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| 1 | Oxidative stress and nitric oxide in rats with alcohol-induced acute pancreatitis显示文摘AIM: Oxygen free radical mediated tissue damage is well established in pathogenesis of acute pancreatitis (AP).Whether nitric oxide (NO) plays a deleterious or a protective role is unknown. In alcohol-induced AP, we studied NO, lipooxidative damage and glutathione in pancreas, lung and circulation.METHODS: AP was induced in rats (n = 25) by injection of ethyl alcohol into the common biliary duct. A sham laparatomy was performed in controls (n = 15). After 24 h the animals were killed, blood and tissue sampling were done.RESULTS: Histopathologic evidence confirmed the development of AP. Marked changes were observed in the pulmonary tissue. Compared with controls, the AP group displayed higher values for NO metabolites in pancreas and lungs, and thiobarbituric acid reactive substances in circulation. Glutathione was lower in pancreas and in circulation. Glutathione and NO were positively correlated in pancreas and lungs of controls but negatively correlated in circulation of experimental group. In the experimental group, plasma thiobarbituric acid reactive substances were negatively correlated with pancreas thiobarbituric acid reactive substances but positively correlated with pancreas NO.CONCLUSION: NO increases in both pancreas and lungs in AP and NO contributes to the pathogenesis of AP under oxidative stress. | Gülnur Andican Remisa Gelisgen Ethem Unal Osman Baran Tortum Sergülen Dervisoglu Tayfun Karahasanoglu Gülden Bur(?)ak | 2005 | World Journal of Gastroenterology2005，11，15： | 18 |
| 2 | 伪狂犬病防制的最新进展显示文摘 | Lens,S 冯敏燕 | 1990 | 国外兽医学(畜禽传染病)1990，10，1： | 17 |
| 3 | Gut bless you:The microbiota-gut-brain axis in irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a common clinical label for medically unexplained gastrointestinal symptoms,recently described as a disturbance of the microbiota-gut-brain axis.Despite decades of research,the pathophysiology of this highly heterogeneous disorder remains elusive.However,a dramatic change in the understanding of the underlying pathophysiological mechanisms surfaced when the importance of gut microbiota protruded the scientific picture.Are we getting any closer to understanding IBS’etiology,or are we drowning in unspecific,conflicting data because we possess limited tools to unravel the cluster of secrets our gut microbiota is concealing?In this comprehensive review we are discussing some of the major important features of IBS and their interaction with gut microbiota,clinical microbiota-altering treatment such as the low FODMAP diet and fecal microbiota transplantation,neuroimaging and methods in microbiota analyses,and current and future challenges with big data analysis in IBS. | Eline Margrete Randulff Hillestad Aina van der Meeren Bharat Halandur Nagaraja Ben RenéBjørsvik Noman Haleem Alfonso Benitez-Paez Yolanda Sanz Trygve Hausken Gülen Arslan Lied Arvid Lundervold Birgitte Berentsen | 2022 | World Journal of Gastroenterology2022，28，4： | 15 |
| 4 | Effect of harmless acute pancreatitis score, red cell distribution width and neutrophil/lymphocyte ratio on the mortality of patients with nontraumatic acute pancreatitis at the emergency department显示文摘BACKGROUND: Harmless acute pancreatitis score(HAPS), neutrophile/lymphocyte ratio and red blood cell distribution width(RDW) are used to determine the early prognosis of patients diagnosed with nontraumatic acute pancreatitis in the emergency department(ED).METHODS: Patients diagnosed with acute pancreatitis(K 85.9) in the ED according to the ICD10 coding during one year were included in the study. Patients with chronic pancreatitis and those who had missing data in their files were excluded from the study. Patients who did not have computed tomography(CT) in the ED were not included in the study.RESULTS: