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| 1 | Discussion on Sustainable Urbanization in Tibet显示文摘After 1995, Tibet entered the stage of accelerated urbanization. The large floating population from outside Tibet has become the driving force for urban expansion and the rising of urbanization rate. After analyzing the changes of urban functions and spatial structure of urban system in Tibet, this paper argues that before 1995 the urbanization in Tibet was mainly driven by administrative function, resulting in certain population migration, whereas in the past decade economic function has become the key factor accelerating urban expansion with the market mechanism creating large-scale inflow of population. The floating population-based urbanization and high population growth in the agricultural and pastoral areas of Tibet has promoted the regional economic prosperity, but exerted resources and environmental pressure and brought some problems for Tibetan culture protection at the same time. The conflicts and contradictions between urbanization and the sustainability of natural resources, environment and social development have been intensified. Addressing these problems, this paper proposes some countermeasures for improving the sustainability of Tibetan urbanization. | FAN Jie WANG Hongyuan CHEN Dong ZHANG Wenzhong WANG Chuansheng | 2010 | Chinese Geographical Science2010，20，3： | 21 |
| 2 | Environmental change inferred from Rb and Sr of lacustrine sediments in Huangqihai Lake,Inner Mongolia显示文摘从侧面 H3 与三不同谷物尺寸部分在沉积基于 geochemical 元素 Rb 和 Sr 在上北湖河边低地在在 1986 的胡昂基海·莱克表面上面的 13 m,纸调查 palaeolake | CHEN Lei SHEN Hongyuan JIA Yulian WU Jinglu LI Xusheng WEI Ling WANG Pengling | 2008 | Journal of Geographical Sciences2008，18，3： | 11 |
| 3 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 4 | Underwater explosion in centrifuge Part Ⅱ:Dynamic responses of defensive steel plate显示文摘Part II of this paper is focused on the dynamic response of a steel plate of the centrifuge model which is fixed on the container. This plate is 5 cm thick, allowing for non-destructive elastic response to all the 19 blasts. Three accelerators and 10 sets of strain gauges are installed on the plate to monitor the acceleration and deformation histories induced by shock waves and bubble oscillations.This article presents the characteristic values measured for shock waves and bubble oscillations response. The detailed information can be found in a database available on the web. In order to obtain the correct acceleration time history, the cut-off frequency of low-pass filtering by Fourier transformation was applied. The results indicated that the acceleration and strain induced by shock wave was nearly unaffected by the increasing gravity, while the effect of gravity has remarkable influence on those induced by bubble oscillation. A preliminary study of comparing the measured dynamic response with numerical simulations has been carried out using ANSYS LS-DYNA. The results captured the dynamic response in terms of characteristics and trends, but deviated in magnitude due the theoretical and technological limitations involved in both the physical and numerical models. It certainly deserves further studies. | LONG Yuan ZHOU HongYuan LIANG XiangQian SONG Ge CHEN ZuYu HU Jing WANG QiuSheng ZHANG XueDong LIANG JianHui HUANG ZhiJie | 2017 | Science China(Technological Sciences)2017，60，12： | 8 |
| 5 | Effect of VC addition on the microstructure and properties of Ti(C,N)-based nano cermets显示文摘In this paper,Ti(C,N)-based nano cermets were prepared by nano particles,and the effect of VC addition on the microstructure and proper-ties of Ti(C,N)-based nano cermets was investigated.The results showed that there existed black-core grayish-rim structure as well as gray-core grayish-rim structure in VC-doped Ti(C,N)-based nano cermets.With the increase of VC addition,the number of gray cores in-creased,the lattice parameter of Ti(C,N) phase increased,the grain size decreased,the hardness and fracture toughness of Ti(C,N)-based nano cermets were enhanced,and nearly full densification could be achieved.However,excessive addition of VC to 1 wt% resulted in slight decrease in hardness and fracture toughness.Some deep dimples were found in the fracture surface of cermets with VC addition,which cor-responded to ductile fracture. | YING Xiayu XIONG Ji GUO Zhixing CHEN Jianzhong XIONG Sujian YANG Mei FAN Hongyuan | 2011 | Rare Metals2011，30，6： | 7 |
