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| 1 | Hepatocellular carcinoma: current management and recent advances显示文摘BACKGROUND: Hepatocellular carcinoma (HCC) is a major health problem worldwide. It is the fifth most common cancer in the world, and the third most common cause of cancer-related death. Without specific treatment, the prognosis is very poor. The goal of management is 'cancer control' - a reduction in its incidence and mortality as well as an improvement in the quality of life of patients with HCC and their families. This article aims to review the current management of HCC and its recent advances. DATA SOURCES: A MEDLINE database search was performed to identify relevant article using the keyworks 'hepatocellular carcinoma', 'hepatectomy', 'liver transplantation', and 'local ablative therapy'. Additional papers and book chapters were identified by a manual search of the references from the key articles. RESULTS: Liver resection and liver transplantation remain the options that give the best chance of a cure. Recent evidence suggests that local ablative therapy may offer comparable survival results in patients with small HCC, and preserved liver function. Transarterial chemoembolization (TACE) is the most promising palliative modality for unresectable HCC, but other techniques, such as transarterial radioembolization (TARE), and local ablative therapy, have also shown comparable results. CONCLUSIONS: Early diagnosis of HCC remains a key goal in improving the prognosis of patients. During the last two decades, operative mortality and surgical outcome of liver resection and liver transplantation for HCC have improved. Progress also has been made in multi-modality therapy which can increase the chance of survival and improve the quality of life for patients with advanced HCC. | Wan-Yee Lau Eric C. H. Lai | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，3： | 100 |
| 2 | Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation显示文摘AIM: To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 controls.METHODS: Constipation was diagnosed by Rome Ⅱ criteria.Coping ability and anxiety/depression were assessed by validated questionnaires. Transit time and balloon distension test were performed.RESULTS: 34.5% patients were classified as slow transit type of constipation. The total colonic transit time (56 h vs 10 h, P<0.0001) and rectal sensation including urge sensation (79 mL vs 63 mL, P = 0.019) and maximum tolerable volume (110 mL vs95 mL, P = 0.03) differed in patients and controls. Constipated subjects had significantly higher anxiety and depression scores and lower SF-36 scores in all categories. They also demonstrated higher scores of'monitoring' coping strategy (14+6 vs9+3, P = 0.001),which correlated with the rectal distension sensation (P = 0.005), urge sensation (P=0.002), and maximum tolerable volume (P = 0.035). The less use of blunting strategy predicted slow transit constipation in both univariate (P = 0.01) and multivariate analysis (P = 0.03).CONCLUSION: Defective or ineffective use of coping strategies may be an important etiology in functional constipation and subsequently reflected in abnormal anorectal physiology. | Annie OO Chan Cecilia Cheng Wai Mo Hui Wayne HC Hu Nina YH Wong KF Lam Wai Man Wong Kam Chuen Lai Shiu Kum Lam Benjamin CY Wong | 2005 | World Journal of Gastroenterology2005，11，34： | 92 |
