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| 1 | The molecular machinery of regulated cell death显示文摘Cells may die from accidental cell death(ACD)or regulated cell death(RCD).ACD is a biologically uncontrolled process,whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms.A growing number of novel nonapoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies.Here,we critically review the current state of the art regarding non-apoptotic types of RCD,including necroptosis,pyroptosis,ferroptosis,entotic cell death,netotic cell death,parthanatos,lysosome-dependent cell death,autophagy-dependent cell death,alkaliptosis and oxeiptosis.The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidanee of pathogenic cell loss. | Daolin Tang Rui Kang Tom Vanden Berghe Peter Vandenabeele Guido Kroemer | 2019 | Cell Research2019，29，5： | 143 |
| 2 | Autophagy: for better or for worse显示文摘Autophagy 是降级的降级小径损坏了的 lysosomal 或过剩房间部件进基本 biomolecules,它然后回来被再循环进 cytosol。在这个方面, autophagy 在一个连续降级新生周期驾驶 biomolecules 的流动。Autophagy 通常被认为在应力或差的滋养的条件下面保护房间的支持幸存的机制。当前的研究清楚地证明 autophagy 在重要生物过程完成众多的功能。它在开发被含有,区别,天生、适应的免疫,变老并且房间死亡。另外,积累证据表明在 autophagy 和几人的疾病和肿瘤开发之间的有趣的连接。因此, autophagy 似乎是在细胞和有机体的生活和死亡的一个重要播放器。尽管有 autophagy 的增长知识, autophagic 机械通过调整这些多样的过程的机制完全没被理解。在这评论,我们给表明小径的 autophagic 的全面概述,它的角色一般来说细胞的过程和它的连接到房间死亡。另外,我们在场发信号到疾病的有缺点的 autophagic 的可能的贡献的简短概述。 | Ellen Wirawan Tom Vanden Berghe Saskia Lippens Patrizia Agostinis Peter Vandenabeele | 2012 | Cell Research2012，22，1： | 70 |
| 3 | Neutrophil extracellular trap cell death requires both autophagy and superoxide generation显示文摘嗜中性的细胞外的陷井(网) 是能套住并且降级的细胞外的染色质结构微生物。他们从激活称为网络房间死亡,或 NETosis 的一个房间死亡程序的 neutrophils 产生。NETosis 的激活被显示了包含 NADPH oxidase 活动,原子信封的崩溃和大多数小粒膜,网的原子染色质和形成的 decondensation。我们报导在 phorbol,十四酸盐醋酸盐(PMA ) 刺激了 neutrophils,细胞内部的染色质 decondensation 和网形成跟随 autophagy 和 superoxide 生产,哪个被要求调停导致 PMA 的 NETosis 并且独立于对方发生。从有长期的 granulomatous 疾病的病人的 Neutrophils,缺乏 NADPH oxidase 活动,仍然展出导致 PMA 的 autophagy。相反地,导致 PMA 的 NADPH oxidase 活动没被 autophagy 的药理学抑制影响。有趣地,任何一个 autophagy 的抑制或 NADPH oxidase 阻止细胞内部的染色质 decondensation,它为 NETosis 和网形成是必要的,并且导致 apoptosis 的特点描绘的房间死亡。当 autophagy 或 NADPH oxidase 活动被阻止时,这些结果显示 apoptosis 可能为 NETosis 作为一个备份节目工作。 | Quinten Remij sen Tom Vanden Berghe Ellen Wirawan Bob Asselbergh Eef Parthoens Riet De Rycke Sam Noppen Michel Delforge Jean Wlllems Peter Vandenabeele | 2011 | Cell Research2011，21，2： | 46 |
| 4 | China’s 1-3-7 surveillance and response strategy for malaria elimination: Is case reporting, investigation and foci response happening according to plan?显示文摘Background:The China’s 1-3-7 strategy was initiated and extensively adopted in different types of counties(geographic regions)for reporting of malaria cases within 1 day,their confirmation and investigation within 3 days,and the appropriate public health response to prevent further transmission within 7 days.Assessing the level of compliance to the 1-3-7 strategy at the county level is a first step towards determining whether the surveillance and response strategy is happening according to plan.This study assessed if the time-bound targets of the 1-3-7 strategy were being sustained over time.Such information would be useful to improve implementation of the 1-3-7 strategy in China.Methods:This cross-sectional study involved country-wide programmatic data for