| 6 | Research progress on ecological protection technology of highway slope: status and challenges显示文摘Slope protection has always been a major concern in highway construction and later operation.Ecological protection technology is widely used in highway slope,which takes into account functions of protection,ecology,and landscape.Ecological protection technology is mainly to improve the stability of the slope through the combination of supporting structure and plants,and vegetation restoration can reduce the negative impact of highway construction.In this paper,the latest research progress of ecological protection technology was first reviewed to identify the main construction process and types,which revealed the protection mechanism of ecological protection technology.The comprehensive benefits of ecological slope protection technology were analysed from the aspects of air,water circulation,landscape and biodiversity.It has found that ecological protection technology of highway slope mainly forms the atmosphere-plant-soil system.Ecological protection technology of highway slope improved the stability of the slope through the supporting structure and the anchoring effect of plant roots.And the restoration of the surface vegetation on the slope promoted the photosynthesis and transpiration of plants and purifies the air quality along the highway.Ecological protection technology of highway slope could quickly restore the ecological balance,overall landscape and biodiversity of the region. | Hongyuan Fu Huanyi Zha Ling Zeng Caiying Chen Chuankun Jia Hanbing Bian | 2020 | Transportation Safety and Environment2020，2，1： | 6 |
| 7 | Brain neural effects of the ’tonifying kidney and benefiting marrow’ method in the treatment of osteoporosis显示文摘In Traditional Chinese Medicine(TCM),the'tonifying kidney and benefiting marrow'(TKBM)method is based on the theory that kidney controls bones,while marrow moistens bones.There have been aboundant theoretical studies on kidney controlling bones since Huangdi's Internal Classics.Howev-er,there are too few ones about the marrow moistening the bones.Researchers generally use the tonifying kidney method instead of the TKBM method,which causes lack of a unified standard and theoretical basis in evaluating the TKBM method.Herein,we first proposed the hypothesis that deficiency of marrow sea causes osteoporosis.Next,we prove the scientific validity of this hypothesis from the side of the TCM theory on the relationship among kidney,bone and marrow sea physiologically and pathologically.Based on this,we find that the TCM theory provides theoretical basis for deficiency of marrow sea causing osteoporosis.On the other side,Western Medicine theory holds that(a)physiologically,the brain regulates the bone mass via three pathways:the neuro-osteogenic network,neuro-endocrine-bone network,and neuropeptide-bone network;(b)pathologically,brain impacts bone mass via three major passways including the regulation of the sympathetic nervous system,secreting hormones that directly act on bone cells and regulating the synthesis and secretion of hormones in the intermediary organs,and neuropeptides such as neuropeptide Y(NPY),substance P(SP),and calcitonin gene-related peptide(CGRP).Evidences involving estrogen deficiency,sympatheticotonia,or neuropeptides imbalance prove that brain-bone mass regulation plays an important role in the pathogenesis of osteoporosis.Finally,we find that kidney invigoration method can change the concentrations of central neurotransmitters of norepinephrine and glutamate to regulate neuro-osteogenic network,and promote the recovery of ovarian function and have an estrogen-like effect by regulating the hypothalamus-pituitary-ovarian axis,which thus influences bone metabolism without clinically significant estro-gen-like side effects,and regulate NPY,CGRP and SP involved in the bone metabolism.These further support our hypothesis by revealing the brain neural mechanism of the TCM kidney invigoration method for preventing and treating osteoporosis.In the future,neuroimaging techniques may be useful in exploring its neural effects and also aid in developing new strategies for treating osteoporosis. | Xu Yunxiang Liu Xueqin Li Haolan Liu Hongyuan Pan Zhanxia Chen Guizhen | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 5 |
