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| 1 | 利用AFLP遗传连锁图定位大麦苗期对叶锈病的部分抗性基因显示文摘借助大麦染色体AFLP标记遗传连锁图和MapQTLV3.0作图软件,对大麦叶锈病的数量抗性基因(QRL)进行了定位分析,明确了大麦部分抗性品种Vada对叶锈病的潜育期由分别位于染色体1、2、6、7上离短臂末端79cM、186cM、58cM和117cM处的4个数量抗性基因所控制。发现位于第7染色体上的QRL存在着病菌致病类型的专化性。讨论了区间作图法(IM)和复合区间作图法(CIM)的优缺点,建议以多种方法构建QTL图谱,并优先标定共同检测到的QTL。 | 陈万权 漆小泉 R E Niks | 1999 | Acta Genetica Sinica1999，26，6： | 26 |
| 2 | Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn’s disease显示文摘In 2018,the pan-Janus kinase(JAK)inhibitor tofacitinib was launched for the treatment of ulcerative colitis(UC).Although tofacitinib has proven efficacious in patients with active UC,it failed in patients with Crohn’s disease(CD).This finding strongly hints at a different contribution of JAK signaling in both entities.Here,we review the current knowledge on the interplay between the JAK/signal transducer and activator of transcription(STAT)pathway and inflammatory bowel diseases(IBD).In particular,we provide a detailed overview of the differences and similarities of JAK/STAT-signaling in UC and CD,highlight the impact of the JAK/STAT pathway in experimental colitis models and summarize the published evidence on JAK/STAT-signaling in immune cells of IBD as well as the genetic association between the JAK/STAT pathway and IBD.Finally,we describe novel treatment strategies targeting JAK/STAT inhibition in UC and CD and comment on the limitations and challenges of the new drug class. | Friederike Cordes Dirk Foell John Nik Ding Georg Varga Dominik Bettenworth | 2020 | World Journal of Gastroenterology2020，26，28： | 16 |
| 3 | Synthesis of ion imprinted polymers for selective recognition and separation of rare earth metals显示文摘Lanthanide-ion imprinted polymers(L-IIPs) were synthesized by stoichiometric amounts of rare earth ions and the cavities in the polymers were created for the corresponding lanthanide ions. The maximum sorption capacities were estimated to be 125.3, 126.5, 127.6, 128.2 and 129.1 mg/g for Pr, Nd, Sm, Eu and Gd, respectively at p H 6. In the selectivity study, the L-IIPs exhibited good selectivity to the specific rare earth ions in the presence of coexisting cations. The imprinting results were found to be excellent with some rare earth ions over other competitor rare earth ions with the same charges and close ionic radius. | Mashitah M.Yusoff Nik Rohani Nik Mostapa Md Shaheen Sarkar Tapan Kumar Biswas Md Lutfor Rahman Sazmal Effendi Arshad Mohd Sani Sarjadi Ajaykumar D.Kulkarni | 2017 | Journal of Rare Earths2017，35，2： | 6 |
| 4 | Numerical and experimental investigation of three-dimensionality in the dam-break flow against a vertical wall显示文摘The three-dimensionality extent of the dam break flow over a vertical wall is investigated numerically and experimentally in this paper. The numerical method is based on Reynolds averaged Navier-Stokes(RANS) equation that describes the three-dimensional incompressible turbulent flow. The free surface is captured by using the unstructured multi-dimensional interface capturing(UMTHINC) scheme. The equations are discretized on 2-D and 3-D unstructured grids using finite volume method. The numerical simulations are compared with newly conducted experiment with emphasis on the effect of three-dimensionality on both free surface and impact pressure. The comparison between the numerical and experimental results shows good agreement. Furthermore, the results also show that 3-D motion of the flow originates at the moment of impact at the lower corners of the impact wall and propagates to the inner region as time advances. The origin of the three-dimensionality is found to be the turbulence development as well as the relative velocity between the side wall region and the inner region of the wave front at the moment of impact. | Mohamed M.Kamra Nik Mohd Cheng Liu Makoto Sueyoshi Changhong Hu | 2018 | Journal of Hydrodynamics2018，30，4： | 5 |
