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| 1 | Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis显示文摘The 'a disintegrin and metalloprotease' (ADAM) family contributes to regulation of the cell-cell and cell-matrix interactions that are critical determinants of malignancy. To determine the relationship between metastasis and ADAM proteins, we compared the mRNA levels of ADAM9,-10,-12,-15, and-17 in sublines of an EBC-1 lung cancer cell line that were highly metastatic to either brain or bone. ADAM9 mRNA levels were significantly higher in highly brain-metastatic sublines than in the parent or highly bonemetastalic sublines. To elucidate the role ofADAM9 in brain metastasis, we stably transfected A549 and EBC-1 cells with a fulllength ADAM9 expression vector. Compared with mock-transfectants, ADAM9 overexpression resulted in increased invasive capacity | Shintani Y Higashiyama S Ohta M Hirabayashi H Yamamoto S Yoshimasu T Matsuda H Matsuura N | 2004 | 中国神经肿瘤杂志2004，2，2： | 36 |
| 2 | Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: A review and report of personal experience显示文摘选择 cyclooxygenase (艇长)-2 禁止者(coxibs ) 作为反煽动性的药之一被开发避免 non-steroidal 的各种各样的副作用反煽动性的药(NSAID ) 。然而, coxibs 也有一个能力禁止各种各样的类型的肿瘤开发 NSAID 的一样的方法。用细胞线和动物模型的许多试验性的研究表明了一个能力阻止 COX-2 禁止者的肿瘤增长。在为息肉 chemoprevention 执行使随机化的研究以后,与家庭腺瘤息肉病( FAP )在病人学习,它证明有 celecoxib 的治疗, coxibs 之一,显著地减少了颜色的数字在 2000 的表面的息肉,美国食物药品管理局(食物及药品管理局)立即为 FAP 病人同意了临床的使用 celecoxib 。然而,某 coxibs 最近被报导包括心脏病和击增加严肃的心血管的事件的风险。在这篇文章,我们在胃肠道的致癌作用考察 COX-2 的一个角色,例如食管,胃和 colorectum,并且也为胃肠道肿瘤的 chemoprevention 分析 coxibs 的前景。 | Takashi Fujimura Tetsuo Ohta Katsunobu Oyama Tomoharu Miyashita Koichi Miwa | 2006 | World Journal of Gastroenterology2006，12，9： | 33 |
| 3 | Surgical anatomy of innervation of the gallbladder in humans and Suncus murinus with special reference to morphological understanding of gallstone formation after gastrectomy显示文摘瞄准:澄清人的胆囊的神经分布,与在胃切除术以后的胆石形成的词法理解的特殊参考。方法:肝,胆囊和包围结构在乙醇沉浸于茜素红 S 的 10 mg/L 答案在死尸染色周围神经(n = 10 ) 。在区域的神经分布完全在一台双目显微镜下面被把。同样,在 10 Suncus murinus 的一样的区域的神经分布(S。murinus ) 被检验采用整个山免疫组织化学。结果:胆囊的神经分布通过二条线路主要发生了。一个人从前面的肝的丛,神经分布沿着膀胱的动脉和管发生了。总是,这条线路通过了肝十二指肠系带。另外的线路从以后的肝的丛,神经分布沿着膀胱的管 vent 集合发生了。这条线路也通过了肝十二指肠系带欧洲粪金龟子突围。类似的结果在 S 被获得。murinus。结论:从经由膀胱的动脉或管的前面的肝的丛的线路为保存胆囊神经分布是关键的。淋巴节点解剖可以明确地在胃切除术以后在肝十二指肠系带影响胆石的发生。而且,从经由到胆囊的胆总管和膀胱的管的以后的肝的丛的线路不应该被不顾。丛的保藏可以在胃切除术以后稀释胆石形成的发生。 | Shuang-Qin Yi Tetsuo Ohta Akihiko Tsuchida Hayato Terayama Munekazu Naito Jun Li Heng-Xiao Wang Nozomi Yi Shigenori Tanaka Masahiro Itoh | 2007 | World Journal of Gastroenterology2007，13，14： | 19 |
| 4 | Enhancement patterns of pancreatic adenocarcinoma on conventional dynamic multi-detector row CT:Correlation with angiogenesis and fibrosis显示文摘AIM:To evaluate retrospectively the correlation between enhancement patterns on dynamic computed tomography (CT) and angiogenesis and fibrosis in pancreatic adenocarcinoma.METHODS: Twenty-three patients with pancreatic adenocarcinoma underwent dynamic CT and tumor resection. In addition to the absolute and relative enhanced value that was calculated by subtracting the attenuation value on pre-contrast from those on contrast-enhanced CT in each phase, we defined one parameter, 'tumor-aorta enhancement ratio', which was calculated by dividing enhancement of pancreatic cancer by enhancement of abdominal aorta in each phase. These enhancement patterns were correlated with the level of vascular endothelial growth