| 8 | In situ localization of calmodulin mRNA in the developing tobacco anthers显示文摘The temporal and spatial expression patterns of calmodulin mRNA in the developing tobacco anthers were investigated by in situ RNA hybridization, using digoxigening-labeled anti-RNA probe. Calmodulin mRNA was distributed in various developmental stages of tobacco anthers, but the expression level had temporal and spatial differences distinctly. During early stage of anther development, the expression level of calmodulin mRNA was significantly high, mainly distributed in epidermis, tapetum and transfusion parenchyma cells and so on. Especially, more mRNA was accumulated in the nuclei and chromosomes of microspore mother cells prior to and during meiosis. With the development of anther,mRNA was decreased gradually in the anther wall and pollen. By mature pollen stage, only a stronger positive reaction still existed in the epidermis of anther wall and transfusion parenchyma cells. The results suggest that the temporal and spatial expression of calmodulin mRNA is closely correlated with cell division, | Shaorong Chen Yingtang Lu Hongyuan Yang | 1999 | Chinese Science Bulletin1999，44，2： | 4 |
| 9 | Magnetic particles and cadmium sulfide nanoparticles tagging for signal-amplifying detection of nucleic acids显示文摘A versatile DNA recognition system using cadmium sulfide nanoparticles (CdS NPs) as labels was proposed for ultrasensitive detection of specific sequence DNA based on target recycling. This strategy utilized the magnetic particles (MNPs) for the immobilization of linker DNA and CdS NPs and the subsequent target DNA hybridization. Using the unique characteristic of nicking endonuclease for cutting one specific strand of double strand DNA (ds DNA), the linker DNA could be transected and the target DNA could be liberated for re-hybridization and hence the amount of released CdS NPs was enhanced. Due to the advantage of the MNPs and signal amplification from the target recycling, the analyte DNA could be detected by the square-wave stripping voltammetry (SWV) in a wide linear range from 0.4 fM to 100 fM with the detection limit down to 0.08 fM. The proposed DNA detection strategy possesses high sensitivity, satisfactory reproducibility and excellent stability, which might have potential in other DNA biological assays. | DONG XiaoYa, ZHAO WeiWei, XU JingJuan & CHEN HongYuan State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China | 2011 | Science China Chemistry2011，54，8： | 4 |
| 10 | Progress in the studies of photoelectrochemical sensors显示文摘Photoelectrochemical sensor is a new kind of developing analytical device based on the photoelectrochemical properties of materials.Because of its remarkable sensitivity,inherent miniaturization,portability and easy integration,photoelectrochemical analysis is becoming a promising analytical technique.This review focuses on the basic principles,classification,characteristics,and research progress of photoelectrochemical sensors with 94 references.The prospect of the development of photoelectrochemical sensors is also evaluated and discussed. | WANG GuangLi XU JingJuan CHEN HongYuan | 2009 | Science China Chemistry2009，52，11： | 3 |
| 11 | Simultaneous optical and electrochemical recording of single nanoparticle electrochemistry显示文摘单个 nanoparticle 碰撞为由与电极表面在随机的碰撞期间决定短暂水流学习单个 nanoparticles 的电气化学的活动变得流行。然而,真希望,电气化学的水流被测量,识别并且描绘为在一个碰撞事件的一座特定的当前的山峰负责的单个粒子仍然保持挑战性;这妨碍结构活动关系的理解。此处,我们报导同时光、电气化学单个 nanoparticle 碰撞记录;电气化学的信号与单个 nanoparticle 的活动相应,并且光信号揭示一样的 nanoparticle 的尺寸和地点。因而,结构(光信号) 活动(电气化学的信号) 关系能在单个 nanoparticle 水平被阐明;这包括电池, electrocatalysts,和电气化学的传感器为各种各样的应用有含意。另外,我们的以前的研究建议了一个 optical-to-electrochemical 变换模型独立地从光信号计算单个 nanoparticles 的电子转移率。同时光、电气化学记录在现在的工作完成了启用 optical-to-electrochemical 变换模型的直接、量的确认。 | Linlin Sun Yimin Fang Zhimin Li Wei Wang Hongyuan Chen | 2017 | Nano Research2017，10，5： | 3 |
