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| 1 | 光电化学免疫分析研究进展显示文摘光电化学分析是近年建立起来的一种基于物质的光电转换特性而进行检测的新型分析方法,它具有灵敏度高、设备简单、易于微型化等特点.光电化学免疫分析则是光电化学分析与免疫反应的结合,体现了光电化学传感的高灵敏度和免疫反应的高特异性.其基本方法原理是,在光照条件下,光电活性物质将免疫反应转变为电信号,从而实现对待测物的定量测定.在过去10年中,伴随着光电化学分析技术的进步,光电化学免疫分析经历了快速发展的过程.本文介绍了光电化学免疫分析的方法原理和特点,对其代表性的研究工作进行介绍和评述,并展望其未来的发展趋势. | 赵伟伟 马征远 徐静娟 陈洪渊 | 2014 | 科学通报2014，59，2： | 5 |
| 2 | Development of Science China Chemistry during 2008-2012:From the perspective of Special Issues/Topics显示文摘1 Introduction Science China Press Co.,Ltd.(SCP) is a science and technology(ST) journal publishing company of the Chinese Academy of Sciences(CAS).SCP publishes 16 kinds of academic journals,Science China Series and Chinese Science Bulletin,of which 8 journals are in English and 8 | SONG GuanQun ZHU XiaoWen | 2012 | Science China Chemistry2012，55，12： | 2 |
| 3 | Disposable paper-based bipolar electrode array for multiplexed electrochemiluminescence detection of pathogenic DNAs显示文摘A novel disposable paper-based bipolar electrode(BPE) array is fabricated for multiplexed electrochemiluminescence(ECL) detection of pathogenic DNAs. This proposed BPE array device consists of 15 units, each consisting of six sensing cells and two reporting cells patterned using hydrophobic wax. A hairpin structure DNA assembled on the cathodes of BPEs hybridizes with Pt nanoparticles(NPs) labeled probe DNA in the presence of complementary target DNA. The introduction of Pt NPs catalyzes the reduction of dissolved O2 at cathodes and induces an enhanced ECL signal from Ru(bpy)32+/tripropylamine(TPr A) at the anodes of BPEs. The dissolved O2 lost in reduction reaction could be promptly replenished due to the relatively large contact area of the paper-based cells with air, which ensures the stability of ECL signal. This obtained paper-based BPE array sensor showed excellent performances for the multiplexed analysis of the syphilis(Treponema pallidum) gene, the immunodeficiency virus gene(HIV) and hepatitis B virus gene(HBV). | Qiumei Feng Hongyuan Chen Jingjuan Xu | 2015 | Science China Chemistry2015，58，5： | 2 |
| 4 | Spectroscopic and electrochemical studies on molecular recognition of tetrathiafulvalene derivative with P-glycoprotein and drug-resistant leukemia cells显示文摘Cancer is still one of the important diseases that threatens the health of people. Multidrug resistance(MDR) is the main factor that leads to the failure of cancer chemotherapy. Thus, MDR diagnosis could facilitate the monitoring of the therapy process and realization of efficient treatment of tumors. In this study, we have tried to use a new tetrathiafulvalene(TTF) derivative(TTF-(COONBu4)2) to sensitively recognize the MDR through the multi-signal responsive strategy. The relevant electrochemical and spectroscopic studies demonstrate the specific binding behavior of TTF-(COONBu4)2 with P-glycoprotein(P-gp) as well as drug-resistant leukemia cells. Especially due to the over-expression of specific components of P-gp on the plasma membranes of drug resistant cells, the electrochemical and hydrophilic/hydrophobic features of drug resistant-leukemia cells are apparently different from those of other kinds of leukemia cells. Meanwhile, Fourier transform infrared spectroscopic study illustrates that the most intense vibration band of TTF moieties in the 1400–1600 cm-1 range is almost smeared out upon binding to P-gp, and the binding of TTF-(COONBu4)2 to P-gp may also lead to changes in protein secondary structure and backbone. This observation may advance the development of the new TTF agent for the promising clinical diagnosis and monitoring of MDR of tumors with the aim of successful chemotherapy for human cancer. | Yuanyuan Zhang Changyu Wu Hui Jiang Jinglin Zuo Xuemei Wang | 2015 | Science China Chemistry2015，58，7： | 0 |
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