维普期刊资源整合服务平台（V6.5）

51篇 您的检索式：作者名="padget"

选中清除导出查看参考文献查看引证文献引用追踪共3页首页上一页第1页下一页末页 /3 跳转

	题名	作者	年代	出处	被引量
1	Engineering osteoarthritic cartilage model through differentiating senescent human mesenchymal stem cells for testing disease-modifying drugs显示文摘Significant cellular senescence has been observed in cartilage harvested from patients with osteoarthritis(OA).In this study,we aim to develop a senescence-relevant OA-like cartilage model for developing disease-modifying OA drugs(DMOADs).Spe-cifically,human bone marrow-derived mesenchymal stromal cells(MSCs)were expanded in vitro up to passage 10(P10-MSCs).Following their senescent phenotype formation,P10-MSCs were subjected to pellet culture in chondrogenic medium.Results from qRT-PCR,histology,and immunostaining indicated that cartilage generated from P10-MSCs displayed both senescent and OA-like phenotypes without using other OA-inducing agents,when compared to that from normal passage 4(P4)-MSCs.Interestingly,the same gene expression differences observed between P4-MSCs and P10-MSC-derived cartilage tissues were also observed between the preserved and damaged OA cartilage regions taken from human samples,as demonstrated by RNA sequencing data and other analysis methods.Lastly,the utility of this senescence-initiated OA-like cartilage model in drug development was assessed by testing several potential DMOADs and senolytics.The results suggest that pre-existing cellular senescence can induce the generation of OA-like changes in cartilage.The P4-and P10-MSCs derived cartilage models also represent a novel platform for predicting the efficacy and toxicity of potential DMOADs on both preserved and damaged cartilage in humans.	Ning Wang Yuchen He Silvia Liu Meagan J.Makarcyzk Guanghua Lei Alexander Chang Peter G Alexander Tingjun Hao Anne-Marie Padget Nuria de Pedro Tsapekos Menelaos Hang Lin	2022	Science China(Life Sciences)2022，65，2：	5
2	Histone deacetylase inhibition redistributes topoisomerase IIβfrom heterochromatin to euchromatin显示文摘	Cowell IG Papageorgiou N Padget K	2011	Nucleus2011，2，1：	1
3	The development of the cranial arteries in the human embryo显示文摘	PADGET D H	1948	Contrib Embryol1948，32，：	1
4	Aqeous polyurethanes for surface coatings显示文摘	SATGURU R MAHON J Mc PADGET J C	1994	Surface Coating International1994，77，10：	1
5	Polymers for water-based coatings显示文摘	Padget J C	1994	Journal of Coatings Technology1994，66，：	1
6	Designation of the embryonic intersegmental arteries in reference to the vertebral artery and subclavian stem 显示文摘	Padget DH	1954	Anat Rec1954，119，：	1
7	The devclopment of the cranial arteries in the human embryo显示文摘	Padget DH	1948	Contrib Embryot1948，39，：	1
8	Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile显示文摘	Kimberly Cramer-Morales Margaret Nieborowska-Skorska Kara Scheibner Michelle Padget David A. Irvine Tomasz Sliwinski Kimberly Haas Jaewoong Lee Huimin Geng Darshan Roy Artur Slupianek Feyruz V. Rassool Mariusz A. Wasik Wayne Childers Mhairi Copland Markus	2013	Blood2013，，7：	1
9	显示文摘	Satguru R Mcmahon J Padget J C Coogan R G	1994	Coat J Technol1994，66，830：	1
10	The development of cranial arteries in the human embryo显示文摘		1948	Contribut Embryol1948，212，：	1
11	Additives for Water-based Coatings-A Polymer Chemist's View 显示文摘	Padget J C	1994	J COAT Technol1994，66，89：	1
12	PCNN models and application显示文摘	Johnson J L Padget T MI	1999	IEEE Transactions on Neural Networks1999，10，3：	1
13	Aqueous polyurethanes for surface coatings显示文摘	Satguru R McMahon J Padget J C	1994	Surface Coatings International1994，77，10：	1
14	Development of cranial arteries in human embryo 显示文摘	Padget DH	1948	Contr Embryol1948，32，：	1
15	Aqueous polyurethanes for surface显示文摘	SATGURU R MCMAHON J PADGET J C	1994	Coatings International1994，，10：	1
16	Aqueous polyurethanes for surface coatings 显示文摘	Satguru R McMahon J Padget J C	1994	Surface Coating International1994，77，10：	1
17	PCNN models and ap- plications显示文摘	JOHNSON J L PADGET'I' M L	1999	IEEE Transactions on Neural Network1999，10，3：	1
18	Aqueous polyurethanes for surface coatings显示文摘	Satguru R Mahon J Mc padget J C Coogan R C	1994	Surface Coating International1994，77，10：	1
19	Aqeous polyurethanes for surface coatings显示文摘	Satguru R Mahon J Mc padget J C Coogan R C	1994	Surface Coating International1994，77，10：	1
20	Aqueous polyurethanes for surface coating 显示文摘	SATGURU R MCMAHON J PADGET J C	1994	Surface Coating International1994，77，10：	1

返回顶部每页显示：

共3页首页上一页第1页下一页末页 /3 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示