| 5 | The neuroprotective effects of(S)-3,5-dihydroxyphenylglycine preconditioning in middle cerebral artery occluded rats: a perspective as a contrivance for stroke显示文摘Stroke is one of the fearsome causes of death that leads to high mortality and morbidity worldwide.Apparently,the management of choice for ischemic stroke is either by thrombolysis or thrombectomy.The paramount challenge in most clinical cases is that those interventions are time-dependent as they | Nik Nasihah Nik Ramli Rosfaiizah Siran | 2015 | Neural Regeneration Research2015，10，8： | 3 |
| 6 | Physical, Psychological, and Social Health Impact of Temperature Rise Due to Urban Heat Island Phenomenon and Its Associated Factors显示文摘The Urban Heat Island Effect(UHI)has now become a commonly observed phenomenon worldwide.Indeed,it has become a significant environmental effect of urbanisation.In Malaysia,research results showed that UHI effects are very evident in several cities such as Kuala Lumpur and Putrajaya[1,2].UHI effect has long been observed to cause temperature of cities.Temperature rise associated to UHI phenomenon may have | Li Ping WONG Haridah Alias Nasrin Aghamohammadi Sima Aghazadeh Nik Meriam Nik Sulaiman | 2018 | Biomedical and Environmental Sciences2018，31，7： | 3 |
| 7 | GAJA:3D CAD methodology for developing a parametric system for the automatic(re)modeling of the cutting components of compound washer dies显示文摘For the designing of cutting-dies is a complex and experience-based process,it is poorly supported by conventional 3D CAD software.Thus,the majority of design activities,including the(re)modeling of those cutting die-components that are directly responsible for performing shaping operations on a sheet-metal stamping part,traditionally still need to be carried-out repetitively,separately,and manually by the designer.To eliminate some of these drawbacks and upgrade the capabilities of conventional 3D CAD software,this paper proposes a new methodology for the development of a parametric system capable of automatically performing a(re)modeling process of compound washer dies' cutting-components.The presented methodology integrates CATIA V5 built-in modules,including Part Design,Assembly Design and Knowledge Advisor,publication mechanism,and compound cutting die-design knowledge.The system developed by this methodology represents an 'intelligent' assembly template composed of two modules GAJA1 and GAJA2,respectively.GAJA1 is responsible for the direct input of the die-design problem regarding the shape,dimensions and material of the stamping part,its extraction in the form of geometric features,and the transferring of relevant design parameters and features to the module GAJA2.GAJA2 interprets the current values for the input parameters and automatically performs the modeling process of cutting die-components,using die-design knowledge and the company's internal design and manufacturing standards.Experimental results show that this system significantly shortens the modeling-time for cutting the die-components,improves the modeling-quality,and enables the training of inexperienced designers. | David POTONIK Bojan DOLAK Miran ULBIN | 2013 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2013，14，5： | 2 |
