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| 1 | Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies显示文摘Lung cancer is currently the leading cause of cancer death in Western nations.Non-small cell lung cancer(NSCLC)represents 80%of all lung cancers,and adenocarcinoma is the predominant histological type.Despite the intensive research carried out on this field and therapeutic advances,the overall prognosis of these patients remains unsatisfactory,with a 5-year overall survival rate of less than 15%.Nowadays,pharmacogenetics and pharmacogenomics represent the key to successful treatment.Recent studies suggest the existence of two distinct molecular pathways in the carcinogenesis of lung adenocarcinoma:one associated with smoking and activation of the K-Ras oncogene and the other not associated with smoking and activation of the epidermal growth factor receptor(EGFR).The K-ras mutation is mainly responsible for primary resistance to new molecules which inhibit tyrosine kinase EGFR(erlotinib and gefitinib)and most of the EGFR mutations are responsible for increased tumor sensitivity to these drugs.This article aims to conduct a systematic review of the literature regarding the molecular pathways involving the EGFR,K-Ras and EGFR targeted therapies in NSCLC tumor behavior. | Ramon Andrade de Mello Dania Sofia Marques Rui Medeiros António MF Araújo | 2011 | World Journal of Clinical Oncology2011，2，11： | 16 |
| 2 | Auto immune hepatitis显示文摘To provide an update of the latest trends in epidemiology, clinical course, diagnostics, complications and treatment of auto immune hepatitis(AIH). A search ofthe MEDLINE database was performed using the search terms: 'auto immune hepatitis', 'clinical presentation', 'symptoms', 'signs', 'diagnosis', 'auto antibodies', 'laboratory values', 'serology', 'histopathology', ' h i s t o l o g y ', ' g e n e t i c s ', 'HLA g e n e s ', 'non-HLA genes', 'environment', 'epidemiology', 'prevalence', 'incidence', 'demographics', 'complications', 'HCC', 'PBC', 'PSC', 'corticosteroid', 'therapy', 'treatment', 'alternative treatment'. English-language full-text articles and abstracts were considered. Articles included reviews, meta-analysis, prospective retrospective studies. No publication date restrictions were applied. AIH is an immune meditated progressive inflammatory liver disease that predominantly affects middle-aged females but may affect people of all ages. The clinical spectrum of AIH is wide, ranging from absent or mild symptoms to fulminant hepatic failure. The aetiology of AIH is still unknown, but is believed to occur as the consequence of an aberrant immune response towards an un-known trigger in a genetically susceptible host. In the absence of a gold standard, diagnosis is based on the combination of clinical, biochemical and histopathological criteria. Immunosuppressive treatment has been the cornerstone of treatment since the earliest description of the disease in 1950 by Waldenstr?m. Such treatment is often successful at inducing remission and generally leads to normal life expectancy. Nevertheless, there remain significant areas of unmet aetiological a clinical needs including fundamental insight in disease pathogenesis, optimal therapy, duration of treatment and treatment alternatives in those patients unresponsive to standard treatment regimens. | nicole mf van gerven ynto s de boer chris jj mulder carin mj van nieuwkerk gerd bouma | 2016 | World Journal of Gastroenterology2016，22，19： | 3 |
| 3 | Osteogenic differentiation of human adipose-derived stem cells: comparison of two different inductive media显示文摘 | de Girolamo L Sartori MF Albisetti W | 2007 | Tissue Eng Regen Med2007，1，2： | 1 |
| 4 | Coagulation and cancer:impli- cation for diagnosis and management显示文摘 | Loreto MF De Martinis M Corsi MP | 2000 | Pathol Oncol Res2000，6，： | 1 |
| 5 | Adverseeffects of propranolol when used in the treatment of hemangio -mas: a case series of 28 infants显示文摘 | de GRAAF M BREUR JM RAPHAEL MF | 2011 | J Am Acad Dermatol2011，65，2： | 1 |
| 6 | The early history of tubulation in nerve repair显示文摘 | IJpma FF Van De Graaf RC Meek MF | | 0，，05： | 1 |
| 7 | Influence of loading types on the shear strength of the dentin-resin inter- face bonding显示文摘 | Sinhoreti MA Consani S De Goes MF | 2001 | J Mater Sci Mater Med2001，12，1： | 1 |
| 8 | Morphological conse-quences of temporal lobe seizures in immature monkey 显示文摘 | Wenzel H J Born DE Dubanch MF | 1999 | Epilepsia1999，40，7： | 1 |
| 9 | ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR显示文摘 | Diez-Freire C V~zquez J Correa de Adjounian MF | 2006 | Physiol Genomics2006，27，1： | 1 |
| 10 | Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis显示文摘 | De Souza Setubal Desteo MF Bitu CC Zecchin KG | 2010 | Int J Oncol2010，36，1： | 1 |
| 11 | Renal failure is a risk factor for cefepime-induced encephalopathy显示文摘 | Garces EO Andrade de Anzambuja MF da Silva D | 2008 | J Nephrol2008，21，4： | 1 |
| 12 | Representations for multidocument event clus- tering 显示文摘 | De Smet W Moens MF | 2013 | Data Mining and Knowledge Discovcry2013，26，3： | 1 |
| 13 | Effect of hygroscopic expansion on the push-out resistance of glass ionomer-based cements used for the luting of glass fiber posts 显示文摘 | Cury AH Goracei C de Lima Navarro MF | 2006 | Endod2006，32，6： | 1 |
| 14 | Systematic analysis of FKBP inducible degradation domain tagging strategies for the human malaria parasite Plasmodium falciparum 显示文摘 | de Azevedo MF Gilson PR Gabriel HB | 2012 | PLoS One2012，7，40： | 1 |
| 15 | Adverse effects of propranolol when used in the treatment of hemangiomas:a case series of 28 infants显示文摘 | De Graaf M Breur JM Raphaěl MF | | 0，，02： | 1 |
| 16 | Selective silencing of angiotensin receptor subtype la (AT1 aR) by RNA interference显示文摘 | Correa de Adjounian MF Sumners C | 2005 | Hypertension2005，45，： | 1 |
| 17 | Erythrocyte Na^+-K^+-ATPase activity and diabetes:relationship with Cpeptide level显示文摘 | De La Tour DD Raccah D Jannot MF | 1998 | Diabetologia1998，41，： | 1 |
| 18 | Relative adrenal insufficiency as a predictor of disease severity, mortality, and beneficial effects of corticosteroid treatment in septic shock 显示文摘 | de Jong MF Beishuizen A Spijkstra JJ | 2007 | Crit Care Med2007，35，8： | 1 |
| 19 | Fluoroquinolone - induced immune thrombocytopenia: a report and review显示文摘 | CHEAH CY de KEULENAER B LEAHY MF | 2009 | In- tern Med J2009，39，9： | 1 |
| 20 | A metaanalysis of the efficacy of non-operative treatments for idiopathic scoliosis显示文摘 | Bemstein SM Riddick MF | 1997 | J Bone Joint Surg1997，，： | 1 |
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