| 3 | 恩替卡韦与拉米夫定治疗HBeAg阴性慢性乙型肝炎的对照研究显示文摘Ⅱ期临床试验已经证实恩替卡韦是一种治疗HBeAg阴性慢性乙型肝炎有效和可选择的抗病毒药物。采用双盲法将648例未曾接受过核苷类药物治疗的HBeAg阴性慢性乙型肝炎随机分配进入恩替卡韦(0.5mg/d)治疗组或拉米夫定(100mg/d)治疗组,疗程至少52wk。 | Lai CL Shouval D Lok AS 陈楠(摘译) 张占卿(审校) | 2006 | 世界感染杂志2006，6，4： | 197 |
| 4 | Characterizing ionic species in PM_(2.5) and PM_(10) in four Pearl River Delta cities,South China显示文摘PM2.5 和 PM10 样品在珍珠河三角洲(PRD ) 在四个主要城市被收集,华南,在在 2002 的冬季和夏天期间。六个水溶性的离子, Na (+) , NH4 (+) , K (+) , Cl (?) , NO3 (?) 和 SO4 (2 ?) 用离子层析被测量。平均,离子的种类为 PM2.5 和 PM10 占了 53.3% 和 40.5% ,分别地在冬季并且 39.4% 和 35.2% ,分别地在里面夏天。象硫酸盐,硝酸盐和铵那样的第二等的离子说明了全部的离子的种类的主要部分。硫酸盐是硝酸盐跟随的最丰富的种类。总的来说,一个地区性的污染趋势被看那有另外的 PRD 城市里的比那些的广州城市里的硫酸盐,硝酸盐和铵的更高的集中。重要季节变化也在冬季与种类的高水平被观察,但是在夏天降低。当高度本地工业排出物装载趋于败坏时,亚洲季风系统为在在夏天的 PRD 的空气污染物的移动和散开是有利的空气质量也。NO3 (?)/SO4 (2 )(?) 比率显示活动来源更加有贡献到城市的喷雾器,并且静止来源不应该被忽视。除主要排出物以外,在有利天气条件下面的复杂大气的反应应该在 PRD 区域为主要排放的控制被付更多的注意。 | LAI Sen-chao ZOU Shi-chun CAO Jun-ji LEE Shun-cheng HO Kin-fai | 2007 | Journal of Environmental Sciences2007，19，8： | 76 |
| 5 | Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis显示文摘 | Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang | 2016 | Chinese Medical Journal2016，，7： | 64 |
| 6 | 5-methylcytosine promotes mRNA export--NSUN2 as the methyltransferase and ALYREF as an m5C reader显示文摘 | Yang, Xin Yang, Ying Sun, Bao-Fa Chen, Yu-Sheng Xu, Jia-Wei Lai, Wei-Yi Li, Ang Wang, Xing Bhattarai, Devi Prasad Xiao, Wen Sun, Hui-Ying Zhu, Qin Ma, Hai-Li Adhikari, Samir Sun, Min Hao, Ya-Juan Zhang, Bing Huang, Chun-Min Huang, Niu Jiang, Gui-Bin Zhao, Yong-Liang Wang, Hai-Lin Sun, Ying-Pu Yang, Yun-Gui | 2017 | Cell Research2017，27，5： | 62 |
| 7 | New geological evidence of crustal thickening in the Gangdese block prior to the Indo-Asian collision显示文摘Recent mapping in the Gangdese block has revealed many leucogranites that are similar to those in the High Himalaya. These leucogranites formed at ~140 Ma as indicated by monazite Th-Pb ion-microprobe dating and cooled at ~130 Ma as indicated by muscovite 40Ar/39Ar dating. In conjunction with previous structural and paleogeographic studies, the new data indicate that the Gangdese block underwent crustal thickening and associated exhumation during ~140-130 Ma. In this regard, the southern margin of Eurasia continent was comparable to the modern South American Altiplano-Puna plateau, the prime example of active ocean-continent subduction and associated thickened crust. Specifically, the early stages of crustal thickening and uplifting of the Gangdese block may result from subduction of the Neo-Tethyan Ocean. If the Tibetan Plateau would form by accretion of a series of blocks with thickened crust, an elevated topographic plateau similar to the Altiplano- Puna plateau had formed before collision between the Indian and Eurasian plates. Then the Tibetan Plateau would have quickly thickened, uplifted, and begun to extend soon after onset of the collision. Thus, the deformational mechanism of the Tibetan Plateau is not distributed shortening, but rather concentrating deformation within regions of thin crust between the accreted blocks. | DING Lin & LAI Qingzhou Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China Correspondence should be addressed to Ding Lin (e-mail: dinglin@ mail.igcas.ac.cn) | 2003 | Chinese Science Bulletin2003，48，15： | 73 |
