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| 1 | Survival factors after resection of small hepatocellular carcinoma显示文摘Early resection of hepatocellular carcinoma is a key measure to prolong the survival of patients. This study was designed to summarize our experience in surgical resection of small hepatocellular carcinoma (HCC), and to analyze the factors influencing the postoperative survival of patients. METHODS:The clinicopathologic data of 105 patients with small HCC after resection from 1986 through 2003 were analyzed ; the patients had been followed up for more than half a year (median 33 months). Nine clinicopathologic factors, preoperative α-fetoprotein (AFP) level, liver cirrhosis, Child-Pugh score, tumor size (>2cm vs.≤2 cm) and number (single vs. multiple), capsule formation, portal vein tumor thrombi (PVTT), Edmondson tumor grade and surgical method, were analyzed by the log-rank test and the Cox proportional harzards model analysis. RESULTS:The cumulative 1-,3- and 5-year survival rates after the operation were 86.5%, 70.3% and 55.2%, respectively, and the 1-, 3- and 5-year disease-free survival rates were 78%, 58. 9% and 45. 6%, respectively. One patient died from esophagogastric varices hemorrhage in 2 weeks after reoperation. Thirty-six patients had intrahepatic recurrence or metastasis postoperatively and 34 patients died. The Kaplan-Meier method and the Cox proportional harzards model analysis indicated that poor Child-Pugh score, tumor more than 2 cm in diameter, PVTT and multiple lesions (including satellitic lesions) were adverse factors affecting postoperative survival. The Cox proportional harzards model analysis indicated that tumor size, PVTT and multiple lesions were the factors influencing postoperative disease-free survival. CONCLUSIONS:Limited hepatectomy with a margin more than 1 cm is an appropriate surgical approach. Adverse preoperative Child-Pugh score and postoperative intrahepatic recurrences are the main factors leading to the death of patients with small HCC. | Departments of Surgical Oncology (Wu FS, Zhao WH, Ma ZM, Teng LS and Wang M) and General Surgery ( Liang TB and Zheng SS) , First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 5 |
| 2 | 急性心肌缺血综合征中国地区现状调查显示文摘目的研究分析中国地区急性心肌缺血综合征病人的临床特点和治疗现状.方法此项研究为国际多中心关于急性心肌缺血综合征登记试验(OASIS)的一部分.采用填写加拿大心血管合作协会统一设计的病例记录表(CRF)的方法,自1999年4月开始,收集了各中心因急性心肌缺血入院病人的资料,记录了病人主要临床特征和院内事件.结果共注册急性心肌缺血综合征(包括不稳定心绞痛及非Q波心肌梗死)病人1509例,来自全国范围内34所医院.病人平均年龄62.3岁,其中男性62.2%,就诊时持续胸痛47.8%,心电图异常89.5%,入院诊断不稳定心绞痛91.3%,非Q波心肌梗死8.7%.住院期间溶栓3.3%,冠状动脉造影35.0%,经皮冠状动脉腔内成形术(PTCA)16.8%,冠状动脉旁路移植术(CABG)4.1%,应用硝酸酯制剂96.8%,抗血小板治疗95.5%.院内发生重要并发症18.8%,其中死亡1.2%,主要原因为严重心律失常或猝死.结论中国地区急性心肌缺血病人以不稳定心绞痛就诊居多.我国病人住院期间PTCA治疗率相对较高,CABG治疗率较低.院内死亡最主要的原因为严重心律失常或猝死. | 无 Tan HQ Liang Y Zhu J Liu LS Cronin L | 2002 | Chinese Medical Journal2002，，8： | 3 |
| 3 | Methotrexate loaded poly(L-lae-tic acid)microspheres for intra articular delivery of methotrexate to the joint 显示文摘 | Liang LS Jackson J Min WX | 2004 | Pharmaceutical Sciences2004，93，4： | 1 |
| 4 | Methotrexate loaded poly (L-lactic acid) microspheres for intra-articular deliv- ery of methotrexate to the joint显示文摘 | Liang LS Jackson J Min W | 2004 | J Pharm Sci2004，93，4： | 1 |
| 5 | Conservative treatment of thoracolumbar burst fractures: a long-term follow-up results with special reference to the load sharing classification显示文摘 | Dai LY liang LS liang SO | 2008 | Spine (Phila Pa 1976)2008，33，23： | 1 |
