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| 1 | Different risk factors influence peptic ulcer disease development in a Brazilian population显示文摘AIM: To investigate age, sex, histopathology and Helicobacter pylori (H. pylori) status, as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic patients.tients submitted to upper gastroscopy at Hospital das Clinicas of Marilia, antral biopsy specimens were obtained and subjected to histopathology and H. pylori diagnosis. All patients presenting chronic gastritis (CG) and peptic ulcer (PU) disease localized in the stomach, gastric ulcer (GU) and/or duodenal ulcer (DU) were included in the study. Gastric biopsies (n = 668) positive for H. pylori by rapid urease test were investigated for vacuolating cytotoxin A (vacA ) medium (m) region mosaicism by polymerase chain reaction. Logistic regression analysis was performed to verify the association of age, sex, histopathologic alterations, H. pylori diagnosis and vacA m region mosaicism with the incidence of DU, GU and CG in patients. RESULTS: Of 1466 patients submitted to endoscopy, 1060 (72.3%) presented CG [male/female = 506/554; mean age (year) ± SD = 51.2 ± 17.81], 88 (6.0%) presented DU [male/female = 54/34; mean age (year) ± SD = 51.4 ± 17.14], and 75 (5.1%) presented GU [male/female = 54/21; mean age (year) ± SD = 51.3 ± 17.12] and were included in the comparative analysis. Sex and age showed no detectable effect on CG incidence (overall c 2 = 2.1, P = 0.3423). Sex [Odds ratios (OR) = 1.8631, P = 0.0058] but not age (OR = 0.9929, P = 0.2699) was associated with DU and both parameters had a highly significant effect on GU (overall c 2 = 30.5, P < 0.0001). The histopathological results showed a significant contribution of ageing for both atrophy (OR = 1.0297, P < 0.0001) and intestinal metaplasia (OR = 1.0520, P < 0.0001). Presence of H. pylori was significantly associated with decreasing age (OR = 0.9827, P < 0.0001) and with the incidence of DU (OR = 3.6077, P < 0.0001). The prevalence of m1 in DU was statistically significant (OR = 2.3563, P = 0.0018) but not in CG (OR = 2.678, P = 0.0863) and GU (OR = 1.520, P = 0.2863). CONCLUSION: In our population, male gender was a risk factor for PU; ageing for GU, atrophy and metapla-sia; and H. pylori of vacA m1 genotype for DU. | Rodrigo Buzinaro Suzuki Rodrigo Faria Cola Larissa Tranquilino Bardela Cola Camila Garcia Ferrari Fred Ellinger Altino Luiz Therezo Luis Carlos da Silva André Eterovic Márcia Aparecida Sperana | 2012 | World Journal of Gastroenterology2012，18，38： | 8 |
| 2 | Modulation of inflammatory response by hippocampus of rats exposed to cerebral ischemia/reperfusion显示文摘 | Coll the PPAR ino M Aragno M Ma oxidative stress -gamma agonists in stro and the cola R et a7 | 2006 | Eur J Pharmacol2006，530，： | 1 |
| 3 | Blind source separation applied to rotating machines monitoring by acoustical and vibrations analysis显示文摘 | Gelle G Colas M Delaunay G | 2000 | Mechanical System and Signal Processing2000，14，42： | 1 |
| 4 | 显示文摘 | Colas B Le Meste M | 1992 | J Food Sci1992，57，3： | 1 |
| 5 | Relevance of Subcor- tical Stroke in Dysphagia显示文摘 | Cola Monique G Daniels Stephanie K Corey David M | 2010 | Stroke2010，41，3： | 1 |
| 6 | Blind sources separation applied to rotating machines monitoring by acoustical and vibrations analysis 显示文摘 | Gelle G Colas M Delaunay G | 2000 | Mechanical Systems and Signal Processing2000，14，3： | 1 |
| 7 | Blind sources separation:A tool for rotating machine monitoring by vibrations analysis显示文摘 | Gelle G Colas M | 2001 | Journal of Sound and Vibration2001，248，5： | 1 |
| 8 | Blind source separation : a tool for rotating machines monitoring by vibrations analysis 显示文摘 | C elle G Colas M | 2001 | Journal of Sound and Vibration2001，248，5： | 1 |
| 9 | Blind source separation applied to rotating machin-es monitoring by acoustical and vibrations analysis显示文摘 | GELLE G COLAS M DELAUNAY G | 2000 | Mechanical Systems and Signal Processing2000，14，3： | 1 |
| 10 | Blind Source Separation:A New Pre-Processing Tool for Rotating Machines Monitoring?显示文摘 | G Gelle M Colas C Servière | 2003 | IEEE Transactions on Instrumentation and Measurement2003，52，3： | 1 |
| 11 | Blind sources separation applied to rotating machines monitoring by acoustical and vibrations analysis 显示文摘 | Gelle G Colas M Delaunay G | 2000 | Mechanical Systems and Signal Processing2000，14，3： | 1 |
| 12 | Physicochemical and dynamic properties of caseins modified by chemical phosphorylation显示文摘 | MDINA L COLAS M MESTLE L E | 2006 | Food Sci2006，57，3： | 1 |
| 13 | Blind soures separation applied to rotating machines monitoring by acoustical and vibrations analysis 显示文摘 | G Gelle M Colas G Delaunay | 2000 | Mechanical Systems and Signal Processing2000，14，3： | 1 |
| 14 | A model for heat conduction through the oxide layer of steel during hot rolling显示文摘 | Torres M Colas R | 2000 | Journal of Materials Processing Technology2000，105，3： | 1 |
| 15 | Stress Analysis of a 900MW Pressurizer Surge Line Including Stratification Effects显示文摘 | Ensel C Colas A Barthez M | 1995 | Nuclear Engineering and Design1995，153，： | 1 |
| 16 | Blind source separation:A new pre-processing tool for rotating machines monitoring显示文摘 | Gelle G Colas M C Serviere | 2003 | IEEE Transactions on Instrumentation and Measurement2003，52，3： | 1 |
| 17 | High Temperature Oxidation of a Work Roll Grade High Speed Steel 显示文摘 | Garza-Montes-de-Oca N F Colas R Rainforth W M | 2011 | Oxid Met2011，76，56： | 1 |
| 18 | Global optimal real-time control of the Quebec urban drainage system? 显示文摘 | Pleau M Colas H Lavallee P | 2005 | Environmental Modelling & Software2005，20，4： | 1 |
| 19 | LDL from obese patients with the metabolic syndrome show increased lipid peroxidation and activate platelets显示文摘 | Colas R Sassolas A Guichardant M | | 0，，11： | 1 |
| 20 | Blind source separation: a tool for rotating machine monitoring by vibrations analysis 显示文摘 | Gelle G Colas M Serviere C | 2001 | Journal of Sound and Vibration2001，248，5： | 1 |
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