| 12 | The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems显示文摘Vascular endothelial growth factor receptor 2(VEGFR-2)and neuropilin-1(NRP-1)are two prominent antiangiogenic targets.They are highly expressed on vascular endothelial cells and some tumor cells.Therefore,targeting VEGFR-2 and NRP-1 may be a potential antiangiogenic and antitumor strategy.A7R,a peptide with sequence of Ala-Thr-Trp-Leu-Pro-Pro-Arg that was found by phage display of peptide libraries,can preferentially target VEGFR-2 and NRP-1 and destroy the binding between vascular endothelial growth factor 165(VEGF165)and VEGFR-2 or NRP-1.This peptide is a new potent inhibitor of tumor angiogenesis and a targeting ligand for cancer therapy.This review describes the discovery,function and mechanism of the action of A7R,and further introduces the applications of A7R in antitumor angiogenic treatments,tumor angiogenesis imaging and targeted drug delivery systems.In this review,strategies to deliver different drugs by A7R-modified liposomes and nanoparticles are highlighted.A7R,a new dual targeting ligand of VEGFR-2 and NRP-1,is expected to have efficient therapeutic or targeting roles in tumor drug delivery. | Lu Lu Hongyuan Chen Dake Hao Xinke Zhang Fengshan Wang | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，6： | 3 |
| 13 | The outbreak of rabbit hemorrhagic virus type 2 in the interior of China may be related to imported semen显示文摘Dear Editor,Rabbit hemorrhagic disease(RHD)is a fatal infectious disease that primarily affects adult rabbits and causes great economic losses in the rabbit industry(Mitro and Krauss,1993).The causative pathogen is rabbit hemorrhagic disease virus(RHDV),which belongs to the genus Lagovirus and the family Calicivirus(Moussa et al.,1992).In 1984,RHDV was first documented in China. | Ruibin Qi Chunchun Meng Jie Zhu Hang Li Qiuhong Miao Jingyu Tang Aoxing Tang Hongyuan Guo Chuncao Liu Chuanfeng Li Zongyan Chen Fang Wang Qinwen Zhang Guangqing Liu | 2022 | Virologica Sinica2022，37，4： | 3 |
| 14 | Littoral-cell angioma of the spleen:a case report显示文摘Littoral-cell angioma(LCA), a primary angioma which clinically belongs to splenic hemangioma, can be mostly found in normal spleen red sinus shore cells of reticuloendothelial cell system. The cells of LCA strongly express endothelial and tissue cell associated antigens that indicate a dual differentiation characteristic; whereas only endothelial cell markers are positive in normal spleen red sinus shore cells. Diagnosis of LCA relies on histopathology. Regular follow-up is needed to monitor recurrence and metastasis. | Dongming Liu Zhaohui Chen Tongtong Wang Baichang Zhang Hongyuan Zhou Qiang Li | 2017 | Cancer Biology & Medicine2017，14，2： | 3 |
| 15 | Changes in Soil Enzyme Activity and Nutrient Content in Different Years of Continuous Cropping Tobacco Fields显示文摘In order to find out changes in the main fertility indicators of continuous cropping tobacco fields in Henan Province with years of continuous cropping,5 typical tobacco fields( Jia County,Shaoling District,Fangcheng County,Xiangcheng County,and Song County) were studied. Indicators in question included activity of main enzymes( sucrase,urease,catalase,and acid phosphatase),p H value,organic matters,total nitrogen,available phosphorus and available potassium. The results indicate that in most tobacco fields,the activity of sucrase and urease increased in two years of continuous cropping,later,it showed a declining trend with increase in years of continuous cropping; in some fields,it directly declined with increase in years of continuous cropping; the activity of catalase increased in two years of continuous cropping,later,it showed a declining trend with increase in years of continuous cropping,and it became stable after three years of continuous cropping;generally,the activity of acid phosphatase declined with increase in the years of continuous cropping within 3 years continuous cropping,later,it became stable. Except Fangcheng County,the soil p H value of other districts( counties) generally declined with increase in years of continuous cropping,and it was in the range of 5. 