| 8 | Predictive control of plug-in electric vehicle chargers with photovoltaic integration显示文摘This paper presents a model predictive control(MPC) for off-board plug-in electric vehicle(PEV)chargers with photovoltaic(PV) integration using two-level four-leg inverter topology. The PEV charger is controlled by a unified controller that incorporates direct power and current MPC to dynamically control decoupled active-reactive power flow in a smart grid environment as well as to control PEV battery charging and discharging reliably. PV power generation with maximum power tracking is seamlessly integrated with the power flow control to provide additional power generation. Fast dynamic response and good steady-state performance under all power flow modes and various environmental conditions are evaluated and analyzed. From the results obtained, the charger demonstrates less than 1.5% total harmonic distortion as well as low active and reactive power ripple of less than 7% and 8% respectively on the grid for all power flow modes. The PEV battery also experiences a low charging and discharging current ripple of less than 2.5%. Therefore,the results indicate the successful implementation of the proposed charger and its control for PV integrated offboard PEV chargers. | Adrian Soon Theam TAN Dahaman ISHAK Rosmiwati MOHD-MOKHTAR Sze Sing LEE Nik Rumzi Nik IDRIS | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，6： | 2 |
| 9 | 单乙醇胺对水基钻井液体系中淀粉热稳定性的影响显示文摘为了提高水基钻井液体系中淀粉的热稳定性,在其中添加单乙醇胺,并对其效果进行了室内实验研究。研究表明,单乙醇胺的存在使钻井液的表观黏度、塑性黏度、动切力、静切力等提高,且显著降低了钻井液的滤失速率、减小了泥饼厚度。通过与淀粉聚合物建立氢键,单乙醇胺的存在可以避免高温下淀粉的水解,提高淀粉的热稳定性。淀粉作为天然聚合物可以提高钻井液流变性能、降低滤失量,但其发挥作用的最高温度仅为121℃,而单乙醇胺会使淀粉的耐温提高至160℃。单乙醇胺存在最佳浓度,高于最佳浓度时,其功效会下降。 | NASIRI Alireza NIK Mohammad Amin Sharif HEIDARI Hamidreza VALIZADEH Majid | 2018 | 石油勘探与开发2018，45，1： | 2 |
| 10 | 尿素中添加腐植酸、黄腐酸、重过磷酸钙和氯化钾能抑制氨的挥发显示文摘该试验比较了不同混合物,尿素-重过磷酸钙-氯化钾、尿素-重过磷酸钙-氯化钾-腐植酸、尿素-重过磷酸钙-氯化钾-黄腐酸、尿素-重过磷酸钙-氯化钾-酸性混合物(黄腐酸+腐植酸)在对氨损失,土壤pH值,铵态氮和可利用硝态氮积累等方面的影响,以尿素单独施用作为对照。方法:在实验室条件下,利用一个封闭式动态空气流量系统来评估是否混有重过磷酸钙、氯化钾、腐植酸、黄腐酸的情况下尿素的有效性。氨损失、土壤pH值、土壤中铵态氮以及可利用硝态氮是由标准程序测定的。结果:与对照组(单独施用尿素)相比,处理尿素-重过磷酸钙-氯化钾,尿素-重过磷酸钙-氯化钾-腐植酸,尿素-重过磷酸钙-氯化钾-黄腐酸,尿素-重过磷酸钙-氯化钾-酸性混合物(黄腐酸+腐植酸)中氨损失明显地减少,减少率由12.92%、20.12%、25.94%达到100%,土壤中的铵态氮也有类似的变化。从所有的处理来看,只有尿素-重过磷酸钙-氯化钾-黄腐酸,尿素-重过磷酸钙-氯化钾-酸性混合物(腐植酸+黄腐酸)明显地积累了土壤中可利用硝态氮,这一结果与本研究中pH值的结果一致。结论:尿素、重过磷酸钙、氯化钾中混合腐植酸或者酸性的腐植酸和黄腐酸混合物能够显著减少氨损失。这项研究结果有助于提高尿素中N,P,K使用的有效性,同时减少环境污染。 | Shamsuddin Rosliza Osumanu Haruna Ahmed Nik Muhamad Ab.Majid 张丽娜 宋丽艳 | 2010 | 腐植酸2010，，2： | 2 |
| 11 | 有机氮肥对马来西亚沙捞越州酸性土壤玉米干物质产量及铵态氮和硝态氮含量的影响显示文摘腐殖质中的腐植酸和黄腐酸可以提高土壤中可交换性铵(NH4+)的回收率。这两种酸固定和保持NH4+的能力已经在许多研究中得到了证实,二者通过提高植株的光合作用速率、促进根系发育影响植物的生长和养分吸收。因此,本研究调查了这两种酸(液态)对玉米干物质产量、土壤铵态氮和硝态氮(NO3-)含量的影响。根据液态有机氮肥的组成,采用标准方法分离提纯腐植酸。有机氮肥在玉米种植后第10天、第28天分别施入盆栽土壤,然后在种植后第54天或孕穗期采集植株和土壤样品。土壤样品分析pH、铵态氮和硝态氮含量,植株样品测定干物质产量。结果表明,在酸性条件下,液态有机氮肥(黄腐酸、腐植酸或二者同时施用)的施用可以提高土壤中NH4+的累积量。随土壤活性碳储量的增加,腐植酸分子上羧基官能团对土壤NH4+的吸附能力增强。然而,酸含量较低时对干物质产量的影响明显减小。各处理间硝态氮的有效性没有达到统计上的差异显著水平。较低的pH值能抑制土壤硝化作用进程,同时降低土壤NO3-含量。这表明液态腐植酸和/或黄腐酸在提高尿素利用效率方面发挥着重要作用。然而,与腐植酸分子特性有关的作用机理还需要进一步详细研究。本研究为液态和叶面有机肥料的发展提供一定的依据。 | Susilawati Kasim Osumanu Haruna Ahmed Nik Muhamad Ab.Majid Mohd Khanif Yusop Mohamadu Boyie Jalloh 王艳群 孙志梅 | 2011 | 腐植酸2011，，2： | 2 |
| 12 | SATVPC:Secure-agent-based trustworthy virtual private cloud model in open computing environments显示文摘Private clouds and public clouds are turning mutually into the open integrated cloud computing environment,which can aggregate and utilize WAN and LAN networks computing,storage,information and other hardware and software resources sufficiently,but also bring a series of security,reliability and credibility problems.To solve these problems,a novel secure-agent-based trustworthy virtual private cloud model named SATVPC was proposed for the integrated and open cloud computing environment.Through the introduction of secure-agent technology,SATVPC provides an independent,safe and trustworthy computing virtual private platform for multi-tenant systems.In order to meet the needs of the credibility of SATVPC and mandate the trust relationship between each task execution agent and task executor node suitable for their security policies,a new dynamic composite credibility evaluation mechanism was presented,including the credit index computing algorithm and the credibility differentiation strategy.The experimental system shows that SATVPC and the credibility evaluation mechanism can ensure the security of open computing environments with feasibility.Experimental results and performance analysis also show that the credit indexes computing algorithm can evaluate the credibilities of task execution agents and task executor nodes quantitatively,correctly and operationally. | 徐小龙 涂群 BESSIS Nik 杨庚 王新珩 | 2014 | Journal of Central South University2014，21，8： | 2 |
