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| 1 | Tumor-infiltrating lymphocytes in the immunotherapy era显示文摘The clinical success of cancer immune checkpoint blockade(ICB)has refocused attention on tumor-infiltrating lymphocytes(TILs)across cancer types.The outcome of immune checkpoint inhibitor therapy in cancer patients has been linked to the quality and magnitude of T cell,NK cell,and more recently,B cell responses within the tumor microenvironment.State-of-the-art single-cell analysis of TIL gene expression profiles and clonality has revealed a remarkable degree of cellular heterogeneity and distinct patterns of immune activation and exhaustion.Many of these states are conserved across tumor types,in line with the broad responses observed clinically.Despite this homology,not all cancer types with similar TIL landscapes respond similarly to immunotherapy,highlighting the complexity of the underlying tumor-immune interactions.This observation is further confounded by the strong prognostic benefit of TILs observed for tumor types that have so far respond poorly to immunotherapy.Thus,while a holistic view of lymphocyte infiltration and dysfunction on a single-cell level is emerging,the search for response and prognostic biomarkers is just beginning.Within this review,we discuss recent advances in the understanding of TIL biology,their prognostic benefit,and their predictive value for therapy. | Sterre T.Paijens Annege Vledder Marco de Bruyn Hans W.Nijman | 2021 | Cellular & Molecular Immunology2021，18，4： | 37 |
| 2 | 饲料中补充植酸酶的新策略显示文摘 | Karl De Bruyne 陆文清 王秀坤 | 2000 | 国外畜牧科技2000，27，6： | 10 |
| 3 | Experimental Basis of Determining Maximum Coronary, Myocardial, and Collateral Blood Flow by Pressure Measurements for Assessing Functional Stenosis Severity Before and After Percutaneous Transluminal Coronary Angioplasty显示文摘 | Nico H.J. Pijls Jacques A.M. van Son Richard L. Kirkeeide Bernard De Bruyne Lance K. Gould | 1993 | Circulation1993，，4： | 6 |
| 4 | Connecting Growth of Brassinosteroids Immunity and Defense: The and Gibberellins Emerging Roles in Plant Innate显示文摘 | Lieselotte De Bruyne Monica HOfte David De Vleesschauwer | 2014 | Molecular Plant2014，7，6： | 5 |
| 5 | Economic growth and emissions: reconsidering the empirical basis of environmental Kuznets curves显示文摘 | S.M de Bruyn J.C.J.M van den Bergh J.B Opschoor | 1998 | Ecological Economics1998，，2： | 4 |
| 6 | Physiological Assessment of Coronary Artery Disease in the Cardiac Catheterization Laboratory: A Scientific Statement From the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology显示文摘 | Morton J. Kern Amir Lerman Jan-Willen Bech Bernard De Bruyne Eric Eeckhout William F. Fearon Stuart T. Higano Michael J. Lim Martijn Meuwissen Jan J. Piek Nico H.J. Pijls Maria Siebes Jos A.E. Spaan | 2006 | Circulation2006，，12： | 3 |
| 7 | The influence of temperature on mechanical characteristics of Boom clay: The results of an initial laboratory programme显示文摘 | D. De Bruyn J.-F. Thimus | 1996 | Engineering Geology1996，，1： | 2 |
| 8 | Developments in the throughput-income relationship: theoretical and empirical observations显示文摘 | S.M. de Bruyn J.B. Opschoor | 1997 | Ecological Economics1997，，3： | 2 |
| 9 | Developments in the throughput-income relationship: theoretical and empirical observations显示文摘 | S.M. de Bruyn J.B. Opschoor | 1997 | Ecological Economics1997，，3： | 2 |
| 10 | Comparison of exercise electrocardiography and dobutamine echocardiography with invasively assessed myocardial fractional flow reserve in evaluation of severity of coronary arterial narrowing显示文摘 | Bartunek J Van Schuerbeeck E De Bruyne B | | Am J Cardiol0，1，： | 2 |
| 11 | Fractional Flow Reserve Versus Angiography for Guiding Percutaneous Coronary Intervention in Patients With Multivessel Coronary Artery Disease显示文摘 | Nico H.J. Pijls William F. Fearon Pim A.L. Tonino Uwe Siebert Fumiaki Ikeno Bernhard Bornschein Marcel van't Veer Volker Klauss Ganesh Manoharan Thomas Engstr?m Keith G. Oldroyd Peter N. Ver Lee Philip A. MacCarthy Bernard De Bruyne | 2010 | Journal of the American College of Cardiology2010，，3： | 2 |
| 12 | In vitro anticomplementary activity of constituents from Morinda moorindoides 显示文摘 | Cimanga K De Bruyne T Lasure A | 1995 | J Nat Prod1995，58，3： | 1 |
| 13 | Flavonoid glu-curonides from Picria fel-tarrae显示文摘 | DE BRUYNE TESS APERS SANDRA | 1999 | Phytochemistry1999，52，8： | 1 |
| 14 | Microsatellite loci in the eastern form of the giant freshwater prawn ( Macrobrachium rosenbergii) 显示文摘 | Chand V de Bruyn M Mather P B | 2005 | Mol Ecol Res2005，，5： | 1 |
| 15 | Assessment of renal artery stenosis severity by pressure gradient measure- ments显示文摘 | Bruyne DB Manoharan G Pijls NH | 2006 | J Am Coil Cardiol2006，48，9： | 1 |
| 16 | Human brain activity related to speed discrimination tasks显示文摘 | Orban GA Dupont P De Bruyn B | 1998 | Exp Brain Res1998，122，1： | 1 |
| 17 | Explaining the Environmental Kuznets Curve: Structural Change and International Agreements in Reduc- ing Sulfur Emissions 显示文摘 | De Bruyn S M | 1997 | Environment and Development Eco- nomics1997，2，4： | 1 |
| 18 | Spring: A general framework for collaborative, real-time surgical simulation 显示文摘 | Montgomery K Bruyns C Brown J | 2002 | Studies in health technology and informatics2002，85，： | 1 |
| 19 | Feasibility of Robotic Laparoscopic Surgery: 146 Cases显示文摘 | Guy-Bernard Cadière M.D. Ph.D. Jacques Himpens M.D. Olivier Germay Rachel Izizaw Michel Degueldre M.D. Jean Vandromme M.D. Elie Capelluto M.D. Jean Bruyns M.D | 2001 | World Journal of Surgery2001，，11： | 1 |
| 20 | Explaining the Environmental Kuznets Curve: Structural Change and International Agreements in Reducing Sulphur Emissions显示文摘 | De Bruyn S M | 1997 | Environment and Development Economics1997，20，3： | 1 |
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