the period January 1st 2013 to June 30th 2014.Data variables were extracted from the national malaria information system and included socio-demographic information,type of county,date of diagnosis,date of reporting,date of case investigation,case classification(indigenous,or imported,or unknown),focus investigation,date of reactive case detection(RACD),and date of indoor residual spraying(IRS).Summary statistics and proportions were used and comparisons between groups were assessed using the chi-square test.Level of significance was set at a P-value≤0.05.Results:Of a total of 5,688 malaria cases from 731 counties,there were 55(1%)indigenous cases(only in Type 1 and Type 2 counties)and 5,633(99%)imported cases from all types of counties.There was no delay in reporting malaria cases by type of county.In terms of case investigation,97.5%cases were investigated within 3 days with the proportion of delays(1.5%)in type 2 counties,being significantly lower than type 1 counties(4.1%).Regarding active foci,96.4%were treated by RACD and/or IRS.Conclusions:The performance of 1-3-7 strategy was encouraging but identified some challenges that if addressed can further improve implementation. | Shui-Sen Zhou Shao-Sen Zhang Li Zhang Aafje ECRietveld Andrew RRamsay Rony Zachariah Karen Bissell Rafael Van den Bergh Zhi-Gui Xia Xiao-Nong Zhou Richard ECibulskis | 2015 | Infectious Diseases of Poverty2015，4，1： | 21 |
| 5 | 神经网络补偿机床热变形误差的机器学习技术显示文摘研究了以神经网络(NN)为模型的软件补偿不同机床热误差。提出知识获取是神经网络建模的关键环节。两种数控机床被用来研究分析热变形,通过测量实验获取学习数据,特别是温度测量和传感器数目的选取。介绍了机器学习技术和学习数据组织方法,包括归纳学习和推理学习。给出了预报补偿的结果和精度评价。 | 杨庆东 Van Den Bergh C Venherck P KruthJP | 2000 | 机械工程学报2000，36，1： | 15 |
| 6 | Medically unexplained dyspnea:psychophysiological characteristics and role of breathing therapy显示文摘Background Medically unexplained dyspnea occurs commonly in medical settings and remains poorly understood. This study was conducted to investigate the psychophysiological characteristics of medically unexplained dyspnea and the efficacy of breathing retraining for these patients. Methods A group of patients with medically unexplained dyspnea were compared to patients with a variety of organic lung diseases and healthy subjects. In another group of patients,the influence of breathing therapy on complaints,anxiety, and breath-holding was evaluated for an average of 1.5 years. Results Patients with medically unexplained dyspnea reported more intense dyspnea than patients with a variety of organic lung diseases. Additionally,they were anxious and presented a broad range of symptoms in daily life and under challenge,for instance voluntary hyperventilation. More than one third of them qualified for panic disorder. They had shorter breath-holding time at rest,less increase in breath-holding time and higher chances of showing a “paradoxical” decrease of breath-holding time after hyperventilation. A combination of PaO2,forced expiratory volume in one second (FEV1),and anxiety measures distinguished them from organic dyspnea. Breathing retraining profoundly improved their symptoms and decreased the level of state and trait anxiety. Moreover,they better tolerated the voluntary hyperventilation and the symptoms induced were also markedly decreased after therapy. Breath-holding time was prolonged and PetCO2 in a representative group of