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| 1 | Early palliative care for patients with metastatic non-small-cell lung cancer显示文摘Comments This landmark article demonstrates that integration of early palliative care with standard oncologic practice shortly after diagnosis may improve quality of life,mood,and overall survival for adults with advanced non-small-cell lung cancer(NSCLC).If validated,these findings could support a paradigm shift in the care of adults with metastatic NSCLC and possibly patients with other tumor types characterized by short survival and high symptom burden. | Temel JS Greer JA Muzikansky A Gallagher ER Admane S Jackson VA Dahlin CM Blinderman CD Jacobsen J Pirl WF Billings JA Lynch TJ | 2010 | 中国肺癌杂志2010，13，9： | 165 |
| 2 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 3 | 轨道尺度的亚洲夏季风演变:“困惑”与探索显示文摘亚洲夏季风影响着亚洲大陆数十亿人口.半个世纪以来,亚洲夏季风研究取得了许多重要成就,但一些科学问题依然有待深入探索.这其中包括轨道时间尺度的两个难题:(1)中国黄土的磁化率序列显示亚洲夏季风变化以冰期-间冰期~100kyr周期为主,而中国石笋氧同位素(δ18O)序列则以~20kyr岁差周期为主,两者主导周期的差异成为了悬而未决的'中国的100kyr周期问题';(2)亚洲大陆石笋δ18O序列与许多海洋沉积记录在岁差波段上的显著相位差异,是争议已久的'海-陆岁差相位的困惑'.应当如何解答这些难题呢?首先,伴随着轨道尺度数值模拟的不断发展,岁差波段上降水量和风场变化在亚洲夏季风广大区域中的不均匀性及其区域模态差异逐渐明朗,不同气候记录的分歧在很大程度上可能只是这种降水和风场空间不均一性的体现.其次,不同记录载体有其固有的优势和局限,而此间差异则部分反映了这些局限性.总体而言,亚洲夏季风的黄土、海洋和石笋记录之间并不存在相互否定的关系,而是具有互补性;它们各自刻画了亚洲夏季风动力学系统的不同方面.因此,从整体季风系统的视角审视这些记录,能够基本解释亚洲季风的'中国的100kyr周期问题'和'海-陆岁差相位的困惑'这两个科学难题. | 程海 张海伟 蔡演军 石正国 易亮 邓成龙 郝青振 彭友兵 Ashish SINH A 李瀚瑛 赵景耀 田野 Jonathan BAK ER Carlos PEREZ-M EJIAS | 2021 | 中国科学:地球科学2021，51，4： | 6 |
| 4 | 中年直立性低血压和晕倒的风险显示文摘每年有1/3老年人晕倒。直立性低血压(orthostatic hypotension,OH)被认为是晕倒的重要危险因素之一,但先前对此研究的结论并不一致。 | Juraschek SP Daya N Appel LJ Miller ER Windham BG Pompeii L Griswold ME Kucharska-Newton A Selvin E 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，10： | 3 |
| 5 | Chromosomal damages by ethanol and acetaldehyde in saccharomyces gel electrophoresis显示文摘 | Ristow H Seyfarth A Lochmann ER | 1995 | Mutation research1995，326，： | 2 |
| 6 | Combination of a biopharmaceutic classification system and physiologically based pharmacokinetic models to predict absorption properties of baicalein in vitro and in vivo显示文摘Objective: To determine the in vitro and in vivo absorption properties of active ingredients of the Chinese medicine, baicalein, to enrich mechanistic understanding of oral drug absorption.Methods: The Biopharmaceutic Classification System(BCS) category was determined using equilibrium solubility, intrinsic dissolution rate, and intestinal permeability to evaluate intestinal absorption mechanisms of baicalein in rats in vitro. Physiologically based pharmacokinetic(PBPK) model commercial software GastroPlus~(TM) was used to predict oral absorption of baicalein in vivo.Results: Based on equilibrium solubility, intrinsic dissolution rate, and permeability values of main absorptive segments in the duodenum, jejunum, and ileum, baicalein was classified as a drug with low solubility and high permeability. Intestinal perfusion with venous sampling(IPVS) revealed that baicalein was extensively metabolized in the body, which corresponded to the low bioavailability predicted by the PBPK model. Further, the PBPK model predicted the key indicators of BCS, leading to reclassification as BCS-II. Predicted values of peak plasma concentration of the drug(C_(max)) and area under the curve(AUC)fell within two times of the error of the measured results, highlighting the superior prediction of absorption of baicalein in rats, beagles, and humans. The PBPK model supported in