| 6 | Cage subsidence doesnot, but cervical lordosis improvement dose affect the long-term results of anterior cervical fusion with stand- alone cage for degenerative cervical disc disease:a ret- rospective study显示文摘 | Wu WJ Jiang LS Liang Y | 2012 | Eur Spine J2012，21，7： | 1 |
| 7 | Cage subsidence does not, but cervical lordosis improvement does affect the long-term results of anterior cervical fusion with stand-alone cage for degenerative cervical disc disease: a retrospective study 显示文摘 | Wu WJ Jiang LS Liang Y | 2012 | Eur Spine J2012，21，7： | 1 |
| 8 | Methotrexate loaded poly(L-lactic acid)microspheres for intra-articular delivery of methotrexate to the joint显示文摘 | Liang LS Jackson J Min W | 2004 | J Pharm Sci2004，93，4： | 1 |
| 9 | Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-κB oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig显示文摘 | Bonham CA Peng LS Liang XY | 2002 | J Immunol2002，169，： | 1 |
| 10 | Methotrexate loaded po- ly(L-lactic acid) microspheres for intra-artieular delivery of methotrexate to the joint显示文摘 | Liang LS Jackson JK Min W etal | 2004 | J Pharm Sci2004，93，： | 1 |
| 11 | Pharmacokinetic study of methotrexate following intra-articular injection of methotrexate loaded poly(L lactic acid) microspheres in rabbits显示文摘 | Liang LS Wong W Burt HM | 2005 | J Pharm Sci2005，94，： | 1 |
| 12 | Dehydroepiandrosterone induces apoptosis of thymocyte through Fas/Fas-L pathway显示文摘 | Liang J Yao GH Yang LS | 2004 | Int Immunopharmacol2004，4，12： | 1 |
| 13 | Ultra-large gain step-up switched-capacitor DC-DC converter with coupled inductor for alternative sources of energy 显示文摘 | Liang T J Chen S M Yang LS | 2012 | IEEE Trans Circuits Syst2012，59，4： | 1 |
| 14 | Cage subsidence does not, but cervical lordosis improvement does affect the long-term results of anterior cervical fusion with stand-alone cage for degenerative cervical disc disease, a retrospective study显示文摘 | Wu WJ Jiang LS Liang Y | 2012 | Eur Spine J2012，21，7： | 1 |
| 15 | Development and characterizationof SSR markers in Chinese jujube {Ziziphus jujuba Mill) and itsrelated species显示文摘 | QH Ma GX Wang LS Liang | 2011 | Scientia Horticulturae2011，129，： | 1 |
| 16 | The encapsulation of ribozymes in biodegradable polymeric matrices 显示文摘 | JACKSON JK LIANG LS HUNTER WL | 2002 | Int J Pharm2002，243，12： | 1 |
| 17 | Dehydroepiandrosterone induces apoptosis of thymocyte through Fas/FasL pathway显示文摘 | Liang J Yao GH Yang LS | 2004 | Int Immunopharmacol2004，4，： | 1 |
| 18 | Intra-articular treatment of inflammatory arthritis with microsphere formulations of methotrexate : pharmacokineties and efficacy determination in antigen-induced arthritic rabbits显示文摘 | Liang LS Salo PT Hart DA | 2009 | Inflamm Res2009，58，8： | 1 |
| 19 | Intra-articular treatment of inflammatory arthritis with microsphere formulations of methotrexate:Pharmacokinetics and efficacy determination in antigeninduced arthritic rabbits显示文摘 | Liang LS Salo PT Hart DA | | 0，，08： | 1 |
| 20 | Cage subsidence does not, but cervical lordosis im- provement does affect the long - term results of anterior cervical fusion with stand - alone cage for degenerative cervical disc disease: a retro- spective study 显示文摘 | Wu W J Jiang LS Liang Y | 2012 | Eur Spine J2012，21，7： | 1 |
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