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| 1 | Obesity and colorectal cancer:Role of adipokines in tumor initiation and progression显示文摘Obesity-associated diseases account for a large portion of public health challenges.Among obesity-related disorders,a direct and independent relationship has been ascertained for colorectal cancer(CRC).The evidence that adipocyte hypertrophy and excessive adipose tissue accumulation(mainly visceral)can promote pathogenic adipocyte and adipose tissue-related diseases,has led to formulate the concept of'adiposopathy',defined as adipocyte and adipose tissue dysfunction that contributes to metabolic syndrome.Adipose tissue can,indeed,be regarded as an important and highly active player of the innate immune response,in which cytokine/adipokine secretion is responsible for a paracrine loop between adipocytes and macrophages,thus contributing to the systemic chronic low-grade inflammation associated with visceral obesity,which represents a favorable niche for tumor development.The adipocyte itself participates as a central mediator of this inflammatory response in obese individuals by secreting hormones,growth factors and proinflammatory cytokines,which are of particular relevance for the pathogenesis of CRC.Among adipocyte-secreted hormones,the most relevant to colorectal tumorigenesis are adiponectin,leptin,resistin and ghrelin.All these molecules have been involved in cell growth and proliferation,as well as tumor angiogenesis and it has been demonstrated that their expression changes from normal colonic mucosa to adenoma and adenocarcinoma,suggesting their involvement in multistep colorectal carcinogenesis.These findings have led to the hypothesis that an unfavorable adipokine profile,with a reduction of those with an anti-inflammatory and anti-cancerous activity,might serve as a prognostic factor in CRC patients and that adipokines or their analogues/antagonists might become useful agents in the management or chemoprevention of CRC. | Silvia Riondino Mario Roselli Raffaele Palmirotta David Della-Morte Patrizia Ferroni Fiorella Guadagni | 2014 | World Journal of Gastroenterology2014，20，18： | 20 |
| 2 | 金属W中辐照缺陷的产生、演化与热回复机制显示文摘金属W是核聚变反应堆中面向等离子体部件的主要候选材料。服役期间,钨部件需要承受高温、高通量聚变反应中子轰击带来的辐照级联损伤。这些损伤主要表现为高浓度的点缺陷及团簇。它们与氢氦等离子体、嬗变反应的多种产物相互作用,导致辐照硬化、韧脆转变温度升高、导热能力下降等问题。本文围绕金属W的辐照级联损伤,基于显微缺陷实验表征与材料多尺度模拟计算,系统总结了辐照缺陷的产生、演化与热回复行为及作用机制。这些信息反映了材料中辐照缺陷特征的统计规律,构成定量描述微观损伤组织随时间尺度与空间尺度变化的依据,有利于钨部件性能的预测、服役可靠性评价以及未来新型材料部件的研发。 | 易晓鸥 韩文妥 刘平平 FERRONI Francesco 詹倩 万发荣 | 2021 | 金属学报2021，57，3： | 4 |
| 3 | Peripheral CD45RO, PD-1, and TLR4 expression in metastatic colorectal cancer patients treated with bevacizumab, fluorouracil, and irinotecan (FOLFIRI-B)显示文摘 | Vincenzo Formica Vittore Cereda Maria-Giovana Bari Italia Grenga Manfredi Tesauro Palmirotta Raffaele Patrizia Ferroni Fiorella Guadagni Mario Roselli | 2013 | Medical Oncology2013，，4： | 2 |
| 4 | 政府和社会资本合作模式与农业可持续发展显示文摘由于投资不足,尤其是在农产品市场发展、农作物改良和农业系统可持续管理方面投资乏力,造成非洲粮食平均产量几十年停滞不前,导致非洲农业发展的不可持续。公共部门用于农业研究的资金少,而私营部门在无市场领域经营的动力匮乏,这在很大程度上导致许多进口粮食的发展中国家粮食产量出现缺口。然而,公共部门和私营部门能够通过有效方法进行合作,共同提高贫穷国家农业发展的可持续性。公共部门可为农产品市场发展和农村基础设施投资提供良好的制度环境,促进当地商业发展,并为当地的研究提供资金支持,而私营部门则可在产品开发和配置方面提供专业知识。本文展示了在极具挑战的环境中,新型公私合作伙伴关系如何发生作用,促进农业发展。本文讨论了3个可能成功的公私合作伙伴关系实例,先正达可持续农业发展基金会均积极参与其中。同时,本文表明,在努力实现农业可持续发展的过程中,实验性方法有时比社会规划更有效率。 | Marco FERRONI Paul CASTLE 崔计顺 | 2016 | 世界农业2016，，10： | 2 |
