 1993 and 2020. | Sriram Amirneni Nils Haep Mohammad A Gad Alejandro Soto-Gutierrez James E Squires Rodrigo MFlorentino | 2020 | World Journal of Gastroenterology2020，26，47： | 17 |
| 2 | Opportunities and challenges in CO_(2) utilization显示文摘CO_(2) utilizations are essential to curbing the greenhouse gas effect and managing the environmental pollutant in an energy-efficient and economically-sound manner.This paper seeks to critically analyze these technologies in the context of each other and highlight the most important utilization avenues available thus far.This review will introduce and analyze each major pathway,and discuss the overall applicability,potential extent,and major limitations of each of these pathways to utilizing CO_(2).This will include the analysis of some previously underreported utilization avenues,including CO_(2) utilization in industrial filtration and the processing of raw industrial materials such as iron and alumina.The core theme of this paper is to seek to treat CO_(2) as a commodity instead of a liability. | Sriram Valluri Victor Claremboux Surendra Kawatra | 2022 | Journal of Environmental Sciences2022，34，3： | 8 |
| 3 | Early stage colon cancer: Current treatment standards, evolving paradigms, and future directions显示文摘Colon cancer continues to be one of the leading causes of mortality and morbidity throughout the world despite the availability of reliable screening tools and effective therapies.The majority of patients with colon cancer are diagnosed at an early stage(stages I to III),which provides an opportunity for cure.The current treatment paradigm of early stage colon cancer consists of surgery followed by adjuvant chemotherapy in a select group of patients,which is directed at the eradication of minimal residual disease to achieve a cure.Surgery alone is curative for the vast majority of colon cancer patients.Currently,surgery and adjuvant chemotherapy can achieve long term survival in about two-thirds of colon cancer patients with nodal involvement.Adjuvant chemotherapy is recommended for all patients with stage III colon cancer,while the benefit in stage II patients is not unequivocally established despite several large clinical trials.Contemporary research in early stage colon cancer is focused on minimally invasive surgical techniques,strategies to limit treatment-related toxicities,precise patient selection for adjuvant therapy,utilization of molecular and clinicopathologic information to personalize therapy and exploration of new therapies exploiting the evolving knowledge of tumor biology.In this review,we will discuss the current standard treatment,evolving treatment paradigms,and the emerging biomarkers,that will likely help improve patient selection and personalization of therapy leading to superior outcomes. | Sakti Chakrabarti Carrie Y Peterson Deepika Sriram Amit Mahipal | 2020 | World Journal of Gastrointestinal Oncology2020，12，8： | 4 |
| 4 | 内镜下胆管插管困难时十二指肠乳头括约肌预切开的早期应用:一项传统技术与改良技术比较的前瞻性研究显示文摘Background: Pre-cutting techniques have been used to gain biliary access at the expense of an increased complication rate. This may be because of the multiple attempts to achieve cannulation by using standard methods before pre-cutting and causing excess edema and papillary trauma. There are limited data on the early use of pre-cutting techniques. Methods: We performed a prospective study of the early introduction of needle-knife techniques in patients with difficult biliary cannulation. Standard biliary cannulation was attempted with a sphincterotome and a guidewire. If this failed within 10 minutes or if there were more than 5 pancreatic cannulations, the needle-knife