vitro and in vivo evidence and provided excellent prediction for this BCS class II drug.Conclusion: BCS and PBPK are complementary methods that enable comprehensive research of BCS parameters, intestinal absorption rate, metabolism, prediction of human absorption fraction and bioavailability, simulation of PK, and drug absorption in various intestinal segments across species. This combined approach may facilitate a more comprehensive and accurate analysis of the absorption characteristics of active ingredients of Chinese medicine from in vitro and in vivo perspectives. | Yang Liu Jing Sun Linying Zhong Yu Li A Na Er Tong Li Le Yang Ling Dong | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，3： | 2 |
| 7 | Early biochemical detection of delayed neurotoxieity resulting from developmental exposure to chlorpyrifos显示文摘 | Johnson D E Seldl ER Slitkin T A | 1998 | Brain Res Bull1998，45，： | 1 |
| 8 | Complete computer system simulation: the SimOS approach显示文摘 | Rosenblum M Herrod S A Witchel E er al | 1995 | Parallel & Distributed Tectmology: Systems & Applications IEEE1995，3，4： | 1 |
| 9 | Basic fibroblast growth factor in a porcine model of chronic myocardial ischemia:a comparison of angiogenic,echocardiographic and coronary flow parameters显示文摘 | Edelman ER Stamler A | 1997 | JPET1997，282，： | 1 |
| 10 | Exposure to carbon nanotube material : Assessment of nanotube cytotoxieity using human kerat inoeyte cells 显示文摘 | Shvedova A Cast Ranova V Kisin ER | 2003 | Toxicol Environ Health A2003，66，20： | 1 |
| 11 | Supervisory control of dynamic voltage restorers显示文摘 | Ramachandaramurthy V K ArVlampalam A Fitz- er C | 2004 | IEE Proceedings Generation Trans- mission and Distribution2004，151，4： | 1 |
| 12 | Safety,tolerability,efficacy and plasma concentrations of tropisetron after administration at five dose to children receiveing cancer chemotherapy显示文摘 | Suarez A Stettle ER Rey S et a1 | 1994 | Euro J Cancer1994，30，10： | 1 |
| 13 | Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer显示文摘 | Razandi M Pedram A Levin ER | 2000 | Mol Endocrinol2000，14，9： | 1 |
| 14 | Trazodone and venlafaxine in treatment of depressive disorders显示文摘 | Florkowski A Gruszczynski W Galecki P er al | 2005 | Pol Merkuriusz Lek2005，18，107： | 1 |
| 15 | Development of cortical and subcortical brain structures in childhood and adolescence: a structural MRI study显示文摘 | Sowell ER Tmuner DA Gamst A | 2002 | Dev Med Child Neurol2002，44，1： | 1 |
| 16 | Measuring blood pressure in pregnant won: a comparison of direct and indirect methods显示文摘 | BROWN M A RErI'ER L SMITH B | 1994 | AmJ Ohtet Gynecol1994，171，： | 1 |
| 17 | A Practical Simple Geometry and Gain/Phase Calibration Technique for An- tenna Array Processing显示文摘 | Ng B P Lie J P Er M H Feng A | 2009 | IEEE Transactions on Anten- nas and Propagation2009，57，7： | 1 |
| 18 | Performance of ^18F- fluoro-ethyl-tyrosine (lSF-FET) PET for the differential diag- nosis of primary brain tumor: a systematic review and Metaanalysis 显示文摘 | Dunet V Rossi er C Buck A | 2012 | J Nucl Med2012，53，2： | 1 |
| 19 | Novel efficient DOPObased flame-retardants for PWB relevant epoxy resins with high glass transition temperatures显示文摘 | Ciesielski M Sch(a)er A D(o)ring M | 2008 | Polym Advan Techn2008，19，6： | 1 |
| 20 | Potential atherogenic roles of lipids,lipoprotein(a)and lipid peroxidation in preeclampsia显示文摘 | Bayhan G Kocyigit Y Atam er A et a1 | 2005 | Gynecol Endocrinol2005，21，： | 1 |
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