| 13 | Spatial and temporal variation in soil respiration in a Southeast Asian tropical rainforest显示文摘 | Yoshiko Kosugi Tomonori Mitani Masayuki Itoh Shoji Noguchi Makoto Tani Naoko Matsuo Satoru Takanashi Shinjiro Ohkubo Abdul Rahim Nik | 2007 | Agricultural and Forest Meteorology2007，，1： | 2 |
| 14 | In situ biosynthesized silver nanoparticle-incorporated synthesized zeolite A using Orthosiphon aristatus extract for in vitro antibacterial wound healing显示文摘The capability of synthesized zeolite A(SZ)to immobilize Ag ions(Ag-SZ)and Ag nanoparticles(AgNp-SZ)were comparatively studied.A novel approach of in situ biosynthesized AgNP-incorporated synthesized zeolite A(AgNp-SZ)was synthesized at an optimum volume of 0.4mL of the Orthosiphon aristatus(O.aristatus)leaves plant extract(5%)using an in situ approach.In comparison,Ag-Sz was produced by loading the synthesized zeolite with Ag ions.All synthesized materials were characterized for their morphologies and physicochemicalproperties.The characterization analysesvalidate thathe biosynthesized AgNP(<100 nm)using O.aristatus leaves extract was incorporated into the zeolite A.The antibacterial testing confirmed that these materials have antibacterial activity against Escherichia coliATCC11229 and Staphylococcus aureus ATCC 6538.MIC/MBC analysis demonstrated that in 0.9%saline solution,AgNP-SZ had higher antibacterial activity than Ag-Sz.The in vitro cell viability and migration assays were further examined towards human skin fibroblast cells HSF 1184.Results show that the materials are not cytotoxicto HSF1184,and the biosynthesized AgNP-SZ promotes cell migration and proliferation higher than Ag-SZ.This research proved that the biocompatible antibacterial wound healing agent of AgNP-SZ can be synthesized using an in situ approach where the reduction process of Ag ions in the zeolite Acan be performed using plant extract. | Muhammad Hariz Asraf Nor Suriani Sani Craig Denver Williams Khairunadwa Jemon Nik Ahmad Nizam Nik Maliek | 2022 | Particuology2022，20，8： | 2 |
| 15 | Markov Chain Modelling of Reliability Analysis and Prediction under Mixed Mode Loading显示文摘The reliability assessment for an automobile crankshaft provides an important understanding in dealing with the design life of the component in order to eliminate or reduce the likelihood of failure and safety risks.The failures of the crankshafts are considered as a catastrophic failure that leads towards a severe failure of the engine block and its other connecting subcomponents.The reliability of an automotive crankshaft under mixed mode loading using the Markov Chain Model is studied.The Markov Chain is modelled by using a two-state condition to represent the bending and torsion loads that would occur on the crankshaft.The automotive crankshaft represents a good case study of a component under mixed mode loading due to the rotating bending and torsion stresses.An estimation of the Weibull shape parameter is used to obtain the probability density function,cumulative distribution function,hazard and reliability rate functions,the bathtub curve and the mean time to failure.The various properties of the shape parameter is used to model the failure characteristic through the bathtub curve is shown.Likewise,an understanding of the patterns posed by the hazard rate onto the component can be used to improve the design and increase the life cycle based on the reliability and dependability of the component.The proposed reliability assessment provides an accurate,efficient,fast and cost effective reliability analysis in contrast to costly and lengthy experimental techniques. | SINGH Salvinder ABDULLAH Shahrum NIK MOHAMED Nik Abdullah MOHD NOORANI Mohd Salmi | 2015 | Chinese Journal of Mechanical Engineering2015，28，2： | 2 |