Ultimately, 322 patients were included in the study. The median age of the patients was 53.1(IQR=36–64). Of the patients, 68.1%(n=226) had etiological causes of the biliary tract. The mortality rate of these patients within the first 48 hours was 4.3%(n=14). In the logistic regression analysis performed by using Balthazar classification, HAPS score, RDW, neutrophile/lymphocyte ratio, age, diabetes mellitus and systolic blood pressure, the only independent variable in determining mortality was assigned as Balthazar classification(OR: 15; 95% CI: 3.5 to 64.4).CONCLUSIONS: HAPS, neutrophile/lymphocyte ratio and RDW were not effective in determining the mortality of nontraumatic acute pancreatitis cases within the first 48 hours. The only independent variable for determining the mortality was Balthazar classifi cation. | Bedia Gülen Ertan Sonmez Serpil Yaylaci Mustafa Serinken Cenker Eken Ali Dur Figen Tunali Turkdogan ?zgür S?güt | 2015 | World Journal of Emergency Medicine2015，6，1： | 13 |
| 5 | Sonography of the small intestine显示文摘In the last two decades, there has been substantial development in the diagnostic possibilities for examining the small intestine. Compared with computerized tomography, magnetic resonance imaging, capsule endoscopy and double-balloon endoscopy, ultrasonography has the advantage of being cheap, portable, flexible and user-and patient-friendly, while at the same time providing the clinician with image data of high temporal and spatial resolution. The method has limitations with penetration in obesity and with intestinal air impairing image quality. The flexibility ultrasonography offers the examiner also implies that a systematic approach during scanning is needed. This paper reviews the basic scanning techniques and new modalities such as contrast-enhanced ultrasound, elastography, strain rate imaging, hydrosonography, allergosonography, endoscopic sonography and nutritional imaging, and the literature on disease-specific findings in the small intestine. Some of these methods have shown clinical benefit, while others are under research and development to establish their role in the diagnostic repertoire. However, along with improved overall image quality of new ultrasound scanners, these methodshave enabled more anatomical and physiological changes in the small intestine to be observed. Accordingly, ultrasound of the small intestine is an attractive clinical tool to study patients with a range of diseases. | Kim Nylund Svein Фdegaard Trygve Hausken Geir Folvik Gülen Arslan Lied Ivan Viola Helwig Hauser Odd-Helge Gilja | 2009 | World Journal of Gastroenterology2009，15，11： | 9 |
| 6 | Is increased red cell distribution width an indicating marker of nonalcoholic steatohepatitis and fibrotic stage?显示文摘AIM:To evaluate the red cell distribution width(RDW)as an indicator of the presence of non-alcoholic steatohepatitis(NASH)and its association with fibrotic scores.METHODS:A retrospective study was carried out that included sixty-two biopsy proven NASH,32 simple steatosis patients and 30 healthy controls.The correlation between the clinical and histopathological features of NASH patients and RDW values was evaluated.Liver fibrosis scores were measured using a 0 to 4 point scale and were divided in to two groups;fibrosis scores0-1 were termed mild and fibrosis scores 2-4 were termed advanced fibrosis.RDW values were compared between NASH,simple steatosis and healthy controls.Univariate and multivariate analyses were performed to evaluate the independent predicting factors for the presence of liver fibrosis caused by NASH.RESULTS:Patients with NASH had higher RDW values compared with simple steatosis and healthy control groups[14.28%±0.25%vs 13.37%±0.12%,12.96%±0.14%(P<0.01),respectively].Patients with advanced fibrosis had higher RDW values than the mild fibrosis group(15.86%±0.4%vs 13.63%±0.67%,P<0.01,respectively).RDW also correlated with fibrotic scores(r=0.579 andP<0.01).The variables that were significant in the univariate analysis were evaluated in multivariate logistic regression analysis,and RDW was an independent predicting factor of NASH(OR=1.75,95%CI:1.129-2.711,P<0.05).CONCLUSION:RDW a new non-invasive marker that can be used to demonstrate the presence of NASH and indicate advanced fibrotic scores. | Mustafa Cengiz Burcu Aslan Candir Güldal Yilmaz Gülen Akyol Seren Ozenirler | 2013 | World Journal of Gastroenterology2013，19，42： | 8 |