factor (VEGF), microvessel density (MVD), and extent of fibrosis.RESULTS: The absolute enhanced value in the arterial phase correlated with the level of VEGF and MVD (P=0.047, P=0.001). The relative enhanced value in arterial phase and tumor-aorta enhancement ratio (arterial) correlated with MVD (P=0.003, P=0.022). Tumor-aorta enhancement ratio (arterial) correlated negatively with the extent of fibrosis (P=0.004). The tumors with greater MVD and higher expression of VEGF tended to show high enhancement in the arterial dominant phase. On the other hand, the tumors with a larger amount of fibrosis showed a negative correlation with the grade of enhancement during the arterial phase.CONCLUSION: Enhancement patterns on dynamic CT correlated with angiogenesis and may be modified by the extent of fibrosis. | Yuki Hattori Toshifumi Gabata Osamu Matsui Kentaro Mochizuki Hirohisa Kitagawa Masato Kayahara Tetsuo Ohta Yasuni Nakanuma | 2009 | World Journal of Gastroenterology2009，15，25： | 15 |
| 5 | CT-maximum intensity projection is a clinically useful modality for the detection of gastric varices显示文摘AIM: To evaluate the efficacy of CT-maximum intensity projection (CT-MIP) in the detection of gastric varicesand their inflowing and outflowing vessels in patientswith gastric varices scheduled to undergo balloonoccluded retrograde transvenous obliteration (B-RTO). METHODS: Sixteen patients with endoscopicallyconfirmed gastric varices were included in this study. All patients were evaluated with CT-MIP using threedimensional reconstructions, before and after B-RTO. RESULTS: CT-MIP clearly depicted gastric varices in 16 patients (100%), the left gastric vein in 6 (32.5%),the posterior gastric vein in 12 (75.0%), the short gastric veins in 13 (81.3%), gastrorenal shunts in 16 (100%), the hemiazygos vein (HAZV) in 4 (25.0%), the pericardiophrenic vein (PCPV) in 9 (56.3%), and the left inferior phrenic vein in 9 patients (56.3%). Although flow direction itself cannot be determined from CT-MIP,this modality provided clear images of the inflowing and the outflowing vessels. Moreover, in one patient, short gastric veins were not seen on conventional angiographic portography images of the spleen, but were clearly revealed on CT-MIP,CONCLUSION: We suggest that CT-MIP should be considered as a routine method for detecting and diagnosing collateral veins in patients with gastric varices scheduled for B-RTO. Furthermore, CT-MIP is more useful than endoscopy in verifying the early therapeutic effects of B-RTO. | Toru Ishikawa Takashi Ushiki Ken-ichi Mizuno Tadayuki Togashi Kouji Watanabe Kei-ichi Seki Hironobu Ohta Toshiaki Yoshida Keiko Takeda Tomoteru Kamimura | 2005 | World Journal of Gastroenterology2005，11，47： | 13 |
| 6 | Cytomegalovirus infection in severe ulcerative colitis patients undergoing continuous intravenous cyclosporine treatment in Japan显示文摘AIM: To investigate active cytomegalovirus (CMV) infection following the cyclosporine A (CyA) treatment of steroid-refractory ulcerative colitis (UC).METHODS: Twenty-three patients with severe UC not responding to steroid therapy (male 14, and female 9) enrolled at Nagoya University Hospital from 1999 to 2005. They received continuous intravenous infusion of CyA (average 4 mg/kg per day) for 1 mo. Serum and colonic biopsy samples were collected before CyA treatment and 4 d, 10 d, 20 d, and 30 d after treatment. Patients were evaluated