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| 1 | Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression显示文摘 | María J. Bueno Ignacio Pérez de Castro Marta Gómez de Cedrón Javier Santos George A. Calin Juan C. Cigudosa Carlo M. Croce José Fernández-Piqueras Marcos Malumbres | 2008 | Cancer Cell2008，，： | 2 |
| 2 | Genetic ancestry analysis in non-alcoholic fatty liver disease patients from Brazil and Portugal显示文摘AIM:To study the association between genetic ancestry,non-alcoholic fatty liver disease(NAFLD) metabolic characteristics in two cohorts of patients,from Brazil and Portugal. METHODS:We included 131 subjects from Brazil [(n = 45 with simple steatosis(S. Steatosis) and n = 86 with nonalcoholic steatohepatitis(NASH)] and 90 patients from Portugal(n = 66,S. Steatosis; n = 24,NASH). All patients had biopsy-proven NAFLD. In histologic evaluation NAFLD activity score was used to assess histology and more than 5 points defined NASH in this study. Patients were divided into two groups according to histology diagnosis:simple steatosis or non-alcoholic statohepatitis. Genetic ancestry was assessed using real-time polymerase chain reaction. Seven ancestry informative markers(AT3-I/D,LPL,Sb19.3,APO,FYNull,PV92,and CKMM) with the greatest ethnicgeographical differential frequencies(≥ 48%) were used to define genetic ancestry. Data were analyzed using R PROJECTS software. Ancestry allele frequencies between groups were analyzed by GENEPOP onlineand the estimation of genetic ancestry contribution was evaluated by ADMIX-95 software. The 5% alpha-error was considered as significant(P < 0.05). RESULTS:In the Brazilian sample,NASH was significantly more frequent among the elderly patients with diabetes(NASH 56 ± 1.1 years old vs S. Steatosis 51 ± 1.5 years old,P = 3.7 x 10-9),dyslipidemia(NASH 63% vs S. Steatosis 37%,P = 0.009),higher fasting glucose levels(NASH 124 ± 5.2 vs S. Steatosis 106 ± 5.3,P = 0.001) and Homeostatic Model of Assessment index > 2.5 [NASH 5.3(70.8%) vs S. Steatosis 4.6(29.2%) P = 0.04]. In the Portuguese study population,dyslipidemia was present in all patients with NASH(P = 0.03) and hypertension was present in a larger percentage of subjects in the S. Steatosis group(P = 0.003,respectively). The genetic ancestry contribution among Brazilian and Portuguese individuals with NASH was similar to those with S. Steatosis from each cohort(Brazilian cohort:P = 0.75; Portuguese cohort:P = 0.97). Nonetheless,the genetic ancestry contribution of the Brazilian and Portuguese population were different,and a greater European and Amerindian ancestry contribution was detected in the Portuguese population while a higher African genetic ancestry contribution was observed in Brazilian population of both NASH and S. Steatosis groups.CONCLUSION:There was no difference between the genetic ancestry contribution among Brazilian and Portuguese individuals with NASH and S. Steatosis from each cohort. | Lourianne Nascimento Cavalcante Jose Tadeu Stefano Mariana V Machado Daniel F Mazo Fabiola Rabelo Kiyoko Abe Sandes Flair Jose Carrilho Helena Cortez-Pinto Andre Castro Lyra Claudia P de Oliveira | 2015 | World Journal of Hepatology2015，7，10： | 2 |
| 3 | A census of mitotic cancer genes:new insights into tumor cell biology and cancer therapy显示文摘 | De Castro I P De Cácer G Malumbres M | | 0，，05： | 1 |
| 4 | Business and so- cial reputation: Exploring the concept and main Dimen- sions of corporate reputation 显示文摘 | De Castro G M Lopez J E N Sdez P L | 2006 | Journal of Business Ethics2006，63，4： | 1 |
| 5 | Correlation between symptom fatigue and muscular fatigue in multiple sclerosis显示文摘 | Iriarte J de Castro P | 1998 | Eur J Neurol1998，5，6： | 1 |
| 6 | Sequential(step-by-step) detection,identification and quantization of extra virgin olive oil adulteration by chemo metric treatment of chromatographic profiles显示文摘 | CAPOTE F P JIMINEZ J R LUQUE de CASTRO M D | 2007 | Analytical and Bioanalytical Chemistry2007，338，8： | 1 |
| 7 | Anaerobic sludge granulation显示文摘 | Hulshoff P L W de Castro L S I Lettinga G | | 0，，06： | 1 |
| 8 | Interpretation of chloride profiles from concrete exposed to tropical marine environments显示文摘 | CASTRO P DE RINCON O T PAZINI E J | 2001 | Cement and Concrete Research2001，31，4： | 1 |
| 9 | Concurrent and Simple Digital Controller of an AC/DC Converter with Power Factor Correction Based on an FPGA显示文摘 | De Castro A Zumel P Garcia O | 2003 | IEEE Trans on Power Electronics2003，18，1： | 1 |
| 10 | Rosiglitazone improves postprandial triglyceride and free fatty acid metabolism in type 2 diabetes显示文摘 | Van Wijk J P de Koning E J Castro C M | 2005 | Diabetes Care2005，28，4： | 1 |
| 11 | Correlation between valsalva leak point pressure and maximal urethral closure pressure in women with stress urinary incontinence 显示文摘 | Feldner P C Jr Bezerra L R de Castro R A | 2004 | Int Urogynecol J Pelvic Floor Dysfunct2004，15，3： | 1 |
| 12 | Astringency removal of ' Giombo' persimmon fruits submitted to different temperatures 显示文摘 | Antoniolli L R De Camargo e Castro P R Kluge R A | 2002 | Pesquisa Agropecuaria Brasileira2002，37，5： | 1 |
| 13 | Does socioeconomic status matter? A meta-analysis on parent training effectiveness for disruptive child behavior显示文摘 | Leijten P Raaijmakers MA de Castro BO | 2013 | J Clin Child Adolesc Psychol2013，42，3： | 1 |
| 14 | An improved multiaxial rainflow algorithm for non-proportional stress or strain histories Part II: The Modified Wang- Brown method 显示文摘 | Meggiolaro M A De Castro J T P | 2012 | International Journal of Fatigue2012，42，： | 1 |
| 15 | A faulttolerant architectural approach for dependable systems显示文摘 | de Lemos R de Castro P A G Rubira C M | 2006 | IEEE Software2006，23，2： | 1 |
| 16 | Does music perception have an impact on quality of life following cochlear implantation?显示文摘 | Luis Lassaletta Alejandro Castro Marta Bastarrica Rosa Pérez-Mora Rosario Madero Josefa De Sarriá Javier Gavilán | 2007 | Acta Oto-Laryngologica2007，，7： | 1 |
| 17 | Interlami-nar fracture studies in Portugal: past, present and future显示文摘 | de Morais A B Rebelo C C de Castro P | 2004 | Fatigue Fracture of Engineering Material Struc-tures2004，27，9： | 1 |
| 18 | Antiproli-ferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates 显示文摘 | Urdiales JL Morata P Nú?ez De Castro I | 1996 | Cancer Lett1996，102，： | 1 |
| 19 | Vascular anomalies of the head and neck:a review of genetics显示文摘 | Yadav P De Castro D K Waner M | 2013 | Semin Ophthal- mol2013，28，56： | 1 |
| 20 | Tilt and decentration of intraoeular lenses in vivo from Purkinje and Scheimpflug imaging;validation study显示文摘 | De Castro A Resales P Marees S | 2007 | Cataract Refract Surg2007，33，15： | 1 |
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