| 7 | 临床上有显著门静脉高压症的患者口服抗HCV药物治疗后的血流动力学变化及临床结果显示文摘【据Journal of Hepatology 2020年5月报道】题:临床上有显著门静脉高压症的患者口服抗HCV药物治疗后的血流动力学变化及临床结果(作者Lens S等)在使用直接抗病毒药物治疗的丙型肝炎肝硬化患者中,有显著临床意义的门静脉高压症(CSPH,HVPG≥10 mm Hg)在持续病毒学应答(SVR)24周后持续存在。这些患者仍有失代偿的风险。然而,长期配对的临床和血流动力学数据不适用于该人群。 | 武彤 辛桂杰 LENS S BAIGES A ALVARADO E | 2020 | 临床肝胆病杂志2020，36，9： | 8 |
| 8 | 与HBeAg阴性慢性乙型肝炎患者成功停药相关的病毒和免疫因素显示文摘【据Journal of Hepatology 2020年12月报道】与HBeAg阴性慢性乙型肝炎患者成功停药相关的病毒和免疫因素(作者García-López M等)目前,与HBeAg阴性慢性乙型肝炎(CHB)患者成功停用核苷(酸)类似物(NA)治疗的相关因素尚未阐明。为了分析停用NA患者的HBV特异性T淋巴细胞反应以及外周和肝内病毒参数,来自西班牙巴塞罗那大学的García-López等对27例病毒完全抑制(>3年)HBeAg阴性CHB非肝硬化患者进行了前瞻性研究。在基线时定量检测肝内HBV DNA(iHBV DNA)、肝内HBV RNA(iHBV RNA)和共价闭合环状DNA(cccDNA)。此外,在基线和整个随访过程中,对血清标志物(HBV DNA、HBsAg、HBcrAg和HBV RNA)和HBV特异性T淋巴细胞反应进行了分析。 | GARCIA-LOPEZ M LENS S PALLETT LJ 孟方园 高沿航 | 2021 | 临床肝胆病杂志2021，37，2： | 8 |
| 9 | A New Isoflavone Glucoside from Astragalus membranaceus显示文摘A new isoflavone glucoside, 3’-methoxy-5’-hydroxy-isoflavone-7-O-β-D-glucoside, was isolated from the roots of Astragalus membranaceus and its structure waselucidated by spectroscopic data. | Cao, ZZ Cao, Y Yi, YJ Wu, YP Len, ZK Li, D Owen, NL | 1998 | Chinese Chemical Letters1998，9，6： | 4 |
| 10 | Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications. | Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns | 2015 | World Journal of Gastroenterology2015，21，17： | 4 |
| 11 | Automated brain tumor segmentation on multi-modal MR image using SegNet显示文摘The potential of improving disease detection and treatment planning comes with accurate and fully automatic algorithms for brain tumor segmentation.Glioma, a type of brain tumor, can appear at different locations with different shapes and sizes. Manual segmentation of brain tumor regions is not only timeconsuming but also prone to human error, and its performance depends on pathologists’ experience. In this paper, we tackle this problem by applying a fully convolutional neural network SegNet to 3 D data sets for four MRI modalities(Flair, T1, T1 ce, and T2)for automated segmentation of brain tumor and subtumor parts, including necrosis, edema, and enhancing tumor. To further improve tumor segmentation, the four separately trained SegNet models are integrated by post-processing to produce four maximum feature maps by fusing the machine-learned feature maps from the fully convolutional layers of each trained model. The maximum feature maps and the pixel intensity values of the original MRI modalities are combined to encode interesting information into a feature representation.Taking the combined feature as input, a decision tree(DT) is used to classify the MRI voxels into different tumor parts and healthy brain tissue. Evaluating the proposed algorithm on the dataset provided by the Brain Tumor Segmentation 2017(BraTS 2017)challenge, we achieved F-measure scores of 0.85, 0.81,and 0.79 for whole tumor, tumor core, and enhancing tumor, respectively.Experimental results demonstrate that using SegNet models with 3 D MRI datasets and integrating the four maximum feature maps with pixel intensity values of the original MRI modalities has potential to perform well on brain tumor segmentation. | Salma Alqazzaz Xianfang Sun Xin Yang Len Nokes | 2019 | Computational Visual Media2019，5，2： | 3 |