| 16 | 成为一名网络志愿者显示文摘我曾在本地一家儿童收容所当志愿者,在它的宿舍和义卖商店帮忙。这使我意识到,我想了解其他的志愿工作机会,以及如何参与到非营利组织和慈善机构当中。 | Nik Kellet 海月 | 2013 | 疯狂英语(初中天地)2013，，12： | 2 |
| 17 | The History of Saffron in China:From Its Origin to Applications显示文摘Saffron(Stigma Croci)is an autumn-flowering perennial plant,and its use has a history of over 3500 years.Saffron has often been considered as the costliest medicinal plant,a premium spice,and the best dye with a golden yellowish color.Iran currently produces the finest quality saffron and dominates its global production(>90%).Other countries such as Australia,Canada,the USA,China,and some countries in Central Africa,produce saffron at a lower yield.In China,saffron is celebrated as“red gold”owing to the red stigmas of the flower and its price,which is comparable to the price of gold.Saffron has been one of the most attractive traditional Chinese medicine(TCM)herbs in the Zhong Guo Yao Dian(《中国药典》Chinese Pharmacopoeia)since its inclusion in the 2005 edition.The earliest use of saffron in TCM was recorded in the Ben Cao Shi Yi(《本草拾遗》Supplement to Materia Medica)written during the Tang dynasty(741 A.D.).However,saffron grown in inland China has been widely mistaken as originating from Tibet.This is because its Chinese name begins with“Xi”or“Zang,”which sounds similar to its Tibetan name(“Xi Zang”).In this review,we clarify the origin of saffron and its introduction to China and summarize its various applications. | Rong-Chen Dai Wan Najbah Nik Nabil Hong-Xi Xu | 2021 | Chinese Medicine and Culture2021，4，4： | 2 |
| 18 | Risk Assessment of Metal Contamination in Soil and Groundwater in Asia: A Review of Recent Trends as well as Existing Environmental Laws and Regulations显示文摘Asia is experiencing a more rapid economic growth compared to any other regions. The contamination of soil and groundwater with metals can mainly be attributed to human activities; therefore, risk assessments to characterize the nature and magnitude of risks to humans and ecological receptors from contaminants are important. Risk assessments are often iterative processes, which involve identification and filling data gap. Experimental samplings, geostatistical and multivariate statistical methods as well as multimedia risk assessment modeling are the three major methodologies used in the assessment of metal contamination in soil and groundwater.This review highlights a number of measurements for improving risk calculation methods and expounds scientific approaches that involve the identification of the major source of contamination, exposure pathways and bioavailability of metals. In general, risk assessments of metals in soil and groundwater worldwide are mainly focused on the levels of contamination, identification of exposure pathways, and prediction of the probability of contamination. To date, very limited studies have reported the development of relevant environmental laws and policies in the regulation of soil and groundwater contamination in Asia. The development, variations and limitations in the regulations of soil and groundwater contamination among developed countries may provide helpful guidance for the developing countries in Asia. | Tianlik TEH Nik Abdul Rahman NIK NORULAINI Mohammad SHAHADAT Yoonsing WONG Abdul Kadir MOHD OMAR | 2016 | Pedosphere2016，26，4： | 2 |