for CMV by using serology (IgM antibody by ELISA), quantitative real-time PCR for CMV DNA, and histopathological assessment of hematoxylin and eosin (HE)-stained colonic biopsies. CMV infection was indicated by positive results in any test. RESULTS: No patients had active CMV infection before CyA treatment. Eighteen of 23 UC patients treated with CyA were infected with active CMV (IgM antibody in 16/23 patients, 69.6%; CMV DNA in 18/23 patients, 78.2%; and inclusion bodies in 4/23 patients, 17.3%). There was no difference in the active CMV-infection rate between males and females. Active CMV infection was observed after approximately 8 d of CyA treatment, leading to an exacerbation of colitis. Fifteen of these 18 patients with active CMV infection (83.3%) required surgical treatment because of severe deteriorating colitis. Treatment with ganciclovir rendered surgery avoidable in three patients. CONCLUSION: Our results suggest that active CMVinfection in severe UC patients treated with CyA is associated with poor outcome. Further, ganciclovir is useful for treatment of CMV-associated UC after immuno-suppressive therapy. | Masaaki Minami Michio Ohta Teruko Ohkura Takafumi Ando Naoki Ohmiya Yasumasa Niwa Hidemi Goto | 2007 | World Journal of Gastroenterology2007，13，5： | 13 |
| 7 | Effects of Diffuser Vane Geometry on Interaction Noise Generated from a Centrifugal Compressor显示文摘相互作用音调噪音的特征与 vaned 从一台离心的压缩机放射了更弥漫被实验讨论,包括用油电影方法的可视化技术。研究注意对是的更弥漫的翼的前缘几何学被给予深深地与相互作用音调噪音的产生机制有关。散发压缩机的噪音能被在压力上升系数与某衰落一起将一些清理放在中心和更弥漫的墙的笼罩表面被几分贝减少。自从结果被第二等的流动被流动冲击并且也在更弥漫的段落以内引起的衰落,不从表演和噪音水平毁损的更弥漫的翼几何学的几种新类型为实验被开发并且利用。介绍的更弥漫的翼几何学将为更弥漫的翼设计为一些提供基本指南。关键词离心的压缩机 - vaned 更弥漫 - 相互作用噪音 - 噪音减小 CLC 数字 TK474. | Yutaka OHTA Naho TAKEHARA Yasuhiko OKUTSU Eisuke OUTA | 2005 | Journal of Thermal Science2005，14，4： | 10 |
| 8 | Clinical significance of serum levels of vascular endothelial growth factor and its receptor in biliary disease and carcinoma显示文摘AIM: To investigate the clinical significance of serum vascular endothelial growth factor (VEGF) and soluble VEGF receptor-1 (VEGFR1/Flt-1) (sVEGFR1) levels in biliary diseases.METHODS: We analyzed the serum levels of these proteins in patients with acute cholangitis (group 1), biliary malignancies (group 2), and primary biliary cirrhosis or primary sclerosing cholangitis (group 3), and in healthy donors (group 4). The influence of inflammation was also analyzed. Serum VEGF levels were expressed as VEGF per platelet (VEGF/PLT, pg/106) in order to exclude the influence of platelet counts.RESULTS: sVEGFR1 levels were significantly higher in groups 1 and 2 than in the control group, but did not correlate with inflammatory markers. VEGF/PLT levels were generally higher in patients with active inflammation than in those with carcinoma. C-reactive protein strongly correlated with the levels of serum VEGF independently of platelet and leukocyte counts, even in cancer patients. In cancer patients, VEGF/PLT and sVEGFR1 levels might be indicators for evaluating the effect of medical treatment or the disease progression.CONCLUSION: Serum VEGF and VEGFR1 might be useful markers for gauging the clinical effect of various treatments on patients. | Munechika Enjoji Makoto Nakamuta Koji Yamaguchi Satoshi Ohta Kazuhiro Kotoh Marie Fukushima Masami Kuniyoshi Tomomi Yamada Masao Tanaka Hajime Nawata | 2005 | World Journal of Gastroenterology2005，11，8： | 9 |