| 12 | Interval Training Normalizes Cardiomyocyte Function, Diastolic Ca2+ Control, and SR Ca2+ Release Synchronicity in a Mouse Model of Diabetic Cardiomyopathy显示文摘 | Tomas O. St?len Morten Andre H?ydal Ole Johan Kemi Daniele Catalucci Marcello Ceci Ellen Aasum Terje Larsen Natale Rolim Gianluigi Condorelli Godfrey L. Smith Ulrik Wisl?ff | 2009 | Circulation Research2009，，6： | 2 |
| 13 | 澳洲西花蓟马及番茄病毒性萎蔫病显示文摘西花蓟马(Franklienella occidentalis)是传播番茄、马铃薯、芦笋及辣椒病毒性萎蔫病的最主要的害虫之一。西花蓟马喜食辣椒、黄瓜和豆类作物的果实。其嚼食叶片和果实后,留下疤痕或使其畸形,尤其是幼苗和鲜嫩的组织更容易受其侵害。 | Sandra McDougall Len Tesoriero 郭利红 | 2010 | 世界农药2010，32，3： | 2 |
| 14 | High rate sulfate reduction in a submerged anaerobic membrane bioreactor (SAMBaR) at high salinity显示文摘 | Marcus V.G. Vallero Gatze Lettinga Piet N.L. Lens | 2005 | Journal of Membrane Science2005，，1： | 2 |
| 15 | Interferon-Free Regimens in the Liver-Transplant Setting显示文摘 | Sabela Lens Martina Gambato María-Carlota Londo?o Xavier Forns | 2014 | Semin Liver Dis2014，，01： | 2 |
| 16 | Confocal microscopic evaluation of cornea after AquaLase liquefaction cataract extraction显示文摘AIM: The most recent and innovative AquaLase liquefaction technology has offered an alternative to lens extraction.Many studies have investigated its functions and advantages.This article focuses on evaluating the in vivo microscopic cornea changes after AquaLase liquefaction by using a laser confocal microscope.METHODS: In this perspective,randomized case study,37 eyes of 35 patients submitted to cataract surgery were chosen to undergo AquaLase liquefaction cataract extraction.Each patient was assessed before the operation,on the 1st,7th,and 30th postoperative days,and 6 months after the cataract extraction.The morphologies and quantitative comparisons of corneal cells and corneal nerves layer by layer were evaluated in vivo with the Heidelberg Retina Tomograph III-Rostock Cornea Module (HRT-III RCM) confocal microscope.ANOVA and Post-Hoc Bonferroni test were carried out to compare the results preand post-operation.RESULTS: ANOVA results indicated no post-operation changes for epithelium and anterior stroma cells.Irregular segments of sub-basal nerve fiber were most pronounced seven days post-operation.In the mid and posterior stroma,keratocytes were obvious compared with the preoperative condition.Corneal endothelium cells became obviously swollen in cytoplasm and nucleus.The mid and posterior stroma cell density decreased from the 1st to 7th postoperative days (P <0.05).The corneal endothelium cell density decreased (P <0.05) and did not revert to the preoperative level after six months (P <0.05).CONCLUSION: Slight microstructural abnormalities were identified in the corneal recovery process after AquaLase liquefaction.AquaLase liquefaction cataract extraction is safe for cornea. | Jiang-Yue Zhao 1,Ming-Wu Wang 2,Qi Sun 1,Jin-Song Zhang 1 1 Eye Hospital of China Medical University Department of Ophthalmology,the Fourth Affiliated Hospital of China Medical University Provincial Key Laboratory of Lens Research,Liaoning,China 2 Department of Ophthalmology and Vision Science,the University of Arizona,Tucson,Arizona,USA | 2011 | International Journal of Ophthalmology(English edition)2011，4，3： | 2 |
| 17 | EUS-guided fiducial markers placement with a 22-gauge needle for image-guided radiation therapy in pancreatic cancer显示文摘 | Raquel Dávila Fajardo Selma J. Lekkerkerker Astrid van der Horst Eelco Lens Jacques J. Bergman Paul Fockens Arjan Bel Jeanin E. van Hooft | 2013 | Gastrointestinal Endoscopy2013，，： | 2 |
| 18 | 线性稳压器在便携产品中的应用显示文摘 | Len Sherman Darryl Phillips | 2002 | 电子产品世界2002，9，06B： | 2 |
| 19 | Characterization of the human CD27 ligand, a novel member of the TNF gene family显示文摘 | Hintzen RQ Lens SM Beckmann MP | 1994 | J Immunol1994，152，4： | 1 |
| 20 | Cluster structure of anaerobic aggregates of an expanded granular sludge bed reactor显示文摘 | Gonzalez-Gil G Lens P van Aelst AC | 2001 | Appl Environ Microbiol2001，67，8： | 1 |
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