technique was used. Either a standard method of pre-cutting (below-up-ward) from the papillary orifice or the modified technique of pre-cutting (above-downward), stopping short of the papillary orifice, was adopted, as per the discretion of the endoscopist. If pre-cutting failed, the cannulation was reattempted 24 to 48 hours later. Results: A total of 346 therapeutic biliary ERCP procedures were performed between April and August 2003. Of these, 70 patients (20%) (mean age, 54 years; 38 men) underwent needle-knife pre-cut sphincterotomy (16 with the standard technique). In 58 patients (83%), the procedure was successful with the initial pre-cutting, making the total success at initial ERCP 334/346 (96.5%). Nine patients in whom pre-cut failed, returned for a second-attempt ERCP, with 7 completed successfully. The total success rate of pre-cutting was 65/70 (93%). The overall success rate of biliary cannulation, after two ERCP attempts, was 341/346 (98.5%). Six patients had mild bleeding, and one had mild pancreatitis. There was no difference in these complications between the two types of precut techniques. Conclusions: The early use of needle knife for difficult biliary cannulation is safe and effective, irrespective of the technique used. | Kaffes A.J. Sriram P.V.J. 赵萌 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，3： | 2 |
| 5 | Neuroinflammation and subarachnoid hemorrhage: a revised look at the literature显示文摘A key topic for aneurysmal subarachnoid hemorrhage is neuroinflammation.Neuroinflammation can predispose to aneurysm formation and rupture.Neuroinflammation can also result from the blood breakdown products after aneurysm rupture.Recent evidence has shown that perpetual neuroinflammation can contribute to vasospasm and hydrocephalus.Targeting neuroinflammation is a novel mechanism for preventing subsequent neurologic sequalae.In this review,we highlight the pathophysiology of aneurysm formation,the neuroinflammatory surge after rupture including the involved cytokines,and ultimately tie in the contributory clinical relevance.In the last sections,we look at the pre-clinical data and novel avenues for further discovery.This paper will be a useful resource to both the clinician and scientific investigator. | Sai Sriram Christopher Cutler Mohammed Azab Ramya Reddy Rodeania Peart Brandon Lucke-Wold | 2022 | Clinical Research Communications2022，5，3： | 2 |
| 6 | SiC for microwave power transistors 显示文摘 | SRIRAM S SIERGIEJ R R CLARKE R C etal | 1997 | Phys Status Solidi A1997，162，： | 2 |
| 7 | The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease:more than just a barrier显示文摘The choroid plexus is a complex structure which hangs inside the ventricles of the brain and consists mainly of choroid plexus epithelial(CPE) cells surrounding fenestrated capillaries.These CPE cells not only form an anatomical barrier,called the blood-cerebrospinal fluid barrier(BCSFB),but also present an active interface between blood and cerebrospinal fluid(CSF).CPE cells perform indispensable functions for the development,maintenance and functioning of the brain.Indeed,the primary role of the choroid plexus in the brain is to maintain homeostasis by secreting CSF which contains different molecules,such as nutrients,neurotrophins,and growth factors,as well as by clearing toxic and undesirable molecules from CSF.The choroid plexus also acts as a selective entry gate for leukocytes into the brain.Recent findings have revealed distinct changes in CPE cells that are associated with aging and Alzheimer's disease.In this review,we review some recent findings that highlight the importance of the CPE-CSF system in Alzheimer's disease and we summarize the recent advances in the regeneration of brain tissue through use of CPE cells as a new therapeutic strategy. | Sriram Balusu Marjana Brkic Claude Libert Roosmarijn E.Vandenbroucke | 2016 | Neural Regeneration Research2016，11，4： | 2 |