| 9 | 精确测量的地幔体波走时及地幔非均匀性的强度(英文)显示文摘用波形相关法精确地测定了在世界各地发生的87个6级以上地震的P波, PP波和Pdiff波的503个走时数据。记录这些地震波形的是新建于西太平洋地区的海洋半球地震观测网。我们利用这些高精度的走时数据研究了地幔体波的走时残差的范围及地幔非均匀性的强度。结果表明,P波、PP波和Pdiff波的走时残差最大分别为9 s ,11 s和15 s ,这为地幔层析成像反演中应该使用的体波走时残差数据的范围提供了重要信息。超出这一范围的走时残差数据不应该用于反演中,以免歪曲成像结果。我们发现,当震中距小于40°时,P波走时残差的范围为-6到+9 s。而对于40°到99°之间的震中距,P波走时残差的范围为-3到+5s。由于震中距越大,P波穿透地幔越深,我们这一结果提供了直接和确凿的证据,表明上地幔和地幔转换带中的横向非均匀性的强度要远胜于下地幔。我们精确测量的Pdiff波的走时数据表明,在地幔底部存在显著的低速异常,可能与地幔热柱或者超级地幔柱有关。我们使用了一个最新的三维全球层析成像模型来解释这些体波走时数据的空间变化。 | Akira YAMADA Yuhei OHTA | 2006 | 地学前缘2006，13，2： | 9 |
| 10 | Improved survival for hepatocellular carcinoma with portal vein tumor thrombosis treated by intra-arterial chemotherapy combining etoposide,carboplatin,epirubicin and pharmacokinetic modulating chemotherapy by 5-FU and enteric-coated tegafur/uracil:A pilo显示文摘AIM: To investigate the poor prognosis of HCC with PVTT,we evaluated the efficacy by a new combination chemotherapy for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). METHODS: From 2002 to 2007,a total of 10 consecutive patients with Stage IVA HCC accompanied by PVTT were studied prospectively to examine the efficacy of treatment by intra-arterial infusion of a chemotherapeutic agents consisting of etoposide,carboplatin,epirubicin and pharmacokinetic modulating chemotherapy by 5-FU and enteric-coated tegafur/uracil. RESULTS: The mean course of chemotherapy was 14.4 (range,9-21) mo. One patient showed complete response (CR) with disappearance of HCC and PVTT after treatment,and the two patients showed partial response (PR),response rate (CR + PR/All cases 30%). The median survival time after the therapy was 457.2 d. The one-year survival rate was 70%. Adverse reactions were tolerable. CONCLUSION: Although the prognosis of most patients with Stage IVA HCC by PVTT is poor,our combination chemotherapy may induces long-term survival and is an effective treatment and produced anti-tumor activity with tolerable adverse effects in patients for advanced Stage IVA HCC accompanied by PVTT. | Toru Ishikawa Michitaka Imai Hiroteru Kamimura Atsunori Tsuchiya Tadayuki Togashi Kouji Watanabe Kei-ichi Seki Hironobu Ohta Toshiaki Yoshida Tomoteru Kamimura | 2007 | World Journal of Gastroenterology2007，13，41： | 8 |
| 11 | Unsteady Behavior of Leading-edge Vortex and Diffuser Stall in a Centrifugal Compressor with Vaned Diffuser显示文摘The characteristics of a rotating stall of an impeller and diffuser and the evolution of a vortex generated at the diffuser leading-edge(i.e., the leading-edge vortex(LEV)) in a centrifugal compressor were investigated by experiments and numerical analysis. The results of the experiments revealed that both the impeller and diffuser rotating stalls occurred at 55 and 25 Hz during off-design flow operation. For both, stall cells existed only on the shroud side of the flow passages, which is very close to the source location of the LEV. According to the CFD results, the LEV is made up of multiple vortices. The LEV is a combination of a separated vortex near the leading-edge and a longitudinal vortex generated by the extended tip-leakage flow from the impeller. Therefore, the LEV is generated by the accumulation of vorticity caused by the velocity gradient of the impeller discharge flow. In partial-flow operation, the spanwise extent and the position of the LEV origin are temporarily transmuted. The LEV develops with a drop in the velocity in the diffuser passage and forms a significant blockage within the diffuser passage. Therefore, the LEV may be regarded as being one of the causes of a diffuser stall in a centrifugal compressor. | Nobumichi FUJISAWA Shotaro HARA Yutaka OHTA | 2016 | Journal of Thermal Science2016，25，1： | 8 |
