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| 1 | Different risk factors influence peptic ulcer disease development in a Brazilian population显示文摘AIM: To investigate age, sex, histopathology and Helicobacter pylori (H. pylori) status, as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic patients.tients submitted to upper gastroscopy at Hospital das Clinicas of Marilia, antral biopsy specimens were obtained and subjected to histopathology and H. pylori diagnosis. All patients presenting chronic gastritis (CG) and peptic ulcer (PU) disease localized in the stomach, gastric ulcer (GU) and/or duodenal ulcer (DU) were included in the study. Gastric biopsies (n = 668) positive for H. pylori by rapid urease test were investigated for vacuolating cytotoxin A (vacA ) medium (m) region mosaicism by polymerase chain reaction. Logistic regression analysis was performed to verify the association of age, sex, histopathologic alterations, H. pylori diagnosis and vacA m region mosaicism with the incidence of DU, GU and CG in patients. RESULTS: Of 1466 patients submitted to endoscopy, 1060 (72.3%) presented CG [male/female = 506/554; mean age (year) ± SD = 51.2 ± 17.81], 88 (6.0%) presented DU [male/female = 54/34; mean age (year) ± SD = 51.4 ± 17.14], and 75 (5.1%) presented GU [male/female = 54/21; mean age (year) ± SD = 51.3 ± 17.12] and were included in the comparative analysis. Sex and age showed no detectable effect on CG incidence (overall c 2 = 2.1, P = 0.3423). Sex [Odds ratios (OR) = 1.8631, P = 0.0058] but not age (OR = 0.9929, P = 0.2699) was associated with DU and both parameters had a highly significant effect on GU (overall c 2 = 30.5, P < 0.0001). The histopathological results showed a significant contribution of ageing for both atrophy (OR = 1.0297, P < 0.0001) and intestinal metaplasia (OR = 1.0520, P < 0.0001). Presence of H. pylori was significantly associated with decreasing age (OR = 0.9827, P < 0.0001) and with the incidence of DU (OR = 3.6077, P < 0.0001). The prevalence of m1 in DU was statistically significant (OR = 2.3563, P = 0.0018) but not in CG (OR = 2.678, P = 0.0863) and GU (OR = 1.520, P = 0.2863). CONCLUSION: In our population, male gender was a risk factor for PU; ageing for GU, atrophy and metapla-sia; and H. pylori of vacA m1 genotype for DU. | Rodrigo Buzinaro Suzuki Rodrigo Faria Cola Larissa Tranquilino Bardela Cola Camila Garcia Ferrari Fred Ellinger Altino Luiz Therezo Luis Carlos da Silva André Eterovic Márcia Aparecida Sperana | 2012 | World Journal of Gastroenterology2012，18，38： | 8 |
| 2 | Evolving role of FDG-PET/CT in prognostic evaluation of resectable gastric cancer显示文摘Gastric cancer(GC) remains a leading cause of cancer death worldwide. Radical gastrectomy is the only potentially curative treatment, and perioperative adjuvant therapies may improve the prognosis after curative resection. Prognosis largely depends on the tumour stage and histology, but the host systemic inflammatory response(SIR) to GC may contribute as well, as has been determined for other malignancies. In GC patients, the potential utility of positron emission tomography/computed tomography(PET/CT) with the imaging radiopharmaceutical 18F-fluorodeoxyglucose(FDG) is still debated, due to its lower sensitivity in diagnosing and staging GC compared to other imaging modalities. There is, however, growing evidence that FDG uptake in the primary tumour and regional lymph nodes may be efficient for predicting prognosis of resected patients and for monitoring tumour response to perioperative treatments, having prognostic value in that it can change therapeutic strategies. Moreover, FDG uptake in bone marrow seems to be significantly associated with SIR to GC and to represent an efficient prognostic factor after curative surgery. In conclusion, PET/CT technology is efficient in GC patients, since it is useful to integrate other imaging modalities in staging tumours and may have prognostic value that can change therapeutic strategies. With ongoing improvements, PET/CT imaging may gain further importance in the management of GC patients. | Emilio De Raffele Mariateresa Mirarchi Dajana Cuicchi Ferdinando Lecce Bruno Cola | 2017 | World Journal of Gastroenterology2017，23，38： | 5 |