| 5 | Correlation between tumor necrosis factor-alpha and D-dimer levels in non- small cell lung cancer patients 显示文摘 | Guadagni F Ferroni P Basili S | 2004 | Lung Cancer2004，44，3： | 1 |
| 6 | Circulating Transforming Growth Factor- 1 Levels in Asymptomatic Carotid Plaques显示文摘 | Ferroni P Novo S Davi V | 2005 | Stroke2005，36，3： | 1 |
| 7 | Effects of Ta/Nb-doping on titania-based thin films for gas-sensing 显示文摘 | COMINI E FERRONI M GUIDI V | 2005 | Sens Actuators B2005，108，： | 1 |
| 8 | Endothelial dysfunction and ox- idative stress in arterial hypertension显示文摘 | Ferroni p Basili S Paoletti V | 2006 | Nutr Metab Cardiovasc Dis2006，163，： | 1 |
| 9 | Association between increased tumor necrosis factor alpha levels and acquired Activated protein C resistance in patients with metastatic colorectal cancer显示文摘 | FERRONI P RIONDINO S PORTARENA I | 2012 | International Journal of Colorectal Disease2012，27，12： | 1 |
| 10 | Soluble P-selectin as a marker of in vivo platelet activation 显示文摘 | Ferroni P Martini F Riondino S | 2009 | Clin Chim Acta2009，399，12： | 1 |
| 11 | Serum metallo-proteinase 9 levels in patients with coronary artery disease:a novel marker of inflammation显示文摘 | Ferroni P Basili S Hoyhtya M | 2003 | J Invest Med2003，51，9： | 1 |
| 12 | Platelet activation in type 2 diabetes mellitus 显示文摘 | Ferroni P Basili S Falco A | 2004 | Thromb Haemost2004，2，8： | 1 |
| 13 | Detection of Acidithiobacillus ferrooxidans in acid mine drainage environments using fluorescent in situ hybridization (FISH)显示文摘 | MAHMOUD KK LEDUC LG FERRONI GD | 2005 | Journal of Microbiological Methods2005，61，： | 1 |
| 14 | Serum met all protein as eqlevelsin patients with coronary artery disease: a novel marker of inflamma-tion 显示文摘 | Ferroni P Basili S Hotya M ef al | 2003 | J Invest Med2003，51，5： | 1 |
| 15 | Extraction, Semi- Quantification, and Fast On-line Identification of Oligopeptides in Grana Padano Cheese by HPLC- MS显示文摘 | SFORZA S FERRONI L GALAVERNA G | 2003 | AgricFoodChem2003，51，8： | 1 |
| 16 | Experimental evaluation of pressure drop in round tubes provided with physically separated, multiple, short-length twisted tapes 显示文摘 | Ferroni P Block R E Todreas N E | 2011 | Experimental Thermal and Fluid Science2011，35，： | 1 |
| 17 | Real - time identification of bacteria and Candida species in positive blood culture broths by matrix- assisted laser desorption ionization - time of flight mass spectrometry显示文摘 | Ferroni A Suarez S Beretti JL | 2010 | J Clin Microbiol2010，48，： | 1 |
| 18 | Overexpression, purification, and biochemical and spectroscopic characterization of copper-containing nitrite reductase from Sinorhizobium meliloti 2011. Study of the interaction of the catalytic copper center with nitrite and NO显示文摘 | Félix M. Ferroni Sergio A. Guerrero Alberto C. Rizzi Carlos D. Brondino | 2012 | Journal of Inorganic Biochemistry2012，，： | 1 |
| 19 | Novel High-Sensitive D-Dimer Determination Predicts Chemotherapy-Associated Venous Thromboembolism in Intermediate Risk Lung Cancer Patients显示文摘 | Patrizia Ferroni Francesca Martini Ilaria Portarena Gioia Massimiani Silvia Riondino Francesca La Farina Sabrina Mariotti Fiorella Guadagni Mario Roselli | 2012 | Clinical Lung Cancer2012，，6： | 1 |
| 20 | Real-time identification of bacteria and Candida species in positive blood culture broths by matrix-assisted laser desorption ionization-time of flight mass spectrometry显示文摘 | Ferroni A Suarez S Beretti JL | 2010 | J Clin Microbiol2010，48，15： | 1 |
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