| 12 | 用于空气中水蒸气吸-脱附的微孔泡沫炭制备研究(英文)显示文摘以蜜胺泡沫体为模板,采用氟化聚酰亚胺制备了微孔泡沫炭。测定了其对环境中水气的吸附/脱附行为,发现:泡沫炭在空气中400℃活化1h,可以提高其对水气的吸附能力。与活化前相比,对水气的吸附量几乎高达3倍,尽管其微孔容积仅增大了1.5倍。对环境水气中的可逆吸附率与微孔容积成线性关系,微孔容积为0.75mL/g的泡沫炭,其水气吸附率约为质量分数40%。 | Naoto Ohta Yoko Nishi Takahiro Morishita Yumiko Ieko Akifumi Ito Michio Inagaki | 2008 | 新型炭材料2008，23，3： | 7 |
| 13 | 温带混交林碳水通量模拟及其对冠层分层方式的响应--耦合的气孔导度-光合作用-能量平衡模型显示文摘利用Leuning建立的耦合的光合作用、气孔导度和能量平衡方程,以将冠层分成多层的方式,包括Gaussian五点积分法、将冠层平均分为多层的方法,逐层计算温带混交林的碳水通量,最后累加至冠层尺度,以模拟CO2和H2O通量。该模型以常规气象观测数据作为驱动变量,计算出冠层与大气之间的碳水交换,与涡动相关系统的通量观测数据进行比较,分析了不同的冠层分层方式对多层模型模拟结果的影响。从3个温带混交林通量站涡动相关系统的能量平衡闭合度来看,中国长白山站CBS、韩国GDK和日本MMF站点的能量平衡比率(EBR)分别为0.76、0.66和1.07,居于国际同类观测范围(0.34—1.2)的中上水平,因此,涡动相关系统的观测数据较为可靠。从碳水通量的日变化来看,用Gaussian五点积分法将冠层分为五层的模型能较好的模拟碳水通量的'单峰形'日变化趋势。夜间Fc为负值且变化趋势较为平缓,表明生态系统进行呼吸作用释放CO2,从日出开始Fc逐渐变为正值,表明生态系统进行光合作用吸收CO2,Fc在中午时分达到最大值,下午Fc逐渐减小,日落之后又回复到夜间的负值。H2O通量的日变化曲线与CO2通量相似,且模拟值与涡动相关实测值具有较好的一致性。在多层模型中,对冠层采用不同的分层方法,对碳水通量模拟结果有一定的影响。以Gaussian五点积分法将冠层分为五层的方法作为对照,分别将冠层平均分为2、5、10、20层的方法得到的碳水通量与其进行比较。从平均值来看,分层越多,H2O通量模拟值越低,而CO2通量模拟值越高。不同的分层方法产生的差异,主要来自于不同层的辐射吸收、温湿度、风速等环境要素的垂直廓线差异,且叶片光合作用对光的响应是非线性的。 | 施婷婷 高玉芳 袁凤辉 Takeshi Ohta | 2012 | 生态学报2012，32，15： | 7 |
| 14 | Successful treatment of multiple lung metastases of hepatocellular carcinoma by combined chemotherapy with docetaxel, cisplatin and tegafur/uracil显示文摘We report the successful treatment of multiple lung metastases after hepatic resection for hepatocellular carcinoma (HCC) with combined docetaxel, cisplatin (CDDP), and enteric-coated tegafur/uracil (UFT-E). A 68-year-old man was diagnosed with multiple lung metastases of HCC 7 mo after partial hepatectomy for HCC. Oral UFT-E was given daily and docetaxel and CDDP were given intra-arterially (administered just before the bronchial arteries) every 2 wk via a subcutaneous injection port. One month after starting chemotherapy, levels of tumor marker, protein induced by vitamin K absence(PIVKA--), decreased rapidly,and after a further month, chest X-ray and computed tomography revealed the complete disappearance of multiple liver metastases. Two years after the combined chemotherapy, HCC recurred in the liver and was treated but no pulmonary recurrence occurred. In the absence of a standardized highly effective therapy, this combined chemotherapy with docetaxel, CDDP and UFT-E may be an attractive option for multiple lung metastases of HCC. | Atsunori Tsuchiya Michitaka Imai Hiroteru Kamimura Tadayuki Togashi Kouji Watanabe Kei-ichi Seki Toru Ishikawa Hironobu Ohta Toshiaki Yoshida Tomoteru Kamimura | 2009 | World Journal of Gastroenterology2009，15，14： | 7 |
| 15 | 胶质肉瘤和巨细胞胶质母细胞瘤的遗传学改变显示文摘Oh J E, Ohta T, Nonoguchi N, et al. Genetic alterations in gliosarcoma and giant cell glioblastoma. Brain Pathol, 2015 Oct 7. doi: 10.111/bpa. 12328. [Epub ahead of print].大多数胶质母细胞瘤进展迅速、临床病史短(IDH野生型原发性胶质母细胞瘤),然而继发性胶质母细胞瘤是由弥漫性星形细胞瘤或间变性星形细胞瘤进展而来。IDH突变是继发性胶质母细胞瘤的遗传学标志。胶质肉瘤和巨细胞胶质母细胞瘤是胶质母细胞瘤罕见的组织学变异亚型,通常进展迅速。 | Oh J E Ohta T Nonoguchi N 陈达阳 刘雪咏 | 2016 | 临床与实验病理学杂志2016，32，2： | 7 |