| 8 | Mianlüe tectonic zone and Mianlüe suture zone on southern margin of Qinling-Dabie orogenic belt显示文摘The Mianle tectonic zone (Mianle zone), an ancient suture zone in addition to the Shangdan suture in the Qinling-Dabie orogenic belt, marks an important tectonic division geo-logically separating north from south and connecting east with west in China continent. To de-termine present structural geometry and kinematics in the Mianle tectonic zone and to recon-struct the formation and evolution history involving plate subduction and collision in the Qinling-Dabie orogenic belt, through a multidisciplinary study, are significant for exploring the mountain-building orogenesis of the central orogenic system and the entire process of the major Chinese continental amalgamation during the Indosinian. | ZHANG Guowei1, DONG Yunpeng1, LAI Shaocong1, GUO Anlin1, MENG Qingren2, LIU Shaofeng3, CHENG Shunyou1, YAO Anping1, ZHANG Zongqing4, PEI Xianzhi5 & LI Sanzhong6 1. Department of Geology, Northwest University, Xian 710069, China 2. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100101, China 3. Earth Science and Resource Faculty, China University of Geosciences, Beijing 100083, China 4. Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China 5. Changan University, Xian 710054, China 6. Qingdao University of Oceanography, Qingdao 266003, China | 2004 | Science China Earth Sciences2004，47，4： | 57 |
| 9 | Natural history of hepatitis-related hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is an important cause of cancer death in the world.It has great regional differences in the pathology and epidemiology.The variation is greatly influenced by the aetiologies of the disease.Hepatitis B and C infection are the most important risk factors.HCC incidence rates are higher but in decreasing trend in developing countries. However,the figures in the developed countries are contrary.Successful hepatitis B virus(HBV)vaccination programs,better food hygiene,increased global hepatitis C virus(HCV)prevalence and population migration are the possible explanations.A number of clinical and pathogenic differences exist between HBV- and HCV- related HCC.HBV infection leads to the development of HCC through direct and indirect pathways as it has the ability to integrate into the host genome affecting cellular signaling and growth control.HCV causes HCC mainly through indirect pathways:chronic inflammation, cell deaths and proliferation.As a result,HCC is almost exclusively found in cirrhotic HCV patients while HCC is sometimes found in HBV patients without significant liver cirrhosis.Due to the different severities of liver cirrhosis and HCC extent,therapeutic strategies from resection, liver transplantation to symptoms palliation are available. Poorly differentiated histology,lack of fibrous capsule, large tumour size,early vascular invasion and elevated serum levels of alpha fetoprotein(AFP)are the features for more aggressive disease.Combined with markers of liver reserve and performance status,accurate scoring systems and models have been developed to predict patients'survival and match best treatment option. | David Yiu-Kuen But Ching-Lung Lai Man-Fung Yuen | 2008 | World Journal of Gastroenterology2008，14，11： | 56 |