| 3 | Simultaneous curative resection of double colorectal carcinoma with synchronous bilobar liver metastases显示文摘Synchronous colorectal carcinoma(SCRC) indicates more than one primary colorectal carcinoma(CRC) discovered at the time of initial presentation, accounts for 3.1%-3.9% of CRC, and may occur either in the same or in different colorectal segments. The accurate preoperative diagnosis of SCRC is difficult and diagnostic failures may lead to inappropriate treatment and poorer prognosis. SCRC requires colorectal resections tailored to individual patients, based on the number, location, and stage of the tumours, from conventional or extended hemicolectomies to total colectomy or proctocolectomy, when established predisposing conditions exist. The overall perioperative risks of surgery for SCRC seem to be higher than for solitary CRC. Simultaneous colorectal and liver resection represents an appealing surgical strategy in selected patients with CRC and synchronous liver metastases(CRLM), even though the cumulative risks of the two procedures need to be adequately evaluated. Simultaneous resections have the noticeable advantage of avoiding a second laparotomy, give the opportunity of an earlier initiation of adjuvant therapy, and may significantly reduce the hospital costs. Because an increasing number of recent studies have shown goodresults, with morbidity, perioperative hospitalization, and mortality rates comparable to staged resections, simultaneous procedures can be selectively proposed even in case of complex colorectal resections, including those for SCRC and rectal cancer. However, in patients with multiple bilobar CRLM, major hepatectomies performed simultaneously with colorectal resection have been associated with significant perioperative risks. Conservative or parenchymal-sparing hepatectomies reduce the extent of hepatectomy while preserving oncological radicality, and may represent the best option for selected patients with multiple CRLM involving both liver lobes. Parenchymal-sparing liver resection, instead of major or two-stage hepatectomy for bilobar disease, seemingly reduces the overall operative risk of candidates to simultaneous colorectal and liver resection, and may represent the most appropriate surgical strategy whenever possible, also for patients with advanced SCRC and multiple bilobar liver metastases. | Emilio De Raffele Mariateresa Mirarchi Dajana Cuicchi Ferdinando Lecce Claudio Ricci Riccardo Casadei Bruno Cola Francesco Minni | 2018 | World Journal of Gastrointestinal Oncology2018，10，10： | 3 |
| 4 | Oligomeric Procyanidins Induce Generation of Reactive Oxygen Species and Collapse of Mitochchondrial Membrane Potential in Glioblastoma Cell Lines显示文摘Objective The aim of the present study was to clarify the mechanism underlying glioma cell death upon oligomeric procyanidins (F2) exposure. Methods The cytotoxicity of F2 on U87 (human malignant glioblastoma cell line) and C6 (rat glioma cell line) cancer cells was evaluated, and changes of mitochondrial membrane potential (MMP) and production of reactive oxygen species (ROS) in drug-treated cells were monitored. Moreover, morphological changes associated with F2-induced cells death were examined. Results F2 induced a concentration-dependent increase in ROS production and decrease in MMP. Furthermore, pre-incubation with N-acetylcysteine (NAC) and rotenone (Rt), resulted in partial inhibition of F2-induced ROS generation and marked attenuation of cell death and the cytoplasmic vacuolization induced by F2. In addition, pretreatment with Rt markedly attenuated the MMP loss in F2-treated cells. However, pretreatment with NAC only markedly attenuated the MMP loss in F2-treated C6 cells. Conclusion The increase in ROS level is at least one of mechanisms associated with F2-induced glioma cell death as well as the cytoplasmic vacuolization formation that contribute to the cytotoxicity of F2 in glioma cells. | ZHANG Feng-jiao1, YANG Jing-yu1, MOU Yan-hua1, SUN Bao-shan2, WANG Ji-ming3, WANG Fang1, WU Chun-fu1 1. Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China 2. Estaco Vitivinícola Nacional, Instituto National de Investigaco Agrária, Dois Portos 2565-191, Portugal 3. Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick Maryland 21702, USA | 2009 | Chinese Herbal Medicines2009，1，1： | 3 |
