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| 1 | Effects of major ozonated autohemotherapy in the treatment of dry age related macular degeneration: a randomized controlled clinical study显示文摘AIM: To evaluate the effect of systemic ozonated major autohaemotherapy (O3-AHT) in patients affected by dry age related macular degeneration (AMD). METHODS: This study was a randomized, controlled clinical study. One hundred and forty patients with the diagnosis of AMD in both eyes, with the study eye presenting dry AMD and soft drusen, were randomly assigned in a 1:1 ratio to either receive 27 major ozonated autohemotherapy treatments during 12-month period, or a standardized multi-vitamin therapy. Primary outcome was the change in best corrected visual acuity (mean logMar change) between the baseline and 6 and 12 months, end point of the study. In addition, to investigate the safety of prolonged ozonated autohaemotherapy, we measured the routine haemato- chemical parameters and biochemical oxidative stress values at baseline and after 12 months treatment time. RESULTS: The mean baseline best corrected visual acuity in study eyes was 0.36 in the treatment group and 0.38 in the control group (difference not statistically significant). At the primary endpoint, 6 months post-baseline, the mean logMAR change in the treated group improved by 0.1 and the values of the control group at the same time impaired by 0.2 respect to the baseline. Four percent and twenty-five percent of eyes in the group treated with O3-AHT gained 1 or more lines after 6 and 12 months respectively compared to 0% in the eyes which received no treatment (P <0.05 at 12 months). None of the treated patients experienced a loss in visual acuity in their study eye at 6 and 12 months, compared to 16% and 40 % of patients in the control group who lost 2 lines or more at 6 months and 12 months respectively (P <0.05 treated vs control group)). Major ozonated autohemotherapy was shown to be safe and well- tolerated by the patients. Moreover, the haematochemical parameters showed a decrease in the Reactive Oxygen Metabolites (300±10.1 UCARR at 12 months compared to a baseline value of 380±10.4 UCARR, P <0.05) and an increase in Biological Antioxidant Potential plasma values (2100±34.8 micromoles/ C vitamin after 12 months compared to the baseline value of 1610±36.2, P <0.05) in the treated patients when compared to the control group. This data suggests that major ozonated autohaemotherapy may exert a role in reducing oxidative stress by endogenously stimulating the production of antioxidant molecules. CONCLUSION: The results of this study suggests that major ozonated autohaemotherapy could be a safe and effective therapeutic option for high-risk patients with dry AMD, and that a series of such treatments could improve the natural course of AMD. | Emma Borrelli Angelica Diadori Alessandro Zalaffi Velio Bocci | 2012 | International Journal of Ophthalmology(English edition)2012，5，6： | 10 |
| 2 | Influence of rejuvenators on bitumen ageing in hot recycled asphalt mixtures显示文摘The use of reclaimed asphalt pavement(RAP) in new hot mix asphalt(HMA) by means of hot recycling techniques generates the advantage linked to the exploitation of both lytic and bituminous component, consequently leading to the decrease of both virgin aggregates and bitumen supplying. However, many agencies and public administration authorise RAP percentages ranges from 10% to 30% in hot recycling. The main reason for such a low amount of allowable RAP content is related to the aged bitumen contained in the RAP materials, which is more brittle than a virgin bitumen leading to a final mixture more susceptible to fatigue, thermal and reflection cracking. The use of rejuvenators has the potential to restore rheology and chemical components of aged RAP bitumen, thus allowing a significant increase in the amount of RAP to be properly implemented in HMA.The experimental investigation is described in this paper and carried out through a dynamic shear rheometer(DSR) which provides the rheological characterisation of a paving grade bitumen during