| 10 | Dual function of Arabidopsis A TAF1 in abiotic and biotic stress responses显示文摘NAC 家庭基因编码涉及多样的生物过程的植物特定的抄写因素。在这研究, Arabidopsis NAC 基因 ATAF1 被发现被干旱导致,高咸度, abscisic 酸(骆驼毛的织物) ,甲基 jasmonate,机械伤害,并且 Botrytis cinerea 感染。ATAF1 的重要正式就职在受到干旱或高咸度的骆驼毛的织物缺乏的变异的 aba2 被发现,揭示表示的骆驼毛的织物无关的机制。Arabidopsis ATAF1-overexpression 线显示了许多改变的显型,包括侏儒症和短主要的根。而且,在 vivo,实验显示 ATAF1 是真正的管理者 modulating 植物对许多不能生活的压力和 necrotrophic 病原体感染的回答。在 Arabidopsis 的 ATAF1 的 Overexpression 增加了植物敏感到骆驼毛的织物,盐,和氧化压力。特别, ATAF1 overexpression 种,然而并非异种排队显示出的显著地提高的植物忍耐到干旱。另外, ATAF1 overexpression 提高了植物危险性到 necrotrophic 病原体 B。cinerea,但是没改变 P 的无毒害或剧毒的紧张引起的疾病症状。syringae pv 西红柿 DC3000。转基因的植物 overexpressing ATAF1 对氧化应力过分敏感,建议反应的氧中介可能与响应病原体和不能生活的压力的调停 ATAF1 的发信号有关。 | Yaorong Wu Zhiyong Deng Jianbin Lai Yiyue Zhang Cuiping Yang Bojiao Yin Qingzhen Zhao Ling Zhang Yin Li Chengwei Yang Qi Xie | 2009 | Cell Research2009，19，11： | 56 |
| 11 | Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing显示文摘COVID-19,caused by SARS-CoV-2[1,2],has been contained in China through stringent non-pharmaceutical interventions.Border control and quarantine have effectively prevented the virus from being spread by infected travellers,but the risk of resurgence caused by other routes of introduction and transmission remains unclear,and current strategies to prevent resurgence could be flawed.Since July,SARS-CoV-2 RNA contaminations in frozen food imported from countries with ongoing epidemics have been reported in nine provinces in China[3,4].However,there is no robust evidence of COVID-19 outbreaks initiated by environmentto-human transmission.Here we add to evidence of such transmission by investigating the recent COVID-19 resurgence in Beijing. | Xinghuo Pang Lili Ren Shuangsheng Wu Wentai Ma Jian Yang Lin Di Jie Li Yan Xiao Lu Kang Shichang Du Jing Du Jing Wang Gang Li Shuguang Zhai Lijuan Chen Wenxiong Zhou Shengjie Lai Lei Gao Yang Pan Quanyi Wang Mingkun Li Jianbin Wang Yanyi Huang Jianwei Wang COVID-19 Field Response Group COVID-19 Laboratory Testing Group | 2020 | National Science Review2020，7，12： | 51 |
| 12 | Expression,purification and characterization of enterovirus-71 virus-like particles显示文摘瞄准:Enterovirus 71 (EV71 ) 作为为在亚太区域与严重神经病学的疾病联系的手,脚和嘴疾病的最近的爆发负责的病因学的代理人被含有。方法:集会过程被假设发生经由一由病毒的朊酶 3CD 的 P1 先锋的安排解朊的处理。测试这个假设,我们构造了 3 recombinant baculoviruses:表示 P1 的 Bac-P1;表示 3CD 的 Bac-3CD;并且 Bac-P1-3CD 共同表示 P1 和 3CD。结果:由 Bac-P1-3CD 的两单个感染和由 Bac-P1 和 Bac-3CD 的合作感染导致了 P1 的正确劈开产出单个蛋白质 VP0, VP1 和 VP3,当以前的途径产出更高的 VLP 生产时。在房间,进类似于真 EV71 粒子总数的像病毒的粒子(VLP ) 的簇自我装配的结构的蛋白质。在 ultracentrifugation 纯化以后,驱散的 VLP 与在尺寸,外观,作文和表面 epitopes 的真病毒难区分,作为由标记的 SDS 页,西方的污点,传播电子显微镜学和免疫黄金决定了。结论:我们的数据第一次,在 EV71 结构的蛋白质采用一个处理和类似于脊髓灰质炎病毒汇编的汇编小径的昆虫房间建议那。粒子形态学和作文的保藏建议 VLP 可以是一个珍贵疫苗的候选人阻止 EV71 流行病。 | Yao-Chi Chung Jen-Huang Huang Chia-Wei Lai Heng-Chun Sheng Shin-Ru Shih Mei-Shang Ho Yu-Chen Hu | 2006 | World Journal of Gastroenterology2006，12，6： | 42 |