patients increased. Conclusions Patients with medically unexplained dyspnea appear to have the feature of a “psychosomatic” patient: an anxious patient with a wide variety of symptoms of different organ systems that do not have an organic basis. They can be distinguished from organic dyspnea using a small set of physiological and psychological measures. Breathing retraining turns out to be an effective therapy for those “difficult to treat patients”. | 韩江娜 朱元珏 李舜伟 雒冬梅 胡征 Van Diest I De Peuter S Van de Woestijne KP Van den Bergh O | 2004 | Chinese Medical Journal2004，，1： | 10 |
| 7 | 高通气综合征?还是惊恐障碍?显示文摘 | 韩江娜 R Schepers K Stegen O Van den Bergh KP Van de Woestijne | 2001 | 中华结核和呼吸杂志2001，24，9： | 9 |
| 8 | 沥青自修复微胶囊研究进展显示文摘微胶囊技术在世界上已应用于多个领域,包括医药、食品和化工等,具有广阔的应用前景。将微胶囊引入到沥青材料自修复中,可提高沥青材料的自修复能力并在裂缝产生初期即可自我修复,延长路面使用寿命。与传统的裂缝修补方法相比,微胶囊自修复技术具有节能减排、降低养护成本和防止微裂缝扩展至宏观裂缝等优势。然而,沥青自修复微胶囊技术仍处于初步探索阶段,将微米级微胶囊应用于沥青材料自修复领域还存在着微胶囊强度控制范围不够明确,微胶囊破裂理论尚不成熟,且微胶囊制备工艺参数设计尚不统一等问题。因此,研究者们除研究制备工艺的影响外,还主要从选择合适的制备工艺影响参数和微胶囊的结构与性能方面不断尝试,并取得了丰硕的成果。随着制备工艺的不断成熟和影响参数的不断优化,经原位聚合法制备的微胶囊结构致密、性能优良。目前对掺微胶囊的沥青材料自修复的研究仍存在对沥青材料自修复提升效果的评价方法和评价指标尚不统一等问题。掺微胶囊的沥青材料自修复效果主要通过不同的指标来体现,包括延度、复数模量、拉伸强度、试件的载荷和沥青混合料的疲劳寿命等。其中,还对掺微胶囊的沥青混合料进行了路用性能研究。通过不同的评价指标表明,微胶囊显著提升了沥青材料的自修复效果;掺微胶囊的沥青混合料的水稳定性和高温稳定性略有下降,低温抗裂性下降较大,但仍满足规范要求。为总结沥青自修复微胶囊的研究进展,本文对比分析了多种自修复微胶囊制备方法的优势和特点,解析了影响微胶囊质量的主要因素(芯壁比、反应温度、终点pH值、乳化转速、酸化时间),总结了微胶囊的结构与性能的表征方法,介绍了掺微胶囊沥青材料自修复性能的评价方法与提升效果,阐述了微胶囊对沥青混合料路用性能的影响,探讨了借助分子动力学手段研究掺微胶囊的沥青材料自修复行为理论的可行性并展望了其未来发展前景,以期为微米级微胶囊的应用与发展提供参考。 | 何亮 黄胡端 Wim Van den bergh Tóth Csaba 高杰 Karol Kowalski Jan Valentin | 2020 | 材料导报2020，34，15： | 7 |
| 9 | 动态肺量测定在支气管哮喘中的应用显示文摘目的探讨动态肺量测定技术在支气管哮喘中的应用。方法建立动态肺量测定技术,对20例支气管哮喘患者每天清晨、下午和入睡前连续14d动态监测气道功能、症状和情绪。结果白天标准肺功能检查结果正常的支气管哮喘患者,第一秒用力呼气量(FEV1)和最大呼气峰流量(PEF)在夜间和凌晨可出现明显下降。肺功能指标与支气管哮喘症状的相关分析发现,只有7例患者(35%)支气管哮喘症状与FEV1和PEF存在相关关系。4例患者(20%)肺功能基本正常,但有很多症状,症状与FEV1和PEF无相关关系,但与负面情绪相关。另外2例患者(10%)肺功能损害严重,但几乎没有症状。结论动态肺量测定技术能客观反映支气管哮喘患者气道功能的昼夜自然变化,因此可以更准确地反映支气管哮喘的严重程度。动态肺量测定技术结合症状和情绪的同步监测,可以帮助识别出特殊症状感觉类型的支气管哮喘患者。 | 尹小文 韩江娜 朱元珏 许文兵 KP Van de Woestijne O Van den Bergh | 2005 | 中国医学科学院学报2005，27，3： | 6 |
| 10 | 旅游和民族性的再创造显示文摘这是一篇对社会学家和人类学家编写的论文集做介绍的文章,主要论述旅游在保持、改变和重新创造民族边界中的作用。旅游被看成是民族交往的一种特别形式,导致了三个主要角色的形成,即游客、旅游对象和中间人。文章主要关涉:国家在发展民族旅游中扮演的角色、作为旅游结果的民族特征和民族意识的改变和再创造、在旅游交易中艺术形式的转变、旅游代理商的角色以及在民族旅游主客互动交往中形成了民族“刻板印象”。 | Pierre L.Van den Berghe Charles F.Keyes 徐赣丽 | 2006 | 民俗研究2006，，1： | 6 |
| 11 | Interpretation of illness in patients with chronic diseases from Shanghai and their associations with life satisfaction, escape from illness, and ability to reflect the implications of illness显示文摘OBJECTIVE: The aim of this study is to analyze how patients with chronic diseases from Shanghai interpret their disease, and how these interpretations infl uence patients' life satisfaction, intention to escape from their illness and their ability to refl ect on the implications of their illness.METHODS: A cross-sectional study enrolling 142 patients(mean age(50 ± 16) years; 63% men, 37% women) with chronic diseases(60% cancer) was recruited in the Changhai Hospital of Traditional Chinese Medicine, Shanghai, China and surveyed using standardized questionnaires.RESULTS: Patients with chronic diseases from Shanghai interpreted their illness mostly as an Adverse Interruption of Life(55%), as a Threat/Enemy(50%), but also as a Challenge(49%), and