| 16 | Combined choriocarcinoma, neuroendocrine cell carcinoma and tubular adenocarcinoma in the stomach显示文摘We described a patient with adenocarcinoma of the stomach combined with choriocarcinoma and neuroendocrine cell carcinoma. An 85-year-old man visited our hospital because of appetite loss. Gastric fiberscopy revealed a large tumor occupying the cardial region and anterior wall of the gastric body. The patient underwent total gastrectomy with lymphnode dissection and partial resection of the liver. Choriocarcinoma, small cell carcinoma and tubular adenocarcinoma existed in the gastric tumor. The choriocarcinomatous foci contained cells positive for beta-subunit of human chorionic gonadotropin (B-hCG) and human placental lactogen mainly in syncytiotrophoblastic cells. The small cell carcinomatous foci contained cells positive for synaptophysin, neuron-specific enolase (NSE), and chromogranin A. The prognosis for gastric adenocarcinoma with choriocarcinoma and neuroendocrine cell carcinoma is exceedingly poor. This patient died about 2 mo after the first complaint from hepatic failure. This is the first reported case of gastric cancer with these three pathological features. | Yasumitsu Hirano Takuo Hara Hiroshi Nozawa Kaeko Oyama Naohiro Ohta Kenji Omura Go Watanabe Hideki Niwa | 2008 | World Journal of Gastroenterology2008，14，20： | 6 |
| 17 | Characterization of CD133^+ parenchymal cells in the liver:Histology and culture显示文摘AIM:To reveal the characteristics of CD133+ cells in the liver.METHODS:This study examined the histological characteristics of CD133+ cells in non-neoplastic and neoplastic liver tissues by immunostaining,and also analyzed the biological characteristics of CD133+ cells derived from human hepatocellular carcinoma(HCC) or cholangiocarcinoma cell lines.RESULTS:Immunostaining revealed constant expression of CD133 in non-neoplastic and neoplastic biliary epithelium,and these cells had the immunophenotype CD133+/CK19+/HepPar-1-.A small number of CD133+/CK19-/HepPar-1+ cells were also identified in HCC and combined hepatocellular and cholangiocarcinoma.In addition,small ductal structures,resembling the canal of Hering,partly surrounded by hepatocytes were positive for CD133.CD133 expression was observed in three HCC(HuH7,PLC5 and HepG2) and two cholangiocarcinoma cell lines(HuCCT1 and CCKS1).Fluorescence-activated cell sorting(FACS) revealed that CD133+ and CD133-cells derived from HuH7 and HuCCT1 cells similarly produced CD133+ and CD133-cells during subculture.To examine the relationship between CD133+ cells and the side population(SP) phenotype,FACS was performed using Hoechst 33342 and a monoclonal antibody against CD133.The ratios of CD133+/CD133-cells were almost identical in the SP and non-SP in HuH7.In addition,four different cellular populations(SP/CD133+,SP/CD133-,non-SP/CD133+,and non-SP/CD133-) could similarly produce CD133+ and CD133-cells during subculture.CONCLUSION:This study revealed that CD133 could be a biliary and progenitor cell marker in vivo.However,CD133 alone is not sufficient to detect tumor-initiating cells in cell lines. | Seiichi Yoshikawa Yoh Zen Takahiko Fujii Yasunori Sato Tetsuo Ohta Yutaka Aoyagi Yasuni Nakanuma | 2009 | World Journal of Gastroenterology2009，15，39： | 6 |