| 13 | Relationship between coronary atherosclerosis plaque characteristics and high sensitivity C-reactive proteins, interleukin-6显示文摘背景在煽动性的标记和冠的动脉粥样硬化匾的特征之间的关系是不明确的。现在的学习的目的是评估在象高敏感那样的冠的动脉粥样硬化匾和煽动性的标记的特征之间的关系C反应的蛋白质( Hs-CRP )和所有病人怀疑了有冠的心疾病( CHD )的 .Methods 经历了的 interleukin-6 ( IL-6 )西门子64片 CT angiography ( 64-SCTA )区分冠的动脉损害的匾的质量。血样品被拿为由 64-SCTA 检测冠的动脉匾的敏感是的冠的动脉 plaque.Results 的察觉在不同的匾组和控制组并且与 64-SCTA 的价值相比测量浆液 Hs-CRP 和 IL-6 的层次87.4%,特性是87.1%,积极预兆的价值是82.2%,并且否定预兆的价值是91.0%。在匾组,之中比较浆液 Hs-CRP 和 IL-6 的层次在三个匾组的浆液 Hs-CRP 和 IL-6 的吝啬的层次比在控制组(P 0.01 ) 的那些显著地高。在软匾组和混合的匾组的浆液 Hs-CRP 和 IL-6 的吝啬的层次比在难匾组(P0.01 ) 的那些显著地高。在软匾组和混合的匾组的匾负担比在难匾组(P 0.01 ) 显著地高,但是软匾组之间没有统计差别并且混合了匾组(P=0.246 ) 。在软匾组在 CT 规模和 Hs-CRP 和 IL-6 层次之间有否定关联(r=-0.621, P0.01,和 r=-0.593, P 0.01 分别地) 。在软匾组在匾负担和 Hs-CRP 和 IL-6 层次之间有积极关联(r=0.579, P0.05 和 r=0.429, P0.05 分别地).Conclusions 64-SCTA 是区分冠的动脉粥样硬化匾的不同质量的一个有效方法。浆液 Hs-CRP 和 IL-6 层次能被看作这些索引判定 CHD 的度并且可以在 CHD 病人反映匾的活动。因此它为临床的诊断和急性冠的症候群(交流) 的风险评估是重要的病人。 | LAI Chun-lin JI You-rui LIU Xiao-hong XING Jin-ping ZHAO Jian-qiang | 2011 | Chinese Medical Journal2011，，16： | 48 |
| 14 | Anticoagulation therapy prevents portal-splenic vein thrombosis after splenectomy with gastroesophageal devascularization显示文摘AIM:To compare the incidence of early portal or splenic vein thrombosis(PSVT) in patients treated with irregular and regular anticoagulantion after splenectomy with gastroesophageal devascularization.METHODS:We retrospectively analyzed 301 patients who underwent splenectomy with gastroesophageal devascularization for portal hypertension due to cirrhosis between April 2004 and July 2010.Patients were categorized into group A with irregular anticoagulation and group B with regular anticoagulation,respectively.Group A(153 patients) received anticoagulant monotherapy for an undesignated time period or with aspirin or warfarin without low-molecular-weight heparin(LMWH) irregularly.Group B(148 patients) received subcutaneous injection of LMWH routinely within the first 5 d after surgery,followed by oral warfarin and aspirin for one month regularly.The target prothrombin time/international normalized ratio(PT/INR) was 1.25-1.50.Platelet and PT/INR were monitored.Color Doppler imaging was performed to monitor PSVT as well as the effectiveness of thrombolytic therapy.RESULTS:The patients' data were collected and analyzed retrospectively.Among the patients,94 developed early postoperative mural PSVT,including 63 patients in group A(63/153,41.17%) and 31 patients in group B(31/148,20.94%).There were 50(32.67%) patients in group A and 27(18.24%) in group B with mural PSVT in the main trunk of portal vein.After the administration of thrombolytic,anticoagulant and antiaggregation therapy,complete or partial thrombus dissolution achieved in 50(79.37%) in group A and 26(83.87%) in group B.CONCLUSION:Regular anticoagulation therapy can reduce the incidence of PSVT in patients who undergo splenectomy with gastroesophageal devascularization,and regular anticoagulant therapy is safer and more effective than irregular anticoagulant therapy.Early and timely thrombolytic therapy is imperative and feasible for the prevention of PSVT. | Wei Lai Shi-Chun Lu Guan-Yin Li Chuan-Yun Li Ju-Shan Wu Qing-Liang Guo Meng-Long Wang Ning Li | 2012 | World Journal of Gastroenterology2012，18，26： | 46 |