only rarely as a Call for Help(18%) or as a Punishment(13%). Particularly fatalistic negative(i.e., Threat/Enemy, Adverse Interruption of Life) and strategy-associated disease interpretations(i.e., Relieving Break, Call for Help) were moderately associated with patients' intention to escape from illness. In contrast, positive interpretations(i.e., something of Value, Challenge) and also the guilt-associated negative interpretation Failure were moderately related with patients' ability to refl ect on their illness. However, life satisfaction was weakly associated only with the view that illness might be a Challenge. Interestingly, 58% of those who would see their illness as an Adverse Interruption(AI+) could see it also as a Challenge(Ch+). Detailed analyses showed that AI+Ch+ patients differ from their AI+Ch- counterparts signifi cantly with respect to their ability to refl ect life and implications of illness(F=9.1; P=0.004).CONCLUSION: The observed interpretations of illness, particularly the negative perceptions, could be used as indicators that patients require further psychological assistance to cope with their burden. Helping AI+ patients see their illness also as a Challenge, and thus develop a higher Refl ection on Life Concerns, would be greatly benefi cial, and encourages further research. | Arndt Büssing Ariane von Bergh Xiao-feng Zhai Chang-quan Ling | 2014 | Journal of Integrative Medicine2014，12，5： | 4 |
| 12 | Economic growth and emissions: reconsidering the empirical basis of environmental Kuznets curves显示文摘 | S.M de Bruyn J.C.J.M van den Bergh J.B Opschoor | 1998 | Ecological Economics1998，，2： | 4 |
| 13 | 呼吸前反馈调节、情景想象和过度通气显示文摘 | Ilse Van Diest 韩江娜 Karel P.Vande Woestijne Stephan Devriese Winnie Winters Omer Vanden Bergh | 2002 | 中华结核和呼吸杂志2002，25，5： | 4 |
| 14 | Introductory to the ESPEN Guidelines on Enteral Nutrition: Terminology, Definitions and General Topics显示文摘 | H. Lochs S.P. Allison R. Meier M. Pirlich J. Kondrup St. Schneider G. van den Berghe C. Pichard | 2006 | Clinical Nutrition2006，，2： | 3 |
| 15 | 闭环光纤陀螺仪的简化控制理论显示文摘 | Bergh,RA 袁红蓓 | 1994 | 惯导与仪表1994，，3： | 3 |
| 16 | 少年儿童非器质性呼吸困难34例分析显示文摘目的 总结分析 1996~ 2 0 0 2年间在北京协和医院诊断的 34例少年儿童非器质性呼吸困难病例。方法 非器质性呼吸困难的临床诊断标准 :有突出的呼吸困难 ,经过询问病史、体格检查和相关的实验室检查 ,没有心肺或其他器质性病因。结果 少年儿童非器质性呼吸困难最小发病年龄 8岁 ,13~ 16岁为高峰发病年龄 ,17岁以后发病人数明显减少。大多数为慢性病程 ,伴症状急性发作。表现为呼吸困难 ,伴随明显的过度通气、低碳酸血症的症状。少年儿童患者焦虑不明显 ,与成人形成鲜明对比。多数患儿有明显的心因性诱因 ,中学阶段学习压力大为最重要的诱因。 13例患儿接受腹式呼吸训练治疗 2~ 3个月后复查 ,呼吸困难和伴随症状得到明显改善。结论 少年儿童非器质性呼吸困难呈慢性过程 ,需要引起足够的重视 ,提高医师警觉性是正确诊断处理的关键。 | 韩江娜 朱元珏 李舜伟 雒冬梅 尹小文 陈育智 O Van den Bergh KP Van de Woestijne | 2004 | 中华儿科杂志2004，42，4： | 3 |
| 17 | Intensive insulin therapy in the critically ill patients显示文摘 | Van den Berghe G Wouters P Weekers F | | 0，，19： | 3 |
| 18 | Intensive insulin therapy in the medical ICU显示文摘 | Van den Berghe G Wilmer A Hermans G | | New England Journal of Medicine0，，： | 3 |
| 19 | L1 use during L2 writing: An empirical study of a complex phenomenon显示文摘 | Daphne van Weijen Huub van den Bergh Gert Rijlaarsdam Ted Sanders | 2009 | Journal of Second Language Writing2009，，4： | 2 |
| 20 | Apoptosis and necrosis: Detection, discrimination and phagocytosis显示文摘 | Dmitri V. Krysko Tom Vanden Berghe Katharina D'Herde Peter Vandenabeele | 2008 | Methods2008，，3： | 2 |
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