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    题名 作者 年代 出处 被引量
1Reduced prostate branching morphogenes,s in stromal fibroblast, but not in epithelial, estrogen receptor a knockout mice显示文摘早研究建议了那雌激素受体 alpha (ERα) 涉及调停雌激素的印在前列腺开发的效果。我们最近报导了更完全的 ERα经由交配 β 的大美人(击倒) 老鼠模型;有 floxed ERα 的肌动朊 Cre 转基因的老鼠;老鼠。这些 ACTB-ERα击倒雄的老鼠在 prostatic 分叉形态发生显示出缺点,它表明那 ERα是必要的在前列腺维持 proliferative 事件。然而,在哪个以内前列腺房间类型 ERα施加那些重要功能遗体被阐明。探讨这,我们引起了 floxed ERα有也的老鼠产生一只老鼠的转基因的老鼠建模的成纤维细胞特定的蛋白质(FSP )-Cre 或 probasin-Cre 那删除了 ERα在任何一个 stromal 成纤维细胞的基因(FSP-ERα击倒) 或上皮(pes-ERα击倒) 前列腺房间。我们发现那传播睾丸激素和富饶没在 FSP-ERα 被改变;击倒和 pes-ERα击倒雄的老鼠。FSP-ERα 的前列腺;击倒老鼠与野类型的同窝出生的人的相比有更少的分叉的形态发生。进一步的分析显示了 stromal ERα 的那损失;导致增加了 stromal apoptosis,减少了像胰岛素的生长 factor-1 (IGF-1 ) 和 FGF10 的表示,并且增加了 BMP4 的表示。一起,我们在 vivo 前列腺 stromal 和上皮的选择 ERα 建立了第一;从这些老鼠的击倒老鼠模型和结果显示了那 stromal 成纤维细胞 ERα经由 paracrine 时尚在 prostatic 分叉形态发生起重要作用。ERα 的选择删除;在由 probasin-Cre 的上皮的房间不影响的老鼠前列腺的基因常规前列腺发展和动态平衡。Ming Chen Chiuan-Ren Yeh Chih-Rong Shyr Hsiu-Hsia Lin Iun Da Shuyuan Yeh 2012Asian Journal of Andrology2012,14,4:2
2Spatial and temporal temperature trends on the Yurman Plateau (Southwest China) during 1961-2004 显示文摘Fan Z Br/iuning A Thomas A 2011International Journal of Climatology2011,31,14:1
3Phacoemulsification ofeataract in patients with high myopia显示文摘Mamikonian VR Iusef IUN Iusef SM 2004Vestn oftalmol2004,120,6:1
4Fe304@Pt nanoparticles with enhanced peroxidase-like catalytic activity显示文摘Ma Ming Xie Iun Zhang Yu 2013Mater Lett2013,1050,:1
5IL-17 expression after cerebral isehemia of the rat显示文摘Guo Zhong L Hu Iun L Di Z 2002J Apoplexy Nervous Dis2002,19,:1
6Membrane Computing and Economics: Numerical P Systems显示文摘Pitun G P~iun R 2006Fundamenta Informaticae2006,73,12:1
7Promotion of tumorigenesis by heterozygous disruption of the Beclinl autophagy gene 显示文摘QU Xia YU Iun Bhagat G 2003J Clin Invest2003,112,12:1
8Programmed irrigation and drain- age in the treatment of patients with suppurative arthritis and intramedullary phlegmons显示文摘Iusupov IuN Epifanov MV 2000Vestnik Khirurgii Imeni II Grekova2000,159,3:1
9Role of cytokines in the development of immunologic and homeostatic disorders in advanced dysplasia and carcinoma of the uterine cervix显示文摘Belokrinitskaia TE Vitkovskit IuA Ponomareva IuN 2003Vopr Onkol2003,49,1:1
10A study of orthogonal multi-wavelets显示文摘Chui C K l iun J A 1996Appt Numer Math1996,20,3:1
11Necked ZnO nanoparticlebased N02 sensors with high and fast response显示文摘Iun J H Yun J Cho K 2009Sensors Actuators B2009,140,:1
12Peak load shifting control using different cold thermal energy storage facilities in commercial buildings: a review 显示文摘Sun Yong iun Wang Shengwei Xiao Fu 2013Energy Conversion and Management2013,71,:1
13Gallbladder adenomyomatosi显示文摘Il'chenko AA Orlova IuN 2010Eksp Klin Gastroenterol2010,,4:1
14Adenomyomatosis of the gallbladder the analysis of 328 operating cases显示文摘Il'chenko AA Orlova IuN Bystrovskaia EV 2013Eksp Klin Gastroenterol2013,,5:1
15Phacoemulsification of cataract in patients with high myopia 显示文摘Mamikonian VR lusef IUN Iusef SM 2004Vestn oftalmol2004,120,6:1
16Measurement of peripheral venous pressure using Doppler uhrasound显示文摘IuM B Babenko N I IuN G 1983Kardiolo- gila1983,23,10:1
17Problems in the deinfintion and treatment of early gastric cancer显示文摘Iune K Tobe T Han M 1991Br J Srug1991,78,7:1
18Strontium chloride(89Sr-chloride)fractional injection method for bone metastases treatment显示文摘Fomin DK Smirnov IuN Tararukhina OB 2012Vopr Onkol2012,58,1:1
19Lipoprotein-as-sociated phospholipase A2: relation to development of ischemicstroke in patients with essential hypertension 显示文摘Polupanov AG Lomteva IuN Khalmatov AN 2014Kardiologiia2014,54,6:1
20Does participative leadership enhance work performance by inducing empowerment or trust? The differential effects on managerial and non-managerial subo- rdinates 显示文摘Huang X Iun J Liu A 2010Journal of Organizational Behavior2010,31,1:1
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