6-6. 8. With the increase in continuous cropping,the soil organic matters( SOM) in tobacco fields of Jia County and Song County declined,changes of SOM in tobacco fields of Fangcheng County and Xiangcheng County were not obvious,and SOM showed the trend of first decline then rise in Shaoling District. In most tobacco fields( Jia County,Xiangcheng County,and Song County),the total nitrogen showed a declining trend; in Shaoling District,it showed a trend of first decline then rise; in Fangcheng County,it showed a rising trend. The available phosphorus firstly slightly declined then rose in tobacco fields of Shaoling District and Song County; it showed a trend of first rise then decline in Jia County; there were no obvious changes in Fangcheng County and Xiangcheng County. Changes in the available potassium were different in tobacco fields. In sum,there are certain rules for changes in soil enzyme activity and nutrient content in tobacco fields in Henan Province,but changes are not completely the same. It is concluded that the site conditions and farming activities exert a certain influence on soil enzyme activity,p H value,organic matters,and nitrogen,phosphorus and potassium content. Therefore,to solve obstacles in continuous cropping of tobacco fields,different regions should take different measures. | Jifeng CHEN Hui SUN Yang XIA Kaixuan CAI Hongyuan LIU Yuanyuan LI Ruiliang GUO Bei HOU Shuai FENG Xiaoxin JIANG | 2017 | Asian Agricultural Research2017，9，5： | 2 |
| 16 | Bioactive extracellular matrix scaffolds engineered with proangiogenic proteoglycan mimetics and loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing显示文摘Diabetic ischemic wound treatment remains a critical clinical challenge.Neovascularization plays a significant role in wound healing during all stages of the tissue repair process.Strategies that enhance angiogenesis and neovascularization and improve ischemic pathology may promote the healing of poor wounds,particularly diabetic wounds in highly ischemic conditions.We previously identified a cyclic peptide LXW7 that specifically binds to integrinαvβ3 on endothelial progenitor cells(EPCs)and endothelial cells(ECs),activates vascular endothelial growth factor(VEGF)receptors,and promotes EC growth and maturation.In this study,we designed and synthesized a multi-functional pro-angiogenic molecule by grafting LXW7 and collagen-binding peptides(SILY)to a dermatan sulfate(DS)glycosaminoglycan backbone,named LXW7-DS-SILY,and further employed this multi-functional molecule to functionalize collagen-based extracellular matrix(ECM)scaffolds.We confirmed that LXW7-DS-SILY modification significantly promoted EPC attachment and growth on the ECM scaffolds in vitro and supported EPC survival in vivo in the ischemic environment.When applied in an established Zucker Diabetic Fatty(ZDF)rat ischemic skin flap model,LXW7-DS-SILY-functionalized ECM scaffolds loaded with EPCs significantly improved wound healing,enhanced neovascularization and modulated collagen fibrillogenesis in the ischemic environment.Altogether,this study provides a promising novel treatment to accelerate diabetic ischemic wound healing,thereby reducing limb amputation and mortality of diabetic patients. | Siqi He Tanaya Walimbe Hongyuan Chen Kewa Gao Priyadarsini Kumar Yifan Wei Dake Hao Ruiwu Liu Diana L.Farmer Kit S.Lam Jianda Zhou Alyssa Panitch Aijun Wang | 2022 | Bioactive Materials2022，7，4： | 2 |