| 18 | Evaluating 3D position and velocity of subject in parabolic flight experiment by use of the binocular stereo vision measurement显示文摘A practical method for evaluating the three-dimensional(3D) position and velocity of a moving object used in the parabolic flight experiment is developed by using the binocular stereo vision measurement theory. The camera calibration mathematic model without considering the lens distortion is introduced.The direct linear transformation(DLT) algorithm is improved to accomplish the camera calibration.The camera calibration result and optimization algorithm are used to calculate the object's world coordinate from image coordinate.The 3D position and the velocity of the moving object are obtained.The standard uncertainty in estimating the velocity is 0.0024 m/s,which corresponds to 1%level of the velocity of the object in the experiment.The results show that this method is very useful for the parabolic flight experiments. | 金涛 贾宏志 侯文玫 Ryo Yamamoto Norihiro Nagai Yusaku Fujii Koichi Maru Naoya Ohta Kazuhito Shimada | 2010 | Chinese Optics Letters2010，8，6： | 6 |
| 19 | Unsteady Behavior and Control of Vortices in Centrifugal Compressor显示文摘Two examples of the use of vortex control to reduce noise and enhance the stable operating range of a centrifugal compressor are presented in this paper.In the case of high-flow operation of a centrifugal compressor with a vaned diffuser,a discrete frequency noise induced by interaction between the impeller-discharge flow and the diffuser vane,which appears most notably in the power spectra of the radiated noise,can be reduced using a tapered diffuser vane(TDV) without affecting the performance of the compressor.Twin longitudinal vortices produced by leakage flow passing through the tapered portion of the diffuser vane induce secondary flow in the direction of the blade surface and prevent flow separation from the leading edge of the diffuser.The use of a TDV can effectively reduce both the discrete frequency noise generated by the interaction between the impeller-discharge flow and the diffuser surface and the broadband turbulent noise component.In the case of low-flow operation,a leading-edge vortex(LEV) that forms on the shroud side of the suction surface near the leading edge of the diffuser increases significantly in size and blocks flow in the diffuser passage.The formation of an LEV may adversely affect the performance of the compressor and may cause the diffuser to stall.Using a one-side tapered diffuser vane to suppress the evolution of an LEV,the stable operating range of the compressor can be increased by more than 12 percent,and the pressure-rise characteristics of the compressor can be improved.The results of a supplementary examination of the structure and unsteady behavior of LEVs,conducted by means of detailed numerical simulations,are also presented. | Yutaka Ohta Nobumichi Fujisawa | 2014 | Journal of Thermal Science2014，23，5： | 5 |
| 20 | The ultra-low-frequency magnetic disturbances associated with earthquakes显示文摘The ultra-low-frequency(ULF) electromagnetic emission is recently recognized as one of the most promising candidates for short-term earthquake(EQ) prediction.This paper reviews previous convincing evidence on the presence of ULF emissions before three major EQs.Then,we present further statistical study on the ULF occurrence,our networks of ULF monitoring in different spatial scales in Japan and finally we present several signal processings to identify the seismogenic emissions by showing latest results for recent large EQs. | Masashi Hayakawa Yasuhide Hobara Kenji Ohta Katsumi Hattori | 2011 | Earthquake Science2011，24，6： | 5 |
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