| 8 | 两种AZT-氟喹诺酮偶联物体外抗HIV-1及抗菌活性的研究显示文摘目的体外测定两种AZT-氟喹诺酮偶联物SRLZ和SROZ的抗HIV-1活性及抗菌活性。方法通过合胞体抑制、HIV-1感染细胞保护、HIV-1 p24抗原测定等方法检测急性感染中化合物对HIV-1实验株、临床分离株的抑制作用和对慢性感染细胞中的病毒复制影响;通过体外金黄色葡萄球菌的抑制实验检测化合物的抗菌活性。结果AZT-氟喹诺酮偶联物SRLZ和SROZ能抑制HIV-1实验株诱导的合胞体形成,减少病毒感染细胞的死亡和抑制病毒在细胞内的复制;SRLZ和SROZ对HIV-1临床分离株也有较好的抑制作用;SRLZ和SROZ对HIV-1的抑制活性与AZT相近;AZT-氟喹诺酮偶联物也能抑制金黄色葡萄球菌,其MIC值与其相应的阳性药物相近。结论SRLZ和SROZ有很好的抗HIV-1活性和抗菌活性。 | 龙晶 Dharmarajan Sriram 张高红 郑永唐 | 2009 | 中国药理学通报2009，25，1： | 2 |
| 9 | The Effects of Online User Reviews on Movie Box Office Performance: Accounting for Sequential Rollout and Aggregation Across Local Markets显示文摘 | Pradeep K. Chintagunta Shyam Gopinath Sriram Venkataraman | 2010 | Marketing Science2010，，5： | 2 |
| 10 | 肺癌全基因组测序显示文摘肺癌是全球肿瘤发病率和病死率的主因,且预后很差。加强对肿瘤生物学的认识对肺癌研究至关重要。被誉为'下一代测序技术'的NGS技术(next-generation sequencing)是一种针对全基因组鉴定的有力工具,可以对致癌体细胞突变进行全面检测。大多数的NGS技术是基于平台特异性DNA文库进行多重聚合酶链反应(polymerase chain reaction,PCR),从而对目的基因扩增后测序。这种技术适用于高通量测序,可以检测出肿瘤中出现的全部基因组变异。缺点是这种技术需要在时间、实验设备、计算机数据分析、生物信息技术等各方面的大量投入。NGS技术已广泛应用于全基因组、外显子组、转录组和表观基因组的研究中,为肺癌研究和医疗模式带来改变。这项新技术的开展将转变当前对致癌信号通路的认识,可为癌症诊疗提供新的分子靶点。肺癌体细胞突变已有NGS技术的分析报道,但大规模基因组研究仍在进行中。个体化治疗策略将改善那些潜在获益患者的治疗方式,避免'无辜'患者受无效治疗带来的高额费用和不良反应。NGS的组织化、计算机化和生物信息化技术推动了科技的进步,同时,患者知情权和数据发布的相关伦理问题也浮现出来。信号通路中,驱动基因(driver gene)突变和传递基因(passenger gene)突变的区别,需要对测序结果进行细致解读。解读准确与否取决于DNA提取的样本类型、样本处理技术和样本含量。肿瘤异质性也会降低肿瘤基因突变的检测效能。NGS技术将推动对肿瘤基因突变的基础和临床研究,而且,也可应用于单细胞和游离的循环DNA,未来还将用于从体液和肿瘤亚群中获取的DNA样本。如果能进一步降低费用、提高检验速度和精度,NGS技术无疑将会成为肺癌研究的绝佳选择。 | Marissa Daniels Felicia Goh Casey M. Wright Krishna B. Sriram Vandana Relan Belinda E. Clarke Edwina E. Duhig Rayleen V. Bowman Ian A Yang Kwun M. Fong 孙岚 何建行 | 2013 | 国际病理科学与临床杂志2013，33，4： | 2 |
| 11 | Basement tectonics and flexural subsidence along western continental margin of India显示文摘The Paleocene-recent post-rift subsidence history recorded in the Mumbai Offshore Basin off western continental margin of India is examined. Results obtained through 2-D flexural backstripping modelling of new seismic data reveal considerable thermo-tectonic subsidence over last ca. 56 Myr. Reverse postrift subsidence modelling with variable β stretching factor predicts residual topography of ca. 2000 m to the west of Shelf Margin Basin and fails to restore late Paleocene horizon and the underlying igneous basement to the sea level. This potentially implies that:(1) either the igneous basement formed during the late Cretaceous was emplaced under open marine environs; or(2) a laterally varying cumulative subsidence occurred within Mumbai Offshore Basin(MOB) during ca. 68 to ca. 56 Ma. Pre-depositional topographic variations at ca. 56 Ma across the basin could be attributed to the extensional processes such as varied lower crustal underplating along Western Continental Margin of India(WCMI). Investigations about basement tectonics after unroofing of sediments since late Paleocene from this region support a transitional and heavily stretched nature of crust with high to very high β factors. Computations of past sediment accumulation rates show that the basin sedimentation peaked during late Miocene concurrently with uplift of Himalayan-Tibetan Plateau and intensification of Indian monsoon system. Results from basin subsidence modelling presented here may have significant implications for further studies attempting to explore tectono-climatic interactions in Asia. | D.K.Pandey Nisha Nair Anju Pandey G. Sriram | 2017 | Geoscience Frontiers2017，8，5： | 2 |