| 17 | Inhibitory Effect of Short-Term Palpebral Margin Cleaning with Antibiotic Eye Drops on Ocular Surface Flora before Cataract Extraction:A New Preoperative Antibacterial Method显示文摘Objective To explore the clinical significance of the combined application of palpebral margin cleaning and antibiotic eye drops in inhibiting bacterial growth in the palpebral margin and conjunctival sacs before cataract extraction.Methods In this study,61 patients(97 eyes)with age-related cataract who underwent phacoemulsification and intraocular lens implantation were selected,and randomly grouped.In the experimental group,the combined application of palpebral margin cleaning with cotton pads and levofloxacin eye drops was given for three days before the surgery.In the control group,levofloxacin eye drops alone were applied for three consecutive days.Bacteria samples from the conjunctival sac and eyelid margins were cultivated and identified before and three days after taking antimicrobial measures,respectively.Results In the experimental group,the positive rates of the two bacteria samples were 100%(50/50)and 40%(20/50)before and 10%(5/50)and 0%(0/50)after the treatment.In the control group,the positive rates of the two bacteria samples were 97.9%(46/47)and 29.8%(14/47)before and 40.4%(19/47)and 10.6%(5/47)after the treatment.The positive rates between the two groups were not significantly different before taking antimicrobial measures(P=0.485 and 0.395),while they were significantly different after taking antimicrobial measures(P=0.001 and 0.024).Conclusion Combined application of eyelid and palpebral margin cleaning with cotton pads and antibiotic eye drops before cataract extraction imparted excellent antibacterial effects. | Xiaoyong Chen Hongyuan Cai Yinan Liu Jing Hong | 2022 | Chinese Medical Sciences Journal2022，37，2： | 2 |
| 18 | Smoke suppressant in flame retarded thermoplastic polyurethane composites: Synergistic effect and mechanism study显示文摘Considerable smoke and toxic volatiles generation has compromised the application of thermoplastic polyurethane (TPU) and caused a great threat to human life. Here, nano-MgFe layered double hydroxide (MgFe-LDH) with uniform particle size was synthesized to reduce smoke density and toxic gases of TPU composites using ammonium polyphosphate (APP) as a flame retardant agent. The results show that the combination of 16 wt.% APP and 4 wt.% MgFe-LDH greatly decreased the smoke density (D20min and Ds, max), smoke production rate (SPR) and heat release rate (HRR) of TPU composites. Furthermore, the MgFe-LDH synergist demonstrated high efficiency in decreasing total volatiled products and toxic volatiles evolved, such as the CO, HCN and isocyanates. The reason was mainly attributed to the chemical reaction between MgFe-LDH and APP, which can promote the compactness of char layers with fine microstructure formed in the decomposition process of MgFe-LDH/APP/TPU composites. The protective char layers could act as barriers between combustion zone and matrix to protect the unburned substrate and promote smoke suppression effect. | Hongyuan Ren Kelan Qing Ying Chen Yanjun Lin Xue Duan | 2021 | Nano Research2021，14，11： | 2 |
| 19 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 20 | PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure显示文摘Brown adipose tissue (BAT) plays an essential role in non-shivering thermogenesis. The phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) is identified as a lipid transporter that reciprocally transfers phospholipids between intracellular membrane structures. However, the physiological significance of PITPNC1 and its regulatory mechanism remain unclear. Here, we demonstrate that PITPNC1 is a key player in thermogenesis of BAT. While Pitpnc1^(−/−) mice do not differ with wildtype mice in body weight and insulin sensitivity on either chow or high-fat diet, they develop hypothermia when subjected to acute cold exposure at 4℃. The Pitpnc1^(−/−) brown adipocytes exhibit defective β-oxidation and abnormal thermogenesis-related metabolism pathways in mitochondria. The deficiency of lipid mobilization in Pitpnc1^(−/−) brown adipocytes might be the result of excessive accumulation of phosphatidylcholine and a reduction of phosphatidic acid. Our findings have uncovered significant roles of PITPNC1 in mitochondrial phospholipid homeostasis and BAT thermogenesis. | Guoqing Tang Chengxin Ma Liangkui Li Shaoyan Zhang Fengsheng Li Jin Wu Yesheng Yin Qing Zhu Yan Liang Ru Wang He Huang Tong-Jin Zhao Hongyuan Yang Peng Li Feng-Jung Chen | 2022 | Science China(Life Sciences)2022，65，11： | 2 |
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