| 15 | A preliminary study of rare-metal mineralization in the Himalayan leucogranite belts, South Tibet显示文摘The Himalayan leucogranite occurs as two extensive(>1000 km) E-W trending belts on the Tibetan Plateau with the unique features. The leucogranite comprised biotite granite, two-mica/muscovite granite, tourmaline granite and garnet granite, which have been identified in previous studies, as well as albite granite and granitic pegmatite that were identified in this investigation. Fifteen leucogranite plutons were studied and 12 were found to contain rare-metal bearing minerals such as beryl(the representative of Be mineralization), columbite-group minerals, tapiolite, pyrochlore-microlite, fergusonite, Nb-Ta rutile(the representative of Nb-Ta mineralization), and cassiterite(the representative of Sn mineralization) mainly based on the field trip,microscope observation and microprobe analysis. The preliminary result shows that the Himalayan leucogranite is commonly related to the rare-metal mineralization and warrants future investigation. Further exploration and intensive research work is important in determining the rare-metal resource potential of this area. | WANG RuCheng WU FuYuan XIE Lei LIU XiaoChi WANG JiaMin YANG Lei LAI Wen LIU Chen | 2017 | Science China Earth Sciences2017，60，9： | 45 |
| 16 | Clinical and procedural predictors of no-ref low in patients with acute myocardial infarction after primary percutaneous coronary intervention显示文摘BACKGROUND: The treatment of acute myocardial infarction(AMI) is thought to restore antegrade blood flow in the infarct-related artery(IRA) and minimize ischemic damage to the myocardium as soon as possible. The present study aimed to identify possible clinical predictors for no-refl ow in patients with AMI after primary percutaneous coronary intervention(PCI).METHODS: A total of 312 consecutive patients with AMI who had been treated from January 2008 to December 2010 at the Cardiology Department of East Hospital, Tongji University School of Medicine were enrolled in this study. Inclusion criteria were:(i) patients underwent successfully primary PCI within 12 hours after the appearance of symptoms; or(ii) patients with ischemic chest pain for more than 12 hours after a successful primary PCI within 24 hours after appearance of symptoms. Exculsion criteria were:(i) coronary artery spasm;(ii) diameter stenosis of the culprit lesion was ≤50% and coronary blood f low was normal;(iii) patients with severe left main coronary or multivessel disease, who had to require emergency revascularization. According to thrombolysis in myocardial infarction(TIMI), the patients were divided into a reflow group and a no-reflow group. The clinical data, angiography f indings and surgical data were compared between the two groups. Univariate and multivariate logistic regressions were used to determine the predictors for no-ref low.RESULTS: Fifty-four(17.3%) of the patients developed NR phenomenon after primary PCI. Univariate analysis showed that age, time from onset to reperfusion, systolic blood pressure(SBP) on admission, Killip class of myocardial infarction, intra-aortic balloon pump(IABP) use before primary PCI, TIMI flow grade before primary PCI, type of occlusion, thrombus burden on baseline angiography, target lesion length, reference luminal diameter and method of reperfusion were correlated with no-reflow(P<0.05 for all). Multiple