| 12 | Simultaneous removal of CO_(2), NO_(x) and SO_(x) using single stage absorption column显示文摘Capturing flue gases often require multiple stages of scrubbing, increasing the capital and operating costs. So far, no attempt has been made to study the absorption characteristics of all the three gases(NO, SO_(2) and CO_(2)) in a single stage absorption unit at alkaline p H conditions. We have attempted to capture all the three gases with a single wet scrubbing column. The absorption of all three gases with sodium carbonate solution promoted with oxidizers was investigated in a tall absorption column. The absorbance was found to be 100% for CO_(2), 30% for NO and 95% for SO_(2) respectively. The capture efficiency of sodium carbonate solution was increased by 40% for CO_(2) loading, with the addition of oxidizer. Absorption kinetics and reaction pathways of all the three gases were discussed individually in detail. | Sriram Valluri S.Komar Kawatra | 2021 | Journal of Environmental Sciences2021，33，5： | 2 |
| 13 | Synthesis and antimycobacterial screening of new N-(4-(5-aryl-3-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-pyrazol-1-yl)phenyl)-4-amide derivatives显示文摘This article demonstrates the synthesis, characterization and the study of in vitro antitubercular activities of twenty four new N-(4-(5-aryl-3-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-pyrazol-1-yl)phenyl)-4-amide derivatives(8a–x). The antitubercular activity of the compounds against Mycobacterium tuberculosis H37Rv(MTB) revealed that 2-chloro-N-(4-(5-(4-chlorophenyl)-3-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-pyrazol-1-yl)phenyl)benzamide(8n) is the most promising lead molecule with a MIC of1.56 mg/m L, while the corresponding unsubstituted benzamide derivative(8o) is the next most active molecule with a MIC of 3.13 mg/m L. Interestingly, the pyrazole intermediate 5b containing chlorophenyl and N-acylcarbohydrazide substituents also showed significant activity(MIC = 3.13 mg/m L). Further, the active molecules did not show toxicity against a normal NIH 3T3 cell line, signifying their suitability for further drug development. | Nagabhushana Nayak Jurupula Ramprasad Udayakumar Dalimba Perumal Yogeeswari Dharmarajan Sriram | 2016 | Chinese Chemical Letters2016，27，3： | 2 |
| 14 | Microstructure, tensile deformation and fracture behaviour of aluminium alloy 7055显示文摘 | T. S Srivatsan S Sriram D Veeraraghavan V. K Vasudevan | 1997 | Journal of Materials Science1997，，11： | 2 |
| 15 | Effect of cerium addition on the corrosion behaviour of carbon-alloyed iron aluminides显示文摘 | SRIRAM S BALASUBRAMANIAM R MUNGGOLE M N | 2006 | Corrosion Science2006，48，： | 1 |
| 16 | A product information modeling framework for product lifeeycle management 显示文摘 | Sudarsan R Fenves S J Sriram R D | 2005 | Computer Aided Design2005，37，13： | 1 |
| 17 | Synthesis and characterization of cationomeric AB crosslinked polyurethane polymers based on different chain extenders显示文摘 | SRIRAM V SUNDAR S DATTATHEREYAN A | 2005 | Reactive and Functional Polymers2005，64，1： | 1 |
| 18 | Innovation, Marketing Stratege, Environment and Performance 显示文摘 | Manu F A Sriram V | 1996 | Journal of Business Research1996，35，3： | 1 |
| 19 | Antioxidant activity of seed extracts of Annona squamosa and Carica papaya显示文摘 | Vijay Kothari Sriram Seshadri | 2010 | Nutrition & Food Science2010，40，4： | 1 |
| 20 | Short-course chemot herapy for tuberculosis of the spine: A comparison between ambulant treatment and radical surgery-ten-year report显示文摘 | Parthasarathy R Sriram K Santha T | 1999 | J Bone Joint Surg Br1999，81，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员