| 5 | Fuzzy C-means Rule Generation for Fuzzy Entry Temperature Prediction in a Hot Strip Mill显示文摘Variable estimation for finishing mill set-up in hot rolling is greatly affected by measurement uncertainties,variations in the incoming bar conditions and product changes.The fuzzy C-means algorithm was evaluated for rulebase generation for fuzzy and fuzzy grey-box temperature estimation.Experimental data were collected from a reallife mill and three different sets were randomly drawn.The first set was used for rule-generation,the second set was used for training those systems with learning capabilities,while the third one was used for validation.The performance of the developed systems was evaluated by five performance measures applied over the prediction error with the validation set and was compared with that of the empirical rule-base fuzzy systems and the physical model used in plant.The results show that the fuzzy C-means generated rule-bases improve temperature estimation;however,the best results are obtained when fuzzy C-means algorithm,grey-box modeling and learning functions are combined.Application of fuzzy C-means rule generation brings improvement on performance of up to 72%. | Jose Angel BARRIOS Cesar VILLANUEVA Alberto CAVAZOS Rafael COLAS | 2016 | Journal of Iron and Steel Research(International)2016，23，2： | 2 |
| 6 | Relevance of Subcortical Stroke in Dysphagia显示文摘 | Monique G. Cola Stephanie K. Daniels David M. Corey Lisa C. Lemen Maryellen Romero Anne L. Foundas | 2010 | Stroke2010，，3： | 2 |
| 7 | 导尿管硅胶涂层显示文摘两种成分的硅胶弹性体分散液用于乳胶导管涂层有许多优点。此外,硅胶的物理特性和生物相容性使得插入比较容易,端头和孔中结壳较少,从而使病人比较舒适。处理方便,制作容易。使用硅胶涂层代替全硅胶制品,既简易可行,又经济实惠。 | Jason Siang 杨金龙 André Colas | 2006 | 中国医疗器械信息2006，12，5： | 2 |
| 8 | Modulation of inflammatory response by hippocampus of rats exposed to cerebral ischemia/reperfusion显示文摘 | Coll the PPAR ino M Aragno M Ma oxidative stress -gamma agonists in stro and the cola R et a7 | 2006 | Eur J Pharmacol2006，530，： | 1 |
| 9 | Blind source separation applied to rotating machines monitoring by acoustical and vibrations analysis显示文摘 | Gelle G Colas M Delaunay G | 2000 | Mechanical System and Signal Processing2000，14，42： | 1 |
| 10 | From carotid plaque biology to serologic markers of vulnerability to predictthe risk of cerebrovascular events 显示文摘 | Cola C Clementi E Biondi-Zoccai G | 2007 | Acta Chit Belg2007，107，2： | 1 |
| 11 | of wear resistant high chromium, high carbon cast irons显示文摘 | Maldonado-ruiz S I lopez Mierostruetural evaluation D Velasco A Colas R | 2004 | Material Science and Technology2004，20，3： | 1 |
| 12 | 显示文摘 | Colas B Le Meste M | 1992 | J Food Sci1992，57，3： | 1 |
| 13 | Non-oxidative propane dehydrogenation over Pt-Zn-containing zeolites 显示文摘 | Patrizia Laura De Cola Roger Glaser Jens Weitkamp | 2006 | Applied Catalysis A : General2006，306，7： | 1 |
| 14 | From carotid plaque bi ology to serologic markers of vulnerability to predict the risk of cerebrovascular events显示文摘 | Cola C Clementi E Biondi-Zoccai G | 2007 | Acta Chir Belg2007，107，： | 1 |
| 15 | Oxygen dynamics in coastal and lagoon ecosystems显示文摘 | Lunardini F Cola G | 2000 | Mathematical and Computer Modelling2000，31，： | 1 |
| 16 | Use of piezocone to predict maximum stiffness of Venetian soils显示文摘 | SIMONINI P COLA S | 2000 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2000，126，4： | 1 |
| 17 | Relevance of Subcor- tical Stroke in Dysphagia显示文摘 | Cola Monique G Daniels Stephanie K Corey David M | 2010 | Stroke2010，41，3： | 1 |
| 18 | Relevance of Subcortical Stroke in Dysphagia显示文摘 | Cola MG Daniels SK Corey DM | 2010 | Stroke2010，41，3： | 1 |
| 19 | Rapid Differential Diagnosis of Rinderpest and Pest des Petits Ruminants Using an lmmunocapture ELISIA显示文摘 | G libeau A Diallo F Colas | 1994 | Thr Vererinary record1994，134，12： | 1 |
| 20 | Study of apopto - sis-related markers in ram spennatozoa显示文摘 | MART'I E EREZ-PE P COLAS C | 2008 | Animal Reproduction Science2008，106，12： | 1 |
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