logistic regression analysis identified that age >65 years [OR=1.470, 95% confi dence interval(CI) 1.460–1.490, P=0.007], long time from onset to reperfusion >6 hours(OR=1.270, 95%CI 1.160–1.400, P=0.001), low SBP on admission <100 mmHg(OR=1.910, 95%CI 1.018–3.896, P=0.004), IABP use before PCI(OR= 1.949, 95%CI 1.168–3.253, P=0.011), low(≤1) TIMI fl ow grade before primary PCI(OR=1.100, 95%CI 1.080–1.250, P<0.001), high thrombus burden(OR=1.600, 95%CI 1.470–2.760, P=0.030), and long target lesion(OR=1.948, 95%CI 1.908–1.990, P=0.019) on angiography were independent predictors of no-refl ow.CONCLUSION: The occurrence of no-refl ow after primary PCI for acute myocardial infarction can predict clinical, angiographic and procedural features. | Hua Zhou Xiao-yan He Shao-wei Zhuang Juan Wang Yan Lai Wei-gang Qi Yi-an Yao Xue-bo Liu | 2014 | World Journal of Emergency Medicine2014，5，2： | 46 |
| 17 | Mechanism underlying treatment of ischemic stroke using acupuncture:transmission and regulation显示文摘The inflammatory response after cerebral ischemia/reperfusion is an important cause of neurological damage and repair.After cerebral ischemia/reperfusion,microglia are activated,and a large number of circulating inflammatory cells infiltrate the affected area.This leads to the secretion of inflammatory mediators and an inflammatory cascade that eventually causes secondary brain damage,including neuron necrosis,blood-brain barrier destruction,cerebral edema,and an oxidative stress response.Activation of inflammatory signaling pathways plays a key role in the pathological process of ischemic stroke.Increasing evidence suggests that acupuncture can reduce the inflammatory response after cerebral ischemia/reperfusion and promote repair of the injured nervous system.Acupuncture can not only inhibit the activation and infiltration of inflammatory cells,but can also regulate the expression of inflammation-related cytokines,balance the effects of pro-inflammatory and anti-inflammatory factors,and interfere with inflammatory signaling pathways.Therefore,it is important to study the transmission and regulatory mechanism of inflammatory signaling pathways after acupuncture treatment for cerebral ischemia/reperfusion injury to provide a theoretical basis for clinical treatment of this type of injury using acupuncture.Our review summarizes the overall conditions of inflammatory cells,mediators,and pathways after cerebral ischemia/reperfusion,and discusses the possible synergistic intervention of acupuncture in the inflammatory signaling pathway network to provide a foundation to explore the multiple molecular mechanisms by which acupuncture promotes nerve function restoration. | Bing-Qian Cao Feng Tan Jie Zhan Peng-Hui Lai | 2021 | Neural Regeneration Research2021，16，5： | 43 |