| 19 | Genetically engineered organisms for bioremediation of pollutants in contaminated sites显示文摘Environmental pollution is a major problem which affects biodiversity,public health and ecosystems worldwide.This issue cannot currently be solved using conventional technology because these treatments are expensive,ineffective and time consuming.Conventional methods focus unduly on the separation,rather than the destruction of contaminants.The use of genetically engineered organisms for bioremediation would be an environmentally-friendly and cost-effective alternative for the management and remediation of pollutants in contaminated sites.Different types of genetically engineered microbes have been developed through recombinant DNA and RNA technologies,these have been utilized for the removal of heavy metals and toxic substances from contaminated sites.Transgenic plants can also mobilize or degrade chlorinated solvent,xenobiotic compounds,explosives and phenolic substances.A symbiotic relationship between genetic engineered microbes and transgenic plants can enhance the effectiveness of bioremediation of contaminated sites.This review examines recent developments in the use of genetically engineered microbes and transgenic plants for the bioremediation of contaminated sites.This review will also identify the environmental factors which influence bioremediation by genetically engineered microbes and transgenic plants as well as suggesting future directions for research in these areas. | Md.Abul Kalam Azad Latifah Amin Nik Marzuki Sidik | 2014 | Chinese Science Bulletin2014，59，8： | 2 |
| 20 | An investigation into the effects of particle texture,water content and parallel plates' diameters on rheological behavior of fine sediment显示文摘Siltation,a phenomenon resulted from the presence of fine particles in an aqueous environment,dominated by silt and clay,is a known and common environmental issue worldwide.The accumulation of fine sediments engenders murky water with low oxygen levels,which leads to the death of aquatic life.Thus,investigating the physical and mechanical properties of fine sediment by rheological methods has expanded.Rheology is the science of deformation and flow of matter in stress.This survey investigates the rheological behavior of six samples of soil as the fine particles structure(D < 63 μm) from different regions of Malaysia by using a rotational rheometer with a parallel-plate measuring(using two sizes:25 mm and 50 mm) device to explore the flow and viscoelastic properties of fine particles.The samples were examined in two rheological curve and amplitude sweep test methods to investigate the effect of water content ratio,texture,and structure of patticles on rheological properties.It was found that the content of fine sand,clay,and silt had an effect on the stiffness,structural stability,and shear behavior.Thus,the pseudoplastic and viscoelastic behaviot are respectively shown.Moreover,the amount of fine sediments present in water i.e.the concentration of these particles,has a direct effect on the rheological curve.A reduction in viscosity of samples with higher concentrations of water has been observed.As a consequence,a considerable quantity of fine sediments are distributed within the water body and remain suspended over the time.As a result,the sedimentation rate slows down.It needs to be asserted that the stotage modulus G′,loss modulus G″,and yield point can vary depending on particle type.The G′ and G″were instigated for samples(70%and 45%concentrations) that demonstrated viscoelastic characteristics using the same rotational rheometer with a parallel-plate measuring device. | Masoumeh Moayeri Kashani Lai Sai Hin Shaliza Binti Ibrahim Nik Meriam Binti Nik Sulaiman Fang Yenn Teo | 2016 | International Journal of Sediment Research2016，31，2： | 2 |
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