its overall service life including its reuse in hot recycling by adopting different rejuvenators.Results show that rejuvenators modify bitumen chemistry and consequently rheology by enhancing the viscous response. Moreover, it was observed that oxidation is less harmful, in terms of stiffness increase, on the 50/50 aged bitumen-virgin bitumen blends(rejuvenated or not) than on the virgin bitumen. Moreover, the addition of a rejuvenator in a bituminous blend containing 50% of bitumen reactivated from RAP could lead to a corresponding composite bituminous phase less subjected to ageing phenomena and even less stiff at the end of service life than the associated virgin bitumen alone. | Giorgia Mazzoni Edoardo Bocci Francesco Canestrari | 2018 | Journal of Traffic and Transportation Engineering(English Edition)2018，5，3： | 5 |
| 3 | Antiproliferative and Proapoptotic Activity of Sunitinib on Endothelial and Anaplastic Thyroid Cancer Cells via Inhibition of Akt and ERK1/2 Phosphorylation and by Down-Regulation of Cyclin-D1显示文摘 | Teresa Di Desidero Anna Fioravanti Paola Orlandi Bastianina Canu Riccardo Giannini Nicla Borrelli Shan Man Ping Xu Gabriella Fontanini Fulvio Basolo Robert S. Kerbel Giulio Francia Romano Danesi Guido Bocci | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，9： | 2 |
| 4 | Ozonization of blod for the therapy of viral diseases and immunodeficiencies显示文摘 | Bocci V | 1992 | Med Hypotheses1992，39，1： | 1 |
| 5 | Ozone acting on human blood yields a hormetic dose-response relationship 显示文摘 | Bocci VA Zanardi I Travagli V | 2011 | J Transl Med2011，17，9： | 1 |
| 6 | Thrombospondin 1,a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy显示文摘 | Bocci G Francia G Man S | 2003 | Proc Natl Acad Sci USA2003，100，12： | 1 |
| 7 | Analysis of structural compati- bility at interface between asphalt concrete pavements and orthotropic steel deck surfaces显示文摘 | Bocci E Canestrari F | 2012 | Transportation Research Record: Journal of the Transportation Re- search Board2012，2293，1： | 1 |
| 8 | Ozone as Janus:thiroversial gas can be either toxic or medically useful显示文摘 | Bocci V | 2004 | Mediators Inflamm2004，13，1： | 1 |
| 9 | Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water显示文摘 | Man S Bocci G Francia G | 2002 | Cancer Res2002，62，10： | 1 |
| 10 | Ozone as Janus:this controversial gas can be either toxic or medically useful显示文摘 | Bocci V | 2004 | Modators Inflamm2004，13，1： | 1 |
| 11 | Ozone as a bioregulator,pharmacology and toxicology of ozone therapy today显示文摘 | BOCCI V | 1996 | Biol Regul Homeost Agents1996，10，23： | 1 |
| 12 | Effects of ozone on isolated peripheral blood mononuclear cells显示文摘 | Larini A Bocci V | 2005 | Toxicol In Vitro2005，19，1： | 1 |
| 13 | Biological and clinical effects of ozone: has ozone theraPy afuture in medicine显示文摘 | Bocci V | 1999 | Br J Biomed Sci1999，56，4： | 1 |
| 14 | High concentrations of the vascular endothelial growth factor and interleukin-8 in ovarian endometriomata 显示文摘 | Fasciani A D'Ambrogio G Bocci G | 2000 | Mol Hum Reprod2000，6，1： | 1 |
| 15 | Study on the biological effects of ozone effectinn the total antioxidant status and on interleukin-8 production显示文摘 | Bocci V Valacchi G Corradeschi F ctal | 1998 | Mediat Inflamm1998，7，5： | 1 |
| 16 | A study on the mechanical behaviour of cement-bitumen treated materials显示文摘 | BOCCI M GRILLI A CARDONE F | 2011 | Construction and Building Materials2011，25，2： | 1 |
| 17 | Ozone as Janus:this controversial gas can be either toxic or medically useful显示文摘 | Bocci V | 2004 | Mediators Inflamm2004，13，1： | 1 |
| 18 | Potentiality of oxygen-ozonetherapy to improve the health of aging people 显示文摘 | Bocci V Zanardi I Travagli V | 2010 | Curt Aging Sci2010，3，3： | 1 |
| 19 | Does ozone therapy normalize the cellular redox balance Implications for the therapy of human immunodeficiency virus infection and several other diseases显示文摘 | Bocci V | 1996 | Med Hypotheses1996，46，： | 1 |
| 20 | The ozone paradox: ozone Is a strong oxidant aswell as a medical drug显示文摘 | Bocci V Emma B Valter TG | 2009 | Med Res Rev2009，29，4： | 1 |
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