| 18 | Ideotype root architecture for efficient nitrogen acquisition by maize in intensive cropping systems显示文摘The use of nitrogen(N) fertilizers has contributed to the production of a food supply sufficient for both animals and humans despite some negative environmental impact.Sustaining food production by increasing N use efficiency in intensive cropping systems has become a major concern for scientists,environmental groups,and agricultural policymakers worldwide.In high-yielding maize systems the major method of N loss is nitrate leaching.In this review paper,the characteristic of nitrate movement in the soil,N uptake by maize as well as the regulation of root growth by soil N availability are discussed.We suggest that an ideotype root architecture for efficient N acquisition in maize should include(i) deeper roots with high activity that are able to uptake nitrate before it moves downward into deep soil;(ii) vigorous lateral root growth under high N input conditions so as to increase spatial N availability in the soil;and(iii) strong response of lateral root growth to localized nitrogen supply so as to utilize unevenly distributed nitrate especially under limited N conditions. | MI GuoHua,CHEN FanJun,WU QiuPing,LAI NingWei,YUAN LiXing & ZHANG FuSuo* Key Laboratory of Plant Nutrition,MOA Key Laboratory of Plant-Soil Interaction,MOE College of Resources and Environmental Science,China Agricultural University,Beijing 100193,China | 2010 | Science China(Life Sciences)2010，53，12： | 35 |
| 19 | Relationship between hepatitis B virus DNA levels and liver histology in patients with chronic hepatitis B显示文摘瞄准:与长期的肝炎 B (CHB ) 在病人学习在肝炎 B (HBV ) DNA 层次和肝组织学之间的关系并且决定肝炎 B e 的流行和特征抗原(HBeAg )negative 病人。方法:有 CHB 的 213 个病人的一个总数被学习,并且浆液 HBV DNA 层次被 COBAS Amplicor HBV 监视器测量测试。所有病人根据 HBeAg 地位被划分成二个组。在浆液 HBV DNA 层次和肝损坏(肝组织学和生物化学) 之间的关联被探索。结果:有比 105 copies/mL 高的浆液 HBV DNA 层次的 213 个病人,(83.6%) 178 是 HBeAg 积极,(16.4%) 35 是 HBeAg 否定。浆液 HBV DNA 层次没在否定的 HBeAg 或 HBeAg 被相关到肝疾病的年龄, CHB 的历史,组织学的等级和阶段积极病人。在 HBV DNA 和丙氨酸 aminotransferanse (中高音) 的浆液层次之间没有关联,在 HBeAg 积极病人的 aspartate aminotrans-ferase (著名计算机生产厂商) 。在 HBeAg 否定病人,当浆液 DNA 层次与中高音相关时,在 HBV DNA 和著名计算机生产厂商的浆液层次之间没有关联(r = 0.351, P = 0.042 ) 。肝疾病的等级(G) 与中高音和著名计算机生产厂商相关(P <
0.05, r = 0.205, 0.327 分别地) 在 HBeAg 积极病人。在 HBeAg 否定病人,关联在中高音,著名计算机生产厂商和 G 之间被显示出(P <
0.01,并且 r = 0.862, 0.802 分别地) 。 HBeAg 否定病人更老( 35 +/- 9 年对 30 +/- 9 年, P <
0.05 )并且有 HBV 感染的更长的历史( 8 +/- 4 年对 6 +/- 4 年, P <
0.05 )并且更低的 HBV DNA 比 HBeAg 积极病人铺平( 8.4 +/- 1.7 木头 HBV DNA 对 9.8 +/- 1.3 木头 HBV DNA , P <
0.001 )。在在二个组之间的两性比率,中高音和著名计算机生产厂商层次和肝组织学没有有效差量。结论:浆液 HBV DNA 水平没与 HBV DNA 在 CHB 病人被相关到肝疾病的组织学的等级或舞台超过 105 copies/mL。比作 HBeAg 积极病人, HBeAg 否定病人更老并且有更低的 HBV DNA 水平和更长的 HBV 感染历史。在在二个组之间的两性比率,中高音和著名计算机生产厂商层次和肝组织学没有有效差量。 | Jie Shao Lai Wei Hao Wang Yan Sun Lan-Fang Zhang Jing Li Jian-Qiang Dong | 2007 | World Journal of Gastroenterology2007，13，14： | 35 |
| 20 | Stress- and Pathogen-Induced Arabidopsis WRKY48 is a Transcriptional Activator that Represses Plant Basal Defense显示文摘植物 WRKY 抄写因素能作为植物的积极或否定的管理者工作基础疾病抵抗。Arabidopsis WRKY48 被机械或渗透的应力由于渗入和病原体感染导致并且因此,可以在植物防卫回答起一个作用。WRKY48 对原子核局部性,在 vitro 与一种高亲密关系认出 TTGACC W 盒子顺序并且在象强壮的 transcriptional 使活跃之物的植物房间工作。直接决定生物功能,我们孤立 loss-of-function T-DNA 插入异种并且产生了转基因的 overexpression 在 Arabidopsis 为 WRKY48 种的 gain-of-function。细菌的病原体 Pseudomonas syringae 的剧毒的紧张的生长在 wrky48 T-DNA 插入异种被减少。loss-of-function 异种的提高的抵抗与水杨酸的增加的正式就职被联系由细菌的病原体的调整酸的 PR1。由对比,转基因的 WRKY48-overexpressing 植物支持 P 的提高的生长。syringae 和提高的危险性与防卫相关的 PR 基因的减少的表示被联系。这些结果建议 WRKY48 是 PR 基因表示和基础抵抗的一个否定管理者到细菌的病原体 P。syringae。 | Deng-Hui Xing Zi-Bing Lai Zu-Yu Zheng K. M. Vinod Bao-Fang Fan Zhi-Xiang Chen | 2008 | Molecular Plant2008，1，3： | 37 |
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